• Journal of Naturopathy
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• v.10 no.1
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• pp.42-47
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• 2021

Purpose: This study investigated the antioxidant activities of water extracts from Hibiscus petals, Moringa oleifera gymnosperm, and Nipa fruticans wurmb. Also, the possibility of their use as a functional cosmetic material and food were searched. Methods: We extracted Hibiscus petals, M. oleifera gymnosperm, and N. fruticans wurmb with water. And then, we measured the content of total polyphenols and flavonoids and the ability to scavenging free groups of ABTS and DPPH to study the antioxidant function. The toxicity of samples evaluated by measuring cell viability. Results: The polyphenol content of the water extract of N. fruticans wurmb was 109 ㎍/mg, which was significantly higher than that of Hibiscus petals (13 ㎍/mg) and M. oleifera gymnosperm (19 ㎍/mg). Radical scavenging ability was also excellent in N. fruticans wurmb, and the cytotoxicity test results of the samples were similar. Conclusions: The water extracts showed antioxidant activity to use for cosmetic materials or natural healing foodstuff.

• Journal of Korean Home Economics Education Association
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• v.33 no.2
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• pp.115-133
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• 2021

The purpose of this study is to develop a teaching-learning plans for middle school Home Economics that practices clothing life in response to climate change. Four steps of analysis, design, development, and evaluation were used for the research. 'Phenomenon and cause, impact (environmental, economic and social) and response (relaxation and adaptation)' were selected as educational content elements for climate change through reviewing the literature related to climate change. Six types of middle school Technology and Home Economics textbooks under the 2015 revised curriculum were analyzed using the selected content elements for climate change as the basis for analysis according to the data type(reading data, picture data, activity data) and clothing use cycle (production, purchase, use, and disposal). Based on the content elements of climate change in the clothing life area extracted through textbook analysis, a total of 12 teaching-learning plans in response to climate change were developed by utilizing various teaching and learning methods, data and media. The teaching-learning plans were designed based on an integrated understanding of the phenomena, causes, effects, and responses of climate change for the students to realize the seriousness of climate change and to exercise positive influence on families and society.

• Journal of Korea Entertainment Industry Association
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• v.14 no.4
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• pp.199-209
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• 2020

"Positive Influence(PI)" of popular star has recently emerged as a social concern, but the lack of prior research has led to confusion over its concept and range of activity. On this point, this study carried out to lay the groundwork for discussions on the systematization of related theories, focused on identifying the current situations by analyzing articles for 15 months from January 2019 to March 2020 when related reports were in full swing. As a result of the analysis of the remarks from the entertainers mentioned in the articles, they were not clearly aware of the concept while doing good deeds under the name of PI in light of the study outcome by Aegean and Singer(2013). The motivations for good deed were classified into six types, including difficulty empathy, fandom reward, participation urge, nidana emphasis, experience subjugation, and memory evocation in the order of frequency of cases. Specific behaviors of PI were followed by donations of money and valuables for 54.4 percent, participation of social agendas for 14.0 percent, volunteering for 13.2 percent, joining campaign for 11.4 percent, other good deeds for 4.0 percent, and philanthropy for 3.0 percent. In occupational analysis, the concentration of donations was also evident. Their activities in the fields of human rights sensitivity, environmental protection and self-management, which are expected to have great effects with their influence, have been extremely poor. The results of the study first require academia to establish a interdisciplinary concept for PI. It also suggests that entertainers and their agencies should take far more strategic approach to evolve the PI event in a way that utilizes the advantages of each job group, such as actors, singers and comedians, and expands the diversity of areas.

• Journal of the Korean BIBLIA Society for library and Information Science
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• v.33 no.4
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• pp.93-114
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• 2022

This study aims to propose the ways to improve the research performance evaluation to support the establishment of a sound research culture. For the study, we analyzed the cases of domestic and foreign research performance evaluation, and a survey and an interview were conducted for faculty and research performance evaluation officials, respectively. In the study, the direction of establishing the principle of research performance evaluation, the method of categorizing the type of research performance, the method and procedure of research performance evaluation, and necessary documents were proposed. First, eight principles were suggested to be considered in evaluating research achievements to ensure the validity, reliability, and transparency of the evaluation while supplementing the limitations of quantitative evaluation. Second, the main types of research achievements were categorized into journal articles, books, and presentations at academic conferences. Third, as a research achievement evaluation method, a hybrid evaluation using quantitative and qualitative and multiple measurement indicators was proposed. Fourth, a total of 11 steps (required 7 steps) were presented as a procedure for research achievement evaluation. Fifth, publications, evaluation documents, and committee chair's reports were proposed as major documents for research achievement evaluation. The research achievement evaluation improvement plan presented in this study should be flexibly applied in consideration of the characteristics of the academic and research fields and universities.

