• 제목/요약/키워드: Acting System

검색결과 902건 처리시간 0.019초

지속적 관여도 및 인지된 위험이 소비자의 온라인 상인선택 프로세스에 미치는 영향에 관한 연구: 요구신뢰 수준 개념을 중심으로 (How Enduring Product Involvement and Perceived Risk Affect Consumers' Online Merchant Selection Process: The 'Required Trust Level' Perspective)

  • 홍일유;이정민;조휘형
    • Asia pacific journal of information systems
    • /
    • 제22권1호
    • /
    • pp.29-52
    • /
    • 2012
  • Consumers differ in the way they make a purchase. An audio mania would willingly make a bold, yet serious, decision to buy a top-of-the-line home theater system, while he is not interested in replacing his two-decade-old shabby car. On the contrary, an automobile enthusiast wouldn't mind spending forty thousand dollars to buy a new Jaguar convertible, yet cares little about his junky component system. It is product involvement that helps us explain such differences among individuals in the purchase style. Product involvement refers to the extent to which a product is perceived to be important to a consumer (Zaichkowsky, 2001). Product involvement is an important factor that strongly influences consumer's purchase decision-making process, and thus has been of prime interest to consumer behavior researchers. Furthermore, researchers found that involvement is closely related to perceived risk (Dholakia, 2001). While abundant research exists addressing how product involvement relates to overall perceived risk, little attention has been paid to the relationship between involvement and different types of perceived risk in an electronic commerce setting. Given that perceived risk can be a substantial barrier to the online purchase (Jarvenpaa, 2000), research addressing such an issue will offer useful implications on what specific types of perceived risk an online firm should focus on mitigating if it is to increase sales to a fullest potential. Meanwhile, past research has focused on such consumer responses as information search and dissemination as a consequence of involvement, neglecting other behavioral responses like online merchant selection. For one example, will a consumer seriously considering the purchase of a pricey Guzzi bag perceive a great degree of risk associated with online buying and therefore choose to buy it from a digital storefront rather than from an online marketplace to mitigate risk? Will a consumer require greater trust on the part of the online merchant when the perceived risk of online buying is rather high? We intend to find answers to these research questions through an empirical study. This paper explores the impact of enduring product involvement and perceived risks on required trust level, and further on online merchant choice. For the purpose of the research, five types or components of perceived risk are taken into consideration, including financial, performance, delivery, psychological, and social risks. A research model has been built around the constructs under consideration, and 12 hypotheses have been developed based on the research model to examine the relationships between enduring involvement and five components of perceived risk, between five components of perceived risk and required trust level, between enduring involvement and required trust level, and finally between required trust level and preference toward an e-tailer. To attain our research objectives, we conducted an empirical analysis consisting of two phases of data collection: a pilot test and main survey. The pilot test was conducted using 25 college students to ensure that the questionnaire items are clear and straightforward. Then the main survey was conducted using 295 college students at a major university for nine days between December 13, 2010 and December 21, 2010. The measures employed to test the model included eight constructs: (1) enduring involvement, (2) financial risk, (3) performance risk, (4) delivery risk, (5) psychological risk, (6) social risk, (7) required trust level, (8) preference toward an e-tailer. The statistical package, SPSS 17.0, was used to test the internal consistency among the items within the individual measures. Based on the Cronbach's ${\alpha}$ coefficients of the individual measure, the reliability of all the variables is supported. Meanwhile, the Amos 18.0 package was employed to perform a confirmatory factor analysis designed to assess the unidimensionality of the measures. The goodness of fit for the measurement model was satisfied. Unidimensionality was tested using convergent, discriminant, and nomological validity. The statistical evidences proved that the three types of validity were all satisfied. Now the structured equation modeling technique was used to analyze the individual paths along the relationships among the research constructs. The results indicated that enduring involvement has significant positive relationships with all the five components of perceived risk, while only performance risk is significantly related to trust level required by consumers for purchase. It can be inferred from the findings that product performance problems are mostly likely to occur when a merchant behaves in an opportunistic manner. Positive relationships were also found between involvement and required trust level and between required trust level and online merchant choice. Enduring involvement is concerned with the pleasure a consumer derives from a product class and/or with the desire for knowledge for the product class, and thus is likely to motivate the consumer to look for ways of mitigating perceived risk by requiring a higher level of trust on the part of the online merchant. Likewise, a consumer requiring a high level of trust on the merchant will choose a digital storefront rather than an e-marketplace, since a digital storefront is believed to be trustworthier than an e-marketplace, as it fulfills orders by itself rather than acting as an intermediary. The findings of the present research provide both academic and practical implications. The first academic implication is that enduring product involvement is a strong motivator of consumer responses, especially the selection of a merchant, in the context of electronic shopping. Secondly, academicians are advised to pay attention to the finding that an individual component or type of perceived risk can be used as an important research construct, since it would allow one to pinpoint the specific types of risk that are influenced by antecedents or that influence consequents. Meanwhile, our research provides implications useful for online merchants (both online storefronts and e-marketplaces). Merchants may develop strategies to attract consumers by managing perceived performance risk involved in purchase decisions, since it was found to have significant positive relationship with the level of trust required by a consumer on the part of the merchant. One way to manage performance risk would be to thoroughly examine the product before shipping to ensure that it has no deficiencies or flaws. Secondly, digital storefronts are advised to focus on symbolic goods (e.g., cars, cell phones, fashion outfits, and handbags) in which consumers are relatively more involved than others, whereas e- marketplaces should put their emphasis on non-symbolic goods (e.g., drinks, books, MP3 players, and bike accessories).

