• Journal of Life Science
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• v.28 no.5
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• pp.597-604
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• 2018

Although the core mechanisms of Attention Deficit/Hyperactivity Disorder (ADHD) are unknown, several ADHD-associated proteins have been studied. G-protein - coupled receptor kinase interacting protein-1 (GIT1) is a multifunctional adapter protein that affects neuron growth and dendrite formation. GIT1-deficient mice have shown ADHD-like behavior and also recovered through amphetamine treatment. In this study, gliotransmitters were investigated in both intracellular and extracellular space from GIT1-deficient mice. To measure the amount of gliotransmitters, primary astrocyte cultures were taken from the cerebral and cerebellar cortices of wild (WT), hetero (HE), and knock-out (KO) mice. Major gliotransmitters were analyzed using high-performance liquid chromatography. It was observed that the amount of excitatory and inhibitory gliotransmitters were dependent on genotype and showed a change in excitation/inhibition ratios. Interestingly, the major excitatory gliotransmitter, glutamate, existed at the lowest level in WT mice, but the amount of inhibitory gliotransmitters, gamma-aminobutyric acid (GABA) and glycine, varied depending on brain region. Remarkably, an increased amount of GABA was measured at the intracellular cerebrum in WT mice compared with KO mice. It was presumed that KO mice would secrete more inhibitory gliotransmitters to compensate for GIT1 depletion or else acquire a defect to reuptake-secreted GABA. This may be a possible mechanism for ADHD pathology.

• Journal of KIISE:Computer Systems and Theory
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• v.31 no.5_6
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• pp.371-378
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• 2004

This paper presents the implementation and performance of the HVIA-GE card, which is a hardware implementation of the Virtual Interface Architecture (VIA) based on Gigabit Ethernet. The HVIA-GE card is a 32-bit/33MHz PCI adapter containing an FPGA for the VIA protocol engine and a Gigabit Ethernet chip set to construct a high performance physical network. HVIA-GE performs virtual-to-physical address translation, Doorbell, and send/receive completion operations in hardware without kernel intervention. In particular, the Address Translation Table (ATT) is stored on the local memory of the HVIA-GE card, and the VIA protocol engine efficiently controls the address translation process by directly accessing the ATT. As a result, the communication overhead during send/receive transactions is greatly reduced. Our experimental results show the maximum bandwidth of 93.7MB/s and the minimum latency of 11.9${\mu}\textrm{s}$. In terms of minimum latency HVIA-GE performs 4.8 times and 9.9 times faster than M-VIA and TCP/IP, respectively, over Gigabit Ethernet. In addition, the maximum bandwidth of HVIA-GE is 50.4% and 65% higher than M-VIA and TCP/IP respectively.

• Journal of Korean Classical Literature and Education
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• no.33
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• pp.185-210
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• 2016

This thesis explores how JobGeuk ShimChungWangWhoJeon and the Devoted daughter ShimChungJeon scenario have transformed ShimChungJeon, a notable work of Pansori literature, dramatically for modern times. By analyzing the adapter's consciousness and changing direction in these two works, it was found that ShimChungJeon was tailored to audiences in the 1900s. JobGeuk and the scenario are attempts to transform ShimChungJeon to meet cultural needs in the 21st century and to make the works appealing to the public. The aspects of the transformation of JobGeuk ShimChungWangWhoJeon are 1) reinforcement of logical causality, 2) weakening the humor and simultaneously emphasizing the work's surreal nature, and 3) dramatic expression by song. The aspects of the change in direction of the Devoted daughter ShimChungJeon scenario are 1)the insertion of a new narrative, 2)trying to evoke both humor and tragic sadness, 3)seeking newness with the reassignment of time and events. JobGeuk ShimChungWangWhoJeon is the first example of the transformation of ShimChungJeon's dramatic style and Devoted daughter ShimChungJeon is the first transformation of its scenario. These two works show how ShimChungJeon can be adapted to modern times and new cultures, and how ShimChungJeon can be made relevant and be enjoyed by the public regardless of the era.

