• Biomolecules & Therapeutics
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• v.27 no.6
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• pp.540-552
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• 2019

To determine the chemopreventive potential of alyssin and iberin, the in vitro anticancer activities and molecular targets of isothiocyanates (ITCs) were measured and compared to sulforaphane in hepatocellular carcinoma cell HepG2. The SR-FTIR spectra observed a similar pattern vis-a-vis the biomolecular alteration amongst the ITCs-treated cells suggesting a similar mode of action. All of the ITCs in this study cause cancer cell death through both apoptosis and necrosis in concentration dependent manner ($20-80{\mu}M$). We found no interactions of any of the ITCs studied with DNA. Notwithstanding, all of the ITCs studied increased intracellular reactive oxygen species (ROS) and suppressed tubulin polymerization, which led to cell-cycle arrest in the S and $G_2/M$ phase. Alyssin possessed the most potent anticancer ability; possibly due to its ability to increase intracellular ROS rather than tubulin depolymerization. Nevertheless, the structural influence of alkyl chain length on anticancer capabilities of ITCs remains inconclusive. The results of this study indicate an optional, potent ITC (viz., alyssin) because of its underlying mechanisms against hepatic cancer. As a consequence, further selection and development of effective chemotherapeutic ITCs is recommended.

• YAKHAK HOEJI
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• v.52 no.3
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• pp.219-224
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• 2008

Clinically isolated methicillin-resistant Staphylococcus aureus strains were exposed to subinhibitory concentration of DW286, DW-224a, gemifloxacin, trovafloxacin, sparfloxacin and ciprofloxacin during 26- to 39-days period. Subculturing led to resistance development, and most of the selected mutants were above susceptible breakpoints. Selected mutants had broad cross resistance to other quinolone antibiotics and only one mutant was completely susceptible to all fluoroquinolones. Twenty five among 42 mutants revealed mutations on DNA gyrase and topoisomerase IV by sequencing. Also 16 mutants had fluoroquinolones MICs that were 4-32 times lower in the presence of reserpine. In conclusion, alterations in DNA gyrase or topoisomerase IV and action of efflux pumping out system are the resistance mechanisms of DW-224a.

• Proceedings of the KSR Conference
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• 2008.11b
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• pp.1487-1493
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• 2008

Railway vehicle is very important to implement the effective maintenance in proper to prevent any failure during operation period. Many railway authorities are making efforts to maintain the railway vehicle through scientific and systematic procedure. To achieve this, Reliability Centered Maintenance(RCM) is partially applied. The efficiency of RCM has proven and its terminology was familiar with nuclear power, military and chemical plant etc. since the commercial aircraft's industries has introduced the maintenance program based on the target of reliability. The application of RCM on railway vehicle can be utilized with systematic analysis method to select the best effective maintenance period and action to prevent the failures by selecting the equipment affecting the its safety and reliability. This paper is presented that the procedure of adequate and effective maintenance for railway vehicle by comparing among the related standards in example IEC60300-3,11, MIL-STD-2173, and technical documents or papers. In accordance with above result, RCM procedure is proposed to apply effectively for maintenance of railway vehicle. That is, (1) Analysis of data and Calculation of criticality per equipment (2) Selection of equipment to analyze (3) Analysis of failure mode and effect (4) Evaluation of maintenance method and period (5) Optimization of maintenance program through renewal of maintenance method and period.

• Journal of Korean Society of Rural Planning
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• v.25 no.1
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• pp.89-97
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• 2019

This study aims to make a revitalizing plan for managing and maintaining of facilities which were installed after the rural development projects. The survey was conducted to examine some issues of operating facilities from the developing plan. There were some factors that should be considered in the establishment stage of the project plan when promoting rural development projects. Among them, the preservation and maintenance of rurality, consistency with business plans, connectivity with local resources, and ease of maintenance were less reflective than its importance. And for each facility, systematic consulting on appropriate scale and operational management plans and detailed planning is needed.. It's also necessary to plan action so that the local community can lead. The current or future rural development project will be succeeded when local governments support to strengthening their local groups or people's abilities.

• World Technopolis Review
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• v.8 no.1
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• pp.8-20
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• 2019

The intent of this paper is to identify key actors of a sustainable Smart City and define metrics that will allow assessment and better management of Sustainable Smart Cities. The paper is organized in two major segments. The first segment reviews the definition, six components, six action items of Smart Cities. It describes briefly a sample Smart City project and presents a selection of different dimensions along which Smart Cities are ranked and the rankings. The segment also discusses the technology architecture of a Smart City and then examines the definition and components of an innovation platform. The second presents the original contributions of the paper. It first introduces the dynamics created seven key actors of a Smart City ecosystem and describes their existing and potential contributions. It then defines Innopreneurship platform and presents a triple bottom line based quality metric to evaluate such a platform. This segment also discusses reengineering an economy and suggests a Smart City's Innovation Platform Score. The actions to be taken by the key actors of a Smart City in order to make it a Sustainable Smart City are described in several subsections. We hope these concepts and metrics will be a good starting point and will be refined over time by others.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.13 no.3
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• pp.1689-1701
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• 2019

In recent years, personal videos have been shared online due to the popular uses of portable devices, such as smartphones and action cameras. A recent report predicted that 80% of the Internet traffic will be video content by the year 2021. Several studies have been conducted on the detection of main video events to manage a large scale of videos. These studies show fairly good performance in certain genres. However, the methods used in previous studies have difficulty in detecting events of personal video. This is because the characteristics and genres of personal videos vary widely. In a research, we found that adding a dataset with the right perspective in the study improved performance. It has also been shown that performance improves depending on how you extract keyframes from the video. we selected frame segments that can represent video considering the characteristics of this personal video. In each frame segment, object, location, food and audio features were extracted, and representative vectors were generated through a CNN-based recurrent model and a fusion module. The proposed method showed mAP 78.4% performance through experiments using LSVC data.