  • PDF

간암 동물 모델에서 2'-fluoro-2'-deoxy-1-${\beta}$-D-arabinofuranosyl-5-[$^{124}I$iodo-uracil ($[^{124}I]FIAU$) 소동물 PET 영상 연구 (Small Animal PET Imaging with [$^{124}I$]FIAU for Herpes Simplex Virus Type 1 Thymidine Kinase Gene Expression in a Hepatoma Model)

  • 채민정;이태섭;김준엽;우광선;정위섭;전권수;김재홍;이지섭;류진숙;천기정;최창운;임상무
    • Nuclear Medicine and Molecular Imaging
    • /
    • 제42권3호
    • /
    • pp.235-245
    • /
    • 2008
  • 목적: 간암은 치명적인 질환으로 유전자 치료가 기존 치료의 대체적 치료로 기대되고 있으며, 이러한 치료법의 발달과 함께 유전자의 발현을 평가할 수 있는 보고 유전자 시스템의 필요하다. 그 중 HSV1-tk 유전자는 보고 유전자로서 필요한 조건을 두루 만족시키고 있을 뿐만 아니라 별도의 치료유전자를 따로 이입할 필요가 없다는 장점을 가지고 있어 가장 많이 사용되는 방법이다. 이 연구는 간암의 유전자 치료를 위해 간암 동물 모델에서 유전자로 HSV1-tk를 사용하고 보고 기질로 방사성 요오드 표지 2'-fluoro-2'-deoxy-1-${\beta}$-D-arabinofuranosyl-5-iodouracil (FIAU)를 사용하여 소동물 양전자 방출영상(positron emission tomography, PET)을 얻어 비침습적 생체 유전자 발현 영상의 가능성을 확인하고 자 하였다. 대상 및 방법: HSV1-tk 보고 유전자 이입 간암세포주인 MCA-tk와 MCA 세포주를 이용하여 in vitro 상에서의 [$^{125}I$]FIAU의 섭취실험과 섭취량과 발현량의 상관성평가를 위해 세포수 백분율에 따른 섭취실험을 실시하였다. 피하 간암 동물모델을 이용하여 [$^{125}I$]FIAU의 생체분포를 평가하였으며 [$^{125}I$]FIAU를 이용하여 소동물 PET을 통한 생체영상을 분석하였다. 결과: HSV1-tk 유전자가 이입된 MCA-tk 세포에서는 특이적인 동위원소의 집적이 발생하였으며 대조군인 MCA에서는 거의 집적이 이루어지지 않았다. 섭취 후 480 분에서 두 세포주의 섭취비는 15 배로 나타났다. MCA-tk 세포주의 백분율이 증가함에 따라 [$^{125}I$]FIAU의 섭취량도 직선적 상관관계($R^2=0.9644$)에 따라 증가하여 기질의 섭취량이 유전자 발현량을 잘 반영하고 있음이 확인되었다. 피하 종양 동물모델의 생체분포 결과 [$^{125}I$]FIAU는 초기에 신장으로 빠르게 배출되며 1 시간 이후 생체내 deiodinase에 의하여 분해되어 위와 갑상선의 섭취가 증가된 값을 보였다. MCA-tk 종양 대 혈액 비와 MCA-tk 종양 대 근육 비는 투여 후 24 시간 사이에 최대 641의 값을 나타내었다. 또한 HSV1-tk 유전자가 발현하지 않은 MCA종양에 비하여 MCA-tk 종양은 192.7 배 높은 섭취를 보여 [$^{125}I$]FIAU의 섭취는 HSV1-tk 유전자 발현에 특이적임을 확인하였다. MCA-tk 종양 대 간의 집적의 경우에도 초기 1시간에 13.8 배, 4 시간에 66.8 배, 24 시간에 혈액 비와 비슷한 정도의 588.3배 이상의 대조도를 보여 주었다. [$^{124}I$]FIAU를 보고 기질로 사용한 소동물 PET 생체영상에서 대조군인 MCA 종양과 보고 유전자가 이입된 MCA-tk 종양에의 집적이 차이가 매우 큰 대조도를 보여주었으며 생체분포 결과와 일치하는 양상을 나타내었다. 결론: $^{125}I$-FIAU가 세포 섭취율 시험과 생체 분포에서 MCA-tk 종양에 높은 집적을 나타내었고 $^{124}I$-FIAU를 이용한 소동물 PET 영상에서 MCA-tk 종양이 표적장기인 간이나 MCA 종양에 비하여 매우 높은 대조도를 나타냈다. 향후, 간암의 유전자 치료에서 FIAU은 HSV1-tk를 보고 유전자로 사용할 때 적절한 기질로서 비침습적으로 핵의학 영상을 이용한 유전자 발현의 평가를 가능하게 할 수 있을 것으로 기대된다.