• The Journal of Internal Korean Medicine
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• v.33 no.2
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• pp.180-187
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• 2012

Objectives : The aim of this study was to investigate weight gain effects of the Sungjangjeungbo-tang (Ch$\acute{e}$ngzh$\check{a}$ngz$\bar{e}$ngb$\check{u}$-tang) on thin Korean preschool children. Methods : Sungjangjeungbo-tang is composed of 9 herbs for treating indigestion. We analyzed 119 preschool children who visited Kim Kijoon Oriental Clinic BOM from Jan. 1, 2006 to Aug. 31, 2011 with three criteria: 1) 2~5yrs of age and BMI < 50th percentile on the baseline visit; 2) the child had taken the Sungjangjeungbo-tang for 1~3 month(s); and 3) the clinic had records of both height and weight on the baseline and at least once over 1~3 month(s). Results : Sungjangjeungbo-tang significantly improved BMI percentile in all groups. The changes in BMI percentile variations were larger in the 3 months group than in other groups, but not significantly. Gender, age and BMI on the baseline had no significant effects on the effectiveness of Sungjangjeungbo-tang. Conclusions : Sungjangjeungbo-tang positively affected on weight gain in thin Korean preschool children within 1~3 month(s) of treatment. However, additional studies on functional dyspepsia or the change of energy intake were needed to know the factors related to weight gains.

• The Journal of Internal Korean Medicine
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• v.22 no.2
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• pp.251-256
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• 2001

In western medicine, there are some reports about herbal medicine induced hepatitis, but in oriental medicine, there are few reports about that. We experienced one case of drug acute cholestatic-hepatitis in the treatment of oriental medicine for HNP. We treated the patient with acupuncture, physical therapy and herb medicine. The patient's symptoms improved after two weeks of treatment. In the course of treatment, the patient intermittently complained of general weakness, nausea, yellowish urin, dyspepsia, and abdominal discomfort. We recognized that total bilirubin(7.2mg/dl), direct bilirubin(5.5mg/dl), serum transaminase(AST 360U/L, ALT 354U/L), alkaline phosphatase(16.6 K/A), urobilinogen(++) and bilirubin(++) were elevated. We diagnosed drug induced hepatitis. We stopped giving herb medicine and began giving Saeng gan gunbi-tang and Injin-oryung-san. Saeng gan gunbi-tang and Injin-oryung-san have been used to treat hepatic disease and have been known to have beneficial effects. After 3weeks on medication, the clinical symptoms and liver function improved. So, we report this case to bring more attention to the safety and toxicity of herbal medicine.

• The Journal of Korean Medical History
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• v.19 no.2
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• pp.87-100
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• 2006

Jang Jong-jeong thought that, because all diseases come from miasma, for treating diseases, it is important to attack or remove miasma infiltrating into the body. Thus, he treated diseases using three methods, namely, vomiting against miasma on the top, sweating against miasma on the surface, and diarrhea against miasma on the bottom. Among them, vomiting is rarely used in contemporary Oriental medicine, but still one of major disease treatment methods. Vomiting is quite meaningful in today's clinics and particularly effective for acute diseases, the miasma of which is in the upper chest. According to the present researcher's experiences, it is effective in cases that the pathological symptoms are observed in the upper chest such as early stroke, dyspepsia, chest congestion and congestion heat. For vomiting, the researcher applied Dokseongsan, Samseongsan, Gwachesan, Gangyeomtang, Bangpungtongseongsan, etc. Dokseongsan was used for vomiting in a cool way, and Samseongsan and Gwachesan were used for vomiting in a warm way. Bangpungtongseongsan was used when inner heat was choked up by the attack of external miasma and when the pathological symptoms of Bangpungtongseongsan were observed.