• Journal of the Korean BIBLIA Society for library and Information Science
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• v.34 no.1
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• pp.209-238
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• 2023

This study aims to propose the main learning contents, functions and activation plans for building an e-learning platform for libraries through a literature review, case analysis and expert survey. Through the literature review, it was found that libraries must play a role in providing high-quality online education for users in the e-learning ecosystem. Based on the previous studies, a learning function analysis tool was developed for the analysis of the library's e-learning platform. Based on this, the learning contents, learning functions and characteristics of library e-learning platforms were analyzed, and expert surveys and interviews were conducted. As a results, the construction of a platform for effectively applying learning processes and technology is essential for the library's sustainable e-learning services. The contents that should be provided for characteristics of library education, reading guidance, information literacy instruction, library usage instruction, and the latest IT technologies. And The main learning functions include the ability to conduct video lectures and real-time classes among learning types, and learning activity support functions, a cloud platform support function and a personalized environment support function. Additionally, suggested re-education for library staff to improve their technical skills and the formation of an e-learning team.

• Journal of Ginseng Research
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• v.46 no.3
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• pp.396-407
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• 2022

Background: Colorectal cancer (CRC) has a high morbidity and mortality worldwide. 20 (S)-ginsenoside Rh2 (G-Rh2) is a natural compound extracted from ginseng, which exhibits anticancer effects in many cancer types. In this study, we demonstrated the effect and underlying molecular mechanism of G-Rh2 in CRC cells in vitro and in vivo. Methods: Cell proliferation, migration, invasion, apoptosis, cell cycle, and western blot assays were performed to evaluate the effect of G-Rh2 on CRC cells. In vitro pull-down assay was used to verify the interaction between G-Rh2 and Axl. Transfection and infection experiments were used to explore the function of Axl in CRC cells. CRC xenograft models were used to further investigate the effect of Axl knockdown and G-Rh2 on tumor growth in vivo. Results: G-Rh2 significantly inhibited proliferation, migration, and invasion, and induced apoptosis and G₀/G₁ phase cell cycle arrest in CRC cell lines. G-Rh2 directly binds to Axl and inhibits the Axl signaling pathway in CRC cells. Knockdown of Axl suppressed the growth, migration and invasion ability of CRC cells in vitro and xenograft tumor growth in vivo, whereas overexpression of Axl promoted the growth, migration, and invasion ability of CRC cells. Moreover, G-Rh2 significantly suppressed CRC xenograft tumor growth by inhibiting Axl signaling with no obvious toxicity to nude mice. Conclusion: Our results indicate that G-Rh2 exerts anticancer activity in vitro and in vivo by suppressing the Axl signaling pathway. G-Rh2 is a promising candidate for CRC prevention and treatment.

• BMB Reports
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• v.55 no.6
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• pp.275-280
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• 2022

The treatment of atopic dermatitis (AD) is challenging due to its complex etiology. From epidermal disruption to chronic inflammation, various cells and inflammatory pathways contribute to the progression of AD. As with immunosuppressants, general inhibition of inflammatory pathways can be effective, but this approach is not suitable for long-term treatment due to its side effects. This study aimed to identify a plant extract (PE) with anti-inflammatory effects on multiple cell types involved in AD development and provide relevant mechanistic evidence. Degranulation was measured in RBL-2H3 cells to screen 30 PEs native to South Korea. To investigate the anti-inflammatory effects of Parasenecio auriculatus var. matsumurana Nakai extract (PAE) in AD, production of cytokines and nitric oxide, activation status of FcεRI and TLR4 signaling, cell-cell junction, and cell viability were evaluated using qRT-PCR, western blotting, confocal microscopy, Griess system, and an MTT assay in RBL-2H3, HEK293, RAW264.7, and HaCaT cells. For in vivo experiments, a DNCBinduced AD mouse model was constructed, and hematoxylin and eosin, periodic acid-Schiff, toluidine blue, and F4/80-staining were performed. The chemical constituents of PAE were analyzed by HPLC-MS. By measuring the anti-degranulation effects of 30 PEs in RBL-2H3 cells, we found that Paeonia lactiflora Pall., PA, and Rehmannia glutinosa (Gaertn.) Libosch. ex Steud. show an inhibitory activity of more than 50%. Of these, PAE most dramatically and consistently suppressed cytokine expression, including IL-4, IL-9, IL-13, and TNF-α. PAE potently inhibited FcεRI signaling, which mechanistically supports its basophil-stabilizing effects, and PAE downregulated cytokines and NO production in macrophages via perturbation of toll-like receptor signaling. Moreover, PAE suppressed cytokine production in keratinocytes and upregulated the expression of tight junction molecules ZO-1 and occludin. In a DNCB-induced AD mouse model, the topical application of PAE significantly improved atopic index scores, immune cell infiltration, cytokine expression, abnormal activation of signaling molecules in FcεRI and TLR signaling, and damaged skin structure compared with dexamethasone. The anti-inflammatory effect of PAE was mainly due to integerrimine. Our findings suggest that PAE could potently inhibit multi-inflammatory cells involved in AD development, synergistically block the propagation of inflammatory responses, and thus alleviate AD symptoms.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.22 no.1
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• pp.153-161
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• 2022

