• Archives of Pharmacal Research
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• v.16 no.3
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• pp.219-226
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• 1993

For the analysis of structure relationship of ar-turmerone analogues, the compounds containing the various substituents on the phenyl ring and 1(or 2)-naphthyl group in the place of phenyl of ar-turmerone were prepared and tested their cytotoxicity against HL-60, K-562, and L1210 leukemia cells in vitro. The substituents at para position are methoxy, phenoxy, methyl, trifluoromethyl, fluoro, and chloro. At meta position methoxy, methyl, trifluoromethyl, or chloro groups at ortho position mathoxy or chloro group were introduced. Against HL-60 and K-562 cells, $ED_{50}$ values of the analogues are ranged from 0.8 to $30.0\;\mu{g/ml}$. Againste L1210 cell, these are located more than $20.0\;\mu{g/ml}$. However, 5-carbone-thoxy-2-methyl-6(1-naphthyl)-2-octen-4-one (5n)possesses $ED_{50}$ valuses 0.8, 2.1, $6.5\;\mu{g/ml}$ against HL-60, L1210 cells, respectively. The electronic nature of the substituents on phenyl ring of ar-tumerone dose not affect the biological activity. Therefore the flat structure of aromatic potion of ar-tumerone analogues is the more important factor for their activity rather than its electronic nature. The potentiation of the cytotoxicity with the enlargement of aromatic ring region also supports the importance of the plane structure of this area. The restriction of the single bond rotation between C-6 and aromatic ring through the introduction of substituents at the ortho position of phenyl ring and the increment of size of alkyl group at C-6 position enhances the activity. Therefore the effective conformation should by the one having the orthogonal arrangement between the aromatic ring and the side chain.

• The Korean Journal of Mycology
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• v.22 no.3
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• pp.247-253
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• 1994

This study was carried out to isolate and characterize $A{\alpha}$ mating locus controlling fruiting body formation directly in the Basidiomycete Schzophyllum commune growing in the North America. Total numbers of genomic library of S. commune UVM1-34 was about $2{\times}10^4$ cells. About 90% library was appeared to have about 35 kb inserted genome DNA in cosmid pTC20 vector. 6 clones were proved to have positive signal to probes within Z and Y region in colony and southern hybridization. In the mating activity test, all the 6 positive clones were appeared to have $A{\alpha}3$ mating activity although they had two different restriction patterns. pSC13 containing 5.7 Kb PstI-fragment of UVM 1-34 $A{\alpha}3$ allele showed about 50% clamp cell formation indicating mating activity when cotransformation was done together with cosmid pTC20.

• The Korean Journal of Franchise Management
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• v.11 no.1
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• pp.45-60
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• 2020

Propose: The expansion of the delivery market in franchise business is a positive means of advertising and promotion for franchisees and contributes to substantial sales growth for stores. However, unrestricted and uncontrolled delivery sales and business activity of franchisee directly lead to encroachment of business territory between franchisees, resulting in increased operating costs of franchisees and conflicts between franchisees over rights and interests on franchise business. Moreover, in relation to the restrictions on the opening of competitors, it is incapacitating the law intent of prohibiting unfair encroachment of business territory, in the issue of the Fair Franchise Act in regard to guarantee of exclusive sales and business activity rights of franchisee. This study aims to point out major problems arising out of franchisee's infinite competition on delivery sales and business activity that are not restricted or controlled and then suggest legal supplements, policy tasks, and practical implications for improvement on the issues. Literature Review: In franchising business transactions, vertical restraints are associated with the exclusive territory establishment, control of transaction area, restriction of intangible sales and business activity of franchisee. Therefore, in the franchise business, it is necessary to take positive interpretation and application on e-commerce, the area of e-commerce, and delivery trading area and find proper and practical ways, by virtue of constructive attitude of each actor, to reduce the encroachment of business territory and various conflicts caused by unrestricted delivery trading area. Conclusion and suggestion: The finding shows that unrestricted or uncontrolled delivery sales and business activity of franchisees cause encroachment of business territory and many conflicts among franchisees. And this matters also weaken the legislation of the law on the protection of the business territory and can be negative factors that disrupt the protection of identity and sound development of the franchise industry in the long run. Therefore, in the franchise business, it is necessary to take positive interpretation and application on e-commerce, the area of e-commerce, and delivery trading area and find proper and practical ways, by virtue of constructive attitude of each actor, to reduce the encroachment of business territory and various conflicts caused by unrestricted delivery trading area.

