생약학회지 (Korean Journal of Pharmacognosy)
- 제29권3호
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- Pages.258-264
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- 1998
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- 0253-3073(pISSN)
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- 2288-9299(eISSN)
생약제제인 이공산(異功散)의 Cisplatin 유도 신장독성 보호 효과
Preventive Effect of Crude Drug Preparation (E-kong-san) on Cisplatin induced Nephrotoxicity
-
Rho, Young-Soo
(College of Pharmacy, Kyung Hee University)
;
- Ahn, Kyoo-Seok (College of Oriental Medicine, Kyung Hee University) ;
- Chang, Sung-Goo (College of Medicine, Kyung Hee University) ;
- Jung, Jee-Chang (College of Medicine, Kyung Hee University) ;
-
Lee, Kyung-Tae
(College of Pharmacy, Kyung Hee University)
- 발행 : 1998.09.30
초록
Nephroprotective effects of a crude drug-preparation (Ekongsan) were determined from cisplatin induced renal injury in vivo and in vitro. Ekongsan decreased cisplatin induced the cytotoxicity on rabbit kidney proximal tubule and human renal cortical cells by MTT assays and sustained glucose consumption on cisplatin-induced human renal cortical tissue. Levels of creatinine and blood urea nitrogen (BUN) in serum after administration of cisplatin (0.75 mg/kg, i.p.) to Ekongsan (0.75 g/kg/d, p.o.) pretreated rats were markedly lower compared to those of cisplatin-treated rats. Moreover, the administration of Ekongsan significantly inhibited the loss of body weight of cisplatin-injected rats. These findings suggest that Ekongsan is an active prescription in protection against nephrotoxicity of cisplatin.