Cordyceps militaris mycelium extracts containing high amounts of cordycepin were evaluated in vitro for their anti-inflammatory and tumor cell growth-inhibitory activities. All extracts dose dependently inhibited the increased production of inflammatory mediators including reactive oxygen species (ROS), nitric oxide (NO), and 𝛽-hexosaminidase in lipopolysaccharide (LPS)-stimulated inflammatory cells. All extracts were evaluated for anti-proliferative activity against normal RBL-2H3 cells and diverse types of cancer cell lines, including HCT, MC5-7, U-87MG, AGS, and A549 cells. The extract showed the strongest growth inhibition (IC50 = 28.13 ㎍/mL) relative to vehicle-treated control cells against fibrosarcoma (MC5-7). We have demonstrated anti-inflammatory activity of C. militaris via inhibition of NO, ROS production, and 𝛽-hexosaminidase release in activated cells. C. militaris mycelium extract was also evaluated mechanistically and found to exert six types of anti-cancer activity, confirming its pharmacological potential. Our study suggests C. militaris use as a potential source of anti-inflammatory and anti-cancer agents. C. militaris may also be considered a functional food.
Unlike other body arts, body painting illuminates the value of art using eco-friendly formative activity and natural environment and highlights the need of eco-friendly activity. However, although body painting has focused on forming right relationship between human beings and nature, there are few researches which are linked with nature art. Therefore, the purpose of this study is to argue the need to study body painting as nature art in connection with natural environment and analyze body painting according to nature art types. The study methods included both theoretical review and empirical review. The theoretical review examined the concept and characteristics of nature art through previous researches and literature and the empirical review looked into the types and works of nature art and applied them to body painting works. The results were as follows. First, an installation type was possible by arranging and attaching certain materials to the body. Second, a physical type was possible by representing body itself as the part of nature. Third, a symbolic type was possible by making body appearance as a some symbol based on artist's idea. Fourth, a sound type was possible by stimulating auditory hallucination using the nature of objects and sensing a sound. Fifth, an ecological type was possible by conveying the message of living things in nature to the body. Sixth, an interior type was possible by inducing indoor installation of works. Seventh, a poetic type was possible by making one feel a poetic inspiration expressed in nature using the mystery of the sea and a simple sequential pattern of floral leaves. Eighth, a drawing type was possible by adding artist's intentional hand with a pictorical technique. Ninth, a indigenous type was possible by reproducing South American indian's primitive style. The review of this study suggests that body painting works have been expressed in experimental and temporary arrangement like nature art in nature and can be applied according to nine types of nature art.
One of the most fundamental problems an ageing society faces is the role deprivation and social isolation of older persons. In this respect, restoring the roles and social status of older persons by promoting their social participation is considered crucial to enhancing their quality of life. From such viewpoint, this study aims at analyzing the social participation of older persons from an actor-oriented perspective. To do so, this study classifies various social participatory activities into representative activity types and analyzes the socio-demographic determinants of each activity types. The findings show that the participatory activities of Korean older persons could be classified into four types : volunteer-focused, religion-focused, occupation-focused and kyungrodang-focused social participation. Also, it has been found that the determinants of each social participation types, including the non-participatory type, differs according to the socio-demographic condition of each older person, thus indicating that differentiated policy measure is required to enhance the activites of Korean older persons.
The reliability of air quality evaluation results for green transportation could be improved by applying correct emission factors. Unlike previous studies, which estimated emission factors that focused on vehicles in laboratory experiments, this study investigates emission factors according to road types and time using real driving data. The real driving data was collected using a Portable Activity Monitoring System (PAMS) according to road types and time, which it compared and analyzed fuel consumption from collected data. The result of the study shows that fuel consumption on national highway is 17.33% higher than the fuel consumption on expressway. In addition, the average fuel consumption of peak time is 4.7% higher than that of non-peak time for 22.5km/h. The difference in fuel consumption for road types and time is verified using ANOCOVA and MANOVA. As a result, the hypothesis of this study - that fuel consumption differs according to road types and time, even if the travel speed is the same - has proved valid. It also suggests correction factor of emission factors by using the difference in fuel consumption. It is highly expected that this study can improve the reliability of emissions from mobile pollution sources.
