• Asian-Australasian Journal of Animal Sciences
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• v.8 no.6
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• pp.533-555
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• 1995

Direct-fed microbials (DFM) have been used to enhance milk production in lactating cattle and to increase feed efficiency and body weight gain in growing ruminants. Primary microorganisms that have been used as DFM for ruminants are fungal cultures including Aspergillus oryzae and Saccharomyces cerevisiae and lactic acid bacteria such as Lactobacillus or Streptococcus. Attempts have been made to determine the basic mechanisms describing beneficial effects of DFM supplements. Various modes of action for DFM have been suggested including : stimulation of ruminal microbial growth, stabilization of ruminal pH, changes in ruminal microbial fermentation pattern, increases in digestibility of nutrients ingested, greater nutrient flow to the small intestine, greater nutrient retention and alleviation of stress, however, these responses have not been observed consistently. Variations in microbial supplements, dosage level, production level and age of the animal, diet and environmental condition or various combinations of the above may partially explain the inconsistencies in response. This review summarizes production responses that have been observed under various conditions with supplemental DFM and also corresponding modification of ruminal fermentation and other changes in the gastrointestinal tract of ruminant animals.

• Journal of Institute of Control, Robotics and Systems
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• v.16 no.10
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• pp.957-962
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• 2010

If we want to recognize the human's emotion via the facial image, first of all, we need to extract the emotional features from the facial image by using a feature extraction algorithm. And we need to classify the emotional status by using pattern classification method. The AAM (Active Appearance Model) is a well-known method that can represent a non-rigid object, such as face, facial expression. The Bayesian Network is a probability based classifier that can represent the probabilistic relationships between a set of facial features. In this paper, our approach to facial feature extraction lies in the proposed feature extraction method based on combining AAM with FACS (Facial Action Coding System) for automatically modeling and extracting the facial emotional features. To recognize the facial emotion, we use the DBNs (Dynamic Bayesian Networks) for modeling and understanding the temporal phases of facial expressions in image sequences. The result of emotion recognition can be used to rehabilitate based on biofeedback for emotional disabled.

• The Journal of Korean Physical Therapy
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• v.22 no.6
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• pp.43-51
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• 2010

Purpose: This study examined the influence of visuomotor congruency on learning a relative phase relationship between a single joint movement and an external signal. Methods: Participants (N=5) were required to rhythmically coordinate elbow flexion-extension movements with a continuous sinusoidal wave (0.375 Hz) at a $90^{\circ}$ relative phase relationship. The congruent group was provided online feedback in which the elbow angle decreased (corresponding to elbow flexion) as the angle trajectory was movingup, and vice versa. The incongruent group was provided online feedback in which the elbow angle decreased as the angle trajectory was moving down, and vice versa. There were two practice sessions (day 1 and 2) and each session consisted of 6 trials per block (5 blocks per session). Retention tests were performed 24 hours after session 2, and only the external sinusoidal wave was provided. Repeated ANOVAs were used for statistical analysis. Results: During practice, the congruent group was significantly less variable than the incongruent group. Phase variability in the incongruent group did not significantly change across blocks, while variability decreased significantly in the congruent group. In retention, the congruent group produced the required $90^{\circ}$ relative phase pattern with significantly less phase variability than the incongruent group. Conclusions: Congruent visual feedback facilitates learning. Moreover, the deprivation of online feedback does not affect the congruent group but does affect the incongruent group in retention.

• The Korean Journal of Physiology and Pharmacology
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• v.5 no.6
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• pp.457-466
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• 2001

Glutamate is the most common excitatory amino acid in the brain. Responsiveness of dendrites to the glutamate greatly varies depending on the application sites. Especially, a point of the maximal response to the glutamate of the dendrite is called as 'hot spot'. In our experiment, the responsiveness of the hot spot to the glutamate was investigated in the CA1 pyramidal neuron of the rat hippocampal slice. CNQX, the antagonist of AMPA receptor, blocked 95% of membrane current to the glutamate focal application $(I_{gl}).$ Train ejection of glutamate on one point of the dendrite increased or decreased the amplitude of $I_{gl}$ with the pattern of train, and the changes were maintained at least for 30 min. In some cases, glutamate train ejection also induced calcium dependent action potentials. To evoke long-term change of synaptic plasticity, we adopted ${\theta}-burst$ in the glutamate train ejection. The ${\theta}-burst$ decreased the amplitude of glutamate response by 60%. However, after ${\theta}-burst$ glutamate train ejection, the calcium dependent action potential appeared. These results indicated that the focal application of glutamate on the neuronal dendrite induced response similar to the synaptic transmission and the trains of glutamate ejection modulated the change of AMPA receptor.