The current National Curriculum clearly states that students should utilize digital information as a core competency. With ICT-based non-face-to-face learning has become commonplace, that ability has become as basic and essential as the competency to read and write in traditional education. Therefore, this work analyzed the characteristics of ICT utilization learning in the social studies curriculum of elementary school to cultivate basic abilities and skills for learners' future, and these discussed from the perspective of digital literacy. The results are as follows. First, the ICT utilization learning could be found in most units for the subject, but most of them were just the searching material and the watching video. Second, when approached from the perspective of digital literacy, the main activities were the 'access' in the lowest level. Third, the higher levels such as 'understand' and 'create' were few activities. This result gave the task of reflecting on the ICT education so far. Rather than just focusing on increasing the frequency of the ICT using, it is necessary to improve the quality of students' activities in ICT learning for progressing digital literacy. For the students' skills of utilizing digital information could be developed differently depending on the type of ICT learning activity.

• Journal of Food Hygiene and Safety
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• v.37 no.4
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• pp.285-295
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• 2022

The ability of volatile components of essential oils (EO) from cinnamon, clove, and lemongrass to inhibit biofilms formed on polyethylene and stainless steel by six types of food poisoning bacteria was investigated. The main components of cinnamon EO were identified as cinnamaldehyde (38.30%), linalool (9.61%), β-caryophyllene (8.90%), and 1,3,4-eugenol (8.19%). 1,3,4-Eugenol (61.84%) was the dominant component of clove EO. The major component of lemongrass EO was citral. Citral is a natural mixture of two isomeric acyclic monoterpene aldehydes: geranial (trans-citral, 19.11%) and neral (cis-citral, 19.23%). Among these major compounds, cinnamaldehyde, linalool, eugenol, and citral exhibited comparatively strong antimicrobial activity in the disc diffusion assay. Treatments with 0.1% eugenol and citral were highly effective on biofilm inhibition on both tested surfaces. Cinnamaldehyde (0.1%) was effective against biofilm formation by Listeria monocytogenes ATCC 19112 and Staphylococcus aureus KCCM 11812. These results suggested the potential of cinnamaldehyde, eugenol, and citral treatments in inhibiting the formation of biofilms by food poisoning bacteria.

• Science of Emotion and Sensibility
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• v.25 no.2
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• pp.79-86
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• 2022

With external air pollution forcing many people indoors, new methods of facilitating healthier indoor life are necessary. This study, therefore, investigates the effects of indoor oxygen concentration and respiration methods on biosignals and cognitive ability. The study included twenty healthy subjects who inhaled air through a mask from a gas delivery system. All subjects were asked to perform three types of breathing (nasal, oral, and oral breathing with high oxygenation) and respond to cognitive stimuli (rest close eye, rest open eye, 1-back and 2-back working memory tasks). The changes in cognitive load according to respiration were analyzed by measuring response time, accuracy, and biosignals to stimuli. The result showed that, in all three respirations, heart rate significantly increased with the increase in cognitive load. Also, in oral respiration, the airway respiration rate significantly increased according to the increase in cognitive load. The change appeared to compensate for insufficient oxygen supply in oral respiration during cognitive activity. Conversely, there was no significant change in airway respiration rate during oral respiration with a high concentration oxygen supply as in nasal respiration. This result suggests that a high concentration oxygen supply might play a role in compensating for insufficient oxygen concentration or inefficient oxygen inhalation, such as oral respiration. Based on the results of this study, a follow-up study is necessary to determine the impact of changes in the autonomic nervous system, such as stress and emotions, to find out more precise and comprehensive effects of oxygen concentration and breathing type.