• Journal of Preventive Medicine and Public Health
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• v.42 no.6
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• pp.371-376
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• 2009

In this article, we reviewed the literature on risk assessment (RA) models with and without molecular genomic markers and the current utility of the markers in the pharmacogenetic field. Epidemiological risk assessment is applied using statistical models and equations established from current scientific knowledge of risk and disease. Several papers have reported that traditional RA tools have significant limitations in decision-making in management strategies for individuals as predictions of diseases and disease progression are inaccurate. Recently, the model added information on the genetic susceptibility factors that are expected to be most responsible for differences in individual risk. On the continuum of health care, from diagnosis to treatment, pharmacogenetics has been developed based on the accumulated knowledge of human genomic variation involving drug distribution and metabolism and the target of action, which has the potential to facilitate personalized medicine that can avoid therapeutic failure and serious side effects. There are many challenges for the applicability of genomic information in a clinical setting. Current uses of genetic markers for managing drug therapy and issues in the development of a valid biomarker in pharmacogenetics are discussed.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2001.11b
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• pp.799-804
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• 2001

Nonlinear normal mode (NNM) vibration, in a nonlinear dual mass Hamiltonian system, which has 6th order homogeneous polynomial as a nonlinear term, is studied in this paper. The existence, bifurcation, and the orbital stability of periodic motions are to be studied in the phase space. In order to find the analytic expression of the invariant curves in the Poincare Map, which is a mapping of a phase trajectory onto 2 dimensional surface in 4 dimensional phase space, Whittaker's Adelphic Integral, instead of the direct integration of the equations of motion or the Birkhotf-Gustavson (B-G) canonical transformation, is derived for small value of energy. It is revealed that the integral of motion by Adelphic Integral is essentially consistent with the one obtained from the B-G transformation method. The resulting expression of the invariant curves can be used for analyzing the behavior of NNM vibration in the Poincare Map.

• Advances in aircraft and spacecraft science
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• v.9 no.3
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• pp.263-278
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• 2022

The time-varying structural reliability of an aeroelastic launch vehicle subjected to stochastic parameters is investigated. The launch vehicle structure is under the combined action of several stochastic loads that include aerodynamics, thrust as well as internal combustion pressure. The launch vehicle's main body structural flexibility is modeled via the normal mode shapes of a free-free Euler beam, where the aerodynamic loadings on the vehicle are due to force on each incremental section of the vehicle. The rigid and elastic coupled nonlinear equations of motion are derived following the Lagrangian approach that results in a complete aeroelastic simulation for the prediction of the instantaneous launch vehicle rigid-body motion as well as the body elastic deformations. Reliability analysis has been performed based on two distinct limit state functions, defined as the maximum launch vehicle tip elastic deformation and also the maximum allowable stress occurring along the launch vehicle total length. In this fashion, the time-dependent reliability problem can be converted into an equivalent time-invariant reliability problem. Subsequently, the first-order reliability method, as well as the Monte Carlo simulation schemes, are employed to determine and verify the aeroelastic launch vehicle dynamic failure probability for a given flight time.

• Wind and Structures
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• v.37 no.1
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• pp.1-13
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• 2023

Due to the irregular shape and the deviation of stiffness center and gravity center, buildings always suffer from complex surface load and vibration response under wind action. This study is dedicated to analyze the surface wind load and wind-induced response of an irregular building, and to discuss the possibility of top swimming pool as a TLD to diminish wind-induced vibration of the structure. Wind tunnel test was carried out on a hotel with irregular shape to analyze the wind load and structural response under 8 wind incident angles. Then a precise numerical model was established and calibrated through experimental results. The top swimming pool was designed according to the principle of frequency modulation, and equations of motion of the control system were derived theoretically. Finally, the wind induced response of the structure controlled by the pool was calculated numerically. The results show that both of wind loads and wind-induced responses of the structure are significantly different with wind incident angle varies, and the across-wind response is nonnegligible. The top swimming pool has acceptable damping effect, and can be designed as TLD to mitigate wind response.