• Journal of Korean Theatre Studies Association
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• no.53
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• pp.89-128
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• 2014

De notre temps, nous faisons face ${\grave{a}}$ un changement du $th{\hat{e}}atre$ dans son ensemble. Le $th{\acute{e}}atre$ contemporain tente de se $d{\acute{e}}marquer$ des autres formes artistiques, mais aussi des formes $litt{\acute{e}}raires$, lorsque la tendance est ${\grave{a}}$ la fusion des genres. Il existe ainsi de plus en plus de $th{\hat{e}}atre$ ${e}xp{\acute{e}}rimentaux$, $n{\acute{e}}s$ sous le nom de $th{\acute{e}}atre$ anthropologique, $th{\acute{e}}atre$ sociologique, $th{\acute{e}}atre$ ethnologique, $th{\acute{e}}atre$ ${\acute{e}}pist{\acute{e}}miologique$ ou $th{\acute{e}}{\hat{a}}tre$ interculturel. La $m{\acute{e}}thodologie$ doit elle s'adapter ${\grave{a}}$ cette tendance de fusion? Au lieu de trouver une $m{\acute{e}}thode$ d'anlyse de chaque "nouveaux genre" $n{\acute{e}}$ de la fusion, nous nous interrogeons sur la $m{\acute{e}}thodologie$ pour ${\acute{e}}tudier$ le $th{\hat{e}}atre$ dans son ensemble. Si une telle $m{\acute{e}}thodologie$ d'analyse existait, quelle serait la $diff{\acute{e}}rence$ avec la $m{\acute{e}}thodologie$ $d{\acute{e}}j{\grave{a}}$ existante? Et si elle n'existait pas, quelle serait la meilleure $m{\acute{e}}thodologie$ $adapt{\acute{e}}e$? Nous $consid{\acute{e}}rons$ la $m{\acute{e}}thode$ d'analyse de la didascalie comme nouvelle $m{\acute{e}}thodologie$ $adapt{\acute{e}}e$. En effet, la didascalie $conna{\hat{i}}t$ sans cesse des $m{\acute{e}}tamorphoses$ dans $l^{\prime}{\acute{e}}criture$. De nombreux $th{\acute{e}}oriciens$ ont $d{\acute{e}}velopp{\acute{e}}$ des $m{\acute{e}}thodes$ d'analyse afin de mieux comprendre les diverses formes de $th{\acute{e}}atre$ comtemporain et ses didascalies. Notre travail est de rassembler les ${\acute{e}}tudes$ des $diff{\acute{e}}rents$ $th{\acute{e}}oriciens$ et de les ordonner ; afin de proposer un outil d'analyse $adapt{\acute{e}}$ pour $l^{\prime}interpr{\acute{e}}tation$ des $pi{\grave{e}}ces$ du $th{\acute{e}}{\hat{a}}tre$ contemporain.

• Biomolecules & Therapeutics
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• v.27 no.3
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• pp.327-335
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• 2019

As the elderly population is increasing, Alzheimer's disease (AD) has become a global issue and many clinical trials have been conducted to evaluate treatments for AD. As these clinical trials have been conducted and have failed, the development of new theraphies for AD with fewer adverse effects remains a challenge. In this study, we examined the effects of Theracurmin on cognitive decline using 5XFAD mice, an AD mouse model. Theracurmin is more bioavailable form of curcumin, generated with submicron colloidal dispersion. Mice were treated with Theracurmin (100, 300 and 1,000 mg/kg) for 12 weeks and were subjected to the novel object recognition test and the Barnes maze test. Theracurmin-treated mice showed significant amelioration in recognition and spatial memories compared those of the vehicle-treated controls. In addition, the antioxidant activities of Theracurmin were investigated by measuring the superoxide dismutase (SOD) activity, malondialdehyde (MDA) and glutathione (GSH) levels. The increased MDA level and decreased SOD and GSH levels in the vehicle-treated 5XFAD mice were significantly reversed by the administration of Theracurmin. Moreover, we observed that Theracurmin administration elevated the expression levels of synaptic components, including synaptophysin and post synaptic density protein 95, and decreased the expression levels of ionized calcium-binding adapter molecule 1 (Iba-1), a marker of activated microglia. These results suggest that Theracurmin ameliorates cognitive function by increasing the expression of synaptic components and by preventing neuronal cell damage from oxidative stress or from the activation of microglia. Thus, Theracurmin would be useful for treating the cognitive dysfunctions observed in AD.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.11
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• pp.529-535
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• 2018