Purpose: Adolescent obesity is a growing problem. This study examined the relationships between different types of physical activity and obesity in male and female middle and high school students. Methods: This study used the Korea National Health and Nutrition Examination Survey data of 2007. The study included 282 male and female middle and high school students who completed health survey questionnaires regarding physical activity. Physical activity was measured with vigorous and moderate activity and walking. BMI was used as an obesity indicator. Analyses were done using descriptive statistics, ANOVA, and chi-square test. In addition, multiple logistic regression were conducted to investigate the relationship between physical activity and obesity when adjusting for covariates. SAS/WIN 9.1 was used. Results: Boys spent more days in vigorous and moderate physical activity than girls (p for vigorous activity: <.001, for moderate activity: <.001). There was no significant difference in walking activity between boys and girls and between middle and high school students. Only days spent in vigorous activity was significantly higher in middle school student compared with high school students (p=.013). According to the relationship between physical activity and obesity, moderate physical activity was significantly related to BMI for high school boys (p=.041). However, when adjusting for age, sex, school, parental income, daily caloric intake, physical activity was not significantly related to obesity. Conclusions: The results showed that male and female middle and high school students spent not enough days in doing low moderate and vigorous physical activity. Thus, this strengthens the need to increase physical activity level in these populations. In spite of non-significant relationship between physical activity and obesity from multivariate analysis, increasing moderate physical activity for high school boy could be effective to prevent and manage obesity, since significant difference between moderate activity and obesity in this population.
Journal of the Korean Society of Physical Medicine
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v.11
no.3
/
pp.65-72
/
2016
PURPOSE: The purpose of this study is to determine the differences between the muscle activity of cranio-cervical flexion and extension muscles according to the types of tools used through a short-term intervention of cranio-cervical static stabilization exercises using small tools. METHODS: A total of fifteen male and female adults in their 20s who showed forward head posture in the overall body posture measurement system participated in this study. Each subject performed cranio-cervical static stabilization exercises about flexion and extension while using a sling, a foam roller, a TOGU ball, and without tools separately, and the muscle activity of the sternocleidomastoid muscle, scalenus anterior and splenius capitis was measured. Each value was measured for 10 seconds a total of three times. The maximum voluntary isometric contraction value was computed using the average during the middle four seconds. RESULTS: Cranio-cervical flexion exercises using various tool types, the average activity of the sternocleidomastoid and scalenus anterior muscles was significantly higher when applying the TOGU ball (p<.05). According to the results of implementing cranio-cervical flexion exercise using various tools, the maximum muscle activity of the sternocleidomastoid muscle was significantly higher for the TOGU ball (p<.05). CONCLUSION: Based on these results, the provision of an unstable surface using small tools rather than a stable surface is recommended as an exercise scheme for proprioceptive stimulation in a forward head posture. Particularly, we recommend using the TOGU ball for the provision of an unstable surface to increase the muscle activity of the sternocleidomastoid muscle and scalenus anterior.
Journal of The Korean Association For Science Education
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v.15
no.1
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pp.116-125
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1995
This study is to consider hypotheses with integral view on the respect of creative thinking. Subjects of this study are Korean students in the 5th grade who participated in the Field Trip Contest of the second Korean Youth Science Festival, an openended inquiry investigation. Objectives of this study are as follows: 1) to measure the inquiry level of the Field Trip Contest activity 2) to find how many hypotheses were made on different types in the inquiry investigation 3) to measure the quality level of hypotheses made in the scientific inquiry investigation 4) to find out the correlation between the 1st and 2nd hypotheses and the final activity score in the two staged scientific investigation In the consequence of it, inquiry level of the Field Trip Contest was very high with good activity topics and openended way of investigation. Hypotheses were made in the prediction, plan, and conclusion parts in the field trip activity report. They used hypothesis-as-prediction typed statements(3.41/team) more than hypothesis-as-explanation(1.28/team) and descriptive hypothesis(0.03/team) types. Content-related hypothesis(5.03/team) and process-related hypothesis(6.16/team) were usually coupled each other. Most of them had difficulties in hypothesis-from-evidence(0.31/team, 10/32 teams) in the comparison of hypothesis-from-simple conjecture(10.62/team). The quality level of content-related hypotheses(0.74point/statement) and process-related hypotheses(1.98point/statement) were very low by the hypothesis-quality scale(Quinn and George, 1975) for the content-related hypotheses and the process-related hypothesis quality scale developed in this study. There was considerable correlation between the activity score and the 1st and 2nd hypothesis in the 2 staged inquiry investigations with the 2nd and 3rd topics($0.41{\ast}$, $0.59{\ast}{\ast}$ repectively).
