• 대한의용생체공학회:의공학회지
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• 제40권1호
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• pp.15-19
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• 2019

In this study, Theta Gamma Coupling (TGC) analysis was carried out after performing simple and repeated upper limb exercise and comparative experiment to observe changes in the motor cortex of the brain through TGC and to see if mobile rehabilitation therapy is actually effective. As a result, exercise using mobile devices showed higher TGC values in motor cortex as compared with simple repeat upper limb exercise. In addition, paired t-test using SPSS showed statistically significant difference between exercise using mobile devices and simple repeat exercise at P3(t=3.390, df(degree of freedom)=12, p value=0.005). Exercise using mobile devices is effective for rehabilitation because it increases the Theta-Gamma Coupling and activates the motor cortex. Also, since the mobile game contents required the subject to detailed athletic ability adjustment with immersion in the task, it may be thought that brain activation is stronger than simple rehabilitation.

• 한국심리학회지ㆍ건강
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• 제16권3호
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• pp.483-500
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• 2011

의학 발전과 함께 소아암이 치료 가능한 질병이 되면서, 소아암 생존자 아동, 청소년의 장기적인 심리사회적인 적응과 관련된 문제가 주목을 받고 있다. 본 연구에서는 우리나라의 소아암 생존자 아동, 청소년의 삶의 질과 문제 행동 수준을 건강 통제 집단과 비교하고, 자녀의 심리적 적응 상태를 평가하는데 나타나는 부모와 자녀의 보고 불일치 양상이 소아암 경험 여부에 따라 차이가 나타나는가를 알아보았다. 소아암 생존자 집단과 건강 통제 집단의 아동, 청소년과 그들의 어머니가 연구에 참여하였다. PedQL의 아동 버전과 부모 버전을 이용하여 삶의 질을 측정하였고, K-CBCL과 K-YSR을 이용하여 문제행동 수준을 측정하였다. 분석 결과, 소아암 생존자 집단은 건강 통제 집단과 비교하여 전반적으로 신체적, 사회적 기능에서 낮은 삶의 질을 경험하고 있었고, 높은 수준의 내재화된 문제 행동을 보이고 있었다. 이 때의 결과는 어떤 정보원을 사용하였느냐에 따라 다소 차이를 보였다. 정보원간의 보고 불일치 양상을 살펴보았을 때, 두 집단 모두에서 부모는 자기 보고에서보다 문제 행동은 더 낮게, 삶의 질은 더 높게 보고하는 경향을 보였다. 소아암 생존자 집단과 건강 통제 집단에서 나타난 부모와 자기 보고의 불일치 정도를 비교해보았을 때, 삶의 질의 대부분의 영역에서는 유의미한 차이가 없었으나 내재화된 문제행동 영역에서 소아암 생존자 집단이 건강 통제 집단보다 부모와 자녀의 보고 차이가 유의미하게 더 큰 것으로 나타났다. 본 결과를 바탕으로 본 연구의 의의와 한계점에 대해 논의하였다.

• 한국콘텐츠학회논문지
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• 제14권3호
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• pp.301-313
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• 2014

본 연구는 간호대학생의 스트레스대처, 유머감각, 대학생활적응 정도와 변수간 상관관계를 확인하고자 하였다. 2012년 6월 B시 일 대학교 간호학생 338명을 대상으로 구조화된 설문지를 이용하여 자료를 수집한 후 SPSS/WIN 21.0 프로그램으로 분석하였다. 연구결과, 대상자의 스트레스대처는 평균 43.33점, 유머감각 72.18점, 대학생활적응 68.02점으로 중간이상의 수준이었다. 대학생활적응 점수는 성별, 학년, 가족구성, 가정형편, 대학생활 만족도, 교수와의 관계, 대학성적, 이성친구 유무에 따라 유의한 차이가 있었다. 대학생활적응은 스트레스대처, 유머감각과 유의하나 약한 상관관계에 있었다. 본 연구결과를 토대로 학생의 개별적 특성을 고려해 대학생활적응을 위한 교육 프로그램 개발 및 적용이 이루어져야 하겠다. 또한 대학생활적응의 영향요인을 규명하는 후속연구가 필요하다.

• 한국사회복지학
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• 제63권1호
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• pp.5-28
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• 2011

본 연구는 정신장애인의 정신질환 발병 이후 생애경험을 '생애사적 진행과정구조'에 주목하여 재구성함으로써 발병이후 위기의 진행과 전환의 과정을 이해하고자 한다. 정신장애인 5명이 연구에 참여했으며, 수집된 자료는 Sch$\ddot{u}$tze의 생애사적 이야기식 인터뷰(narrative interview)분석에 의하여 이루어졌고 위기 상황의 전환을 중심으로 '발병과 혼란단계'와 '집중적 치료 재활단계로' 나누어 재구성하였다. 전자는 '질환에 압도당함, 고통스런 삶의 반복과 감내, 가족으로부터의 분리', 후자는 '정신보건법 제정과 지역사회정신보건서비스의 확대, 사회적 역할변화를 통한 자신의 재발견, 생애사적 잠재성을 깨닫게 해준 중요한 타인, 지역사회통합의 장애물 경험, 가족관계의 재통합, 발병이전의 삶에 대한 고찰을 통한 질병경험의 재해석, 미래에 대한 기대'라는 주제로 분석했다. 그리고 두 단계를 전체적으로 비교분석하였다.