The range extender vehicle runs on a mechanism that allows the small power generation engine to start in the most efficient specific operating range to charge the battery and extend the mileage. In this study, we developed a step motor type intake air supply system that replaces existing throttle body system to develop a simple low cost control logic system. The system was applied to the existing base engine, and in order to improve the performance by increasing the amount of intake air, the effect of changing the length of the intake and exhaust manifold was experimentally examined. As a result, the Type B intake air control actuator operated by one step motor showed higher performance than the Type A in all the operation region, but the performance was lower than that of the base engine due to the increase of flow resistance. To improve this, it was confirmed that the engine performance was improved at both speeds of 2200rpm and 4300rpm when the 140mm adapter was installed in the intake manifold and when the newly designed 70mm exhaust manifold was applied. Through this process, high - precision operation control was realized by connecting the generator load to the optimized engine for the range extender electric vehicle. Experimental results showed that the speed change rate was within ${\pm}2.5%$ at 2200rpm in 1st stage and 4300rpm in 2nd stage and the speed follow-up result of 610 rpm/s was obtained when the speed was increased from 2200rpm to 4300rpm.

• Journal of Korean Library and Information Science Society
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• v.49 no.4
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• pp.147-166
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• 2018

This study is to suggest the considerations in the rules for authorized access points for collocation of music work by figuring out the directions of authorized access points in FRBR, LRM, ICP 2016, RDA, and BIBFRAME, and by analyzing RDA rules for attributes and authorized access points of music works and expression and VIAF examples. First, an aggregated authorized access points were suggested as the direction of authorized access points, and original title may be selected as preferred title and the authorized access point may be based on forms in one of the languages suited to the users, if the original title is not normally suited. Second, music works's authorized access points is consisted of composer authorized access point and preferred title, and of adapter's authorized access point and preferred title in case of lacks of responsibility in composer. Also, the authorized access point of Korean traditional music work must be reviewed according to work types considering the responsibility of composer. Third, the controlled vocabularies for name of music type, medium of performance, and key could be considered for describing the attributes of work and expression. This study would be the foundation study for the authorized access point of music work, and additional research should be completed through surveying music user's need.

• Journal of the Korean Chemical Society
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• v.64 no.6
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• pp.327-333
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• 2020

Performance of a portable GC that can be utilized for the real time determination of volatile organic compounds in air was evaluated. It employs purified/compressed ambient air as the carrier gas eliminating the need for high pressure gas tanks. The compact system with dimensions of 35 × 26 × 15 ㎤ and weight of 5 kg is powered by either a 24 V DC external adapter or battery pack. Chromatograms of the mixture sample including benzene, toluene, ethylbenzene, and oxylene at concentrations of 1 ppmv and 20 ppmv represent a good reproducibility: 3.79% and 0.48% relative standard deviations (RSDs) for peak area variations; 0.40% and 0.08% RSDs for retention times. The method detection limit was 0.09 ppmv. A 30 m long, 0.28 mm I.D. column operated at an optimal condition yielded a peak capacity of 61 with good resolution for a 10 min isothermal analysis. The relative standard deviations (RSD) of the peak area variations and retention times during consecutive measurements over 27 h were less than 2.4%RSD and 0.5%RSD, respectively. Thus, this instrument makes it suitable for continuous and field analysis of low-concentration VOC mixtures in the indoor/outdoor environment as well as the spillage accident of hazardous chemicals.