• Journal of Convergence for Information Technology
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• v.11 no.3
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• pp.54-67
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• 2021

This study is a secondary data study that analyzes the factors affecting the quality of life of the elderly with metabolic syndrome and the elderly with metabolic syndrome with osteoporosis using data from the 7th year of the National Health and Nutrition Survey (2018). The subjects of this study were 639 patients with metabolic syndrome and 161 patients with metabolic syndrome with osteoporosis. For data analysis, the composite sample Rao-Scott χ2 test, general linear model t-test, and regression model were used. As a result of the study, the factors that lowered the quality of life of metabolic syndrome were age, cohabitation, strength training, subjective health status, activity restriction, body mass index and depression, and the explanatory power was 50.4% (F=515.96, p<.001). In metabolic syndrome with osteoporosis, age, subjective health status, activity restriction, and stress were the factors that lowered the quality of life, and the explanatory power was 48.6% (F=10.42, p<.001). Based on these results, it is necessary to develop and provide an intensive multidisciplinary program for the elderly with metabolic syndrome accompanied by osteoporosis to solve the problem of activity restrictions and manage stress reduction through positive acceptance of health status, instrumental and social support, and caring support.

• Management Science and Financial Engineering
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• v.14 no.2
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• pp.45-66
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• 2008

Refuse collection, one of important elements in reverse logistics, is an activity rendering recyclables or wastes and moving them to some points where further treatment is required. Among various decisions in the collection activity, we focus on network design, which is the problem of locating collection points as well as allocating refuses at demand points to collection points while satisfying the capacity restriction at each collection point. Here, the collection point is the place where recyclables or wastes near the point are gathered, and locating the collection points is done by selecting them from a given set of potential sites. The objective is to minimize the sum of fixed costs to open collection points and transportation costs to move refuses from demand points to collection points. An integer programming model is developed to represent the problem mathematically and due to the complexity of the problem, two types of heuristics, one with simultaneous and the others with separate location and allocation, are suggested. Computational experiments were done on test problems up to 500 potential sites, and the results are reported. In particular, some heuristics gave near optimal solutions for small-size test problems, i.e., 2% gaps in average from the optimal solution values.

• Journal of Korean Public Health Nursing
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• v.6 no.2
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• pp.108-132
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• 1992

The purpose of this study· is to identify sources of the caregiving burden, thereby suggesting social welfare alternetives for supporting family caregivers of the elderly with dementia. 23 family caregivers who participated in self-help group of family caregivers of dementia elderly at a welfare facility for the elderly in Seoul were seleted as the study sample. Zarit caregiving burden scale and Zarit functional impairment measurement for the elderly were adapted for this study and a number of additional variables were included in this study. Correlational analysis was utilized. The results of the study were summarized as follows : 1) The impairment of activities of daily living of the elderly was significantly related to the negative elderly. caregiver-family relationship(PADL:r=.6032 IADL : r=.5930 p<.05). 2) The impact on caregiver's health was very significantly related to the impact on the caregiver's task(r=.6233 p<.001). 3) The Impact on caregiver's health was very significantly related to the impact on the caregiver's social activity restriction(r=.6851 p<.001). 4) The impact on the caregiver's social activity was very significantly related to the impact on the caregiver's task(r=.6969 p<.001). 5) Caregiver's income was significantly related to the impact on the caregiver's task(r=.5252 p<.05). 6) Compensation(interpersonal relationship between the elderly and the caregivers, social praise and appreciation of the elderly) was important variables which affect to the feeling of the caregiving burden.

• Korean Chemical Engineering Research
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• v.58 no.4
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• pp.658-664
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• 2020