• Journal of Platform Technology
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• v.9 no.1
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• pp.3-14
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• 2021

Cognitive Radio network (CR) is a promising paradigm that helps the unlicensed user (Secondary User) to analyse the spectrum and coordinate the spectrum access to support the creation of common control channel (CCC). The cooperation of secondary users and broadcasting between them is done through transmitting messages in CCC. In case, if the control channels may get jammed and it may directly degrade the network's performance and under such scenario jammers will devastate the control channels. Hopping sequences may be one of the predominant approaches and it may be used to fight against this problem to confront jammer. The jamming attack can be alleviated using one of the game modelling approach and in this proposed scheme stochastic games has been analysed with more single users to provide the flexible control channels against intrusive attacks by mentioning the states of each player, strategies ,actions and players reward. The proposed work uses a modern player action and better strategic view on game theoretic modelling is stochastic game theory has been taken in to consideration and applied to prevent the jamming attack in CR network. The selection of decision is based on Q learning approach to mitigate the jamming nodes using the optimal MDP decision process

• English & American cultural studies
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• v.18 no.4
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• pp.163-188
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• 2018

Through the action of Major Barbara, Shaw advocates the improvement of human race and civilization through fabian eugenic socialism in the based on the Galtonian eugenics and social Darwinism in late Victorian period. In the play, Shaw contrasts two ideologies, Barbara's spiritual institutionalized Christianity with Undershaft's worldly power to control the conventional society. For the dramatic purpose, Shaw symbolically combines the power of the munitions maker, the intellect of the scholar and the faith of the Salvationist. Shaw seems to believe that the best way of improving the human society can be comprised by effective eugenic agencies regarded Shavian trinities. In relation to the eugenic discourses for social betterment, this essay explores how Shaw's ideas on social eugenic is perceived in Major Barbara through main characters as spiritual, intellectual and economic agencies in terms of social Darwinism for the progress of the human society. As always, Shaw's evolutionary agencies are disillusionized from the idealistic faith through the realistic awareness of economic facts, which is manifested in their practices to advance the institutional society Shaw attacked. It is obvious that the significant facts of eugenic socialism/social eugenics based on social Darwinism are promoted by Barbara, Cusins and Undershaft in Major Barbara to maintain a worthy evolution of society and humanity.

• International Journal of High-Rise Buildings
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• v.10 no.2
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• pp.149-164
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• 2021

Most of high-rise buildings in Japan^*1 are structure with damping systems recently. The design procedure is performance-based design (PBD), which is based on the nonlinear response history procedure (NRHP) using 2 or 3-dimentional frame model. In addition, hysteretic property of steel plates or velocity-dependent property of viscous dampers are common practice for the damping system. However, for the selection of damping system, the easy dynamic analysis of recent date may lead the most of engineers to focus attention on the maximum response only without thinking how it shakes. By nature, the seismic design shall be to figure out the action of inertia forces by complex & dynamic loads including periodic and pulse-like characteristics, what we call seismic ground motion. And it shall be done under the dynamic condition. On the contrary, we engineers engineers have constructed the easy-to-use static loads and devoted ourselves to handle them. The structures with damping system shall be designed considering how the stiffness & damping to be applied to the structures against the inertia forces with the viewpoint of dynamic aspect. In this paper we reconsider the role of damping in vibration and give much thought to the basic of shake with damping from a standpoint of structural design. Then, we present some design examples based on them.

• Journal of information and communication convergence engineering
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• v.20 no.3
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• pp.181-188
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• 2022

An intelligent distributed multi-agent system (IDMS) using reinforcement learning (RL) is a challenging and intricate problem in which single or multiple agent(s) aim to achieve their specific goals (sub-goal and final goal), where they move their states in a complex and cluttered environment. The environment provided by the IDMS provides a cumulative optimal reward for each action based on the policy of the learning process. Most actions involve interacting with a given IDMS environment; therefore, it can provide the following elements: a starting agent state, multiple obstacles, agent goals, and a cluttered index. The reward in the environment is also reflected by RL-based agents, in which agents can move randomly or intelligently to reach their respective goals, to improve the agent learning performance. We extend different cases of intelligent multi-agent systems from our previous works: (a) a proposed environment-clutter-based-index for agent sub-goal selection and analysis of its effect, and (b) a newly proposed RL reward scheme based on the environmental clutter-index to identify and analyze the prerequisites and conditions for improving the overall system.