• The Journal of Internal Korean Medicine
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• v.27 no.1
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• pp.221-227
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• 2006

Kyumsuyukgun-jun has been used for the chronic bronchitis, asthma and other illnesses. This study was carried out for the purpose of determining what effect KS has against allergic inflammatory reaction. The results obtained was that KS had inhibitory effects of following administration routes on PCA in rats. According to the above results, KS is beneficial against allergic inflammatory reaction through inhibition of PCA.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1997.04a
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• pp.3-5
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• 1997

Properties of a good drug include safety, efficacy, half-life and bioavailability. With the current approach to drug discovery based on receptor-based and cell-based screening methods, compounds are frequently moved into development with poor bioavailability. With low bioavailability, drug administration is typically limited to parenteral routes, thus limiting the potential wide-spread utility of these therapeutic agents. The first and most important factor limiting a drug's bioavailability is the intestinal membrane permeability which in turn determines the maximum fi:action of the dose administered that can be absorbed. We have recently utilized new intubation methods for performing permeability measurements in humans and establishing a fundamental human data base for correlating intestinal jejunal membrane permeabilities with permeabilities determined in other systems, e.g., animals, tissue culture, as well as physical chemical properties.

• Journal of Korean Institute of Industrial Engineers
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• v.30 no.4
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• pp.328-337
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• 2004

Tool costs can comprise a significant part of the total operating costs of Flexible Manufacturing Systems. We address the problem of determining the optimal processing times of individual operations and routing mix in FMSs with multiple routes for each part type in order to minimize tool cost, subject to meeting a throughput constraint for each part type. The problem is formulated as a nonlinear program superimposed on a closed queueing network of the FMSs under consideration. Numerical examples reveal the potential of our approach for significant saving in tool costs.

• Proceedings of the KSRS Conference
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• v.1
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• pp.47-50
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• 2006

Tsunami disaster caused great damages and very large victims especially when occurs in urban area along coastal region. Therefore information of evacuation in a map is very important for disaster preparedness in order to minimize the number of victims in affected area. Here, information generated from remote sensing satellite data (SPOT 5 and DEM) and secondary data (administration boundary and field survey data) are used to simulate evacuation route and to produce a map for Padang City. Vulnerability and evacuation areas are determined based on DEM. Landuse/landcover, accessibility areas, infrastructure and landmark are extracted from SPOT 5 data. All the data obtained from remote sensing and secondary data are integrated using geospatial modelling to determine evacuation routes. Finally the simulation of evacuation route in Padang City for tsunami preparedness is provided based on the parameters derived from remote sensing data such as distances from shelters, save zones, city's landmarks and the local community experiences how they can survive with the disaster.

• Journal of Korean Neurosurgical Society
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• v.39 no.2
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• pp.141-143
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• 2006

Vancomycin-resistant enterococci[VRE] are rare cause of meningitis, occurring in immunocompromised patients, severely ill, hospitalized patient, and patients who have undergone neurosurgical procedures. Resistance to vancomycin has increased in frequency during the past few years. Limited therapeutic options are available for VRE infectionsandtheoptimumtherapy has not been established. We report a case of VRE meningitis that was successfully treated with administration of quinupristin-dalfopristin [Synercid] by both intravenous and intraventricular routes. A brief review of the literature is provided, which indicates that optimal management with Synercid should include daily intraventricular doses of at least 2mg and intravenous 0.5mg/kg every 8 hours. We also review the previously reported cases of VRE meningitis.

• Journal of Pharmaceutical Investigation
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• v.38 no.6
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• pp.429-432
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• 2008

Drug delivery systems (DDS) have entered mainstream in the pharmaceutical industry in the recent years. Major pharmaceutical companies as well as small or medium-sized biotechnology companies are developing various DDS-based products. We have established Drug Delivery System Company Database, which is an online searchable database of companies that develop DDS-based products and technologies or supply formulations and/or materials. Company summary, products and key technologies are listed in the database. DDS technology fields also include administration routes and indications of drugs. DDS terminologies, Statistical analysis, Useful Links, Glossary and Comments pages are also provided.