Zeolite HY is wet impregnated with Ni (0.1, 0.3, 0.4, 0.5 wt%), Pt (0.1 wt%) and reduced in presence of hydrogen to form nanosized particles of Ni and Pt. All the catalysts were characterized by XRD, TEM, ESCA, NH₃-TPD, Pyridine adsorbed FT-IR and BET. Characterization results confirm that the Ni and Pt fractions effectively rehabilitated the physio-chemical properties of the zeolite HY catalysts. Further, all the reduced catalyst were screened with hydroisomerization of m-xylene at LHSV = 2.0 h^-1 in the temperature range 250-400 ℃ in steps of 50 ℃ in hydrogen atmosphere (20 ml/g). The addition of Ni to Pt catalyst increases hydroisomerization conversion, as well as maximizes p-xylene selectivity by restricting the pore size. The increasing trend in activity continues up to 0.3 wt% of Ni and 0.1 wt% Pt addition over zeolite HY. The increasing addition of Ni increases the total number of active metallic sites to exposed, which increases the metallic sites/acid sites ratio towards the optimum value for these reactions by better balance of synergic effect for stable activity. The rate of deactivation is pronounced on monometallic catalysts. The results confirm the threshold Ni addition is highly suitable for hydroisomerization reaction for product selectivity over Ni-Pt bimetallic/support catalysts.

• Bulletin of the Korean Chemical Society
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• v.28 no.4
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• pp.561-566
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• 2007

Adenosine kinase (AK) is a ubiquitous intracellular enzyme, which catalyzes the phosphorylation of adenosine (ADO) to adenosine monophosphate (AMP). AK inhibitors have therapeutic potential as analgesic and antiinflammatory agents. A chemical feature based pharmacophore model has been generated from known AK inhibitors (26 training set compounds) by HypoGen module implemented in CATALYST software. The top ranked hypothesis (Hypo1) contained four features of two hydrogen-bond acceptors (HBA) and two hydrophobic aromatics (Z). Hypo1 was validated by 124 test set molecules with a correlation coefficient of 0.905 between experimental and estimated activity. It was also validated by CatScramble method. Thus, the Hypo1 was exploited for searching new lead compounds over 238,819 chemical compounds in NCI database and then the selected compounds were screened based on restriction estimated activity and Lipinski's rules to evaluate their drug-like properties. Finally we could obtain 72 new lead candidates and the two best compound structures from them were posted.

• Archives of Obesity and Metabolism
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• v.2 no.1
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• pp.6-10
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• 2023

Compensatory changes in energy consumption and neuro-hormonal changes following weight loss make it difficult to maintain the reduced weight and may cause weight regain. Therefore, establishing a long-term weight control plan and strategy starting from the initial weight loss period is necessary. Both the patient and doctor should know that weight loss cannot occur continuously, and that maintaining weight after the weight loss period is the basic course of obesity treatment. No single dietary pattern is effective for weight maintenance, and a variety of dietary control methods - such as calorie restriction and healthy proportions of carbohydrates, proteins, fats, and meal replacements - should be used to target an integrated and healthy dietary habit. An increase in physical activity is needed for weight loss and maintenance; however, rather than recommending an excessive amount of exercise, it is better to set realistic and long-term achievable goals. It is necessary to reset the goal according to the patient's weight maintenance stage and continuously apply behavioral therapies, such as self-monitoring and stress management. In previous studies, since the degree of weight loss and changes in behavioral patterns over the course of one year were important factors in maintaining long-term weight loss, obesity therapists should closely examine patient data and behavioral patterns across a period of one year and actively intervene when needed.

• Journal of Korean Public Health Nursing
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• v.15 no.2
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• pp.324-333
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• 2001

The purpose of this cross-sectional study was to explore fear of falling in relation to activity restriction of in the community dwelling elderly. Two hundred ninety-nine community dwelling elderly residing in Seoul and Kyonggi-do were interviewed using a structured questionnaire. The results were as follows : 1. Subjects were predominantly women$(70.6\%)$, an average 72.5 years old; the incidence of falls in last one year was $45.5\%$. 2. The highest level of fear found for activity in those who say they do engage and those who do not engage in the activity was 'going out when it is slippery '(m=2.53, 2.81) and 'reach for something over your head'(m=1.66, 2.60). Fear of falling scores were significant lower for those who say they do engage in eight kinds of activities (excluded activities of given were 'go to the store', 'take a tub bath', 'get out of bed') than for those who do not engage in the activities. 3. Among those who did not perform the activity, the three activities, when it is slippy(n=80), reaching overhead(n=70), and walk outside(n=59),were most often avoided because fear alone as well as for reasons in addition to fear. 4. The significant variables associated with fear of falling were female(p=0.0000), 1 educational status(p=0.000l), poor economic condition(p=0.0007), and experience of falls in last one year(p=0.0007). Fear of falling is common in the community dwelling elderly in Korea and is associated with several demographical variables. Therefore, to prevent falls and to reduce fear of falling, further study for development of education program for the elderly is needed.