• Biomolecules & Therapeutics
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• 제21권3호
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• pp.181-189
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• 2013

Motilitone$^{(R)}$ (DA-9701) is a new herbal drug that was launched for the treatment of functional dyspepsia in December 2011 in Korea. The heterogeneous symptom pattern and multiple causes of functional dyspepsia have resulted in multiple drug target strategies for its treatment. DA-9701, a compound consisting of a combination of Corydalis Tuber and Pharbitidis Semen, has being developed for treatment of functional dyspepsia. It has multiple mechanisms of action such as fundus relaxation, visceral analgesia, and prokinetic effects. Furthermore, it was found to significantly enhance meal-induced gastric accommodation and increase gastric compliance in dogs. DA-9701 also showed an analgesic effect in rats with colorectal distension induced visceral hypersensitivity and an antinociceptive effect in beagle dogs with gastric distension-induced nociception. The pharmacological effects of DA-9701 also include conventional effects, such as enhanced gastric emptying and gastrointestinal transit. The safety profile of DA-9701 is also preferable to that of other treatments.

• 환경영향평가
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• 제22권1호
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• pp.109-116
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• 2013

By IPCC climate change scenario, the socioeconomic actions such as the land use change are closely associated with the climate change as an up zoning action of urban development to increase green gas emission to atmosphere. Prediction of the land use change with rational quality can provide better data for understanding of the climate change in future. This study aims to predict land use change of Cheongju in future and SLEUTH model is used to anticipate with the status quo condition, in which the pattern of land use change in future follows the chronical tendency of land use change during last 25 years. From 40 years prediction since 2000 year, the area urbanized compared with 2000 year increases up to 87.8% in 2040 year. The ratios of the area urbanized from agricultural area and natural area in 2040 are decreased to 53.1% and 15.3%, respectively.

• Journal of Information Display
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• 제9권1호
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• pp.14-19
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• 2008

We demonstrated the capillary force lithography (CFL) method for controlling the azimuthal anchoring energy of a liquid crystal (LC) alignment layer. When a thermoplastic polymer film is heated to over the glass transition temperature, the melted polymer is filled into the mold structure by the capillary action and the aspect ratio of the pattern is determined by the dewetting time of the CFL process. Here, the proposed method showed that the azimuthal anchoring energy of the LC alignment layer could be simply controlled by the surface relief patterns which were determined by the dewetting times during the CFL patterning.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2000년도 추계학술대회 논문집 학회본부 C
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• pp.583-585
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• 2000

This study reports the fluidic handling method using hydrophobic patterns inside PDMS microchannels. In order to obtain hydrophobic patterns, we pattern fluorcarbon(FC) film surfaces by lift-off process. FC films are deposited by spin coating method and plasma polymerization method. Hydrophobic surfaces are used as the barriers to control fluid flow. Injected liquid is spontaneously filled up inside PDMS-microchannels by the capillary action. Liquid flow stops when it meets hydrophobic regions which can be the barrier against fluid flow. Then, again, when liquid is pressurized externally, liquid can move toward another hydrophilic region by external air pressure. Contact angle analyses are performed on fluorocarbon films to estimate the wettability of film surfaces.

• 한국동물학회지
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• 제38권2호
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• pp.220-229
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• 1995

uftraspirocle (usa) gene product (Uspl is a member of the superfamilv of steroid hormone receptors in Drosophila melonogaster which mediate the hormone action by heteromerization with ecdvsone receptor (EcR). Based on the genetic and molecular characterization of usp, it has been proposed that Usp funtions in at least three significant developmental pathway: embrvogenesis, eve morphogenesis, and female reproduction. In this study, the expression patterns of Usp were investigated by immunohistochemistrv in individual tissues from diHernt developmental stases of Drosophila. Usp is localized in the nucleus with ubiquitous distribution throughout development. Usp expression is detected throughout embrvogenesis. Usp is expressed in imaginal and lanral tissues from late third instar 18nra. The expression pattern of Usp is overlapped by those of EcR. Also Usp is expressed in differentiating adult reproductive organs. This result suggests that Usp is not a transcriptional regulatory factor modulating hormonal response during development, but also play some roles in female and male reproduction of Drosophila.

