• 대한간호학회지
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• 제6권1호
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• pp.72-79
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• 1976

Contemper nursing literature place much importance on human- centered and individualized care. Nursing research has related stress during hospitalization of adolescent patients to adaptation to a new environment, isolation from friends, limitation due to illness, over protection of parents and communication with member of the medical team. The investigator conducted this study in the hope that an understanding of adolescents responses to hospitalization, their perceptions, the kinds and levels of stress, and the relationships between stressors and individual characteristics would contribute to the improvement of adolescent patient care. The objective of the study was to obtain informations related to the adolescents psychological stress experience during hospitalization, specifically stress from interpersonal relationships and communication, isolation from the family, social or economic problems, illness and from the treatment environment and nursing care. An interview schedule adopted from Holmes and Rahe's Social Readjustment Rating Scale and selected items from Voicer's instrument on stress-producing events was used with 120 adolescent inpatients aged 13 to 18 years three general hospitals in Seoul during Aug. 10, to Sep. 30, 1975. 1. The sample consisted of 66 male and 54 female patients. Sixty-six percent were late adolescents, aged 16 to 18 years: 4% were early adolescents, aged 13 to 15 years. The primary cause for hospitalization was for orthopedic problems (35.8%). More than half of these (54.4%) were due to injury or accident. 2. Stress eclated to illness revealed the highest score (4.97), followed by stress related to treatment environment and nursing care (4.34) , isolation from family and social or economic problems (4.01) and interpersonal relationships and communication (3.96). 3. The perceived indifference of doctors and nurses was a serious cause of stress (mean=4.83). Fellow patients and visitors caused least stress (mean=2.06). 4. Discontinuation of education or unemployment were major stressful events (mean=4.71). Least stressful was isolation from the family (mean=3.47). 5. More than 94% of the respondents expressed fears related to body image (mean=4.97) 6. Within the category of treatment environment and nursing care, items related to restrictions because of treatment, discomfort because of treatment, inadequate explanation from nurses about procedures were rated as severe stress events (mean=4.6). Items related to the ward environment and to having a relative stay with them were seen by the group as less serious events (mean=3.7). 7. Stress related to interpersonal relationships and communication was correlated positively with female patients and those preferring passive activities. (P〈0.05) 8. Stress related to family problems was positively related to female and early adolescent patients (P< 0.05). Stress related to social problems was positively , elated to students and those preferring active pursuits (P< 0.05). 9. There were no correlation between the high stress related to disease and any of the characteristic items. (P> 0.05) 10. Stress related to treatment environment and nursing care was positively related of early adolescent and female and student patients. (P< 0.05) This group of hospitalized adolescents reported high level of stress related to treatment environment and nursing care, due to lack of consideration of normal growth and development and individual characteristics. The findings have important implications for the planning of effective, individualized, comprehensive nursing care of adolescents during hospitalization.

• Asian-Australasian Journal of Animal Sciences
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• 제18권5호
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• pp.613-619
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• 2005

Indigenous Yakutian cattle' adaptation to the hardest subarctic conditions makes them a valuable genetic resource for cattle breeding in the Siberian area. Since early last century, crossbreeding between native Yakutian cattle and imported Simmental and Kholmogory breeds has been widely adopted. In this study, variations at 22 polymorphic microsatellite loci in 5 populations of Yakutian, Kholmogory, Simmental, Yakutian-Kholmogory and Yakutian-Simmental cattle were analysed to estimate the genetic contribution of Yakutian cattle to the two hybrid populations. Three statistical approaches were used: the weighted least-squares (WLS) method which considers all allele frequencies; a recently developed implementation of a Markov chain Monte Carlo (MCMC) method called likelihood-based estimation of admixture (LEA); and a model-based Bayesian admixture analysis method (STRUCTURE). At population-level admixture analyses, the estimate based on the LEA was consistent with that obtained by the WLS method. Both methods showed that the genetic contribution of the indigenous Yakutian cattle in Yakutian-Kholmogory was small (9.6% by the LEA and 14.2% by the WLS method). In the Yakutian-Simmental population, the genetic contribution of the indigenous Yakutian cattle was considerably higher (62.8% by the LEA and 56.9% by the WLS method). Individual-level admixture analyses using STRUCTURE proved to be more informative than the multidimensional scaling analysis (MDSA) based on individual-based genetic distances. Of the 9 Yakutian-Simmental animals studied, 8 showed admixed origin, whereas of the 14 studied Yakutian-Kholmogory animals only 2 showed Yakutian ancestry (>5%). The mean posterior distributions of individual admixture coefficient (q) varied greatly among the samples in both hybrid populations. This study revealed a minor existing contribution of the Yakutian cattle in the Yakutian-Kholmogory hybrid population, but in the Yakutian-Simmental hybrid population, a major genetic contribution of the Yakutian cattle was seen. The results reflect the different crossbreeding patterns used in the development of the two hybrid populations. Additionally, molecular evidence for differences among individual admixture proportions was seen in both hybrid populations, resulting from the stochastic process in crossing over generations.

