• 대한수의학회지
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• 제40권2호
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• pp.275-282
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• 2000

Substantia nigra is known to highly express glibenclamide binding site, a protein associated to ATP-sensitive $K^{+}$ ($K_{ATP}$) channel in the brain. However, the functional expression of $K_{ATP}$ channels in the area is not yet known. In this work, we attempted to estimate the functional expression of $K_{ATP}$ channels in neurons of the substantia nigra pars compacta (SNC) in young rats using slice patch clamp technique. Membrane properties and whole cell currents attributable to $K_{ATP}$ channel were examined by the current and voltage clamp method, respectively. In SNC, two sub-populations of neurons were identified. Type I (rhythmic) neurons had low frequency rebound action potentials ($4.5{\pm}0.25Hz$, n=75) with rhythmic pattern. Type II (phasic) neurons were characterized by faster firing ($22.7{\pm}3.16Hz$, n=12). Both time constants and membrane capacitance in rhythmic neurons ($34.0{\pm}1.27$ ms, $270.0{\pm}11.83$ pF) and phasic neurons ($23.7{\pm}4.16$ ms, $184{\pm}35.2$ pF) were also significantly different. The current density of $K_{ATP}$ channels was $6.1{\pm}1.47$ pA/pF (2.44~15.43 pA/pF, n=8) at rhythmic neurons of young rats. Our data show that in SNC there are two types of neurons with different electrical properties and the density of $K_{ATP}$, channel of rhythmic neuron is about 600 channels per neuron.

• Preventive Nutrition and Food Science
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• 제12권4호
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• pp.197-201
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• 2007

Genistein is an active component of legumes and other related food shown to be associated with prevention of degenerative diseases such as cancer through inducing signaling pathways. Treatment of genistein resulted in the induction of apoptosis in the cultured cancer cells. This induction of apoptosis was demonstrated by the Tunel assay in these cells. Unveiling the potential of genistein in cytotoxicity via apoptosis when it is treated with estrogen can predict the therapeutic capability of genistein in breast cancers in the presence of endogenous estrogen. We have found that apoptosis induced by genistein treatment in the presence of estrogen is agonistic or antagonistic depending on the concentrations and treatment periods applied in MCF-7 breast cancer cells. For the suppression of cell survival, 24 hr of treatment was required to induce a synergistic agonistic response between estrogen and genistein at low concentrations of genistein. After this period, the agonistic pattern of genistein to estrogen disappeared. The decrement of COX-2 expression in MCF-7 cells treated with genistein was accompanied with the activation of AMPK only at a high concentration of genistein. This association between AMPK activation and down-regulation of COX-2 by genistein was dampened in the presence of estrogen. It was also demonstrated that genistein and estrogen regulate cell survival and apoptosis by modulating p53 and caspase-3 in the opposite direction. These results suggest that genistein has the potential to control breast cancer development, and co-treatment with estrogen can cause agonistic or antagonistic action on breast cancer cell control.

• 대한토목학회논문집
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• 제38권5호
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• pp.703-711
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• 2018

최근 다양한 도시철도 노선이 건설되고, 주변노선과 연계가 이루어짐에 따라 도시철도 이용률이 증가하고 있다. 하지만, 정부는 여전히 기존의 획일적인 운임정책을 고수하고 있어, 다양한 이용패턴에 체계적인 대응을 하지 못할 뿐만 아니라, 공공성 위주의 운임정책으로 인해 운영사의 수익성 악화라는 구조적 문제점이 발생하고 있다. 본 연구는 도시철도 운임정책의 합리성을 제고하기 위해 일본, 영국 등 주요 선진국의 도시철도 운임정책을 검토하였다. 운임정책에 대한 체계적인 분석을 위해 운임결정방식, 카드운임에 대한 할인제도, 운임구조, 그리고 정부 보조금 정책 등의 관점에서 살펴보았으며, 이를 토대로 대한민국 수도권 도시철도 운임정책의 문제점 및 개선방안을 도출하였다. 본 연구를 통해 도시철도 서비스 수준과 수익성에 부합하는 적정 요금정책을 수립하여 합리적인 도시철도 운영에 도움을 줄 수 있을 것으로 기대한다.