• YAKHAK HOEJI
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• v.49 no.6
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• pp.484-489
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• 2005

Streptococcus pmeumoniae is the leading cause of pneumonia and bacterial meningitis. The current polysaccharide vaccine has been reported ineffective in elderly adults and children less than 2 years of age. Thus, in recent many researchers have been focused on a different approach, DNA vaccine. In our laboratory we developed a Streptococcus pneumoniae DNA (SPDNA) vaccine. This SPDNA vaccine was formulated by inserting the region encoding part of the capsule in the S. pneumoniae into the LAMP-1. In present work, with use of the SPDNA vaccine we attempted to establish a certain methodology useful for evaluation of effectiveness and immunoresponse of a DNA vaccine. Results showed that the subcutaneous route was the most effective for production of antisera specific for S. pneumoniae in mice. By isotyping analyses, IgM, IgGl, IgG2a, and IgG2b were determined. In addition, INF-$\gamma$ and IL-4 were predominantly detected. Combination of those data resulted in a pattern of IgGl < IgG2a=IgG2b and INF$\gamma\>$ >IL-4, which indicates the inmmunity towards the Thl response predominantly; furthermore, the SPDNA vaccination induced resistance of the CD4+T lymphocyte-depleted mice against disseminated pneumococcal infection. These data appear to be possibly due to activation of CDS8+T cell-activation. Taken together, this methodology can be applied for evaluating efficacy and mode of action of a DNA vaccine as minimum critera.

• Phonetics and Speech Sciences
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• v.6 no.2
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• pp.123-131
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• 2014

The purpose of this study is to investigate the comprehension and production of various tense markings in Korean-speaking children with and without language delay. Thirty children with language delay(LD) and 30 typically developing(TD) children participated in the study. In each group, half were at the age of 4-years and the other half at 7-years. In both the comprehension and production task, 28 verbs containing four types of tense markings were used: past tense '-et ta', two present progressives '-ko itta', '-enta', and future tense '-elyeko hanta'. In the comprehension task, the children were presented with three printed still-scenes of video recording of a verb action, each representing future, present progressive, and past tense of the verb, respectively. Then they listened to the action verb with one of the 4 tense markings and had to pick the scene that matched the verb tense. In the production task, the children were given one of the three scenes and asked to produce the verb with appropriate tense marking. In both tasks, the LD children performed significantly worse than the TD children, and the older children performed significantly better than the younger children. Interestingly, the pattern of performances across different types of tense markings at the two language-age levels were closely similar in LD children and TD children. This similarity of groups seemed stronger in the comprehension task than the production task.

• Proceedings of the KIEE Conference
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• 1999.07g
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• pp.3092-3094
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• 1999

This paper deals with the gait generation of Biped Walking Robot (IWR-III) to have a continuous walking pattern like human. For this, trajectory planning with the consideration of kick action is done in each walking step, and the coordinate transformation is done for simplifying the kinematics. The trunk moves continuously for all walking time and moves toward Z-axis. Balancing motion is acquired by FDM(Finite Difference Method) during the walking. By combining 4-types of pre-defined steps, multi-step walking is done. Using numerical simulator, dynamic analysis and system stability is confirmed. Walking motion is visualized by 3D-Graphic simulator. As a result, the motion of balancing joints can be reduced by the trunk ahead effect during kick action, and impactless smooth walking is implemented by the experiment.