• Archives of Pharmacal Research
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• v.8 no.2
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• pp.59-65
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• 1985

Besides (-) pimara-8(14), 15-dien-19-oic acid [I] which had already been isolated as an active anti-inflammtory principle of Aralia continentalis, (-) kaur-16-en-19-oic acid [II] was separated as another active component of the plant, by tracing albumin stabilizing activity. $IC_{50}$ of [II] for the protein stabilizing activity was 0.026mg/3ml, when those of [I] and phenylbutazone were 0.032 and 0.32 mg/3ml, respectively. Being investigated employing carrageenin-induced edema test in rat hind paw, the anti-inflammatory activity of [II] administered s. c. was slightly lower than that of phenylbutazone, whereas the activity of [II] administered p. p. was three times greater than that of phenylbutazone. These results of [II] were contrary to those of [I] in the aspect of administration routes.

• The Journal of the Korean dental association
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• v.47 no.11
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• pp.736-749
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• 2009

근래 환자의 불안을 조절하는 것이 성공적인 치료에 매우 중요하다는 인식이 확산되면서 의과, 치과, 영상의학과, 응급실 및 외래 수술센터 등에서 진정요법에 대한 필요가 현저하게 늘어났다. 응급상황이거나 아니거나 진정요법의 필요성은 점차 증가하고 있고 대한 소아치과학회는 이러한 진정요법에 대한 지침을 출간한 바 있다. 이번 개정은 진정요법에 필요한 적절한 환자감시(monitoring)의 필요에 관한 최신지견을 반영한 것이나 그럼에도 불구하고 이 지침에 충실하였다고 해서 특정환자의 결과를 보장하지는 못한다. 그러 나 이번에 소개하는 진정요법 protocol은 널리 받아들여지는 것으로 부작용 역시 최소화한 것이다. 소아 환자의 진정요법은 원하는 수준의 진정이나 투여 방법과는 상관없이 호흡기능 저하와 환자의 방어 반응이 소실될 수도 있다는 인식하에 작성되었다. 이번 호에서는 최근 2006년에 미국소아과학회와 미국소아치과학회가 공동으로 개정된 지침(Guideline for Monitoring and Management of Pediatric Patients During and After Sedation for Diagnostic and Therapeutic Procedures developed and endorsed by AAP a and AAPD)이 어떻게 변경되는지에 중점적으로 알아보며 새로 변경된 지침에 따라 소아치과의의 진정요 법의 진료와 교육도 영향을 미칠 것이다. 이러한 영향으로 다양한 약 투여방법(Alternative routes of d drug administration)과 다양한 약물의 선택에 대해 알아 보기로 한다.

• Journal of Intelligence and Information Systems
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• v.6 no.1
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• pp.113-128
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• 2000

This paper presents a first year report of an ongoing multi-year project to develop a systolic parallel simulation system for dynamic traffic assignment. The fundamental approach to the simulation is systolic parallel processing based on autonomous agent modeling. Agents continuously act on their own initiatives and access to database to get the status of the simulation world. Various agents are defined in order to populate the simulation world. In particular existing modls and algorithm were incorporated in designing the behavior of relevant agents such as car-following model headway distribution Frank-Wolf algorithm and so on. Simulation is based on predetermined routes between centroids that are computed off-line by a conventional optimal path-finding algorithm. Iterating the cycles of optimization-then-simulation the proposed system will provide a realistic and valuable traffic assignment. Gangnum-Gu district in Seoul is selected for the target are for the modeling. It is expected that realtime traffic assignment services can be provided on the internet within 3 years.

• Archives of Pharmacal Research
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• v.24 no.6
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• pp.541-545
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• 2001

The evaluation of the anti-inflammatory analgesic and antipyretic activities of loxoprofen sodium given in intramuscular route was investigated as compared to oral application in rats and mice. The intramuscular $ED_{50}$ values of loxoprofen sodium in carrageenan edema and vascular permeability tests are 1.15 and 7.8 mg/kg, respectively, which represent more potent than in case of oral application. Its therapeutic effects in adjuvant arthritis were shown at 6 mg/kg l.m. and 3mg/kg p.o. Analgesic effect was shown to be more potent as given intramuscularly. Similar potency of antipyretic effects was shown in both administration routes. Considerably weak gastric damages were observed in intramuscular application.