• Journal of Periodontal and Implant Science
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• 제30권2호
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• pp.359-374
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• 2000

Cyclosporine A(CsA) is a widely used immunosuppressant for transplant patients and is also used for the treatment of a wide variety of systemic diseases with immunologic disorders. However, its use is frequently limited because of complications such as nephrotoxicity or gingival hyperplasia. Although several hypotheses have been postulated for CsA-induced gingival hyperplasia, i.e. various cytokine effects of inflammatory cells, existence of plaque or CsA itself, but its pathogenesis is still unclear. For experimental chronic CsA toxicity, salt depletion has been shown to increased susceptibility of rodents to the effects of CsA, and this maneuver facilitates production of arteriolopathy and interstitial fibrosis in kidney that mimic the changes found in human. The purpose of this study was to evaluate pathogenesis of CsA-induced gingival hyperplasia by comparing changes between CsA administration groups of normal standard diet and those of low salt diet group. Specific pathogen-free, 20 to 25 days old(120 to 150 g), male Fisher-344 rats(KIST, Korea), 120 to 150g of body weight, were assigned to four groups of six animals each after one week of adaptation period for powder food. Group 1 received olive oil($300{\mu}l/g\;of\;diet$) with normal standard diet(0.4% of sodium)(NSD). Group 2 received CsA(Cypol-N, Jonggundang, Korea; $300{\mu}g/g\;of\;diet$) with normal standard diet(NSD+CsA). Group 3 received same amount of olive oil with low salt diet(0.05 % of sodium, Teklad Premier, U.S.A.)(LSD). Group 4 received same dose of CsA with low salt diet(LSD+CsA). Rats were pair fed and were sacrificed after six weeks. Renal histologic lesions associated with CsA, consisted of cortical interstitial fibrosis, tubular atrophy and hyalinization of arterioles and the impairment of renal function including increase of serum creatinine and decrease of glomerular filtration rate was more severe in low salt diet group. These were proved as the results of activated of renin-angiotensin system in the kidney by low salt condition. Meanwhile the degree of gingival hyperplasia at incisor and molar tooth was less severe in low salt diet group compared with normal sodium diet group. Hyperplastic gingiva showed mild epithelial hyperplasia and expanded underlyng stroma which consisted of matrix increasement, capillary proliferation and dilatation. While the number and the activation of fibroblasts were increased, inflammatory cells were rare in the stroma. The immunohistochemistry for TGF-${\beta}_1$ in the kidney and gingiva revealed stronger positive in LSD+CsA in kidney but in gingiva of NSD+CsA. These results suggested followings; Gingival hyperplasia can be developed without inflammatory cells infiltration and seemed not induced by CsA by itself. The major role for gingival hyperplasia by CsA would be the secondary effect of TGF-${\beta}$, which maybe upregulated by CsA administration. Low salt diet can attenuate this hyperplasia perhaps by decreasing the activation of $TGF-{\beta}$.

• 벤처창업연구
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• 제16권6호
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• pp.107-117
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• 2021

