The Korea Journal of Herbology (대한본초학회지)
- Volume 20 Issue 3
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- Pages.43-49
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- 2005
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- 1229-1765(pISSN)
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- 2288-7199(eISSN)
Beneficial Effect of Glycyrrhizae Radix Extract on Ischemia-Induced Acute Renal Failure in Rabbits
토끼의 허혈성 신부전 대한 감초(甘草) 추출물의 억제 효과
- Kim, Gyung-Ho (College of Korean Medicine, Dongshin University) ;
- Kim, Min-Ho (College of Korean Medicine, Dongshin University) ;
- Yun, Yeo-Chung (College of Korean Medicine, Dongshin University) ;
- Kim, Young-Gyun (College of Korean Medicine, Dong-Eui University) ;
- Cho, Su-In (College of Korean Medicine, Dongshin University)
- Published : 2005.09.30
Abstract
Objectives : The present study was carried out to determine if Glycyrrhizae Radix extract exerts beneficial effect against the ischemia-induced acute renal failure in rabbits. Glycyrrhizae Radix was known to reinforce the function of the spleen and replenish Qi, remove heat and counteract toxicity, dispel phlegm and relieve cough, alleviate spasmodic pain, and to moderate drug actions. It's indications are weakness of the spleen and the stomach marked by lassitude and weakness; cardiac palpitation and shortness of breath; cough with much phlegm: spasmodic pain in the epigastrium, abdomen and limbs: carbuncles and sores. It is often used for reducing the toxic or drastic actions of other drugs. Methods : Antioxidative effect of 3% concentration of Glycyrrhizae Radix extract was measured. Rabbits were treated with Glycyrrhizae Radix extract via i.v., followed by renal ischemia/reperfusion, and the changes of urine volume, serum creatinine levels, glomerular filtration rate(GFR), fractional Na+ excretion