• The Plant Pathology Journal
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• v.40 no.3
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• pp.290-298
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• 2024

K-Maryblyt has been developed for the effective control of secondary fire blight infections on blossoms and the elimination of primary inoculum sources from cankers and newly emerged shoots early in the season for both apple and pear trees. This model facilitates the precise determination of the blossom infection timing and identification of primary inoculum sources, akin to Maryblyt, predicting flower infections and the appearance of symptoms on various plant parts, including cankers, blossoms, and shoots. Nevertheless, K-Maryblyt has undergone significant improvements: Integration of Phenology Models for both apple and pear trees, Adoption of observed or predicted hourly temperatures for Epiphytic Infection Potential (EIP) calculation, incorporation of adjusted equations resulting in reduced mean error with 10.08 degree-hours (DH) for apple and 9.28 DH for pear, introduction of a relative humidity variable for pear EIP calculation, and adaptation of modified degree-day calculation methods for expected symptoms. Since the transition to a model-based control policy in 2022, the system has disseminated 158,440 messages related to blossom control and symptom prediction to farmers and professional managers in its inaugural year. Furthermore, the system has been refined to include control messages that account for the mechanism of action of pesticides distributed to farmers in specific counties, considering flower opening conditions and weather suitability for spraying. Operating as a pivotal module within the Fire Blight Forecasting Information System (FBcastS), K-Maryblyt plays a crucial role in providing essential fire blight information to farmers, professional managers, and policymakers.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.8 no.1
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• pp.1-23
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• 1998

Work-related Low Back Pain(LBP) is one of tile most important Issues in the field of industrial safety and health. Particularly, manual lifting is known as a major cause of work-related LBP and impairment. Total number of 163 manual lifting tasks in motor assembly processes were investigated. The 1981 and the 1994 equations developed by National Institute for Occupational Safety and Health(NIOSH) were applied to evaluate potential hazards of lifting-related LBP. Comparisons between the 19R I and 1994 NIOSH criteria were made. The relationships between the NIOSH criteria and lifting-related LBP were also analyzed. The results of this study are as follows: 1. The values of Action Limit(AL) by the NIOSH 1981 lifting equation. Recommended Weight Limit(RWL) by the 1994 equation and the weight of the load handled at each manual lifting task were shown log-normal distributions. 2. LI'(the weight of tile load/AL) and LI(the weight of the load/RWL) were calculated estimate the physical stress imposed by each individual lifting task. As a result. 76.7% of the total LI' value exceeded 1 and 12.9% exceeded 3, and 84.7% of the total LI values exceeded 1 and 20.9% exceeded 3. 3. Bus 2 Department showed the highest rate of LI'>1 and LI>1 and Bus 1 Department showed the highest rate of LI'>3 and LI>3 4. In general, the RWLs by the 1994 equation were found lower than the ALs by the 1981 equation. It is assumed to he resulted from the fact that the 1994 equation includes methods evaluating asymmetrical lifting tasks and lifts of objects with less then optimal hand-container couplings, and also covers a larger range of work durations and lifting frequencies than the 1981 equation. 5. Significant correlations were found between LI' and incidence of LBP (R=0.734, p<0.05). LI and incidence of LBP(R=0.671. p<0.10) and load-weights and incidence of LBP(R=0.797, p<0.05). 6. Control measures are required to achieve the value of LI less than 1 for some tasks having high LI values. Engineering control is highly recommended for some tasks having the value of LI above 3.

• Journal of the Korea Concrete Institute
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• v.15 no.2
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• pp.225-233
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• 2003

Even though a lot of advanced researches on analysis, design, and performance evaluation of reinforced concrete (RC) under seismic action have been carried out, there has been only a few study on seismic analysis of underground RC structures surrounding soil medium. Since the underground RC structures interact with surrounding soil medium, a path-dependent soil model which can predict the soil response is necessary for analyzing behavior of the structure inside soil medium. The behavior of interfacial zone between the RC structure and the surrounding medium should be also considered for more accurate seismic analysis of the RC structure. In this paper, an averaged constitutive model of concrete and reinforcing bars for RC structure and path-dependent Ohsaki's model for soil are applied, and an elasto-plastic interface model having thickness is proposed for seismic analysis of underground RC structures. A finite element analysis technique is developed by applying aforementioned constitutive equations and is verified by predicting both static and dynamic behaviors of RC structures. Then, failure mechanisms of underground RC structure under seismic action are numerically derived through seismic analysis of underground RC station structure under different seismic forces. Finally, the changes of failure mode and the damage level of the structures are also analytically derived for different design cases of underground RC structures.

