• Title/Summary/Keyword: Acute Renal Failure

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Studies on the Efficacy of Combined Preparation of Crude Drugs (XVIII) -The effect of ‘Palmiwhan’ on the Nephrogenous Hypertension- (생약복합제제(生藥複合製劑)의 약효(藥效) 연구(硏究) (제18보)(第18報) -팔미환(八味丸)이 신성고혈압(腎性高血壓)에 미치는 영향(影響)-)

  • Rho, Young-Soo;Hong, Nam-Doo;Kim, Soo-Ok;Kim, Nam-Jae
    • Korean Journal of Pharmacognosy
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    • v.15 no.4
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    • pp.179-187
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    • 1984
  • To investigate the recorded efficacy in Oriental medical references and effects in clinics, experimental studies were undertaken to estimate 'Palmiwhan' to the diuretic effect in normal rats, rabbits and rats with $HgCl_2-induced$ acute renal failure and hypotensive effects on the nephrogenous hypertension in rabbits with $HgCl_2-induced$ acute renal failure. The results of this study were summarized as follows; Increase in urinary volume, urinary $Na^+\;and\;Cl^-$ excretions were significantly recognized in normal rats and rabbits. Increase in urinary volume, urinary $Na^+\;and\;Cl^-$ excretions were significantly shown in rats with 2mg/kg $HgCl_2-induced$ acute renal failure. Although plasma electrolyte and creatinine levels were little affected, plasma urea nitrogen levels were significantly elevated in normal rats and 2mg/kg $HgCl_2-induced$ acute renal failure of rats. Although the blood pressure was not affected in normal rabbits and cats, hypotensive actions due to the diuretic effect were recognized in rabbits $HgCl_2-induced$ acute renal failure.

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Minimal Change Nephrotic Syndrome Presented with Acute Renal Failure in a Child (급성 신부전증을 동반한 미세변화 신증후군 1례)

  • Park Soo-Jun;Rho Kwang-Sik;Lee Gu-Hyun;Kim Pyung-Kil;Jeong Hyeon-Joo
    • Childhood Kidney Diseases
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    • v.1 no.1
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    • pp.79-81
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    • 1997
  • Minimal change nephrotic syndrome is characterized by proteinuria, hypoproteinemia, edema, and hyperlipidemia. Children with onset of nephrotic syndrome between the age of 1 and 8 year are likely to have steroid response to minimal chage disease, but we experienced one case of minimal change disease which failed to respond to steroid therapy at beginning and subsequently developed acute renal failure. It was seen in a 5 year-old male child that presented with edema and gross hematuria. Peritoneal dialysis was performed for acute renal failure for 11 days. Patient was completely recorvered from acute renal failure and renal biopsy was done at 27th day after onset of disease which revealed typical picture of minimal change disease complicated by acute tubular necrosis. We beleive this case is very unusual and it may be the first case in the literature in terms of pediatric cases.

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Two Cases of Acute Renal Failure Caused by Acute Paraquat Poisoning (급성 Paraquat 중독 후 발생한 급성 신부전 환자 2예)

  • 장통영;정용준;김관식;서관수;한명아;신선호;김동웅
    • The Journal of Korean Medicine
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    • v.21 no.4
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    • pp.276-285
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    • 2000
  • Paraquat is a very potent herbicide which causes fatal toxicity when ingested, and there is no specific antidote against it. Human ingestion induces acute renal failure, hepatic dysfunction and progressive respiratory failure with high mortality rate. Clinical investigation and medical treatment were done on two cases of acute renal failure caused by paraquat poisoning admitted to the Department of Internal Medicine, Wonkwang University Oriental Chonju Medical Hospital. We report two cases of patients who survived after acute paraquat intoxication, by means of oriental medicine such as Gamdutang, a typical antidote of toxins, chinese ink as an absorbent and burned powder of Rhei Radix et Rhizoma for laxative and so on, western medicine such as gastric lavage, diuretics and fluid therapy. We suggest more experiments and studies related to such treatment for paraquat poisoning be conducted.

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Effects of Sojongchobisunki-tang on Cisplatin-induced Rat Acute Renal Failure (소종조비순기탕(消腫調脾順氣湯)이 Cisplatin으로 유발(誘發)된 흰쥐의 급성신부전(急性腎不全)에 미치는 영향)

