• 대한전기학회논문지
• /
• 제45권2호
• /
• pp.235-241
• /
• 1996

In this paper dielectric and electrostrictive strain properties of (1-y-x)Pb(Mg$_{1/3}$Nb$_{2/3}$)O$_{3}$-PbTiO$_{3}$$-yPbTiO_{3}-xSrTiO_{3}[(1-y-x)PMN-yPT-xST]$ ceramics fabricated by using columbite precursor method have been investigated with the substitution of SrTiO$_{3}$(ST). Dielectric constant of the specimens increased with the increase of ST content up to 5[m/o] and decreased with further substitution of ST. And the pyrochlore phase decreased with the increase of ST content up to 5[m/o] in XRD analysis. The elimination of the pyrochlore phase improved dielectric constants. The electrostrictive strains generated by AC electric field have the highest value at 5[m/o] SrTiO$_{3}$ addition and the hysteresis of strain ranged from 12 to 20[%]. The electrostrictive strain at various temperature investigated in the temperature range of $-50[^{\circ}C]~74[^{\circ}C].$ In higher temperature than phase transition region, it showed paraelectric property which shows very small hystersis.

• 대한기계학회논문집A
• /
• 제30권9호
• /
• pp.1062-1069
• /
• 2006

Reduction schemes approximate the lower eigenvalues that represent the global behavior of the structures. But, they are not efficient to be applied to large-scaled problems because these schemes require considerable amount of computing time in constructing reduced one from the original large-scaled systems. In addition, the selection of the primary degrees of freedom might be localized to cause the excessive emphasis of the lower mode or lost of the important modes. In the present study, a new reduction method combined with the subdomain method is proposed. For the construction of the final reduced system the system of each domain subdivided into primary, slave and interface degrees of freedom. It is remarkably efficient and accurate comparable to full-scale system. Numerical examples demonstrate that the proposed method saves computational cost effectively and provides a reduced system which predicts accurate eigen-pairs of global system.

• 한국환경성돌연변이발암원학회:학술대회논문집
• /
• 한국환경성돌연변이발암원학회 2004년도 춘계학술대회
• /
• pp.27-29
• /
• 2004

Drug transporters play an essential role in the absorption, distribution and elimination of clinical drugs, nutrients and toxicants. The importance of the transporters is exampled by therapeutic failure in cancer chemotherapy that is mainly caused by the overexpression of multidrug resistance (MDR)-related transporters. In addition, the transporters may involve in drug-drug interactions that lead to serious adverse drug responses and some transporters also contribute to inter-individual variation in drug responses. As an effort to understand the mechanism underlying the inter-individual variation of transporters activity, genetic and environmental factors influencing the expression or function of the transporters have extensively explored through last decade. Among them, genetic polymorphism of drug transporter encoding genes has generated much interest since the discovery of functional single nucleotide polymorphisms (SNP) of MDR1 gene. Besides drug transporters, xenobiotic receptors also modulate drug disposition by regulating the transcription of drug metabolizing enzymes and drug transporters. Among many xenobiotic receptors, pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are two most well characterized since these receptors show wide substrate specificities and regulate the expression of various enzymes involved in drug disposition. Recently, several functional genetic polymorphisms were reported in PXR coding gene. In the present study, genetic polymorphisms of two drug transporters, MDR1 and BCRP, and two xenobiotic receptors, PXR and CAR, were investigated in Korean population.

• Journal of Power Electronics
• /
• 제15권1호
• /
• pp.10-17
• /
• 2015

A quasi-constant on-time controlled buck front end in combined discontinuous conduction mode and boundary conduction mode is proposed to improve power factor (PF).When instantaneous AC input voltage is lower than the output bus voltage per period, the buck converter turns into buck-boost converter with the addition of a level comparator to compare input voltage and output voltage. The gate drive voltage is provided by an additional oscillator during distortion time to eliminate the cross-over distortion of the input current. This high PF comes from the avoidance of the input current distortion, thereby enabling energy to be delivered constantly. This paper presents a series analysis of controlling techniques and efficiency, PF, and total harmonic distortion. A comparison in terms of efficiency and PF between the proposed converter and a previous work is performed. The specifications of the converter include the following: input AC voltage is from 90V to 264V, output DC voltage is 80V, and output power is 94W.This converter can achieve PF of 98.74% and efficiency of 97.21% in 220V AC input voltage process.

• 전력전자학회논문지
• /
• 제13권4호
• /
• pp.311-318
• /
• 2008

본 논문은 소프트 스위칭 기법을 적용한 싱크로너스 양방향 DC-DC 컨버터를 제안한다. 제안된 컨버터는 싱크로너스 벅 컨버터를 병렬구성을 하여 인터리브드 기법을 통해 도통 손실을 줄이고, 하나의 공진인덕터를 사용한 ZVT-Cell을 적용함으로써 스위칭 손실을 최소화 하였다. 전 부하 범위에서 CCM(Continuous Conduction Mode) 으로 동작하고 ZVS가 성립되도록 하였으며, 전류주입 기법을 통해 넓은 출력전압 범위에서도 ZVS 조건을 만족하였다. 또한, 기존 싱크로너스 벅 컨버터의 데드타임(dead time)동안 발생하는 역병렬 다이오드의 도통손실 및 dv/dt, di/dt 발생을 저감하는 효과를 얻을 수 있다. 제안된 컨버터의 유효성은 실험을 통해서 검증하였다.

