• Title/Summary/Keyword: Administration Research

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Comparison of the effects of two different styles of orally prescribing prednisolone on postoperative sequelae of surgical extraction of an impacted mandibular third molar: a single-blind randomized study

  • Mohammed Mousa H. Bakri;Faisal Hussain Alabdali;Rashed Hussain Mahzari;Thamer Jabril Rajhi;Norah Mohammed Gohal;Rehab Abdu Sufyani;Asma Ali Hezam;Ahtesham Ahmed Qurishi;Hamed Mousa Bakri;Fareedi Mukram Ali
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.50 no.1
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    • pp.27-34
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    • 2024
  • Objectives: Surgical intervention for removal of an impacted third molar can lead to significant pain and swelling. Corticosteroids show promise for mitigating postoperative sequelae across various surgical contexts. The use of corticosteroids following minor oral surgery, though controversial, has already been proven effective. However, little research has explored peroral prescription of corticosteroids despite its convenience for outpatients and for non-surgeons like implantologists and periodontists and others who don't have access to needle injections. The aim of this study was to address a void in the literature by comparing the effects of two styles of preoral administration of prednisolone after surgical removal of the mandibular third molar and to determine which style minimizes postoperative sequelae. Materials and Methods: A randomized, split-mouth clinical study was conducted to investigate the efficacy of two different styles of preoral prednisolone in mitigating postoperative sequelae following surgical extraction of impacted mandibular third molars. Fifteen participants were enrolled in the study. Random selection was used to determine the prescription style for the right and left mandibular arch. Group A included those who received a single dose of prednisolone 25 mg, while group B received prednisolone 5 mg postoperatively for a period of three days (5 mg three times/day on the first postoperative day, 5 mg twice/day on the second postoperative day; 5 mg once/day on the third postoperative day). Results: There was a significant difference in the distance between the corner of the mouth and tragus, which decreased with the time interval with respect to group B when compared to group A. Conclusion: The present study showed that a three-day tapered dose of prednisolone postoperatively was more effective in reducing post-extraction sequelae than a single-dose regimen.

Analysis of Optimal Index for Heat Morbidity (온열질환자 예측을 위한 최적의 지표 분석)

  • Sanghyuck Kim;Minju Song;Seokhwan Yun;Dongkun Lee
    • Journal of Environmental Impact Assessment
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    • v.33 no.1
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    • pp.9-17
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    • 2024
  • The purpose of this study is to select and predict optimal heatwave indices for describing and predicting heat-related illnesses. Regression analysis was conducted using Heat-related illness surveillance system data for a number of heat-related illnesses and meteorological data from the Korea Meteorological Administration's Automatic Weather Station (AWS) for the period from 2021 to 2023. Daily average temperature, daily maximum temperature, daily average Wet Bulb Globe Temperature (WBGT), and daily maximum WBGT values were calculated and analyzed. The results indicated that among the four indicators, the daily maximum WBGT showed the highest suitability with an R2 value of 0.81 and RMSE of 0.98, with a threshold of 29.94 Celsius. During the entire analysis period, there were a total of 91 days exceeding this threshold, resulting in 339 cases of heat-related illnesses. Predictions of heat-related illness cases from 2021 to 2023 using the regression equation for daily maximum WBGT showed an accuracy with less than 10 cases of error annually, demonstrating a high level of precision. Through continuous research and refinement of data and analysis methods, it is anticipated that this approach could contribute to predicting and mitigating the impact of heatwaves.

Trends in behavioral management techniques for dental treatment of patients with autism spectrum disorder: a 10-year retrospective analysis

  • Gahee Son;Sohee Oh;Jaehee Lee;Saeromi Jun;Jongbin Kim;Jongsoo Kim;Joonhaeng Lee;Miran Han;Jisun Shin
    • Journal of Dental Anesthesia and Pain Medicine
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    • v.24 no.3
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    • pp.187-193
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    • 2024
  • Background: Patients with autism spectrum disorder (ASD) present challenges in dental treatment cooperation owing to deficits in communication skills and social interaction. Behavioral guidance, sedation, and general anesthesia may be employed to ensure the quality of dental care for individuals with ASD. This study aimed to examine the trends in dental treatment for patients with ASD who visited the Department of Pediatric Dentistry at Dankook University Jukjeon Dental Hospital, an oral health center for the disabled in the Gyeonggi region, over the past 10 years. Methods: This study utilized the order communication system to gather data on sex, age, cooperation level, number of quadrants treated, and administration of sedation or general anesthesia for patients with ASD who visited the Department of Pediatric Dentistry at Dankook University Jukjeon Dental Hospital between January 2013 and December 2022. Results: The total number of patients with ASD increased annually, possibly due to an increase in ASD prevalence and the hospital's designation as a center for disabled oral health. General anesthesia was predominant before 2017, with a shift towards N2O-O2 sedation. The most common age group for sedation or general anesthesia was 6-9 years, with a higher prevalence in males than in females. Notably, N2O-O2 and midazolam sedation resulted in better cooperation and fewer treated teeth than general anesthesia. Conclusion: This study highlights the evolving trends in dental treatment for individuals with ASD, indicating a shift towards outpatient methods, particularly N2O-O2 sedation. The sex distribution aligns with national statistics, emphasizing a higher prevalence of ASD in males than in females. These findings underscore the need for further research to establish evidence-based guidelines for optimal dental care strategies tailored to the unique needs of individuals with ASD.

