• BMB Reports
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• 제53권3호
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• pp.133-141
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• 2020

The epidermal growth factor receptor (EGFR), a member of the ErbB family (EGFR, ErbB2, ErbB3 and ErbB4), plays a crucial role in regulating various cellular responses such as proliferation, differentiation, and survival. As a result, aberrant activation of EGFR, mostly mediated through different classes of genomic alterations occurring within EGFR, is closely associated with the pathogenesis of numerous human cancers including lung adenocarcinoma, glioblastoma, and colorectal cancer. Thus, specific suppression of oncogenic activity of mutant EGFR with its targeted drugs has been routinely used in the clinic as a very effective anti-cancer strategy in treating a subset of tumors driven by such oncogenic EGFR mutants. However, the clinical efficacy of EGFR-targeted therapy does not last long due to several resistance mechanisms that emerge in the patients following the drug treatment. Thus, there is an urgent need for the development of novel therapeutic tactics specifically targeting mutant EGFR with the focus on the unique biological features of various mutant EGFR. Regarding this point, our review specifically emphasizes the recent findings about distinct requirements of receptor dimerization and autophosphorylation, which are critical steps for enzymatic activation of EGFR and signaling cascades, respectively, among wildtype and mutant EGFR and further discuss their clinical significance. In addition, the molecular mechanisms regulating EGFR dimerization and enzymatic activity by a key negative feedback inhibitor Mig6 as well as the clinical use for developing potential novel drugs targeting it are described in this review.

• Biomolecules & Therapeutics
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• 제26권3호
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• pp.313-321
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• 2018

Anti-cancer drug resistance is a major problem in colorectal cancer (CRC) research. Although several studies have revealed the mechanism of cancer drug resistance, molecular targets for chemotherapeutic combinations remain elusive. To address this issue, we focused on the expression of cellular prion protein ($PrP^C$) in 5-FU-resistant CRC cells. In 5-FU-resistant CRC cells, $PrP^C$ expression is significantly increased, compared with that in normal CRC cells. In the presence of 5-FU, $PrP^C$ increased CRC cell survival and proliferation by maintaining the activation of the PI3K-Akt signaling pathway and the expression of cell cycle-associated proteins, including cyclin E, CDK2, cyclin D1, and CDK4. In addition, $PrP^C$ inhibited the activation of the stress-associated proteins p38, JNK, and p53. Moreover, after treatment of 5-FU-resistant CRC cells with 5-FU, silencing of $PrP^C$ triggered apoptosis via the activation of caspase-3. These results indicate that $PrP^C$ plays a key role in CRC drug resistance. The novel strategy of combining chemotherapy with $PrP^C$ targeting may yield efficacious treatments of colorectal cancer.

• 한국환경교육학회지:환경교육
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• 제13권1호
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• pp.111-121
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• 2000

The purpose of this study was to investigate and evaluate the state of School Forest Movement by the School Forest Committee of the ‘Forest for Life’, and to provide schools and social communities with alternative, for activation through foreign and domestic case studies. School Forest Movement is very important and has great effect on many aspects, such as the improvement of school environment, the expansion of environmental education in school, the enhancement of local membership and increasing participation of school community. School Forest Movement has expanded from 10 schools in 1999 for pilot implementation to 20 in 2000. Now, it Is broadly recognized that the movement should be expended nationally A few problems were observed through pilot implementation. School community has little consensus away member and hardly participates in the movement, and the process is often underestimated, comparing to the result. For activation of School Forest Movement, school community should be cooperate to local community. Especially, the stepwise execution of School Forest Movement should be well organized and School Forest Movement should be changed into a process-oriented movement for more participation of school community including students, teachers, parents and.

• Journal of Information Technology Applications and Management
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• 제26권1호
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• pp.95-102
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• 2019

Public transportation systems play key roles in supporting dynamic activities and interaction between urban places. Especially, high efficient public transportation systems are required in order to support large traffic demands in urban areas. In this paper, we define a new metric, structural activation level (SAL), to replace the conventional transportation share ratio (TSR) measuring efficiency of public transportation systems. First of all, we access the Korea Transport Database (KTDB) and download origin-destination data by transport types to construct traffic networks with respect to transport types for each city. Then, we calculate the QAP (Quadratic Assignment Procedure) correlation between each traffic network and the total traffic network for each city to investigate SAL by comparing cities one another. The results of our investigation reveal inconsistency between TSR and SAL. In Daegu, TSR of public transportation systems is relatively low while SAL is high. In Deajeon, however, SAL is low while TSR is high. Therefore, we suggest to take into consideration SAL as well as TSR in order to investigate the degree of activation of public transportation.