The purpose of this study was to evaluate the level of SCM activities and the logistics performance by SCM of the three company types in fashion industry· fabric suppliers, apparel manufacturers, and retailers. The level of SCM activities was estimated through the examination of seven factors: commitment and leadership of a top management, flexibility of management, understanding of demand characteristics, integrated management organization, information system, cooperative partnership and communication and exchange of opinion. The logistics performance was measured by improvement in customer service(on time delivery ratio of products, returning rate, treat ratio for A/S, order fill rate, substitute providing capability for being out of stock) and delivery cost reduction. Through questionnaire survey, a total of 214 data for 108 companies of three company types were collected: 46 for 40 fabric suppliers, 123 for 64 apparel manufacturers and 45 for 4 retailers. The analysis of SCM activity levels showed that fabric suppliers had higher degrees in the factor of understanding of demand characteristics, and apparel manufacturers had higher degrees in the factor of information systems. For retailers, the factor of communication and exchange of opinion represented higher degrees. The study on relationship between the SCM activity levels and logistics performance showed that the SCM activity factor of understanding of demand characteristics greatly improved a substitute providing capability for being out of stock in fabric suppliers, and information system improved a substitute providing capability for being out of stock, on time delivery ratio of products and order fill rate in apparel manufacturers. In retailers, the SCM activity factor of understanding of demand characteristics decreased returning rate highly and improved on time delivery ratio of products. The study results showed that SCM activities in fashion industry brought more improvement in customer service levels rather than in delivery cost reduction.
Kim, Byeollee;Han, So-Ra;Lamichhane, Janardan;Park, Hyun;Oh, Tae-Jin
Journal of Microbiology and Biotechnology
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v.29
no.7
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pp.1144-1154
/
2019
There have been several studies regarding lichen-associated bacteria obtained from diverse environments. Our screening process identified 49 bacterial species in two lichens from the Himalayas: 17 species of Actinobacteria, 19 species of Firmicutes, and 13 species of Proteobacteria. We discovered five types of strong antimicrobial agent-producing bacteria. Although some strains exhibited weak antimicrobial activity, NP088, NP131, NP132, NP134, and NP160 exhibited strong antimicrobial activity against all multidrug-resistant strains. Polyketide synthase (PKS) fingerprinting revealed results for 69 of 148 strains; these had similar genes, such as fatty acid-related PKS, adenylation domain genes, PfaA, and PksD. Although the association between antimicrobial activity and the PKS fingerprinting results is poorly resolved, NP160 had six types of PKS fingerprinting genes, as well as strong antimicrobial activity. Therefore, we sequenced the draft genome of strain NP160, and predicted its secondary metabolism using antiSMASH version 4.2. NP160 had 46 clusters and was predicted to produce similar secondary metabolites with similarities of 5-100%. Although NP160 had 100% similarity with the alkylresorcinol biosynthetic gene cluster, our results showed low similarity with existing members of this biosynthetic gene cluster, and most have not yet been revealed. In conclusion, we expect that lichen-associated bacteria from the Himalayas can produce new secondary metabolites, and we found several secondary metabolite-related biosynthetic gene clusters to support this hypothesis.
Sungjoo Hwang;Moonseo Park;Hyun-Soo Lee;SangHyun Lee;Hyunsoo Kim
International conference on construction engineering and project management
/
2013.01a
/
pp.359-366
/
2013
Although many research efforts have been conducted to address the effect of crew members' work skills (e.g., technical and planning skills) on work performance (e.g., work duration and quality) in construction projects, the relationship between skill and performance has generated a great deal of controversy in the field of management (Inkpen and Crossan 1995). This controversy can lead to under- or over-estimations of the overall project schedule, and can make it difficult for project managers to implement appropriate managerial policies for enhancing project performance. To address this issue, the following aspects need to be considered: (a) work performances are determined not only by individual-level work skill but also by the group-level work skill affected by work team members, each member's role, and any working behavior pattern; (b) work planning has significant effects on to what extent work skill enhances performance; and (c) different types of activities in construction require different types of work, skill, and team composition. This research, therefore, develops a system dynamics (SD) model to analyze the effects of both individual-and group-level (i.e., multi-level) skill on performances by utilizing the advantages of SD in capturing a feedback process and state changes, especially in human factors (e.g., attitude, ability, and behavior). The model incorporates: (a) a multi-level skill evolution and relevant behavior development mechanism within a work group; (b) the interaction among work planning, a crew's skill-learning, skill manifestation, and performances; and (c) the different work characteristics of each activity. This model can be utilized to implement appropriate work planning (e.g., work scope and work schedule) and crew management policies (e.g., work team composition and decision of each worker's role) with an awareness of crew's skill and work performance. Understanding the different characteristics of each activity can also support project managers in applying strategic work planning and crew management for a corresponding activity, which may enhance each activity's performance, as well as the overall project performance.
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