• 한국주조공학회지
• /
• 제22권3호
• /
• pp.130-136
• /
• 2002

The growing use of aluminum for castings over the past decade has brought with it the increased scrutiny of component properties. One area that has received much attention is the effect of in inclusions - or impurities particles held in the metal - on casting properties. A new method of electromagnetic separation for removal of inclusions in aluminum alloy melts is proposed. The principle is that as the electromagnetic force induced in metal acts on inclusions due to low electric conductivity, they are moved to the direction opposite to electromagnetic force and can be separated and removed from the melt. Experiments were carried out on A356 melt mixed alumina particles and commercial Al alloys of ADC 10 and 12. In the experiment using A356, it was proved that $Al_2O_3$ particles was separated and removed continuously from matrix melt by electromagnetic force. Based on these results, the continuous separation experiment that used ADC 10, 12 was carried and the cleanliness of melt was assessed by the amount of porosity, hydrogen contents, PoDFA and mechanical properties through tensile test. As the results of analyses, the amount of porosity and hydrogen contents decreased without variation of chemical composition in the specimen that passed the electromagnetic continuous separator. In addition, tensile strength and elongation of this specimen increased by $20{\sim}30%$ because of reduction of inclusions.

• 한국독성학회:학술대회논문집
• /
• 한국독성학회 2004년도 춘계학술대회
• /
• pp.27-29
• /
• 2004

Drug transporters play an essential role in the absorption, distribution and elimination of clinical drugs, nutrients and toxicants. The importance of the transporters is exampled by therapeutic failure in cancer chemotherapy that is mainly caused by the overexpression of multidrug resistance (MDR)-related transporters. In addition, the transporters may involve in drug-drug interactions that lead to serious adverse drug responses and some transporters also contribute to inter-individual variation in drug responses. As an effort to understand the mechanism underlying the inter-individual variation of transporters activity, genetic and environmental factors influencing the expression or function of the transporters have extensively explored through last decade. Among them, genetic polymorphism of drug transporter encoding genes has generated much interest since the discovery of functional single nucleotide polymorphisms (SNP) of MDRl gene. Besides drug transporters, xenobiotic receptors also modulate drug disposition by regulating the transcription of drug metabolizing enzymes and drug transporters. Among many xenobiotic receptors, pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are two most well characterized since these receptors show wide substrate specificities and regulate the expression of various enzymes involved in drug disposition. Recently, several functional genetic polymorphisms were reported in PXR coding gene. In the present study, genetic polymorph isms of two drug transporters, MDR1 and BCRP, and two xenobiotic receptors, PXR and CAR, were investigated in Korean population.

• Molecules and Cells
• /
• 제27권4호
• /
• pp.397-401
• /
• 2009

Olig2 transcription factor is widely expressed throughout the central nervous system; therefore, it is considered to have multiple functions in the developing, mature and injured brain. In this mini-review, we focus on Olig2 in the forebrain (telencephalon and diencephalon) and discuss the functional significance of Olig2 and the differentiation properties of Olig2-expressing progenitors in the development and injured states. Short- and long-term lineage analysis in the developing forebrain elucidated that not all late Olig2+ cells are direct cohorts of early cells and that Olig2 lineage cells differentiate into neurons or glial cells in a region- and stage-dependent manner. Olig2-deficient mice revealed large elimination of oligodendrocyte precursor cells and a decreased number of astrocyte progenitors in the dorsal cortex, whereas no reduction in the number of GABAergic neurons. In addition to Olig2 function in the developing cortex, Olig2 is also reported to be important for glial scar formation after injury. Thus, Olig2 can be essential for glial differentiation during development and after injury.

• Journal of Power Electronics
• /
• 제17권4호
• /
• pp.923-932
• /
• 2017

This paper proposes a novel scheme which can compensate the common-mode voltage (CMV) for five-level active neutralpoint clamped (5L-ANPC) inverters, which is based on modifying the space vector pulse width modulation (SVPWM) and adding an auxiliary leg to the inverter. For the modified SVPWM, only the 55 voltage vectors producing low CMV values among the 125 possible voltage vectors are utilized, which varies over the three voltage levels of $-V_{dc}/12$, 0 V, and $V_{dc}/12$. In addition, the compensating voltage, which is injected into the 5L-ANPC inverter system to cancel the remaining CVM through a common-mode transformer (CMT) is generated by the additional NPC leg. By the proposed method, the CMV of the inverter is fully eliminated, while the utilization of the DC-link voltage is not decreased at all. Furthermore, all of the DC-link and flying capacitor voltages of the inverter are well controlled. Simulation and experimental results have verified the validity of the proposed scheme.

• Journal of Power Electronics
• /
• 제17권4호
• /
• pp.991-1003
• /
• 2017

The conventional sliding mode control (CSMC) has a number of problems. It may cause dc output voltage ripple and it cannot guarantee the robustness of the whole system for a matrix rectifier (MR). Furthermore, the existence of a filter can decrease the input power factor (IPF). Therefore, a novel global sliding mode control (GSMC) based on a hyperbolic tangent function with IPF compensation for MRs is proposed in this paper. Firstly, due to the reachability and existence of the sliding mode, the condition of the matrix rectifier's robustness and chattering elimination is derived. Secondly, a global switching function is designed and the determination of the transient operation status is given. Then a SMC compensation strategy based on a DQ transformation model is applied to compensate the decreasing IPF. Finally, simulations and experiments are carried out to verify the correctness and effectiveness of the control algorithm. The obtained results show that compared with CSMC, applying the proposed GSMC based on a hyperbolic tangent function for matrix rectifiers can achieve a ripple-free output voltage with a unity IPF. In addition, the rectifier has an excellent robust performance at all times.