• Ocean Systems Engineering
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• v.6 no.1
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• pp.61-97
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• 2016

This is the second of two papers on the 3D numerical modeling of nearshore hydro- and morphodynamics. In Part I, the focus was on surf and swash zone hydrodynamics in the cross-shore and longshore directions. Here, we consider nearshore processes with an emphasis on the effects of oceanic forcing and beach characteristics on sediment transport in the cross- and longshore directions, as well as on foreshore bathymetry changes. The Delft3D and XBeach models were used with four turbulence closures (viz., ${\kappa}-{\varepsilon}$, ${\kappa}-L$, ATM and H-LES) to solve the 3D Navier-Stokes equations for incompressible flow as well as the beach morphology. The sediment transport module simulates both bed load and suspended load transport of non-cohesive sediments. Twenty sets of numerical experiments combining nine control parameters under a range of bed characteristics and incident wave and tidal conditions were simulated. For each case, the general morphological response in shore-normal and shore-parallel directions was presented. Numerical results showed that the ${\kappa}-{\varepsilon}$ and H-LES closure models yield similar results that are in better agreement with existing morphodynamic observations than the results of the other turbulence models. The simulations showed that wave forcing drives a sediment circulation pattern that results in bar and berm formation. However, together with wave forcing, tides modulate the predicted nearshore sediment dynamics. The combination of tides and wave action has a notable effect on longshore suspended sediment transport fluxes, relative to wave action alone. The model's ability to predict sediment transport under propagation of obliquely incident wave conditions underscores its potential for understanding the evolution of beach morphology at field scale. For example, the results of the model confirmed that the wave characteristics have a considerable effect on the cumulative erosion/deposition, cross-shore distribution of longshore sediment transport and transport rate across and along the beach face. In addition, for the same type of oceanic forcing, the beach morphology exhibits different erosive characteristics depending on grain size (e.g., foreshore profile evolution is erosive or accretive on fine or coarse sand beaches, respectively). Decreasing wave height increases the proportion of onshore to offshore fluxes, almost reaching a neutral net balance. The sediment movement increases with wave height, which is the dominant factor controlling the beach face shape.

• Journal of the Institute of Electronics Engineers of Korea CI
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• v.40 no.1
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• pp.59-73
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• 2003

As a means of overcoming the linguistic barrier between different languages in the Internet, a new sign-language communication system with CG animation techniques has been developed and proposed. In the system, the joint angles of the arms and the hands corresponding to the gesture as a non-verbal communication tool have been considered. The emotional expression, however, could as play also an important role in communicating each other. Especially, a comic expression is more efficient than real facial expression, and the movements of the cheeks and the jaws are more important AU's than those of the eyebrow, eye, mouth etc. Therefore, in this paper, we designed a 3D emotion editor using 2D model, and we extract AU's (called as PAU, here) which play a principal function in expressing emotions. We also proposed a method of generating the universal emotional expression with Avatar models which have different vertex structures. Here, we employed a method of dynamically adjusting the AU movements according to emotional intensities. The proposed system is implemented with Visual C＋＋ and Open Inventor on windows platforms. Experimental results show a possibility that the system could be used as a non-verbal communication means to overcome the linguistic barrier.

• Journal of Intelligence and Information Systems
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• v.29 no.4
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• pp.111-127
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• 2023

This study is a study on user perception of ChatGPT use. The goal of this study is to analyze the relationship between user policy expectations and user innovativeness on ChatGPT technology acceptance and intention to use using variables of TRA (Theory of Reasoned Action). The impact of policy expectations and user innovativeness on the intention to use by mediating usefulness and hedonic motivation, and the impact of subjective norms on the usefulness and intention to use were analyzed by dividing them into the MZ generation and the non-MZ generation. It was verified whether there was a moderating effect on the effect of age differences on usefulness by interacting with policy expectations. An online survey was conducted on 300 ChatGPT users using PLS (Partial Least Square) structural equations and SPSS Package, and statistical analysis was performed using PLS and SPSS. According to the analysis results, it was confirmed that the higher the initial user's innovativeness, the higher the intention to use ChatGPT. In addition, the moderating effect analysis comparing the differences between the MZ generation and the non-MZ generation showed that policy expectations had a negative effect on the usefulness of ChatGPT use.