• 대한치과교정학회지
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• 제49권4호
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• pp.265-276
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• 2019

Patients with obstructive sleep apnea (OSA) whose phenotype belongs to a craniofacial vulnerability are referred from sleep doctors to orthodontists. In adults, for osseo-pharyngeal reconstruction (OPR) treatment, permanent maxillomandibular advancement (MMA) surgery and use of a temporary mandibular advancement device (MAD) are applied. This case report demonstrates successful treatment of OSA through application of phased MAD and MMA in a 16-year-old male with craniofacial deformity and residual growth potential. This patient showed skeletal and dentoalveolar changes after 7-year MAD use throughout post-adolescence, which affected the design and timing of subsequent MMA surgery, as well as post-surgical orthodontic strategy. This case report suggests that OPR treatment can be useful for treatment of OSA in post-adolescent patients, from an orthodontic point of view, in close collaboration with sleep doctors for interdisciplinary diagnosis and treatment.

• Journal of Periodontal and Implant Science
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• 제25권3호
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• pp.648-658
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• 1995

The present study has been performed to evaluate the clinical, microbiological, biochemical and immunological parameters associated with the periodontal disease activity in adolescent periodontitis. 21 young adolescents with evidences of periodontal attachment loss participated in the study for upto 3 years of examination. Probing pocket depths and attachment levels of whole dentitions were annually recorded and 4 deepest pockets, with initial probing depth ${\geq}$ 4mm, were selected as the representative experimental sites of a patient. Sites experiencing attachment loss ${\geq}$ 1mm during the 3-year experimental period were designated as the active sites and these sites were examined for the microbiological and biochemical profiles at the time when attachment loss occurred. Microbiological assay included cultural studies and PerioScan for monitoring BANA(+) organisms(e.g. Porphyromonas gingivalis, Treponema denticola, Bacteriodes forsythus). Biochemical assay has been performed for monitoring GCF levels of neutral protease. Serum IgG and IgG2 titers against Porphyromonas gingivalis 381 were determined of a patients at the beginning and the end of the study, respectively for patient-based analysis. The results indicated that the parameters consisting of microbiological cultures and GCF neutral protease exhibited low association with the periodontal disease activity in adolescents. However, the specificity for microbiological culture of the selected periodontopathic organisms(Aa,Pg,Pi) were considerably high. Moreover, the clinical pameters such as bleeding on probing and presence of plaque as well as IgG levels against Pg at the baseline exminations were closely associated with the subsequent evidences of attachment loss during the whole experimental period(3-year).

• 대한정형외과학회지
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• 제55권4호
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• pp.354-358
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• 2020

수지상 지방종은 관절에 부종과 통증을 일으키는 매우 드문 질환이다. 수지상 지방종은 주로 편측 슬관절에 나타나고 양측으로 나타나는 경우는 극히 드물다. 또한 성인에 더 많이 나타나며 청소년기에는 극히 드문 것으로 알려져있다. 저자들은 양측 슬관절에 부종과 통증을 주소로 내원한 14세 환아에서 수지상 지방종을 경험을 하였고 이에 대한 진단과 치료에 대해 보고하고자 한다.

• Journal of Genetic Medicine
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• 제21권1호
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• pp.31-35
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• 2024