Detection of Alternaria alternata Associated with Discolored Black Oat Seeds in Korea (귀리 종자흑변병에 관여하는 Alternaria alternata 검출 및 발생원인)

  • Ji-Min Choi;Ji-Hye Song;Joonseob Ahn;Dea-Wook Kim;Kwang-Yeol Yang
    • Research in Plant Disease
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    • v.29 no.4
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    • pp.414-419
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    • 2023
  • In 2023, a number of seeds suspected to be discolored black oat seeds on oat farms in Gangjin were observed and examined for fungal infection. The species Alternaria alternata was predominant, accounting for 84% of all fungal infections. The appearance and quality of seeds harvested in 2022 were compared with seeds harvested in 2023 from the same field. The lightness value was lower in the seeds harvested in 2023, while the electrical conductivity was higher in the seeds harvested in 2023. The content of avenanthramide was found to be 10 times higher in the 2023 seeds than in those harvested in 2022. The accumulated precipitation in Gangjin in May 2023 was 230 times higher than that in May 2022, and the average relative humidity was high. These conditions created an environment suitable for infection of A. alternata, which were thought to have caused discolored black oat seeds.

Stock Price Direction Prediction Using Convolutional Neural Network: Emphasis on Correlation Feature Selection (합성곱 신경망을 이용한 주가방향 예측: 상관관계 속성선택 방법을 중심으로)

  • Kyun Sun Eo;Kun Chang Lee
    • Information Systems Review
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    • v.22 no.4
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    • pp.21-39
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    • 2020
  • Recently, deep learning has shown high performance in various applications such as pattern analysis and image classification. Especially known as a difficult task in the field of machine learning research, stock market forecasting is an area where the effectiveness of deep learning techniques is being verified by many researchers. This study proposed a deep learning Convolutional Neural Network (CNN) model to predict the direction of stock prices. We then used the feature selection method to improve the performance of the model. We compared the performance of machine learning classifiers against CNN. The classifiers used in this study are as follows: Logistic Regression, Decision Tree, Neural Network, Support Vector Machine, Adaboost, Bagging, and Random Forest. The results of this study confirmed that the CNN showed higher performancecompared with other classifiers in the case of feature selection. The results show that the CNN model effectively predicted the stock price direction by analyzing the embedded values of the financial data

Investigating Key Security Factors in Smart Factory: Focusing on Priority Analysis Using AHP Method (스마트팩토리의 주요 보안요인 연구: AHP를 활용한 우선순위 분석을 중심으로)

  • Jin Hoh;Ae Ri Lee
    • Information Systems Review
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    • v.22 no.4
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    • pp.185-203
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    • 2020
  • With the advent of 4th industrial revolution, the manufacturing industry is converging with ICT and changing into the era of smart manufacturing. In the smart factory, all machines and facilities are connected based on ICT, and thus security should be further strengthened as it is exposed to complex security threats that were not previously recognized. To reduce the risk of security incidents and successfully implement smart factories, it is necessary to identify key security factors to be applied, taking into account the characteristics of the industrial environment of smart factories utilizing ICT. In this study, we propose a 'hierarchical classification model of security factors in smart factory' that includes terminal, network, platform/service categories and analyze the importance of security factors to be applied when developing smart factories. We conducted an assessment of importance of security factors to the groups of smart factories and security experts. In this study, the relative importance of security factors of smart factory was derived by using AHP technique, and the priority among the security factors is presented. Based on the results of this research, it contributes to building the smart factory more securely and establishing information security required in the era of smart manufacturing.

A Study on Extending of the Addressable Object of Address of Things (사물주소 부여대상 확대 방안 연구)

  • Yang, Sungchul
    • Journal of Cadastre & Land InformatiX
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    • v.54 no.1
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    • pp.75-87
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    • 2024
  • There There is a difference in terms of administrative power in that the address of things are not an address under Public Act. In terms of location expression, it is possible to express the location more flexibly and in more detail than the road name address, so it should be improved so that it can be assigned and managed in an appropriate location, so that the location of the entire territory can be expressed together with the road name address. As a result of the comparison between the road name address and the address of things based on the analysis results of related laws such as the existing Road Name Address Act, the Building Act, and the Regulations on the Preparation and Management of Basic Address Information, it was confirmed that there are fundamental limitations of the address of things system. Accordingly, this study attempted to suggest ways to improve the address of thing system by broadly dividing it into the legal aspect and the addressable object aspect. From the legal point of view, firstly, it is necessary to improve the upper and lower level laws by unification together with a clear definition of the term subject of addressable object; secondly, according to the Building Act, facilities that are not used for residence among buildings must be given an address of thing; and thirdly, it is necessary to make it easy to use and link with heterogeneous public data by classifying the registration items of the basic address information map by type of geographical feature to be assigned an address. From the point of view of addressability, firstly, it must be given to all facilities in the relevant category so that it can be recognised that all specific facilities have object addresses, and secondly, it is necessary to be able to address the address of things to places that are used by many, even if there are no facilities.