• Nuclear Engineering and Technology
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• 제53권5호
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• pp.1491-1510
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• 2021

This work presents an illustration of Nagra's AMAC (Advanced Methodology for Activation Characterization) approach to the South Korean pressurized water reactor Kori-1 decommissioning. The results achieved are supported by the existing experience from the detailed AMAC applications to Swiss NPPs and are used not only for a demonstration of the applicability of AMAC to South Korean NPPs, but also for a first approximation of the activated waste volumes to be expected from Kori-1. A packaging concept based on the above activation characterization is also presented, using the AMAC algorithmic optimization software ALGOPACK leading to the minimum number of waste containers needed given the selected packaging constraints. Nagra's AMAC enables effective planning before and during NPP decommissioning, including recommendations for cutting profiles for diverse reactor components and building structures. Finally, it is expected to lead to significant cost savings by reducing the number of expensive waste containers, by optimizing a potential melting strategy for metallic waste as well as by significantly limiting the number of radiological measurements. All information about Kori-1 used for the purpose of this study was collected from publicly available sources.

• Journal of Ginseng Research
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• 제47권1호
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• pp.23-32
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• 2023

Coronavirus disease 2019 (COVID-19) is a highly infectious respiratory disease caused by a severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). SARS-CoV-2 infection may cause clinical manifestations of multiple organ damage, including various neurological syndromes. There are currently two oral antiviral drugs-Paxlovid and molnupiravir-that are recognized to treat COVID-19, but there are still no drugs that can specifically fight the challenges of SARS-CoV-2 variants. Nucleotide-binding oligomerization domain-like receptor pyrin domain-containing-3 (NLRP3) inflammasome is a multimolecular complex that can sense heterogeneous pathogen-associated molecular patterns associated with neurological disorders. The NLRP3 activation stimulates the production of caspase-1-mediated interleukin (IL)-1β, IL-18, and other cytokines in immune cells. Panax (P.) ginseng is a medicinal plant that has traditionally been widely used to boost immunity and treat various pathological conditions in the nervous system due to its safety and anti-inflammatory/oxidant/viral activities. Several recent reports have indicated that P. ginseng and its active ingredients may regulate NLRP3 inflammasome activation in the nervous system. Therefore, this review article discusses the current knowledge regarding the pathogenesis of neurological disorders related to COVID-19 and NLRP3 inflammasome activation and the possibility of using P. ginseng in a strategy targeting this pathway to treat neurological disorders.

• 한국유기농업학회지
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• 제31권1호
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• pp.29-44
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• 2023

The activation of consumption of environment-friendly agricultural processed foods means not only the growth of environment-friendly agriculture, but also the development of related industries. Therefore, it is necessary to identify and apply the needs and purchasing attributes of environment-friendly agricultural processed food consumers. For this, survey was conducted to adult men and women in their 20s and 60s and a total of 200 copies were used for empirical analysis. In this study, the average difference between importance-satisfaction for purchase attributes of environment-friendly agricultural processed food was verified, and the IPA Matrix was prepared based on this. As a result, in terms of purchasing importance and satisfaction, it was found that those with no experience in purchasing environment-friendly agricultural processed foods regarded product, price, place, promotion as more important than those with experience in purchasing. In case of IPA, product and price factors were all important and satisfactory regardless of purchasing experience. On the other hand, it was found that the key factors for promotion were neither important nor satisfied with consumers regardless of their purchasing experience. Therefore, it is mainly necessary to focus on marketing and mass media promotion. At the same time, various domestic and foreign best practices should be benchmarked and a 4P marketing strategy should be established and promoted.

• 대한전기학회논문지
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• 제43권6호
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• pp.991-1000
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• 1994

To control nonlinear systems adaptively, we improve learning speed of neural networks and present a novel control algorithm characterized by compensation of control inputs. In an error-backpropagation algorithm for tranining multilayer neural networks(MLNN's) the effect of the slope of activation functions on learning performance is investigated and the learning speed of neural networks is improved by auto-adjusting the slope of activation functions. The control system is composed of two MLNN's, one for control and the other for identification, with the weights initialized by off-line training. The control algoritm is modified by a control strategy which compensates the control error induced by the indentification error. Computer simulations show that the proposed control algorithm is efficient in controlling a nonlinear system with abruptly changing parameters.

• Natural Product Sciences
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• 제26권2호
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• pp.109-117
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• 2020

The canonical Wnt/β-catenin signaling pathways play an important role in the embryonic development, cell proliferation, differentiation, and adhesion. Therefore, the abnormal activation and repression have been associated with uncontrolled homeostasis in human tissues. In particular, the activation of Wnt signaling is highly correlated with a diverse of diseases including cancer. On this regard, a strategy for targeting Wnt/β-catenin signaling has been employed in the discovery and development of antitumor agents. Herein, the evolution of Wnt signaling and the Wnt inhibitors derived from natural products were briefly summarized in the drug discovery of anticancer agents.

• 한국유기농업학회지
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• 제13권1호
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• pp.23-51
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• 2005

In this article the author provided a brief introduction to the function and activation of 4-H fanning organization. The strategies developed to improve the environmental-friendly Agriculture are as following : the efficiency cooperatives of 4-H fanning organization, invitation of the upbringing plan of organization leader for promotion of the pilot region project of environmental-friendly Agriculture connected with green tourism, the establishment of reasonable management plan and strategies. In conclusion, there must be strategic measures to increase the income of environmental-friendly farmers. All of this information could be useful for the further development of the strategy for environmental-friendly Agriculture in organization and management.