Allan-Herndon-Dudley syndrome (AHDS) is a rare X-linked neurodevelopmental disorder with abnormal thyroid function caused by mutation in the solute carrier family 16 member 2 (SLC16A2) gene. Clinical manifestations of AHDS are global or axial hypotonia, a variety of movement disorders, severe intellectual disability, quadriplegia or spastic diplegia, growth failure, and seizures. A 10-year-old boy visited our hospital with the chief complaint of newly onset generalized tonic seizures with vocalization of weekly to daily frequency. He showed early infantile hypotonia, severe intellectual disability, and frequent respiratory infections. He could not walk independently and was non-verbal. Electroencephalogram revealed generalized slow spike and waves with multifocal spikes and slow background rhythms. His tonic seizures were controlled with more than two anti-seizure medications (ASMs). At 11 years of age, he was evaluated for thyroid function as part of regular screening for ASM maintenance and was found to have abnormal thyroid function. We performed whole exome sequencing for severe global developmental delay, drug-resistant epilepsy, and abnormal thyroid function. The hemizygous c.940C>T (p.Arg314Ter) variant in the SLC16A2 gene (NM_006517.5) was identified and confirmed based on Sanger sequencing. Herein, we describe a case of an AHDS patient with late-onset drug-resistant epilepsy combined with congenital hypotonia, global developmental delay, and abnormal thyroid function results. To the best of our knowledge, this is the oldest adolescent among AHDS cases reported in Korea. In this report, clinical characteristics of a mid-adolescence patient with AHDS were presented.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제26권2호
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• pp.86-93
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• 2015

Autism spectrum disorder (ASD) is a neurodevelopmental disorder marked by impaired social communication and repetitive, restricted behaviors and activities. The prevalence of ASD has been increasing for the past 2 decades, but evidence-based therapeutic approaches are lacking for patients with ASD. To date, there is no cure for the core symptoms of ASD, and the existing treatments focus on improving the patient's function and adaptation by using behavioral intervention methods. Behavioral interventions have been proven to show the greatest effect when applied before the age of 2 years, for at least 40-60 hours per week. Many clinicians and ASD families are unfamiliar with the treatment methods, and consequently, may seek unproven and potentially hazardous methods. The purpose of this article was to present an extensive and updated review on evidence-based ASD behavioral interventions that are commonly used in clinical settings.

• 대한치과교정학회지
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• 제32권2호통권91호
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• pp.71-78
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• 2002

보편적인 교정치료의 적기로 알려진 청소년기가 지나 성인 연령이 되어서야 교정치료를 목적으로 내원한 성인교정환자의 정신-심리학적 특성을 파악하기 위하여, 성인 312명, 청소년 765명, 총 1077명을 대상으로 두 가지 종류의 내외통제소재(locus of control) 척도를 측정한 후 연령군, 성별, 술자(교정의)에 의한 환자 협조도 평가, 진료보조원(치과위생사)에 의한 협조도 평가에 따라 분류한 후, 각각의 내외통제소재의 특성을 비교 분석하였다. 연구 결과 교정 환자들은 일반인에 비해 내적통제 경향을 보였으며, 성인은 청소년군에 비해 내적통제 경향을 보였고, 성인과 달리 청소년군은 여자가 남자보다 오히려 더 높은 내적통제 경향을 나타내었다. 협조적으로 분류된 성인환자는 외적통제 경향을 지닌 쪽이었지만, 청소년 환자는 내적통제 경향을 지닌 환자가 협조적인 환자로 분류되었다. 진료보조원은 술자에 비해 성인군에 대하여 더 호감을 보였으며, 전체적으로는 술자 측 분류에 비해 협조 불량군의 빈도가 높았다. 이러한 결과를 토대로 교정치료시에 반드시 필요한 환자측의 치료협조도를 미리 예측 가능하게 하기 위한 방편으로 내외통제소재척도와 같은 정신-심리학적 검사가 진단 자료의 일부로써 유용성을 지닐 수 있는 것으로 생각되었다.