• Korean Journal of Human Ecology
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• v.18 no.1
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• pp.157-166
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• 2009

This study was conducted to evaluate the differences in external appearances and functional qualities between the slacks which were patterned on existing designs and on a new design in order to improve on their level of comfort of ready-made clothes for abdominally fat women. Five abdominally fat women in their 60's were chosen as experimental participants. Twenty-four external evaluation items, and seven different actions involving six moving parts of the body were investigated with a 5-level scale in the repeated wearing test. The results were analyzed by statistical methods. The newly designed pattern in this study was definitely superior to the other two patterns(L-type and K-type) on the external appearance evaluation. The newly pattern removed a waist belt and a dart from the front part of the garment and gave surplus space around the waist. It prevented superfluous wrinkles at the abdominal region and thighs. The superfluous wrinkles at the side regions also disappeared due to the length (inseam) reduction from waist to crotch. The newly pattern made the center-line of the back side slightly sloped to the main pattern in order to remove the drooped line. The newly pattern showed the highest score in the functional test of several actions. It was due to the reduction of the length from waist to crotch as well as the belt width. It made waist-line movement better, and made it easier and more comfortable to sit down. The newly pattern also showed the highest score in the functional test classified by specific movements of parts of the body for the same purpose. The slacks which were made of elastic materials showed better results than the non-elastic ones on external appearances and functional test items. It showed that the elastic materials played a better role in the increase of functional action of abdominally fat, aged women. This study suggests that the newly designed slacks pattern could give abdominally fat, aged women better external features and a more comfortable fitting sensation. As well, the results were significant as basic data to produce ready-made and/or tailer-made garments.

• Korean Journal of Construction Engineering and Management
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• v.14 no.4
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• pp.55-64
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• 2013

As GHG target management is introduced in Korea, designated establishment takes responsibilities to reduce more than 30% of expected GHG emission until 2020. Although decreasing GHG has been requested to universities which consume great amount of energy, there are difficulties to apply high cost countermeasures. Therefore, this research suggest a low cost, easily-applicable energy saving method, and derive potential GHG reduction amount in the case of SNU, Kwan-ak campus. First of all, 11 rooms of different use were chosen as the samples, and energy consumption in each room was measured. Standard models for each room were built through researching on the electric devices in each room. Moreover, energy consumption was computed for each devices through analyzing the pattern of electricity consumption. 32 GHG reduction technology and action program were chosen, and they were applied to the standard models for individual rooms. Through multiplying energy reduction rate of each program to energy consumption of each electric device, maximum energy reduction of each electric device is derived. Through that, Maximum GHG reduction for individual rooms and each month and the total GHG reduction capacity of Kwan-ak campus were computed. It was found out that approximately $5,311tCO_2$-eq can be reduced, when reduction technology and action program suggested by this research are applied. It appeared 24.48% of requested reduction amount to SNU can be reduced, till 2016.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.6
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• pp.3735-3742
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• 2013

Background: Cardamom (Elettaria cardamom), also known as "Queen of Spices", has been traditionally used as a culinary ingredient due to its pleasant aroma and taste. In addition to this role, studies on cardamom have demonstrated cancer chemopreventive potential in in vitro and in vivo systems. Nevertheless, the precise poly-pharmacological nature of naturally occurring chemo-preventive compounds in cardamom has still not been fully demystified. Methods:In this study, an effort has been made to identify the proapoptopic, anti-inflammatory, anti-proliferative, anti-invasive and anti-angiogenic targets of Cardamom's bioactive principles (eucalyptol, alpha-pinene, beta-pinene, d-limonene and geraniol) by employing a dual reverse virtual screening protocol. Experimentally proven target information of the bioactive principles was annotated from bioassay databases and compared with the virtually screened set of targets to evaluate the reliability of the computational identification. To study the molecular interaction pattern of the anti-tumor action, molecular docking simulation was performed with Auto Dock Pyrx. Interaction studies of binding pose of eucalyptol with Caspase 3 were conducted to obtain an insight into the interacting amino acids and their inter-molecular bondings. Results:A prioritized list of target proteins associated with multiple forms of cancer and ranked by their Fit Score (Pharm Mapper) and descending 3D score (Reverse Screen 3D) were obtained from the two independent inverse screening platforms. Molecular docking studies exploring the bioactive principle targeted action revealed that H- bonds and electrostatic interactions forms the chief contributing factor in inter-molecular interactions associated with anti-tumor activity. Eucalyptol binds to the Caspase 3 with a specific framework that is well-suited for nucleophilic attacks by polar residues inside the Caspase 3 catalytic site. Conclusion:This study revealed vital information about the poly-pharmacological anti-tumor mode-of-action of essential oils in cardamom. In addition, a probabilistic set of anti-tumor targets for cardamom was generated, which can be further confirmed by in vivo and in vitro experiments.