• YAKHAK HOEJI
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• v.55 no.2
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• pp.160-167
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• 2011

Cirsium japonicum var. ussuriense (CJ) is used as a folk medicine for diuretic, arthritis, dyspepsia, and bleeding in Korea. Until now, more than fifteen kinds of CJ were identified and among them, Cirsium japonicum var. nakaianum Nakai was selected as experimental material. Both that from The Medical Herb Garden of Seoul National University located at Gayang-dong, Koyang city and native that from a hillock near Dangjin, Chungnam were collected and analyzed to determine whether it is varied in efficacy on their habitats. Extracts and fractions of CJ had a strong effect of antibacterial activity on H. pylori and antioxidant effects. And the CJ from Garden and Dangjin were showed to be more efficient in acute gastritis through the HCl${\cdot}$ethanol-induced gastric lesion test and chronic gastritis through the indomethacin-induced gastric lesion test, respectively. This study proved that the effects of CJ are varied by their habitats. Also, these results suggest that the CJ has potentials for use as functional food and medicine.

• Korean Journal of Health Education and Promotion
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• v.23 no.3
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• pp.121-134
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• 2006

Objectives: This study was conducted to analyze the general properties of beauticians and to analyze correlation between their experiences of indigestion and relevant factors and thus to provide basic data to prevent obstacles to beautician's health. Methods: A self-administered survey on 257 female beauticians in Daegu from March 15 to May 30, 2005 was conducted. Cross-link analysis was used to examine indigestion in relation to the general properties of beauticians, and correlation analysis was used to determine the level of relationship between indigestion and relevant factors, and multiple regression analysis was used to determine the degree of effects of relevant factors on indigestion. Results: The results can be summarized as follows: 1. As for indigestion by general properties and beauty-related properties, there were significant differences in gender(p<0.01), age(p<0.05) and marriage status(p<0.05) among general properties and there were significant differences in the number of holiday(p<0.05), beauty culture career(p<0.01), and the degree of satisfaction on duty(p<0.001) among beauty-related properties. As for indigestion by eating habit and health-related properties, there were significant differences in the degrees of regular eating(p<0.001) and regular living habit(p<0.001), and eating speed(p<0.01). 2. Factors relevant to the eating habit showing significant correlation with indigestion were regular eating habit, taking well-balanced nutrition, and taking salty food. Among them, the regular eating habit was shown to be the most relevant with the correlation coefficient of -0.253(p<0.01). The general and beauty-related factors showing significant correlation with indigestion were beauty culture career, number of holiday, and regular living habit. And regular living habit was shown to be the most relevant with the correlation coefficient of -0.260(p<0.001). 3. Results from the regression analysis showed that relevant factors having significant effects on indigestion were gender, beauty culture career, satisfaction on duty, eating speed, regular eating habit and regular living habit. And satisfaction on duty was found to have the greatest effect on indigestion. Conclusions: The findings of this study could be effectively used to develop a practical management strategy to prevent $beauticia{\acute{n}}s$ indigestion, and to promote $beauticia{\acute{n}}s$ health, and ultimately to improve the $beauticia{\acute{n}}s$ quality of life.

• The Journal of Pediatrics of Korean Medicine
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• v.21 no.2
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• pp.35-50
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• 2007

