Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Anti-inflammatory, Analgesic and Antipyretic Activities of Loxoprofen Sodium Given Intramuscularly in Animals

  • Hyun, Jin-Ee (National Products Research Institute, Seoul National University) ;
  • Li, Da-Wei (National Products Research Institute, Seoul National University) ;
  • Lee, Eun-Bang (National Products Research Institute, Seoul National University) ;
  • Jeong, Choon-Sik (College of Pharmacy, Duksung Women′s University)
  • Published : 2001.12.01
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Abstract

The evaluation of the anti-inflammatory analgesic and antipyretic activities of loxoprofen sodium given in intramuscular route was investigated as compared to oral application in rats and mice. The intramuscular $ED_{50}$ values of loxoprofen sodium in carrageenan edema and vascular permeability tests are 1.15 and 7.8 mg/kg, respectively, which represent more potent than in case of oral application. Its therapeutic effects in adjuvant arthritis were shown at 6 mg/kg l.m. and 3mg/kg p.o. Analgesic effect was shown to be more potent as given intramuscularly. Similar potency of antipyretic effects was shown in both administration routes. Considerably weak gastric damages were observed in intramuscular application.

Keywords

References

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