본 연구는 북한이탈주민의 경제적 자립과 안정적인 정착을 지원하는 하나의 방안인 창업을 촉진하기 위해서 이에 관련된 변인들의 인과관계를 살펴보는데 목적이 있으며, 구체적으로 첫째, 외향성, 자아성취욕구, 사회적 가치체계인 개인주의와 집단주의가 창업의도에 미치는 영향력을 살펴 보고자 하며, 둘쨰, 사회가치체계와 창업의도 간의 관계에서 사회적응성의 매개효과를 검증하고자 한다. 이를 위해 북한이탈주민을 대상으로 설문조사를 실시하였으며, 실증분석 대상은 북한이탈주민 223명 이었으며, 개인성향과 창업의도 간의 인과관계, 가치체계와 창업의도 간의 인과관계에 대한 검증을 위해 PLS 구조방정식을 사용하였으며, 가치체계와 창업의도 간의 관계에서 사회적응성의 매개 효과 검증을 PROCESS for SPSS Macro를 사용하였다. 실증분석결과를 살펴보면, 외향성이 북한이탈주민의 창업의도 수준에 정(+)의 유의한 영향을 미치는 것으로 분석되었으며, 자아성취욕구 요인은 창업의도에 정(+)의 유의한 영향을 미치는 것으로 나타났으며, 개인주의적 가치를 중시하는 비사회주의적 가치관이 북한이탈주민의 창업의도에 정(+)의 영향을 미치는 것으로 나타났으며, 집단주의 가치는 창업의도에 유의한 영향을 미치지 않는 것으로 나타났다. 본 연구에서 개인주의와 집단주의와 창업의도간의 사회적응성의 매개효과를 검증한 결과 개인주의는 사회적응성을 거쳐 창업의도에 미치는 간접효과는 부(-)의 유의한 영향력을 미치는 것으로 나타났다. 이러한 결과를 바탕으로 시시점을 언급하였다.

• Asian-Australasian Journal of Animal Sciences
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• 제24권3호
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• pp.303-321
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• 2011

The availability and efficient use of the feed resources in Asia are the primary drivers of performance to maximise productivity from animals. Feed security is fundamental to the management, extent of use, conservation and intensification for productivity enhancement. The awesome reality is that current supplies of animal proteins are inadequate to meet human requirements in the face of rapidly depleting resources: arable land, water, fossil fuels, nitrogenous and other fertilisers, and decreased supplies of cereal grains. The contribution of the ruminant sector lags well behind that of non-ruminant pigs and poultry. It is compelling therefore to shift priority for the development of ruminants (buffaloes, cattle, goats and sheep) in key agro-ecological zones (AEZs), making intensive use of the available biomass from the forage resources, crop residues, agro-industrial by-products (AIBP) and other non-conventional feed resources (NCFR). Definitions are given of successful and failed projects on feed resource use. These were used to analyse 12 case studies, which indicated the value of strong participatory efforts with farmers, empowerment, and the benefits from animals of productivity-enhancing technologies and integrated natural resource management (NRM). However, wider replication and scaling up were inadequate in project formulation, including systems methodologies that promoted technology adoption. There was overwhelming emphasis on component technology applications that were duplicated across countries, often wasteful, the results and relevance of which were not clear. Technology delivery via the traditional model of research-extension linkage was also inadequate, and needs to be expanded to participatory research-extension-farmer linkages to accelerate diffusion of technologies, wider adoption and impacts. Other major limitations concerned with feed resource use are failure to view this issue from a farming systems perspective, strong disciplinary bias, and poor links to real farm situations. It is suggested that improved efficiency in feed resource use and increased productivity from animals in the future needs to be cognisant of nine strategies. These include priorities for feed resource use; promoting intensive use of crop residues; intensification of integrated ruminant-oil palm systems and use of oil palm by-products; priority for urgent, wider technology application, adoption and scaling up; rigorous application of systems methodologies; development of adaptation and mitigation options for the effects of climate change on feed resources; strengthening research-extension-farmer linkages; development of year round feeding systems; and striving for sustainability of integrated farming systems. These strategies together form the challenges for the future.

• 한국농림기상학회지
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• 제18권3호
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• pp.162-169
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• 2016

