• 생약학회지
• /
• 제29권3호
• /
• pp.258-264
• /
• 1998

Nephroprotective effects of a crude drug-preparation (Ekongsan) were determined from cisplatin induced renal injury in vivo and in vitro. Ekongsan decreased cisplatin induced the cytotoxicity on rabbit kidney proximal tubule and human renal cortical cells by MTT assays and sustained glucose consumption on cisplatin-induced human renal cortical tissue. Levels of creatinine and blood urea nitrogen (BUN) in serum after administration of cisplatin (0.75 mg/kg, i.p.) to Ekongsan (0.75 g/kg/d, p.o.) pretreated rats were markedly lower compared to those of cisplatin-treated rats. Moreover, the administration of Ekongsan significantly inhibited the loss of body weight of cisplatin-injected rats. These findings suggest that Ekongsan is an active prescription in protection against nephrotoxicity of cisplatin.

• 한국어병학회지
• /
• 제27권2호
• /
• pp.85-89
• /
• 2014

Water temperature is a key environmental factor controlling the epizootics of viral diseases in fish. High water temperature is associated with the rapid spread of rock bream iridovirus (RBIV) disease and with high mortality of RBIV infected fish. Although protection of fish against iridoviral disease by active immunization has been reported, little information is available concerning whether fish survived from an epizootic of iridoviral disease can naturally acquire resistance against the viral disease. In the present study, we have demonstrated that juvenile rock bream, which survived from a natural epizootic of RBIV, acquired resistance against recurrence or reinfection of RBIV, and this resistance was established during the subsequent low water temperature period. Furthermore, the possible involvement of the adaptive humoral immune response in the resistance of the juvenile rock bream was suggested by in vivo neutralization experiment.

• 한국응용약물학회:학술대회논문집
• /
• 한국응용약물학회 1998년도 Proceedings of UNESCO-internetwork Cooperative Regional Seminar and Workshop on Bioassay Guided Isolation of Bioactive Substances from Natural Products and Microbial Products
• /
• pp.162-162
• /
• 1998

Various natural compounds act as antioxidants in protection against lipid peroxidation. Lipid peroxidation yields a variety of decomposition products which have been implicated in not only decreasing the nutritional value of food, but also in developing an off-flavor and toxic substances. As a source of safer and more effective natural antioxidants of natural origin have been widely investigated. Some Indonesian plants have evaluated for their antioxidative activity, and suggested the possible existence of various antioxygenic compounds in them. We attempted to study such antioxygenic compounds with simple method evaluation. As we are interested in the natural product compounds, we examined of several sample such as edible sea-weeds, and some edible fruits. Sea-weed, Eisenia bicyclis, one of the edible brown algae, exhibited the activity. As a traditional food additive consumed by Indonesian, Garcinia parvifolia is used as taste supplement in region West Sumatra, have been studied. Our current studies on the semi-polar fractions shows the activity by the thiocyanate method test. Another sample, Garcinia mangostana, a famous fruit with sweet taste, the part kernel have also evaluated. The acidic fraction of the extract showed antioxidative activity. Some other active components were found in the neutral and BuOH fractions.

• 한국신재생에너지학회:학술대회논문집
• /
• 한국신재생에너지학회 2011년도 추계학술대회 초록집
• /
• pp.143.2-143.2
• /
• 2011

Energy foundations and other thermo-active ground structure, energy wells, energy slab, and pavement heating and cooling represent an innovative technology that contributes to environmental protection and provides substantial long-term cost savings and minimized maintenance. This paper focuses on earth-contact concrete elements that are already required for structural reasons, but which simultaneously work as heat exchangers. Pipes, energy slabs, filled with a heat carrier fluid are installed under conventional structural elements, forming the primary circuit of a geothermal energy system. The natural ground temperature is used as a heat source in winter and heat sink in summer season. The system represented very high heating and cooling performance due to the stability of EWT from energy slab. Maximum heat pump unit COP and system COP were 4.9 and 4.3.

• 한국컴퓨터정보학회논문지
• /
• 제12권3호
• /
• pp.19-26
• /
• 2007

최근 포털 시스템이 그리드환경의 사용자 인터페이스로 많이 이용되고 있다. 전통적인 포털 시스템은 아이디와 패스워드를 사용자 인증방식으로 사용하는 반면 그리드 시스템은 공개키와 개인키로 이루어진 대칭키를 기반으로 사용자 인증을 수행한다. 이와 관련하여 포털 시스템의 사용자 계정과 그리드 시스템의 대칭키를 중심으로 포털과 그리드시스템의 통합에 대한 많은 연구가 진행중이다. 특히 GAMA와 PURSE 처럼 아이디, 패스워드 방식에 익숙한 사용자의 편의성에 초점을 둔 연구가 활발하다. 그러나 그리드 환경은 네트워크를 통한 연결을 전제로 하기 때문에 공유되는 데이터와 자원의 보호가 중요하다. 따라서 본 논문에서는 UI 계층에서 대칭키를 사용하여 포털 시스템과 그리드 시스템의 인증 방식을 단일화함으로써 그리드의 사용자 환경에서도 보안 수준을 향상시키는 방안을 제안하고자 한다.

