• Korean Journal of Head & Neck Oncology
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• v.25 no.2
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• pp.123-127
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• 2009

Objectives : The aim of this study was to investigate immunohistochemical expression of CK7, CK19, CK20, SMA and Ki-67 in Adenoid cystic carcinoma(ACC) of the Head and Neck. Material and Methods : Sixteen patients who were treated in Chungbuk National University Hospital from 1992 to 2004, were included in this study. Ten ACCs, 3 MECs, 1 Salivary duct carcinoma, 1 Adenocarcinoma(NOS), and 1 cacinoma ex pleomorphic adenoma were analyzed immunohistochemically for CK7, CK19, CK20, SMA, and Ki-67. Results : CK7 was expressed in 100% of the adenoid cystic carcinoma and 75% of the other tumors. CK19 was expressed in 75% of the adenoid cystic carcinoma and 100% of the other tumors. CK20 was not expressed in all tumors. SMA was expressed in 88.9% of the adenoid cystic carcinoma and not expressed in the other tumors. Ki-67 was expressed in low level in the adenoid cystic carcinoma. Conclusion : The Ki-67 index could explain the natural course of tumor. Immunohistochemistry of CK7, CK19, CK20, SMA and Ki-67 expression in Adenoid cystic carcinoma may provide useful information to diagnosis.

• The Korean Journal of Cytopathology
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• v.6 no.1
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• pp.67-70
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• 1995

Adenoid cystic carcinoma arising from the submucosal glands of the trachea and bronchial tree is rare. The histopathology and natural history of bronchial adenoid cystic carcinoma have been well documented, but detailed descriptions of its cytomorphology are few. We report a case of primary bronchial adenoid cystic carcinoma in a 20-year-old female, diagnosed by bronchial brushing cytology. The cytologic specimens showed large clusters of small cells arranged around cystlike spaces containing globular basophilic material.

• Journal of Chest Surgery
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• v.26 no.6
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• pp.501-504
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• 1993

Adenoid cystic carcinoma of the tracea is rare, but is a very serious critical life-threatening disease.Nearly all the lesions of the trachea are presented as obstructive lesions. Bronchoscopic examination including chest CT, tomogram and air tracheogram are essential for the further definition of these lesions. This is a case report of adenoid cystic carcinoma in a 47 years old male patient. The tumor was located in cervical trachea with wide base and obstructing the lumen almost completely. The patient`s symptom was productive cough and hoarseness for 4 months. The tumor was resected and End-to-End anastomosed. The tumor was confirmed to be adenoid cystic carcinoma histopathologically. The need for removal of tracheal tumor whether complete or incomplete, is clear enough regardless of the histology of the tumor. This patient was treated post-operatively with radiation.

• The korean journal of orthodontics
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• v.15 no.1
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• pp.93-103
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• 1985

Since the fact was known that mouth breathing resulted from the adenoid hypertropy causes malocclusion, many investigators have studied nasopharynx and adenoid in order to clarify the role in relation to the effect on face and occlustion and the development of airway. The author analyzed 13 items in longitudinal cephalometric roentgenograms of 17 boys and 19 girls taken from the age of 7 to 12. The results were as follows. 1. The means and standard deviation for the measured items were obtained. 2. The continual growth of nasopharyngeal cavity was more affected by the height than the depth. 3. The size of adenoid was larger in males than in females, especially on R, $D-AD_2$. 4. Airway percentage was highest in boys at age 10 and girls at age 9. 5. The items showed significant differentiation between males and females were airway percentage, posterior height, $D-AD_1,\;D-AD_2$, and R.

• Tuberculosis and Respiratory Diseases
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• v.42 no.3
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• pp.387-393
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• 1995

Adenoid cystic carcinoma formerly called cylindroma is rare tracheal tumor. Characteristics of adenoid cystic carcinoma are infiltrative nature with local recurrence tendency and long natural course of the disease. Adenoid cystic carcinomas develop most commonly in the trachea. Primary resection and end-to-end anastomosis of the involved airway are treatment of choice. And postoperative radiation therapy might be useful, particularly when the surgical margins are not ample. We report two cases of adenoid cystic carcinoma of trachea diagnosed by flow-volume curve.

