• 제목/요약/키워드: Administration Research

검색결과 14,007건 처리시간 0.038초

Assessment of autoimmunogenic potential of autoimmune disease inducing chmecals using the popliteal lymph node assay

  • Kim, Hyung-Soo;Juno H. Eom;Kim, Jin-Ho;Chung, Seung-Tae;Park, Jae-Hyun;Kang, Sun-Kyung;Kim, Dong-Sub
    • 한국독성학회:학술대회논문집
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    • 한국독성학회 2001년도 International Symposium on Signal transduction in Toxicology
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    • pp.113-113
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    • 2001
  • The popliteal lymph node assay (PLNA) was proposed to predict autoimmunogenic potential of xenobiotics. This study was conducted to establish the popliteal lymph node assay(PLNA) and to investigate the measurement of lymphocyte subsets can be utilized as an additional parameter in PLNA.(omitted)

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15-DEOXY-$\Delta^{12,14}$-PROSTAGLANDIN $J_2$, A LIGAND FOR EROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-$\gamma$ INDUCES APOPTOSIS IN NEUROBLASTOMA CELLS

  • Kim, Eun-Joung;Jung, Kyoung-Mi;Park, Ki-Sook;Oh, Jae-Ho;Song, Chi-Won;Chung, Soo-Youn;Hong, Jin-Tae
    • 한국독성학회:학술대회논문집
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    • 한국독성학회 2001년도 International Symposium on Signal transduction in Toxicology
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    • pp.167-167
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    • 2001
  • Peroxisome proliferator-activated receptors(PPARs) are member of the neuclear hormone receptor superfamiliy of ligand-dependent transcription factors that heterodimerizes with the retinoid X receptor to function as a transcriptional regulator. They are divided into three subtypes(PPAR-$\alpha$, $\beta$ and ${\gamma}$).(omitted)

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Genotoxicity Studies of Chrysin

  • Jee, Seung-Wan;Kang, Ho-Il;Park, Mi-Sun;Eom, Mi-Ok;Ryoeom, Tai-Kyung;Kim, Chang-Hwan;Kim, Ok-Hee
    • 한국환경성돌연변이발암원학회:학술대회논문집
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    • 한국환경성돌연변이발암원학회 2004년도 KSOT/KEMS Fall Annual Meeting
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    • pp.112-112
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    • 2004
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INVESTIGATION OF IN VITRO AND IN VIVO ESTROGENIC OR ANTIESTROGENIC ACTIVITY OF CYPERMETHRIN

  • Kim, Soon-Sun;Rhee, Gyu-Seek;Kwack, Seung-Jun;Sohn, Kyung-Hee;Kim, So-Hee;Lee, Rhee-Da;An, Sang-Mi;Ki-Eun. Jeong;Sheen, Yhun-Yhong
    • 한국독성학회:학술대회논문집
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    • 한국독성학회 2002년도 Molecular and Cellular Response to Toxic Substances
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    • pp.166-166
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    • 2002
  • In the present study, estrogenic or antiestrogenic activity of cypermethrin, a pyrethroid insecticide was investigated. We used immature rat uterotrophic assay, estrogen-responsive calbindin-D9k (CaBP-9k) gene expression assay and luciferase reporter gene assay for measure of estrogenic potential of cypermethrin.(omitted)

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Levels of 14-Polycyclic Aromatic Hydrocarbons in Meat Products

  • Lee, Hyomin;Eunkyung Yoon;Lee, Gunyoung;Kim, Hyeonjeong;Park, Kyungah;Kim, Yunhee;Jisun Yang
    • 한국독성학회:학술대회논문집
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    • 한국독성학회 2003년도 추계학술대회
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    • pp.196-196
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    • 2003
  • Food is a significant source of polycyclic aromatic hydrocarbons (PAHs) to which humans are exposed. In this study, we are analysed 14 PAHs in baked and smoked meats known as major source of PAHs, and defined a correlation between benzo(a)pyrene and pyrene to compare estimating risk from human exposure to PAHs with urinary1-hydroxypyrene.(omitted)

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Adenovirus-Mediated Gene Delivery of Tissue Inhibitor of Metalloproteinase-1 Inhibits Migration of B16F10 Melanoma Cell in Wound Migration Assay

  • Seungwan Jee;Hoil Kang;Park, Sehgeun;Park, Misun;Miok Eom;Taikyung Ryeom;Kim, Okhee
    • 한국독성학회:학술대회논문집
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    • 한국독성학회 2003년도 추계학술대회
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    • pp.177-177
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    • 2003
  • Tumor cell invasion and metastasis are a complex multistep process that involves the degradation of extracellular matrix proteins by matrix metalloproteinases (MMPs). Tissue inhibitor of metalloproteinase-1 (TIMP-1) acts as a negative regulator of matrix metalloproteinase and thus prevents tumor cell invasion and metastasis by preserving extracellular matrix integrity.(omitted)

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