• 해양환경안전학회지
• /
• 제11권1호
• /
• pp.39-45
• /
• 2005

최근 RFID 기술은 유비쿼터스 센서 네트워크 구현을 위한 중요기술로 급부상하고 있다. 본고에서는 RFID 기술, 표준화 동향 및 다양한 응용영역을 분석함으로써 해상분야의 전망있는 응용분야를 발굴하기 위한 조사목적에서 이루어 졌다. RFID 기술개요 및 요소기술, 국내외 표준화 동향 및 응용분야를 소개한 후 해상분야에서 RFID 활용방안을 소개하였다. 해상분야에서 주요 응용영역으로는 선용품 재고관리의 자동화, 컨테이너의 관리, 화물창 상태관리, 이동통신망을 이용한 연안선박의 관리방안 등을 들 수 있다. 결과적으로 기존의 이용가능한 유무선 통신망에 RFID시스템을 효과적으로 적용한다면 선박운항의 효율화, 해양안전 확보 및 해양환경 보호에도 많은 기여를 할 것이다.

• Archives of Pharmacal Research
• /
• 제25권5호
• /
• pp.643-646
• /
• 2002

The succinic semialdehyde dehydrogenase (SSADH) inhibitory component was isolated from the EtOAc fraction of Lactuca sativa through repeated column chromatography; then, it was identified as phytol, a diterpenoid, based on the interpretation of several spectral data. Incubation of SSADH with the phytol results in a time-dependent loss of enzymatic activity, suggesting that enzyme modification is irreversible. The inactivation followed pseudo-first-order kinetics with the second-rate order constant of $6.15{\times}10^{-2}mM^{-1}min^{-1}.$ Complete protection from inactivation was afforded by the coenzyme $NAD^{+}$, whereas substrate succinic semialdehyde failed to prevent the inactivation of the enzyme; therefore, it seems likely that phytol covalently binds at or near the active site of the enzyme. It is postulated that the phytol is able to elevate the neurotransmitter GABA levels in central nervous system through its inhibitory action on one of the GABA degradative enzymes, SSADH.

• 한국식물학회:학술대회논문집
• /
• 한국식물학회 1999년도 제13회 식물생명공학심포지움 New Approaches to Understand Gene Function in Plants and Application to Plant Biotechnology
• /
• pp.41-44
• /
• 1999

Magnaporthe grisea (Hebert) Barr (anamorph: Pyricularia grisea) is a typical heterothallic Ascomycete and the causal agent of rice blast, one of the most destructive diseases on rice (Oryza sativa L.) worldwide. The interactions between cells of the pathogen and those of the host involve a complex of biological influences which can lead to blast disease. The early stages of infection process in particular may be viewed as a sequence of discrete and critical events. These include conidial attachment, gemination, and the formation of an appressorium, a dome-shaped and melanized infection structure. Disruption of this process at any point will result in failure of the pathogen to colonize host tissues. This may offer a new avenue for developing innovative crop protection strategies. To recognize and capture such opportunities, understanding the very bases of the pathogenesis at the cellular and molecular level is prerequisite. Much has been learned about environmental cues and endogenous signaling systems for the early infection-related morphogenesis in M. grisea during last several years. The study of signal transduction system in phytopathogenic filamentous fungi offers distinct advantages over traditional mammalian systems. Mammalian systems often contain multiple copies of important genes active in the same tissue under the same physiological processes. Functional redundancy, alternate gene splicing, and specilized isoforms make defining the role of any single gene difficult. Fungi and animals are closely related kingdoms [3], so inferences between these organisms are often justified. For many genes, fungi frequently possess only a single copy, thus phenotype can be attributed directly to the mutation or deletion of any particular gene of interest.

• 한국식물학회:학술대회논문집
• /
• 한국식물학회 1985년도 워크샵 및 심포지엄 북한산국립공원의 식생
• /
• pp.19-22
• /
• 1985

Magnaporthe grisea (Hebert) Barr (anamorph: Pyricularia grisea) is a typical heterothallic Ascomycete and the causal agent of rice blast, one of the most destructive diseases on rice (Oryza sativa L.) worldwide. The interactions between cells of the pathogen and those of the host involve a complex of biological influences which can lead to blast disease. The early stages of infection process in particular may be viewed as a sequence of discrete and critical events. These include conidial attachment, gemination, and the formation of an appressorium, a dome-shaped and melanized infection structure. Disruption of this process at any point will result in failure of the pathogen to colonize host tissues. This may offer a new avenue for developing innovative crop protection strategies. To recognize and capture such opportunities, understanding the very bases of the pathogenesis at the cellular and molecular level is prerequisite. Much has been learned about environmental cues and endogenous signaling systems for the early infection-related morphogenesis in M. grisea during last several years. The study of signal transduction system in phytopathogenic filamentous fungi offers distinct advantages over traditional mammalian systems. Mammalian systems often contain multiple copies of important genes active in the same tissue under the same physiological processes. Functional redundancy, alternate gene splicing, and specilized isoforms make defining the role of any single gene difficult. Fungi and animals are closely related kingdoms [3], so inferences between these organisms are often justified. For many genes, fungi frequently possess only a single copy, thus phenotype can be attributed directly to the mutation or deletion of any particular gene of interest.

• 로봇학회논문지
• /
• 제15권3호
• /
• pp.286-292
• /
• 2020

This paper is about a fall inducement system for guiding like a real fall. Reliable fall data can be used as an essential element in developing effective fall protection devices. We can get this data if the induced fall is very realistic. The proposed system analyzes gait characteristics and determines when to fall based on the pedestrian's biometric data. To estimate the fall inducement time, an active estimation algorithm was proposed using different biometric values for each pedestrian. The proposed algorithm is designed to response actively to the ratio of gait cycle and a stance period. To verify this system, an experimental environment was implemented using a multi-rail treadmill equipped with a ground reaction force measurement device. An experiment was conducted to induce falls to pedestrians using a fall inducement system. By comparing the experimental scene to the video of the actual fall, it has been confirmed that the proposed system can induce a reliable fall.