기준기상위험이란 한 지역의 평년기후조건이 작물재배에 미칠 수 있는 '농업기상학적 피해가능성'으로서, 동일 작물 재배 시 지역에 따른 재해위험을 비교하는 기준이 된다. 지구온난화로 인하여 겨울 온도는 상승할 것으로 예상되지만, 기상이변의 빈도 또한 늘어날 것으로 전망되기 때문에 미래 기후조건에서 과수의 동해, 상해 등 저온에 의한 재해위험이 주목 받고 있다. 그러나 기후의 변화는 과수 생물계절도 변화시키므로 기상조건에 근거한 단순한 재해위험 전망은 기후변화적응의 실용측면에서 별 도움이 되지 못한다. 본 연구에서는 전국 주요 지역의 과거 및 기후변화시나리오를 이용하여 배, 복숭아, 사과의 생물계절을 예측하고 생육단계별 기온과의 상호작용에 근거하여 저온 유래 기준기상위험을 계산함으로써 미래의 재해가능성을 전망하였다. 휴면해제일은 미래로 갈수록 늦어질 것으로 전망되었으며, 발아일과 개화일의 경우 빨라질 것으로 예상되었다. 대구, 전주, 목포의 경우 휴면해제일의 지연 정도가 미래로 갈수록 커졌으며 발아일과 개화일의 경우 서울, 인천 지역이 다른 지역에 비해 늦게 나타났다. 서울과 인천, 대구와 전주, 부산과 목포가 서로 비슷한 양상을 나타내었다. 휴면기 동안에는 전 지역이 동해에 안전하였으나 휴면해제-발아기 동안에는 전 지역이 동해에 취약하였고, 발아기-개화기의 위험은 미래로 갈수록 대체로 낮아졌지만 지역에 따라 위험이 커지는 곳도 있었다.

• Journal of Microbiology and Biotechnology
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• 제27권9호
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• pp.1701-1710
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• 2017

Classical swine fever virus (CSFV) is the etiologic agent of classical swine fever, a highly contagious disease that causes significant economic losses to the swine industry. The lapinized C-strain, a widely used vaccine strain against CSFV, has low growth efficiency in cell culture, which limits the productivity in the vaccine industry. In this study, a recombinant virus derived from C-strain was constructed and subjected to continuous passaging in PK-15 cells with the goal of acquiring a high progeny virus yield. A cell-adapted virus variant, RecCpp80, had nearly 1,000-fold higher titer than its parent C-strain but lost the ability to induce fever in rabbits. Sequence analysis of cell-adapted RecC variants indicated that at least six nucleotide changes were fixed in RecCpp80. Further adaption of RecCpp80 variant in swine testicle cells led to a higher virus yield without additional mutations. Introduction of each of these residues into the wild-type RecC backbone showed that one mutation, M979R (T3310G), located in the C-terminal region of E2 might be closely related to the cell-adapted phenotype. Rabbit inoculation revealed that $RecCpp40_{+10}$ failed to induce fever in rabbits, whereas $RecCpp80_{+10}$ caused a fever response similar to the commercial C-strain vaccine. In conclusion, the C-strain can be adapted to cell culture by introducing specific mutations in its E2 protein. The mutations in RecCpp80 that led to the loss of fever response in rabbits require further investigation. Continuous passaging of the C-strain-based recombinant viruses in PK-15 cells could enhance its in vitro adaption. The non-synonymous mutations at 3310 and 3531 might play major roles in the enhanced capacity of general virus reproduction. Such findings may help design a modified C-strain for improved productivity of commercial vaccines at reduced production cost.

• 한국재난관리표준학회지
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• 제4권2호
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• pp.57-64
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• 2011

최근 우리나라에서 발생한 홍수와 가뭄 등 물 관련 재해가 분명히 과거와는 다른 패턴을 보이는 원인이 인간의 경제활동과정에서 발생하는 엄청난 양의 이산화탄소 때문인지 아니면 태양의 흑점수의 증가 때문인지는 불확실하지만 최근 수자원 관리에 직접적인 영향을 주는 기상이변들의 발생이 증가한 것은 분명한 사실이다. 빈번히 발생하는 기상이변에 의해 각종 재해의 발생빈도가 높아지고 있는 실정이며, 상당한 원인은 기후변화로 보여진다. 이렇듯 기후변화는 반드시 사회적인 비용을 초래하게 된다. 특히 홍수와 가뭄으로 나타나는 수자원분야의 영향이 많은 부분을 차지하고 있다. 따라서 본 연구는 이러한 기후변화에 의해 발생하는 수자원분야 경제적 파급효과 분석을 통한 cost damage를 도출하고 이를 바탕으로 적절한 적응사업 추진을 위한 새로운 경제성 분석기법 정립을 위한 기초연구이다. 기 연구에서 사용된 기후변화 피해 및 감축비용 분석을 위한 모형은 PAGE, DICE, AIM, IMAGE, MERGE 등 다양했으며, 본 연구에서는 각 모델들의 개략적 특성에 대해 정리하였다. 또한 본 연구에서는 우선 비용적 측면에서 접근이 가능할 수 있도록 기후변화의 물분야에 대한 정의가 이루어졌다. 본 연구결과를 통해 기후변화의 사회경제적 영향평가 연구에서 고려할 수 있는 다양한 평가모델들의 선택에 도움을 줄 것이며 이는 최종적으로 기후변화관련 사업의 시공간적 국가 예산투자 우선순위선정에 활용될 수 있을 것이다.