Objectives The purpose of this study was to revitalize pediatric emergency care in oriental medical hospital. Methods The study was composed of 281 pediatric patients who visited emergency room of the ${\bigcirc}{\bigcirc}$ university oriental hospital, from March 2006 to February 2007. Results The age distribution showed that 1 to 3 year's patients(40.6%) are the most New pediatric patients(59.1%) were more than who received medical treatment in this place. The seasonal distribution of between month's section and the 24 solar terms's section made no differences and pediatric patients who visited in emergency room was most in spring, least in autumn. Moreover the changes of season's patients were more than others. Pediatric patients who visited during the weekends and holidays(50.9%) were more than during the weekdays(49.1%). Systemic division of the major problems were the digestive symptoms(44.5%) and nervous symptoms(30.6%), respiratory symptoms(12.5%), musculoskeletal symptoms(5.3%), dermatological symptoms(1.8%), cardiovascular symptoms(0.7%) and others(4.6%) followed. The time interval between arrival and onset : within 6 hours were the most(54.5%). Pediatric patients who had digestive, nervous, musculoskeletal diseases within 6 hours were the most, but in the case of patients who had respiratory diseases, most of them were visited within 48 hours. Acting and herb-med treatment(77.9%) were the most in medical treatments. Pediatric patients(69.0%) who didn't revisit in this hospital after treatment in emergency room were more than who revisited(29.9%). Conclusions Pediatric patients who visited in emergency room of oriental medical hospital were most not acute form of a serious diseases, patients most visited in disease prefer to oriental medicine; such as dyspepsia, convulsions, crying, ankle sprain. Further studies will be needed for the actual circumstance's reflecion from this hospital and other oriental hospitals nearby or other western emergency rooms for the accurate studies.

• The Journal of Pediatrics of Korean Medicine
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• v.28 no.4
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• pp.30-44
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• 2014

Objectives By analyzing data of the pediatric patients who had visited the emergency room of the oriental medical hospital, we can understand their characteristics and diseases. The purpose of this study was to introduce the excellence of the Oriental medicine, to develop various treatments, and to revitalize pediatric emergency care at the oriental medical hospital. Methods The study was composed of 334 pediatric patients who had visited the emergency room of the ${\bigcirc}{\bigcirc}$ university oriental hospital from January 2011 to December 2013. Results 1. It has showed that between 7 to 12 years old patients (27.8%) were the most common age populations. 2. The number of pediatric patients was increased during February. According to the weekly distribution data, the number of pediatric patients who had visited on Sunday was the highest (28.7%). Also, the number of pediatric patients who had visited the ER between 21 to 24 hours (29.0%) was the highest. 3. The two major reasons for inpatient hospitalization were digestive and nerve-related symptoms. Nerve-related symptoms were the most common in infants while digestive symptoms were the most common in other child development stages. 4. The duration of time interval from the onset of symptoms to the ER visit was most commonly within 6 hours (50.3%). An acupuncture and herbal medication treatment (70.1%) were the most common medical treatments. The majority of the pediatric patients (95.5%) were discharged after their medical treatments. Conclusions A serious acute illness was not the most common reason for the ER visit among the pediatric patients. The most common disease states that have preferred to be treated with the oriental medicine were dyspepsia, crying, facial palsy, and ankle sprain. We have to introduce the excellence of the oriental medicine. We also need to try developing other treatments such as magnetic acupuncture, aromatherapy, and revitalizing pediatric emergency care at the oriental medical hospital.

• Journal of Physiology & Pathology in Korean Medicine
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• v.30 no.1
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• pp.54-60
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• 2016

Amomum cadamomum Linne (ACL) has long been utilized against the inhibited qi movement related diseases such as dyspepsia, acute gastroenteritis, vomiting and diarrhea in Korean medicine. We speculated that ACL could improve the metabolic disorders such as obesity and type 2 diabetes through removing the phlegm-dampness and promoting the qi movement or stagnation. This study was designed to investigate effects and molecular mechanisms of ACL extract on the improvement of adipocyte dysfunction induced by TNF-α in 3T3-L1 adipocytes. Potential roles of ACL extract in the lipogenesis, inhibition of inflammatory cytokines and insulin resistance, were investigated in this study. Also, we examined the adipose genes and signaling molecules related to insulin resistance and glucose uptake to elucidate its mechanism. Our data demonstrated that TNF-α significantly incresed the release of lipid droplets and the production of MCP-1 and IL-6 from adipocytes. In gene expression, TNF-α reduced the expression of aP2, PPARγ, C/EBPα, GLUT4, and IRS-1 related to lipogenesis and insulin sesitivity, while TNF-α increased the expression of MCP-1 related to inflammation. In addition, TNF-α down-regulated the PPARγ and IRS-1 protein and up-regulated the IRS-1 Ser307 phosphorylation. These alterations induced by TNF-α were prevented by the treatment of ACL extract. Thus, our results indicate that ACL extract can be used to prevent from the TNF-α-induced adipocyte dysfunction through insulin and PPARγ pathways.