Protective Effect of Niclosamide on Lipopolysaccharide-induced Sepsis in Mice by Modulating STAT3 Pathway (니클로사마이드를 이용한 STAT3 신호전달 조절을 통해 LPS로 유발된 패혈증 동물모델 보호 효과 검증 연구)

  • Se Gwang JANG
    • Korean Journal of Clinical Laboratory Science
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    • v.55 no.4
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    • pp.306-313
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    • 2023
  • Sepsis is a systemic inflammatory response, with manifestations in multiple organs by pathogenic infection. Currently, there are no promising therapeutic strategies. Signal transducer and activator of transcription 3 (STAT3) is a cell signaling transcription factor. Niclosamide is an anti-helminthic drug approved by the Food and Drug Administration (FDA) as a potential STAT3 inhibitor. C57BL/6 mice were treated with an intraperitoneal injection of lipopolysaccharide (LPS). Niclosamide was administered orally 2 hours after the LPS injection. This study found that Niclosamide improved the survival and lung injury of LPS-induced mice. Niclosamide decreased the levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) in serum. The effects of Niclosamide on phosphoinositide 3-kinase (PI3K), AKT, nuclear factor-κB (NF-κB), and STAT3 signaling pathways were determined in the lung tissue by immunoblot analysis. Niclosamide reduced phosphorylation of PI3K, AKT, NF-κB, and STAT3 significantly. Furthermore, it reduced the phosphorylation of STAT3 by LPS stimulation in RAW 264.7 macrophages. Niclosamide also reduced the LPS-stimulated expression of proinflammatory mediators, including IL-6, TNF-α, and IL-1β. Niclosamide provides a new therapeutic strategy for murine sepsis models by suppressing the inflammatory response through STAT3 inhibition.

Effects of Patient Safety Motivation and Degree of Patient Safety on Patient Safety Management Activities of Geriatric Hospitals Nurses (노인 요양병원 간호사의 환자 안전동기와 환자안전도가 환자안전관리 활동에 미치는 영향)

  • Ju-Yul Lee;Soon-Ok Kim
    • Journal of the Korean Applied Science and Technology
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    • v.40 no.4
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    • pp.773-785
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    • 2023
  • This study is a descriptive research conducted to identify the factors influencing patient safety management activities of geriatric hospitals nurses and use basic data to prevent patient safety accidents. Subjects were 220 nurses and data were collected by questionnaires from february 1 to 28, 2023. Data were analyzed using t-test, ANOVA, Scheffe's test, Pearson correlation coefficients and Multiple regression analysis using the SPSS 29.0 program. Patient safety motivation was positive correlated with degree of patient safety(r=.41, p<.001), and degree of patient safety was positive correlated with patient safety nursing activity(r=.18, p<.01). Degree of patient safety(𝛽=.21, p<.001) and patient safety guidelines(𝛽=.16, p<.001) were main factors that affect patient safety nursing activity, and its explanatory power was 7.5%(Adj R2=.075, p<.001). For patient safety nursing activity, it is proposed to develop and apply a education program that strengthens practical training for effective coping after safety accidents along with risk prediction training to prevent before safety accidents.

The Relationship between Anonymity, Personal and Group Identities, and Discussion Quality in Online Discussion Communities (온라인 토론 커뮤니티에서의 익명성과 개인 및 집단 정체성, 토론의 질 간의 영향 연구)

  • Ae Ri Lee
    • Information Systems Review
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    • v.21 no.3
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    • pp.63-86
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    • 2019
  • As the use of ICT became a part of daily social life, online community has emerged as a new type of social organization. Online community is a virtual space which enables many people to participate and contribute together to collective knowledge. Anonymity in online communities can encourage active social participation by people with various social constraints, however, anonymity can also lead to serious social pathology. As a result, it is necessary to study on what is fundamentally influencing human behavior and how people's behavior is controlled in anonymous online community. This study focuses on human identity and investigate the factors affecting human behavior control in anonymous online environment by examining various aspects of identity in online discussion community. This study empirically verifies the causal relationship between factors, including social & technical anonymities, various identity dimensions, intrinsic motivation to participate in the community, group norm conformity, and quality of discussion. It also analyzes the difference between groups by the level of anonymity, gender, age, community usage period, and discussion topic. Based on the findings, this research provides theoretical and practical implications for online community management strategies and a better culture on Internet discussion.