• Journal of Hospice and Palliative Care
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• 제11권4호
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• pp.181-187
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• 2008

목적: 말기 암 환자에게 있어서 정확한 여명 예측은 환자의 효율적인 치료 계획을 세우고 환자의 삶의 질을 높이는데 있어서 중요하다. 본 연구에서는 말기 암 환자에서 호중구-림프구 비가 생존기간 예측을 위한 예후 인자로서 유용한가를 알아보고자 한다. 방법: 2004년 1월부터 2007년 6월까지 말기 암 환자로 완화 치료를 목적으로 영동세브란스병원 가정의학과에 입원 혹은 전입되어 치료를 받는 중 사망한 67명의 환자를 대상으로 하였다. 호중구-림프구 비에 따라서 3개의 군으로 나누어 과거 병력, 신체 계측, 임상 증상, 혈액검사 소견, 생존기간을 분석하였다. 결과: 호중구-림프구 비가 가장 높은 군(${\geq}12.5$)에서 환자의 생존기간이 단변량 분석에서 통계적으로 유의하게 짧았으며(hazard ratio (HR)=3.270, P=0.001)), 저하된 활동도, 호흡 곤란 증상을 보정한 다변량 분석에서도 통계적 유의성을 보였다(HR=2.907, P=0.007). 완화 치료를 위해 입원 혹은 전입된 시점에 비하여 사망이 임박한 시점에서 호중구-림프구 비는 의미 있는 증가를 보였다(P=0.001). 결론: 호중구-림프구 비는 말기 암환자에서 생존기간 예측을 위한 독립적인 예후 인자로 확인 되었다.

• Physical Therapy Rehabilitation Science
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• 제4권1호
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• pp.44-48
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• 2015

Objective: The purpose of this study was to investigate the relationship between anticipatory postural adjustment (APA), single task, dual tasks and physical performances. The trunk muscles of APA consist of bilateral erector spinae (ES) and bilateral internal oblique (IO) adnominal muscles, during rapid stepping with the affected or unaffected leg in a sitting posture. Design: Cross-sectional study. Methods: In patients with chronic stroke, electrodes of surface electromyography (EMG) were attached on the bilateral erector spinae (ES), bilateral internal oblique adnominal (IO), and bilateral rectus femoris (RF) muscles. RF acts as the prime mover. The stroke patients performed hip flexion until $20^{\circ}$ as fast as possible at each leg in a sitting posture according to a visual cue. The visual cue unexpectedly appeared on monitor in front of the stroke patient. The single task was the Timed Up and Go (TUG) test. The dual tasks were the TUGconitive, which increased cognitive capacity, and the TUGmanual task, which had an external focus. Results: All EMG data showed earlier onset latency before the prime mover. In affected leg raising, the onset time of unaffected ES muscle of the stroke patients was correlated with the single and dual tasks (p<0.05). In unaffected leg raising, the onset time of the affected IO muscle was related to all the tasks (p<0.05). Gait speed showed a relationship with the unaffected ES muscle only. Conclusions: The trunk muscles of the bilateral ES and bilateral IO play an important role in APA. The single and dual tasks using TUG test were correlated with the APA s of ES and IO muscles. Dual task by the TUG test is a good measuring tool for reflecting the real life in patients with chronic stroke.

• Journal of Korean Biological Nursing Science
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• 제7권2호
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• pp.31-48
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• 2005

Purpose: Studies focus on cancer control, prevention, or assessment of psychosocial problems and intervention methods. However, few studies exist concerning psychosocial problems, measuring tools for those problems, and interventions for cancer patients in Korea. One of the purposes of this study was to review studies in this area, to examine various psychosocial problems experienced by cancer patients. This is a crucial area to investigate, since psychosocial problems in turn negatively influence the patients' immune function, which speeds the progress of the disease. Another goal was to identify instruments used to measure psychosocial functioning and problems in cancer patients, to analyze their validity and reliability, with the aim to discover the best instruments. A final goal was to explore and compare the effects of psychosocial interventions, to determine the most effective practices. Method: Journal articles published since 1995 were searched from PubMed Data base, Google search engine, and published cancer-related studies, using search keywords "psychosocial function and intervention for the cancer patients"; whole articles of selected references were reviewed and analyzed. Result: Most common psychosocial problems were depression, fatigue, nausea, pain, distress, resulting in a low quality of life. The seven scales found in the literature to assess the psychosocial functioning were Center for Epidemiological Studies-Depression, State-Trait Anxiety Inventory, Symptom Checklist 90-R, Profile of Mood States, Psychosocial Adjustment to Illness Scale, Brief Symptom Inventory, and SF-36 HRQOL(Health Related Quality of Life). Social support interventions for cancer patients were effective in improving quality of life scores. Conclusion: It is necessary to apply support intervention strategies to help cancer patients in Korea. These strategies can help to reduce the effects of psychosocial symptoms, which in turn affect the development and control of cancer. Strategies developed in Western countries may need to be modified for use within Korea. Further studies are warranted to review the support intervention strategies that were being used to for cancer patients