• The Journal of Pediatrics of Korean Medicine
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• v.24 no.3
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• pp.1-15
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• 2010

Objectives: By analyzing data of pediatric patients who had visited the emergency room of an oriental medical hospital, we can understand their characteristics and diseases. The purpose of this study was to introduce the excellence of Oriental medicine, to develop various treatments and to revitalize pediatric emergency care at oriental medical hospital. Methods: The study was composed of 371 pediatric patients who had visited the emergency room of the $\bigcirc\bigcirc$ university oriental hospital from January 2008 to December 2009. Results: 1. Average age of the pediatric patients was 4.28 years old, and it has showed that 1 to 3 years old patients (36.7%) were the most common age. 2. The number of pediatric patients was increased in June. According to the weekly distribution data, the number of pediatric patients who had visited on Sunday was the most (29.1%). Also, the number of pediatric patients who had visited ER for 18 to 21 hours(35.6%) were the most common. 3. The major problems of hospitalization were digestive symptoms and nervous symptoms. The nervous symptoms were the most at infancy. The musculoskeletal symptoms were the most common in adolescence. The digestive symptoms were common in other stages of development. 4. The time interval between arrival and onset; within 6 hours were the most(48.0%). Acupuncture and herbal medication treatment(75.2%) were the most common medical treatments. Most of the pediatric patients(97.3%) were discharged after medical treatments. Conclusions: Pediatric patients who had visited emergency room at the oriental medical hospital were mostly not due to acute form of serious diseases. The most common disease states that have preferred to treat with oriental medicine were dyspepsia, crying, febrile fit, and ankle sprain. We have to introduce the excellence of oriental medicine, and we need to try to develop other treatments such as magnetic acupuncture, moxa therapy, aroma therapy and revitalize pediatric emergency care at oriental medical hospital.

• The Journal of Pediatrics of Korean Medicine
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• v.26 no.4
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• pp.44-50
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• 2012

Objectives: We investigated weight gain effects of the Bofesungjangjeungbo-tang ($B\check{u}f\grave{e}ich\acute{e}ngzh\check{a}ngz\bar{e}ngb\check{u}$-tang) on thin Korean preschool children with frequent common cold or chronic rhinitis Methods Bofesungjangjeungbo-tang was empirically composed of 14 herbs for treating indigestion, and common cold or chronic rhinitis. We analyzed 60 preschool children who have visited Kim Kijoon Oriental Clinic BOM from Jan. 1, 2006 to Aug. 31, 2011 with three criteria: 1) 2~5yrs of age and BMI<50th percentile 2) children those who had taken the Bofesungjangjeungbo-tang for 1~3 month (s), 3) Availability of records on before/after treatment within 3 months. Weight gain of the children after treatment was evaluated by the changes of BMI percentile compared to pre-treatment. Results Bofesungjangjeungbo-tang significantly improved BMI percentile in all groups (1 month: $21.33{\pm}10.04$ vs $26.43{\pm}13.16$, p<0.001; 2 months: $21.90{\pm}10.28$ vs $29.03{\pm}15.06$, p<0.001; 3 months: $19.06{\pm}10.04$ vs $35.71{\pm}17.40$, p=0.001). Gender, age and pre-treatment BMI had no significant effects on the effectiveness of Bofesungjangjeungbo-tang. Conclusions: Bofesungjangjeungbo-tang positively affected weight gain in 2~5yrs Korean preschool children with BMI below 50 percentile within 1~3 month (s) of treatment. However, additional studies on functional dyspepsia or the change of energy intake are needed to understand the factors related to weight gains.