• 한국농림기상학회지
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• 제23권1호
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• pp.68-81
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• 2021

농업 생태계는 주요 온실가스의 배출원 중 하나로, 농경지에서의 온실가스 배출량을 최소화하면서 최적의 수량을 얻기 위한 기후변화 적응옵션을 도출하기 위해서는, 상세한 공간적 규모에서 여러 모형들을 연계하여 구동하는 것이 유리하다. 본 연구에서는 DSSAT 모형과 DNDC 모형을 연계하여 상세한 공간 규모에서 기후변화 영향평가를 수행할 수 있도록 지원하기 위한 도구를 개발하고자 하였다. 객체 지향 언어인 R과 C++을 사용하여 DNDC 모형의 격자형 입력자료를 생성하기 위한 DRIFT (DNDC Regional Input File Tool)을 구현하였다. 기후변화 조건에서 격자별 작물 생육모의를 위해 생성된 DSSAT 모형의 입력자료 및 출력자료를 사용하여 DNDC 모형의 입력자료를 생성하였다. 생성된 입력자료를 사용하여 미래 기후변화 조건에서의 온실가스 배출량을 모의하였다. 입력자료를 생성하는 시간은 격자 지점의 수에 비례하여 증가하였다. 그 중, DSSAT 모형의 담수 깊이 자료를 DNDC 모형의 담수 기간으로 변환하는 과정에서 시간이 비교적 오래 걸렸으나, 그 외의 입력자료를 생성하는 데에는 짧은 시간만이 소요되었다. 본 연구에서는 비교적 적은 지점을 대상으로 하였으나, 대량의 자료를 처리하고자 할 경우 일부 계산과정을 병렬화함으로써 구동시간을 줄일 필요가 있을 것이다. 이후 다른 모형들에 대한 확장을 통해 모형 간 연계를 위한 입력자료 생성에 소요되는 시간을 줄일 수 있을 것이다.

• Asian-Australasian Journal of Animal Sciences
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• 제20권3호
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• pp.373-377
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• 2007

Alfalfa silage and corn silage are the major dairy feeds in most dairy operations in Michigan, USA. In recent years, the need to improve digestible fiber and dry matter intake of forages to meet the nutrient requirements of high yielding dairy cows and the willingness to plant corn specifically for silage has led plant breeders to focus on the brown mid-rib (BMR) trait. The objective of this study was to investigate the effect of different ratio of alfalfa to BMR corn silage and ration level of forage neutral detergent fiber (NDF) on animal performance of lactating cows in the Upper Peninsula of Michigan. This study was conducted at the Upper Peninsula Experiment Station of Michigan State University in Chatham, Michigan, USA. Two different ratios of forage type (high alfalfa silage/low BMR corn silage, AS, and high BMR corn silage/low alfalfa silage, BMRCS) and two different dietary NDF contents (27% NDF, 27 = low forage/high grain feeding, and 33% NDF, 33 = high forage/low grain feeding) were used. The experimental design was a $4{\times}4$ Latin Square with 20 milking cows (12 multiparous and 8 primiparous). This trial had four 21-day periods with 14 d adaptation and 7 d data collection. Milk yield and body condition score (BCS) on the AS-27, BMRCS-27 and BMRCS-33 treatments were significantly (p<0.05) higher than on the AS-33 treatment. Dry matter intake of the AS-27 and BMRCS-27 treatments was significantly (p<0.05) higher than for the AS-33 and BMRCS-33 treatments. Milk urea nitrogen (MUN) on the AS-33 treatment was significantly (p<0.05) higher than on the other diet treatments. A key finding of this study was that the BMRCS-33 (higher amounts of brown mid-rib corn silage than alfalfa silage, high forage and low grain feeding diet at 33% NDF) led to the equal highest milk production whilst having the equal lowest dry matter intake. This study demonstrated that the diet with higher ratio of highly digestible NDF forage such as brown mid-rib corn silage to alfalfa silage could lower grain feeding in the ration.