• Journal of the Korean Institute of Rural Architecture
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• v.21 no.4
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• pp.53-60
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• 2019

The purpose of this study is to investigate the change of Hidden gates form with the times. Fortresses position is constructed on the Korea mountain ranges. Hidden gate, one of facilities to construct fortress among various factors, represents as route of supplies way, ask for rescue, or counterattack plan to come in. The shape of hidden gate changes depend on land form, function, and time period. Previous research partially based on archeology or history. This research analyze Namhan mountain Namhansansung, one of the highest hidden gates count in Korea, distributive by main fortress, Bong-am fortress, Hanbong fortress. Nahhan Mountain fortress repeatedly affected by King Injo in Joseon Dynasty. As a result, Nahhan Mountain fortress consist of hidden gates alternation depend on the time of establishment or extension which makes different shape or size.

• Korean Journal of Clinical Pharmacy
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• v.3 no.2
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• pp.163-168
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• 1993

The influence of cimetidine pretreatment(100mg/kg, single i.p.) on the hepatic blood flow was investigated using pharmacokinetic parameters of indocyanine green(ICG) in the rat on the basis of hepacc perfusion-limited model. ICG(1mg/kg) was respectively administered via femoral and portal vein to the control and to the cimetidine-pretreated rats. The rate constant K12, K20 and the systemic clearance(CLt) of ICG were significantly(p<0.05) decreased ill the cimetidine-pretrea-to(B rats, but no significant diffirences were observed in hematocrit and liver weight. The biliary excretion rates of ICG were also decreased regardless of the route of administration in the cimetidine-pretreated rats. And also the hepatic blood flow in rats was decreased about $16\%$ by cimetidine. It may be concluded that the decreased hepatic blood flow with cimetidine mainly contributed to the decreased hepatic uptake and the decreased systemic clearance of ICG.

• Archives of Pharmacal Research
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• v.20 no.1
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• pp.24-28
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• 1997

In the present study, a pharmacokinetic model to address the effects of the diffusional barrier between splanchnic bed and enterocytes on the extent of presystemic and systemic intestinal elimination of drugs was developed. The model is composed of five compartments, ie., gut lumen, enterocyte, splanchnic bed, liver and central compartments. The equations for various pharmacokinetic parameters important for estimating the quantitative differences between presystemic and systemic intestinal and hepatic elimination of drugs were derived. A simulation study demonstrated that the diffusions[ barrier present between splanchnic blood and enterocytes can have significant effects on oral bioavailability and systemic clearance of drugs. In conclusion, the model can be useful for a better understanding of the effects of diffusional barrier on the extent of administration-route dependent intestinal and hepatic elimination of drugs, especially those with high hydrophilicity and/or charge(s) under physiological conditions.

• Microbiology and Biotechnology Letters
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• v.21 no.3
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• pp.247-255
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• 1993

Antitumor activity of Lactobacillus casei YIP 9018(LC9018) was studied in mice by using sarcoma 180(S-180) and Lewis lung carcinoma (3LL). Following the eatablishment of in vivo tumor models such as ascites form S-180, solid form S-180 and 3LL for estimating antitumor activity of Lactobacilli, optimal dose and injection route of heat-killed LC9018 for supperssion of local tumor were examined. Administration of 100ng/mouse of LC9018 significantly inhibited the growth of ascites form S-180, solid form S-180 and 3LL.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2001.10a
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• pp.121-124
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• 2001

Dynamic Source Route(DSR) protocol is a simple and efficient routing protocol designed specially for use of the multi-hop Ad Hoc Network. DSR allows the network to be completely self-organized and self-configured without the need for any existing infrastructure or administration. DSR protocol consists of the two mechanisms of Router discovery and Router Maintenance, works entirely On-demand in all aspects. In this paper, we will present the performance of DSR protocol on the multi-hop wireless Ad Hoc Networks, illustrate it with simulation, and then analysis the algorism of DSR.

