Korean Journal of Head & Neck Oncology (대한두경부종양학회지)

The Korean Society for Head and Neck Oncology (대한두경부종양학회)
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C-kit Protein Expression and Mutation Analysis in Adenoid Cystic Carcinomas

샘낭암종에서의 C-kit 단백 발현 및 돌연변이 분석

  • Cho Kyung-Ja (Departments of Pathology, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Choi Jene (Departments of Pathology, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Kim Sang-Yoon (Departments of Otorhinolaryngology, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Nam Soon-Yuhl (Departments of Otorhinolaryngology, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Choi Seung-Ho (Departments of Otorhinolaryngology, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Kim Sung-Bae (Departments of Hematooncology, University of Ulsan College of Medicine, Asan Medical Center)
  • 조경자 (울산대학교 의과대학 서울아산병원 병리과학교실) ;
  • 최진 (울산대학교 의과대학 서울아산병원 병리과학교실) ;
  • 김상윤 (울산대학교 의과대학 서울아산병원 이비인후과학교실) ;
  • 남순열 (울산대학교 의과대학 서울아산병원 이비인후과학교실) ;
  • 최승호 (울산대학교 의과대학 서울아산병원 이비인후과학교실) ;
  • 김성배 (울산대학교 의과대학 서울아산병원 종양혈액내과학교실)
  • Published : 2003.11.01
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Abstract

Objectives: To document the incidence and pattern of c-kit protein expression & mutation in adenoid cystic carcinomas. Materials and Methods: Twenty-five cases of adenoid cystic carcinomas of the major and minor salivary glands and the upper and lower respiratory tract were subjected to the immunohistochemical study for ckit(CD117 ; Dako). Nineteen cases of them were analyzed for mutations in exon 11 and exon 17 by PCR-SSCP, and in cases of need, by DNA sequencing. Results: Twenty-three cases (92%) showed c-kit expression, but none showed mutations in exon 11 and exon 17. The expression was restricted to the inner luminal cells in all tubular types and most of cribriform adenoid cystic carcinomas, while the staining was diffuse in all solid variants and two cribriform types. Conclusion: C-kit expression was common in adenoid cystic carcinomas, regardless of their origins. Although genetic bases await further studies, a clinical trial of tyrosine kinase inhibitors in adenoid cystic carcinomas, especially in solid variants, is considered encouraging.

Keywords

References

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