• Journal of Ginseng Research
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• v.45 no.3
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• pp.390-400
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• 2021

Background: We recently showed that gintonin, an active ginseng ingredient, exhibits antibrain neurodegenerative disease effects including multiple target mechanisms such as antioxidative stress and antiinflammation via the lysophosphatidic acid (LPA) receptors. Amyotrophic lateral sclerosis (ALS) is a spinal disease characterized by neurodegenerative changes in motor neurons with subsequent skeletal muscle paralysis and death. However, pathophysiological mechanisms of ALS are still elusive, and therapeutic drugs have not yet been developed. We investigate the putative alleviating effects of gintonin in ALS. Methods: The G93A-SOD1 transgenic mouse ALS model was used. Gintonin (50 or 100 mg/kg/day, p.o.) administration started from week seven. We performed histological analyses, immunoblot assays, and behavioral tests. Results: Gintonin extended mouse survival and relieved motor dysfunctions. Histological analyses of spinal cords revealed that gintonin increased the survival of motor neurons, expression of brain-derived neurotrophic factors, choline acetyltransferase, NeuN, and Nissl bodies compared with the vehicle control. Gintonin attenuated elevated spinal NAD(P) quinone oxidoreductase 1 expression and decreased oxidative stress-related ferritin, ionized calcium-binding adapter molecule 1-immunoreactive microglia, S100β-immunoreactive astrocyte, and Olig2-immunoreactive oligodendrocytes compared with the control vehicle. Interestingly, we found that the spinal LPA1 receptor level was decreased, whereas gintonin treatment restored decreased LPA1 receptor expression levels in the G93A-SOD1 transgenic mouse, thereby attenuating neurological symptoms and histological deficits. Conclusion: Gintonin-mediated symptomatic improvements of ALS might be associated with the attenuations of neuronal loss and oxidative stress via the spinal LPA1 receptor regulations. The present results suggest that the spinal LPA1 receptor is engaged in ALS, and gintonin may be useful for relieving ALS symptoms.

• Journal of Life Science
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• v.33 no.4
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• pp.349-356
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• 2023

Gout, a chronic inflammatory arthritic disease, is characterized by hyperuricemia. Gout can be induced by an inflammatory response to monosodium urate (MSU) crystals mediated by pro-inflammatory cytokine release following activation of the NOD-like receptor protein 3 (NLRP3) inflammasome. Many sulfur-containing phytochemical compounds in garlic (Allium sativum L.) are considered active ingredients because of their potential pharmacological benefits for various diseases, but their efficacy in NLRP3 inflammasome activation-mediated gout has not been demonstrated. In this study, we investigated whether diallyl disulfide (DADS) and diallyl trisulfide (DATS), representative garlic-derived sulfur compounds, have an inhibitory effect on MSU-induced NLRP3 inflammasome activation. Our results showed that under non-cytotoxic conditions, DADS and DATS significantly blocked nitric oxide production and interleukin (IL)-1β release in response to MSU in lipopolysaccharide (LPS)-primed RAW 264.7 macrophages. DADS and DATS also attenuated enhanced expression of NLRP3 and its adapter protein, apoptosis-associated speck-like protein, which was associated with downregulation of and caspase-1 p20 and IL-1β expression, suggesting that MSU-induced LRP3 inflammasome activation was counteracted by DADS and DATS. Furthermore, DADS and DATS blocked oxidative stress, an upstream event for NLRP3 inflammasome activation, as evidenced by the fact that they scavenged reactive oxygen species (ROS) production. Taken together, our findings demonstrate that DADS and DATS suppressed NLRP3 inflammasome activation by inhibiting the ROS/NLRP3 pathway and that they have potential as treatments for NLRP3-dependent gouty arthritis.