• 한국식품영양과학회지
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• 제18권3호
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• pp.348-355
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• 1989

Alkaline protease 생성능이 강한 Aspergillus fumigatus 균주를 토양에서 분리하고, 생성효소를 정제하여 특성을 조사한 결과 최적 pH는 9.0, pH안정성은 $pH\;8.0{\sim}10.0$, 최적온도는 $50^{\circ}C$였으며, $50^{\circ}C$이하의 온도에서 안정하나 그 이상의 온도에서는 급격한 효소 불활성화를 보였고, 금속염 $Mn^{++},\;Cu^{++},\;Ba^{++},\;Mg^{++}$ 등에 의해서 활성이 다소 증대되나 $K^+,\;Fe^{+++},\;Ag^{++},\;Pb^{++},\;Na^+,\;Ca^{++},\;Hg^+,\;Zn^{++}$에 의해 저해를 받았다. 활성저해제인 EDTA, 2,4-DNP, ${\varepsilon}-amino$ caproic acid에는 큰 저해를 받지 않으나, PCMB에 많은 저해를 받는 것으로 미루어 활성 부위가 SH기인 cystein protease로 추정되었다. Km값은 $8.33{\times}10^{-4}mole/{\ell}$, Vmax는 $47.62{\mu}g/min$였으며, casein과 hemoglobin을 trypsin보다 더 잘 분해하고, casein을 hemoglobin보다 잘 분해하였다.

• Wind and Structures
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• 제10권3호
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• pp.287-300
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• 2007

Wind action is a factor of fundamental importance in the structural design of light or slender constructions. Codes for structural design usually assume that the incident mean wind velocity is parallel to the ground, which constitutes a valid simplification for frequent winds caused by meteorological phenomena such as Extratropical Storms (EPS) or Tropical Storms. Wind effects due to other phenomena, such as thunderstorms, and its combination with EPS winds in so-called squall lines, are simply neglected. In this paper a model that describes the three-dimensional wind velocity field originated from a downburst in a thunderstorm (TS) is proposed. The model is based on a semi empirical representation of an axially-symmetrical flow line pattern that describes a stationary field, modulated by a function that accounts for the evolution of the wind velocity with time. The model allows the generation of a spatially and temporally variable velocity field, which also includes a fluctuating component of the velocity. All parameters employed in the model are related to meteorological variables, which are susceptible of statistical assessment. A background wind is also considered, in order to account for the translational velocity of the thunderstorm, normally due to local wind conditions. When the translation of the TS is caused by an EPS, a squall line is produced, causing the highest wind velocities associated with TS events. The resulting vertical velocity profiles were also studied and compared with existing models, such as the profiles proposed by Vicroy, et al. (1992) and Wood and Kwok (1998). The present model predicts horizontal velocity profiles that depend on the distance to the storm center, effect not considered by previous models, although the various proposals are globally compatible. The model can be applied in any region of interest, once the relevant meteorological variables are known, to simulate the excitation due to TS winds in the design of transmission lines, long-span crossings, cable-stayed bridges, towers or similar structures.

• 동서간호학연구지
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• 제5권1호
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• pp.65-74
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• 2000

This study was attempted to show basic data for search of nursing intervention about sleep improving in home and institute elderly peoples. Research design was cross-sectional survey method for comparison of sleep patterns and another variables between home and institute elderly peoples. Subjects were sampled by purpose as home and institute elderly peoples at age of 65 or older in Seoul or nearly. The survey questionnaire was used by modification of sleep questionnaire which Kim, O, Song & Bak(1997) developed. Data were collected between December, 1999 and April, 2000. And data were analyzed by SPSS PC+ for purpose of research. Results are as follows: 1. Home and institute elderly peoples, all were change of sleep patterns and sleep pattern was showed early sleeping down. But institute elderly peoples slept earlier than home elderly peoples. 2. As rest of morning, difficulty of falling asleep and disturbance of re-asleep, subjective thinking and feeling were showed more negative thing home elderly peoples than institute elderly peoples. As frequency of falling asleep within 5 min in 1 week, frequency of falling asleep over 30 min in 1 week and frequency of awakening in a day, objective frequency were showed more insomnia institute elderly peoples than home elderly peoples. Home elderly peoples didn't nap most and institute elderly peoples napped on very short time. 3. Regarding sleep-disturbing factors, physical factor was popularly joint-disturbance in all, home and institute elderly peoples. Environmental factor was popularly noise, particularly institute elderly peoples. Emotional factor wasn't all. 4. Practiced strategies for better sleep was popularly TV/Radio in home elderly peoples and were popularly regular sleep and religious action in institute elderly peoples. From the results of this study, home elderly peoples need nursing intervention of improving self-satisfaction on sleep and institute elderly peoples need nursing intervention of decreasing falling asleep-disturbing and decreasing frequency of awakening in sleep.