• 한국컴퓨터정보학회지
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• 제15권1호
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• pp.125-129
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• 2007

지능형 홈 네트워크 서비스의 일반적 보급화로 사용자의 필요와 욕구에 밀착한 개인화 서비스를 위한 사용자의 프로파일 및 다양한 상태 정보, 센서 및 기타 환경정보를 통한 동적 상황인지가 가능토록 하는 상황인지(context-aware) 서비스에 대한 필요성이 증대되고 있다. 사용자 행위 학습에 따른 지능적 자동 제어 시스템 구축에서 먼저 고려해야 할 사항은 사용자 행위 학습에 따른 지능적 자동 제어에 대한 기준을 마련하는 것이다. 홈 네트워크 내의 정보가전기기들 환경에 대한 정보를 지속적으로 수집하고 학습 알고리즘을 통하여 분석하며, 분석되어진 정보를 바탕으로 사용자의 성향을 파악하는 것을 주요인으로 간주해야 할 것이다. 이에 따라 본 논문에서는 사용자 능동적 행위에 따른 지능형 홈 제어 시스템을 제안하였다. 또한 지속적인 모니터링을 통하여 사용자의 성향이 파악되면 상황에 따른 최적의 환경을 제공할 수 있도록 홈 네트워크 제어 시스템을 구축하는 것으로 목적으로 하였다. 사용자의 행동 패턴을 분석하고 이를 기반으로 지능적인 서비스를 제공함으로써 사용자 중심의 능동적 서비스 효과들을 얻을 수 있을 것으로 기대한다.

• 대한화학회지
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• 제35권1호
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• pp.78-84
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• 1991

Enkephalin의 작용을 연장하기 위한 연구이 하나로서 수개의 enkephalin aminopeptidase의 저해물을 합성하였다. 이 펩티드성 저해물은 zinc 결합자리로서 3-amino-2-hydroxy amino acid와 기질양상의 곁사슬을 가진다. 펩티드들은 용액 중에서 DCC/HOBt를 축합시약으로 사용하여 C-말단으로부터 사슬 연장법으로 합성하였다. 합성한 펩티드 저해물들은 모두 enkephalin aminopeptidase에 대하여 강한 저해 작용을 나타내었다.

• 해양환경안전학회지
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• 제2권1호
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• pp.143-143
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• 1996

Recent Class requirements and IMO recommendations concerning Hull Strength Monitoring (HSM) have prompted an increasing number of shipowner to adopt monitoring systems on bulk carriers and tanker. Such systems are designed to give warning when stress levels and the frequency and magnitude of ship motions approach levels which require corrective action. When fitted these systems provide enhanced operational safety and efficiency. This paper describes a development beyond the standard BMT HSM system through the integration of stress, motion and radar-based sea state monitoring with powerful, on-board, artificial intelligence (AI) tools. The latter utilises conceptual clustering techniques as an aid to pattern recognition in stress, fatigue. motion and sea state data clusters. This, in turn, provides additional operational guidance for ship's staff. Feedback from applications of the standard BMT HSM and extended HSM systems on board the British Steel Bulk Shipping fleet is described.

• The Korean Journal of Physiology
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• 제29권1호
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• pp.103-111
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• 1995

Intracellular recordings were obtained from Purkinje cells in rat cerebellar slices maintained in vitro. Adding tetrodotoxin to the superfusion solution produced a typical pattern of repetitive burst firing consisting of a cluster of action potentials followed by a long hyperpolarization. TTX-induced oscillatory activity was not due to modulation of membrane potential although underlying mechanisms for maintenance of oscillatory activity were influenced by membrane voltage. The mechanism of TTX-induced oscillation was not related to the presence or amplitude of $I_h$ and could still induce the oscillatory activity after blockade of $I_h$ by cesium. The result from an experiment in which QX-314 was injected intracellularly strongly suggested that TTX-induced oscillatory firing activity was due to blockade of post-synaptic $Na^{+}$ currents intrinsic to PCs.

• 한국게임학회 논문지
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• 제4권3호
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• pp.43-47
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• 2004

FPS 게임이나 액션 게임처럼 빠른 속도의 게임에서는 적의상태와 나의 상태를 분석하여 이성적인 게임플레이를 할 시간적 여유가 없는 경우가 대부분 이다. 이러한 종류의 게임에서 적 캐릭터의 행동은 대부분 패턴으로 정해지는 것이 일반적이다. 그러나 이렇게 패턴이 정해져 있는 적 캐릭터의 경우 게임에 대한 게이머의 숙련도가 높아질수록 대응방법의 한계를 느낄 수 있는 단점이 있다. 따라서 본 연구에서는 판단과 의사결정의 심리를 이용하여 게이머의 행동패턴을 예측한 후 적 캐릭터의 행동에 반영하여 좀 더 다양한 행동패턴을 보이는 적 캐릭터에 대해서 연구한다.