• The Korean Journal of Cytopathology
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• v.9 no.2
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• pp.207-211
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• 1998

Adenoid cystic carcinoma of the uterine cervix is a rare tumor accounting for less than 1% of all cervical adenocarcinoma. This tumor is characterized by aggressive biological behavior with frequent local recurrence or metastatic spread, postmenopausal onset, and occasional association with conventional squamous cell carcinoma. The cytologic diagnosis of adenoid cystic carcinoma in the uterine cervix is often difficult because of negative smear due to intact overlying mucosa, cytologic findings mimicking endometrial cells, and masquerade as squamous ceil carcinoma. Recently we have experienced a case of adenoid cystic carcinoma arising in the uterine cervix, which was identified on the routine Papanicolaou smear and was histologically confirmed by the consequent biopsy. The smear showed abundant cellularity composed of relatively uniform cells. The tumor cells were arranged in small clusters, acini, naked cells, and loose sheets with abortive cribriform pattern. There were scattered globoid basement membrane-like materials and tumor diathesis. The nuclei were pleomorphic and showed hyperchromatic and coarsely granular choromatin with inconspicuous nucleoli. The punch biopsy of the uterine cervix showed typical histologic findings of adenoid cystic carcinoma characterized by tumor nests composed of hyperchromatic uniform basaloid cells, cribriform pattern, and cylindrical hyaline bodies.

• Archives of Plastic Surgery
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• v.35 no.3
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• pp.333-336
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• 2008

Purpose: Adenoid cystic carcinoma is a rare type of eccrine sweat gland carcinoma. Although it is mostly known as a neoplasm of the salivary gland, it could occur as a primary skin tumor. We present a patient with a primary cutaneous adenoid cystic carcinoma at the genital area. Methods: A 60-year-old man had a slowly growing 1 cm sized single tender mass near the left scrotum and he underwent excisional biopsy at a local clinic. A diagnosis of adenoid cystic carcinoma was made and thus he was transferred to our hospital. In physical examination, other specific findings were not detected except a linear scar caused by a previous skin biopsy near the left scrotum. In CT scan, PET-CT scan and endoscopy, there was no evidence of neoplasm in other organs. It was diagnosed as the primary cutaneous adenoid cystic carcinoma and then wide excisions were performed including total 4.5 cm margin of normal skin. Results: Microscopic findings revealed proliferation of tumor cell islands with cribriform or tubular patterns containing several round, pseudocystic structures. The tumor cells showed basaloid cells with uniform and small nuclei. Tumor cells infiltrated into the dermis and upper portion of subcutaneous tissue. There was multifocal perineural invasion of tumor cells. In postoperative 6 months, we found no recurrence and other complications. Conclusion: Herein we found a rare case of primary cutaneous adenoid cystic carcinoma at the genital area.

• Korean Journal of Head & Neck Oncology
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• v.19 no.2
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• pp.158-163
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• 2003

Objectives: To document the incidence and pattern of c-kit protein expression & mutation in adenoid cystic carcinomas. Materials and Methods: Twenty-five cases of adenoid cystic carcinomas of the major and minor salivary glands and the upper and lower respiratory tract were subjected to the immunohistochemical study for ckit(CD117 ; Dako). Nineteen cases of them were analyzed for mutations in exon 11 and exon 17 by PCR-SSCP, and in cases of need, by DNA sequencing. Results: Twenty-three cases (92%) showed c-kit expression, but none showed mutations in exon 11 and exon 17. The expression was restricted to the inner luminal cells in all tubular types and most of cribriform adenoid cystic carcinomas, while the staining was diffuse in all solid variants and two cribriform types. Conclusion: C-kit expression was common in adenoid cystic carcinomas, regardless of their origins. Although genetic bases await further studies, a clinical trial of tyrosine kinase inhibitors in adenoid cystic carcinomas, especially in solid variants, is considered encouraging.

• The Journal of the Acoustical Society of Korea
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• v.28 no.8
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• pp.790-795
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• 2009

This study evaluated the voice of 68 normal children and 50 children with palatine tonsil and adenoid hypertrophy with MDVP to examine the hypothesis that their mouth breathing makes the vocal folds dry and this condition contributes to lower the level of voice quality. The results showed that children with palatine tonsil and adenoid hypertrophy had statistically significant elevations in Jitt, RAP, PPQ, Shim and APQ parameters, and had the lower level of voice quality. Therefore, the children with palatine tonsil and adenoid hypertrophy need vocal hygiene education.

• Journal of Chest Surgery
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• v.20 no.4
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• pp.865-868
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• 1987

Adenoid cystic carcinoma of the esophagus has been relatively an uncommon, slow growing tumor. A 51 year-old man patient had a tumor in the lower third of the esophagus which was incidentally found during an examination for UPPER C-I series, and resected successfully without Thoracotomy. The tumor exhibited a polypoid appearance covered by normal esophageal epithelium, localized entirely in the submucosal layer of the esophagus and morphologically identical to adenoid cystic carcinoma in the salivary glands.