• 한국정보과학회논문지:데이타베이스
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• 제32권6호
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• pp.603-615
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• 2005

워크플로우 관리 시스템은 다양성과 복잡성이 커지고 있는 비즈니스 프로세스 관리의 해결대안으로서 부각되고있다. 본 연구에서는 주어진 프로세스 흐름을 세 가지의 패턴 즉, 반복블록, 직렬블록 및 병렬블록 등으로 단순화하고 노드의 위상적 순서(topological ordering)를 생성하는 알고리즘을 이용하여 사이클을 찾아 반복블록을 제거하고, 다음으로 직렬 및 병렬블록을 반복적으로 검색하는 수로분기 알고리즘을 포함하는 새로운 모델을 제시한다. 그리고 ACTA 형식론에 기반하여 각 블록을 ECA규칙으로 변환하여 사건(event)을 감지하는 워크플로우 시스템으로의 구현 방안을 제시한다. 그 모델의 결과를 컴퓨터가 수행할 수 있도록 만들어주는 과정 즉, 비즈니스 프로세스를 모델에 입각하여 통제하는 데에 사건-조건-처리(ECA)규칙을 사용한다. 유형별로 ECA 규칙에 입각한 통제 논리를 설계하였으며, 이것은 규칙기반 워크플로우 관리시스템의 기초가 될 수 있다. 또한 본 연구의 결과가 현행 DBMS들의 능동형 규칙(active rule)에 적용될 수 있도록 구체적 대안을 제시하였다.

• International Journal of Industrial Entomology and Biomaterials
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• 제14권2호
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• pp.127-135
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• 2007

Precocious metamorphosis was induced in two popular bivoltine breeds i.e. YB and $NB_4D_2$ by an imidazole compound having anti-juvenile hormone activity. The chemical was administered by feeding treatment with mulberry leaf to freshly moulted (0-6 hrs) IV instar larvae. The dose of the chemical was found to be breed specific being 650 ppm for YB and 500 ppm for $NB_4D_2$. The chemical caused complete skipping up of the fifth instar larvae which is most susceptible to diseases. But IV instar was somewhat prolonged. As a result the total larval period was reduced by 4-5 days. However, some of the rearing and reeling parameters like cocoon yield, cocoon weight, shell weight, shell %, filament length and fecundity were reduced for that particular generation only. The effective rate of rearing (ERR %) was significantly increased in trimoulters during the most unfavourable August - September seed crop season. Number of cocoons / kg and number of male moth were significantly higher in trimoulters. These may be useful for preparation of $multi{\times}bi$ hybrid seed. Fine denier was also found in trimoulter cocoon which is the cause of getting fine silk filament from trimoulter cocoons. Normal mating behaviour and emergence pattern was recorded in trimoulters. Bivoltine trimoulter males also showed competence for mating with multivoltine females. These results suggest the possibility of getting trimoulter males during hot and humid seasons when rearing of bivoltine is almost impossible particularly in Eastern and North Eastern India.

• 한국컴퓨터정보학회논문지
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• 제26권11호
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• pp.51-57
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• 2021

본 논문에서는 립모션 디바이스를 이용하여 사용자의 손 움직임을 계산하고, 이로부터 저글링 동작뿐만 아니라 이것을 활용하여 팔 근육을 연습 및 분석할 수 있는 새로운 프레임워크를 제안한다. 제안하는 방법은 실시간으로 사용자의 손동작에 맞춰 가상환경에서 공의 움직임을 매핑 할 수 있고, 근육의 이완과 수축을 시각화하여 운동량을 분석할 수 있다. 제안하는 프레임워크는 크게 세 부분으로 구성된다 : 1) 립모션 디바이스를 이용하여 사용자의 손 위치를 추적한다. 2) 저글링을 하듯이, 사용자가 공을 던지는 행동 패턴을 이벤트로 정의한다. 3) 사용자의 손 위치를 기준으로 저글링 형태의 움직임을 공에 매핑하기 위한 포물선 기반 입자 기법을 제안한다. 결과적으로 본 논문의 프레임워크를 이용하면 실시간 저글링 게임을 할 수 있다.

• 한국콘텐츠학회논문지
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• 제21권7호
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• pp.13-19
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• 2021

영화를 감상하는 동안 관객들은 각기 다양한 감성 반응을 보인다. 슬퍼하고 분노하며, 기뻐하고 화를 내는 등의 감성 반응이 영화가 전개되는 스토리에 따라 나타난다. 영화 전개에서 벌어지는 상황과 사건 등에서 관객이 보인 감성반응이 무엇인지를 뇌파 측정을 통해 알 수 있다. 이것을 연구하기 위해 연구 대상으로 각 장르를 대표하며, 흥행에 성공하여 많은 사람들에게 알려진 미국 영화 4편을 선택하였다. 어드밴처 장르의 <내서널트래저>, 애니메이션 장르의 <토이스토리3>, 액션 장르의 <아이언맨1>, 드라마 장르의 <블라인드사이드>이다. 이들 영화의 감성반응을 측정하기 위해 뇌파의 PPG를 중심으로 4개 경우를 설정하여 시계열 그래프 패턴으로 분석하였다. 그 결과 그래프에 나타난 감성반응이 스토리 전개와 밀접한 상관성이 있음을 알 수 있었다. 본 연구는 향후 영화 제작할 때, 특히 스토리를 어떻게 구성하여 전개시켜 나갈 것인가 할 때 장르 선택에 도움을 줄 것이고, 관객들의 감성을 유도해 내는 데도 도움을 줄 것이라고 기대한다.