• Journal of Acupuncture Research
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• 제33권4호
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• pp.7-14
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• 2016

Objectives : This study was performed to investigate the correlation between Cobb's angle and digital infrared thermographic imaging(DITI) on adolescent idiopathic scoliosis. Methods : A total of 56 patients with adolescent idiopathic scoliosis were classified into four groups according to their Cobb's angle. Four groups were made for each increment of $5^{\circ}$: group $5-10^{\circ}$, group $11-15^{\circ}$, group $16-20^{\circ}$, and group $21-25^{\circ}$. Next we checked thermal differences of 6 acupoints(GB21, BL13, BL15, BL20, BL23, BL26) on DITI and analyzed correlation by SPSS ver. 20.0.0 for windows. Results : 1. The average patient age was approximately 13 years old. 2. The majority of patients complained of pain on both sides. 3. Significant correlation was found between group $11-15^{\circ}$ and group $16-20^{\circ}$, group $16-20^{\circ}$ and group $21-25^{\circ}$ on Simsu(BL15) by Duncan test. Conclusion : Using DITI, Simsu(BL15) is expected to be a valid indicator for the diagnosis and treatment of adolescent idiopathic scoliosis.

• Tuberculosis and Respiratory Diseases
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• 제80권2호
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• pp.113-135
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• 2017

Asthma is traditionally regarded as a chronic airway disease, and recent literature proves its heterogeneity, based on distinctive clusters or phenotypes of asthma. In defining such asthma clusters, the nature of comorbidity among patients with asthma is poorly understood, by assuming no causal relationship between asthma and other comorbid conditions, including both communicable and noncommunicable diseases. However, emerging evidence suggests that the status of asthma significantly affects the increased susceptibility of the patient to both communicable and noncommunicable diseases. Specifically, the impact of asthma on susceptibility to noncommunicable diseases such as chronic systemic inflammatory diseases (e.g., rheumatoid arthritis), may provide an important insight into asthma as a disease with systemic inflammatory features, a conceptual understanding between asthma and asthma-related comorbidity, and the potential implications on the therapeutic and preventive interventions for patients with asthma. This review discusses the currently under-recognized clinical and immunological phenotypes of asthma; specifically, a higher risk of developing a systemic inflammatory disease such as rheumatoid arthritis and their implications, on the conceptual understanding and management of asthma. Our discussion is divided into three parts: literature summary on the relationship between asthma and the risk of rheumatoid arthritis; potential mechanisms underlying the association; and implications on asthma management and research.

• Clinical and Experimental Pediatrics
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• 제52권9호
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• pp.1038-1043
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• 2009

Fitz-Hugh-Curtis syndrome (FHCS)은 골반 내 염증과 동반된 간조직 주위염으로, 담도계 질환과 혼돈되는 우측 상복부 통증이 특징이다. 최근 한국에서도 청소년의 성적 접촉 시작 연령이 빨라짐에 따라 이와 같은 증후군의 발생률 또한 증가할 것으로 예측된다. 저자들은 역동적 복부 전산화 단층 촬영을 이용하여 동맥기의 비정상적인 간주위 피막의 조영 증강 양상으로 진단한 Fitz-Hugh-Curtis Syndrome 2례를 보고하고자 한다.

• 대한치과의사협회지
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• 제51권8호
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• pp.442-450
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• 2013

It is well known that the majority of dental injuries occur in children and adolescent. An injury to the teeth can have serious and long-term consequences, leading to their discoloration, malformation, or possible loss. The emotional impact of such an injury can be far reaching. The majority of dental injuries in the primary and permanent dentitions involve the anterior teeth, especially the maxillary central incisors. Concussion, subluxation, and luxation are the commonest injuries in the primary dentition, while uncomplicated crown fractures are commonest in the permanent dentition. If it is decided to preserve a traumatized primary tooth, it should be carefully observed for clinical and radiographic signs of pulpal or periodontal complications. Radiographs are also examined closely to disclose any damage to the permanent successor. The intervals between reexaminations should be individualized depending on the severity of trauma, the expected type of complications and the age of the patient. Most complications are observed within the first year of the trauma. However, the follow-up evaluation of permanent teeth should continue until treatment of all complications is completed, or until a lost or extracted permanent tooth has been adequately replaced. It is important that the dentist and the other members of the dental team are well prepared to meet the many complex and challenging problems in the care of dental emergencies.