• 한국작물학회:학술대회논문집
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• 한국작물학회 2017년도 9th Asian Crop Science Association conference
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• pp.113-113
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• 2017

Downy mildew (DM), caused by several species in the Peronosclerospora and Scleropthora genera, is a major maize (Zea mays L.) disease in tropical or subtropical regions. DM is an obligate parasite species in the higher plants and spreads by oospores, wind, and mycelium in seed surface, soil, and living hosts. Owing to its geographical distribution and destructive yield reduction, DM is one of the most severe maize diseases among the maize pathogens. Positional cloning in combination with phenotyping is a general approach to identify disease resistant gene candidates in plants; however, it requires several time-consuming steps including population or fine mapping. Therefore, in the present study, we suggest a new combination strategy to improve the identification of disease resistant gene candidates. Downy mildew (DM) resistant maize was selected from five cultivars using the spreader row technique. Positional cloning and bioinformatics tools identified the DM resistant QTL marker (bnlg1702) and 47 protein coding genes annotations. Eventually, 5 DM resistant gene candidates, including bZIP34, Bak1, and Ppr, were identified by quantitative RT-PCR without fine mapping of the bnlg1702 locus. Specifically, we provided DM resistant gene candidates with our new strategy, including field selection by the spreader row technique without population preparation, the DM resistance region identification by positional cloning using bioinformatics tools, and expression level profiling by quantitative RT-PCR without fine mapping. As whole genome information is available for other crops, we propose applying our novel protocol to other crops or for other diseases with suitable adjustment.

• Child Health Nursing Research
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• 제23권3호
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• pp.394-404
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• 2017

Purpose: The purpose of this study was to review interventions available to nurses caring for siblings of children with cancer. Methods: Searches of CINAHL, MEDLINE, PubMed, EMBASE, and RISS identified ten intervention studies published from January, 2000 to November, 2016. Results: Ten studies on interventions for siblings of pediatric cancer patients were identified as follows: 4 included camps, 4 included support groups, and 2 provided individual interventions. Theoretical frameworks were mainly cognitive behavioral theory and most studies were led by psychologists and multidisciplinary teams. The purpose of the interventions was primarily enhancing psychosocial adjustment. Siblings' fear of disease, self-esteem, and social support were improved significantly after the interventions. Findings were inconsistent with regard to depression, anxiety, behavioral problems, post-traumatic stress, health-related quality of life, and siblings' perceptions of the illness. Conclusion: Study findings showed the potential for enhancing emotional and behavioral outcomes in siblings of children with cancer. However, the number of studies was very small, and several methodological limitations were identified. In the future, more randomized controlled trials with larger samples are needed to extend the evidence base. Moreover, future research should identify sibling's characteristics and circumstances most likely to bring benefits to the siblings.

• Nutrition Research and Practice
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• 제17권4호
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• pp.780-788
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• 2023

BACKGROUND/OBJECTIVES: This study examined the relationship between famine exposure in early life and the risk of type 2 diabetes in adulthood during the 1959-1961 Chinese Famine. SUBJECTS/METHODS: A total of 3,418 individuals aged 35-74 years free of diabetes from two studies in 2006 and 2009 were followed up prospectively in 2009 and 2012, respectively. Famine exposure was classified as unexposed (individuals born in 1962-1978), fetal exposed (individuals born in 1959-1961), child exposed (individuals born in 1949-1958), and adolescent/adult exposed (born in 1931-1948). A logistic regression model was used to assess the relationship between famine exposure and diabetes after adjustment for potential covariates. RESULTS: During a three-year follow-up, the age-adjusted incidence rates of type 2 diabetes were 5.7%, 14.5%, 12.7%, and 17.8% in unexposed, fetal-exposed, child-exposed, and adolescent/adult-exposed groups, respectively (P < 0.01). Relative to the unexposed group, the relative risks (95% confidence interval) for diabetes were 2.15 (1.29-3.60), 1.53 (0.93-2.51), and 1.65 (0.75-3.63) in the fetal-exposed, child-exposed, and adolescent/adult-exposed groups, after controlling for potential covariates. The interactions between famine exposure and obesity, education level, and family history of diabetes were not observed, except for the urbanization type. Individuals living in rural areas with fetal and childhood famine exposure were at a higher risk of type 2 diabetes, with relative risks of 8.79 (1.82-42.54) and 2.33 (1.17-4.65), respectively. CONCLUSIONS: These findings indicate that famine exposure in early life is an independent predictor of type 2 diabetes, particularly in women. Early identification and intervention may help prevent diabetes in later life.