  • Yoon, Gyeong-Min;Kang, Seok-Bong
    • The Journal of Internal Korean Medicine
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    • v.32 no.2
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    • pp.278-287
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    • 2011
  • Objectives : The object of this study was to observe the nephroprotective effects of Sojongchobisunki-tang (SCST), which has traditionally been used as Korean medicine for treating various renal diseases, on cisplatin-induced rat acute renal failure. Methods : Three different dosages of SCST were orally administered once a day for 23 days before cisplatin treatment (5 mg/kg, single intraperitoneally administered) and 5 days after cisplatin treatment (once a day for 28 days). 6 groups, of 8 rats per group were used in the present study after 7 days of acclimatization. Changes of the body weight, kidney weight, serum BUN and creatinine levels were observed, as well as changes of the kidney MDA and GSH contents. The results were compared with captopril 100 mg/kg of which the effects on cisplatin-induced acute renal failures are already confirmed. Results : Acute renal failure induced by cisplatin were induced by oxidative stress and related lipid peroxidation in the present study. However, these acute renal failures and inhibition of antioxidant effects induced by cisplatin were dose-dependently reduced by treatment at all three different dosages of SCST extracts. Conclusions : This study suggests that SCST extracts showed favorable effects on the cisplatin-induced rat ARF.

Beneficial Effect of Glycyrrhizae Radix Extract on Ischemia-Induced Acute Renal Failure in Rabbits (토끼의 허혈성 신부전 대한 감초(甘草) 추출물의 억제 효과)

  • Kim, Gyung-Ho;Kim, Min-Ho;Yun, Yeo-Chung;Kim, Young-Gyun;Cho, Su-In
    • The Korea Journal of Herbology
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    • v.20 no.3
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    • pp.43-49
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    • 2005
  • Objectives : The present study was carried out to determine if Glycyrrhizae Radix extract exerts beneficial effect against the ischemia-induced acute renal failure in rabbits. Glycyrrhizae Radix was known to reinforce the function of the spleen and replenish Qi, remove heat and counteract toxicity, dispel phlegm and relieve cough, alleviate spasmodic pain, and to moderate drug actions. It's indications are weakness of the spleen and the stomach marked by lassitude and weakness; cardiac palpitation and shortness of breath; cough with much phlegm: spasmodic pain in the epigastrium, abdomen and limbs: carbuncles and sores. It is often used for reducing the toxic or drastic actions of other drugs. Methods : Antioxidative effect of 3% concentration of Glycyrrhizae Radix extract was measured. Rabbits were treated with Glycyrrhizae Radix extract via i.v., followed by renal ischemia/reperfusion, and the changes of urine volume, serum creatinine levels, glomerular filtration rate(GFR), fractional Na+ excretion$(FE\;Na^+)\;and\;K^+\;excretion(FE\;K^+)$ in ischemia/reperfusion induced acute renal failure were measured. Results : Renal ischemia/reperfusion caused increase of serum creatinine level, which was accompanied by a reduction in glomerular filtration rate(GFR). The fractional excretion of $Na^+\;and\;K^+$ increased in ischemia-induced animals, which was partially prevented by Glycyrrhizae Radix extract treatment. Conclusions : These results indicate that lipid peroxidation plays a critical role in ischemia-induced acute renal failure. Glycyrrhizae Radix extract exerts the protective effect against acute renal failure induced by renal ischemia/reperfusion, and its effect may be attributed to an antioxidant action.

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Effect of Glycyrrhizae Radix Extract on Ischemia-Induced Acute Renal Failure in Rabbits (감초(甘草) 추출물이 허혈에 의한 토끼의 급성 신부전에 미치는 영향)

  • Kim Gyung-Ho;Jeong Hyun-Woo;Park Jin-Young;Lee Young-Joon;Cho Su-In
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.20 no.1
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    • pp.98-102
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    • 2006
  • The present stuby was carried out to determine if Radix Glycyrrhizae extract exerts beneficial effect against the ischemia-induced acute renal failure in rabbits. Radix Glycyrrhizae was known to reinforce the function of the spleen and replenish Qi, remove heat and counteract toxicity, dispel phlegm and relieve cough, alleviate spasmodic pain, and to moderate drug actions. It's indications are weakness of the spleen and the stomach marked by lassitude and weakness; cardiac palpitation and shortness of breath; cough with much phlegm; spasmodic pain in the epigastrium, abdomen and limbs; carbuncles and sores. It is often used for reducing the toxic or drastic actions of other drugs. Rabbits were treated with Radix Glycyrrhizae extract via i.v., followed by renal ischemia/reperfusion. Fractional excretion of glucose and phosphate, lipid peroxidation and light microscopy were done to evaluate the beneficial effect of Radix Glycyrrhizae extract on ischemia/reperfusion induced acute renal failure. Renal ischemia/reperfusion caused increase of fractional excretion of glucose and phosphate increased in ischemia-induced animals, which was partially prevented by Radix Glycyrrhizae extract treatment. Ischemia/reperfusion increased lipid peroxidation, which was prevented by Radix Glycyrrhizae extract administration. And the beneficial effect of Radix Glycyrrhizae extract on ischemia/reperfusion induced kidney injury was shown through the light micrographic observation. These results indicate that lipid peroxidation plays a critical role in ischemia-induced acute renal failure. Radix Glycyrrhizae extract exerts the protective effect against acute renal failure induced by renal ischemia/reperfusion.