• Journal of Korean Society of Rural Planning
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• v.15 no.3
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• pp.33-45
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• 2009

This study tried to establish a tentative renewal guideline on spatial structure of the Hub-myun's center villages which would be positioned as sub-centers in the rural settlement hierarchy in Korea. Space Syntax Method was used to analyze the locational characteristics of community facilities in the center villages of 8 pilot project areas which were selected in the nationwide scale. The base-maps for spatial analysis works were prepared firstly from satellite pictures and adjusted through field check. Generally, connectivity and global integration values of center villages were calculated as higher than hinterland villages, which would mean better accessible spatial characteristics in the center villages. And a tentative renewal guideline was proposed for road route improvement and relocation of community facilities in the Hub-myun's center villages.

• Archives of Pharmacal Research
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• v.24 no.6
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• pp.541-545
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• 2001

The evaluation of the anti-inflammatory analgesic and antipyretic activities of loxoprofen sodium given in intramuscular route was investigated as compared to oral application in rats and mice. The intramuscular $ED_{50}$ values of loxoprofen sodium in carrageenan edema and vascular permeability tests are 1.15 and 7.8 mg/kg, respectively, which represent more potent than in case of oral application. Its therapeutic effects in adjuvant arthritis were shown at 6 mg/kg l.m. and 3mg/kg p.o. Analgesic effect was shown to be more potent as given intramuscularly. Similar potency of antipyretic effects was shown in both administration routes. Considerably weak gastric damages were observed in intramuscular application.

• Proceedings of the Korea Information Processing Society Conference
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• 2004.05a
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• pp.1433-1436
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• 2004

The ad hoc network is a collection of wireless mobile nodes dynamically forming a temporary network without the use of any existing network infrastructure of centralized administration. Load-Balanced Ad hoc Routing(LBAR) protocol is an on-demand routing protocol intended for delay-sensitive applications where users are most concern with packet transmission delay. Although LBAR mechanism is a novel load balancing routing protocol for ad hoc network, it has own limitation in route path maintenance phase. Therefore, in this paper, we propose Advanced Load-Balanced Ad hoc Routing(A-LBAR) that is delay-sensitive and has an efficient path maintenance scheme. The robust path maintenance scheme is maintained by considering about nodal loads all over network and misbehavior of overloaded or selfish nodes. The proposed scheme provides good performance over DSR and AODV in terms of packet delay and packet loss rate when some misbehaving nodes exist in the network.

• Proceedings of the Korea Information Processing Society Conference
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• 2004.05a
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• pp.1529-1532
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• 2004

A Mobile Ad Hoc NETwork (MANET) is a collection of wireless mobile nodes that forms a temporary network without the need for any existing network infrastructure or centralized administration. Therefore, such a network is designed to operate in a highly dynamic environment due to node mobility. In mobile ad hoc network, frequent topological changes cause routing a challenging problem and without the complete view of the network topology, establishing the shortest path from the source node to the destination node is difficult. In this paper, we suggest a routing approach which utilizes location information to setup the shortest possible path between the source node and the destination node. Location information is obtained through Global Positioning System (GPS) and this geographical coordinate information of the destination node is used by the source node and intermediate nodes receiving route request messages to determine the shortest path to the destination from current node.

• Biomolecules & Therapeutics
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• v.31 no.1
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• pp.16-26
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• 2023

Diabetes is an untreatable metabolic disorder characterized by alteration in blood sugar homeostasis, with submucosal insulin therapy being the primary treatment option. This route of drug administration is attributed to low patient comfort due to the risk of pain, distress, and local inflammation/infections. Nanoparticles have indeed been suggested as insulin carriers to allow the drug to be administered via less invasive routes other than injection, such as orally or nasally. The organic-based nanoparticles can be derived from various organic materials (for instance, polysaccharides, lipids, and so on) and thus are prevalently used to enhance the physical and chemical consistency of loaded bioactive compounds (drug) and thus their bioavailability. This review presents various forms of organic nanoparticles (for example, chitosan, dextron, gums, nanoemulsion, alginate, and so on) for enhanced hypoglycemic drug delivery relative to traditional therapies.