Acute Kidney Injury in the Newborn: Etiology, Pathophysiology and Diagnosis (신생아의 급성신손상)

  • Kim, So-Young
    • Neonatal Medicine
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    • v.17 no.2
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    • pp.161-167
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    • 2010
  • Acute kidney injury (AKI), formerly referred to as acute renal failure (ARF) is defined as the sudden impairment of kidney function (estimated from the glomerular filtration rate [GFR]) that results in the lack of excretion of waste products. More than 30 definitions of AKI exist in the literature, most of which are based on serum creatinine. Lack of a uniform and multidimensional AKI definition has led to failure to recognize significant renal injury, delays in treatment, and inability to generalize single-study results. The RIFLE criteria were developed to standardize the diagnosis of ARF and in the process the term AKI has been proposed to encompass the entire spectrum of the syndrome from minor changes in renal function to requirement for renal replacement therapy. Large prospective studies are needed to test definitions and to better understand risk factors, incidence, independent outcomes, and mechanisms that lead to poor short- and long-term outcomes. Early biomarkers of AKI need to be explored in critically ill neonates.

Correction of Acute Renal Failure After Mitral Valve Replacement: A Case Report (승모판 협착증 판막 이식후 발생한 급성 신부전증 치험 1예)

  • 조규석
    • Journal of Chest Surgery
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    • v.11 no.2
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    • pp.117-122
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    • 1978
  • With the increasing performance of open heart surgery during recent years, the occurrence of renal failure associated with cardiopulmonary aypass has received considerable attention. This patient was 33 yaar old woman who undertaken mitral valve replacement under the cardiopulmonary bypass. Acute renal failure developed after 2nd postoperative day. So we report here the course of renal failure as it occur in immediate relation to open heart surgery and examine the role of preoperative, intraoperative and postoderative factors.

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Effect of Acupuncture and Moxibustion at SP6(Sanyinjiao) and BL28(Pangguangshu) on Experimental Acute renal failure in rats (삼음교(三陰交)(SP6), 방광유(膀胱兪)(BL28)의 침자 및 애구자극이 흰쥐의 실험적 급성신부전에 미치는 영향)

  • Kim, Min-ho;Park, Chun-ha;Kim, Hyo-ean;Yun, Yeo-chung
    • Journal of Acupuncture Research
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    • v.19 no.6
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    • pp.49-60
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    • 2002
  • Objective : The aim of this experiment is to investigate the effect of acupuncture and moxibustion at SP6(Sanyinjiao) and BL28(Pangguanshu) on uranyl acetate-induced acute renal failure in rats. Methods : To induce experimental acute renal failure, uranyl acetate was intraperitoneally injected to rats by 5mg/kg. 3 days later acupuncture and moxibustion treatment was done at SP6(Sanyinjiao) and BL28(Pangguanshu) bilaterally of the rats. And then 4 days later, we measured rats' body weight, kidney weight, serum BUN, creatinine and serum eletrolyte levels(Na, K and Cl). Results : In the moxibustion group, hypertrophy index of kidney and serum BUN level were decreased marginally significantly, and serum creatinine, K levels were decreased significantly. But in the acupuncture group, there was no significance at this experiment. Conclusions : SP6(Sanyinjiao) and BL28(Pangguanshu) moxibustion can decrease serum BUN, creatinine, and serum eletrolyte levels on uranyl acetate-induced acute renal failure in rats. And the study will be done continuously about non-effect in the acupuncture group at this experiment.

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A Case Report of Drug-Induced Acute Renal Failure Treated with Herbal Medicine (약인성 급성 신부전 환자의 한약치료에 대한 증례 보고)

  • Kim, Min-ji;Park, Sung-woon;Seo, Yoon-jeong;Ryu, Jae-hwan
    • The Journal of Internal Korean Medicine
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    • v.37 no.5
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    • pp.755-762
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    • 2016
  • Objective: To report the effects of Siryeng-tang (柴苓湯) and Chijasi-tang (梔子豉湯) on a patient with drug-induced acute renal failure. Methods: A female patient was diagnosed with acute renal failure. The symptoms decreased urine output, tachycardia, dyspnea, and chest discomfort. The patient was treated with Siryeng-tang for one day and Chijasi-tang for about 5 days. Results: After taking Siryeng-tang, urine output increased and the values for blood urea nitrogen and creatinine were decreased to normal. Taking Chijasi-tang improved other related symptoms. Conclusions: Siryeng-tang and Chijasi-tang can improve the symptoms of acute renal failure.