• Journal of dental hygiene science
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• v.15 no.6
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• pp.836-844
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• 2015

The objective of this research is to analyze geographical distribution of Korean dental hygienists to provide the geographical basis of supply-side policy for dental hygienists from the perspective of dental geography by using Geographic Information System (GIS) in which the choropleth map has been regarded as the most popular method. The present report is highly meaningful for the policy of dental hygienist on the supply side of dental care market. The data used in the article derive from the statistics-associated portal site provided by Korean government. It includes the statistics on general population, the regional numbers of dental hygiene students, county-based numbers of registered dental hygienists, dentists, and dental clinics and hospitals. Several maps are created by investigating these statistical data with GIS. This study is focused on the comparative analysis between entrants to the department of dental hygiene, registered acting dental hygienists and dentists in terms of county-based distribution per its population. The main result demonstrates that whereas about half of dental hygienists and dentists are respectively concentrated in Seoul and Gyung-gi, just one-fifth of entrants to the department of dental hygiene in the Seoul-metropolitan area. From the perspective of the supply-side policy of dental hygienists, the research argues that the creation or expansion of the department of dental hygiene does not directly meet social need for dental care services.

• Journal of the Society of Naval Architects of Korea
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• v.39 no.3
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• pp.57-63
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• 2002

This paper describes a control algorithm for the buffer of a deep-sea mining system, in which the buffer is connected to a long slender pipe and then to a surface ship on one end, and to a collector on sea floor through a flexible hose on the other end. A mathematical modeling is established for designing the controller for buffer thrusters, in which the dynamic response of the long pipe is taken into account based on the mode superposition method. The fluid loading acting on the pipe is estimated by using Morison's formula. For simplicity, the surface ship is assumed to be kept stationary, the reaction from the flexible hose is ignored and only the lateral motions are considered. In order to guide the buffer to react only to the low-frequency motion of the surface vessel, the FIR digital filter is introduced to a PID-based controller It can be shown numerically that the high frequency component of the ship's motion can be effectively filtered out by using the FIR low pass filter.

• Korean Journal of Clinical Pharmacy
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• v.21 no.4
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• pp.364-375
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• 2011

Given that single blockade with angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) can achieve only partial and undurable suppression of the Renin Angiotensin System (RAS), it has been hypothesized that dual blockage would be more beneficial in the management of blood pressure (BP) reduction and prevention of progressive chronic kidney disease (CKD) than either agent alone. Thus, it has been suggested that the combination of an ACEI and an ARB might provide renal benefits to hypertensive patients over and above BP reduction. However, this might also expose patients to additive or synergistic side effects. We attempted to conduct a systematic review to evaluate the benefits and harms of combination therapy in hypertensive patients with or without kidney diseases. MEDLINE and KoreaMed were searched for relevant randomized clinical trials in adult hypertensive patients with or without diabetes (restricted to 1997, limited to trials published in English). Results were summarized using the random-effects model, and between-studies heterogeneity was estimated with $I^2$. A final analysis of ten trials (23,928 patients) revealed that the combination of an ACEI and an ARB reduced blood pressure (SBP/DBP) by 3.95/2.02 mmHg (95% confidence interval [CI], -4.38 to -3.53/-2.33 to -1.71) compared with ACEI monotherapy, and 2.83/2.64 mmHg (95% CI, -3.25 to -2.41/-4.95 to -0.33) compared with ARB monotherapy. Eight trials (391 patients) demonstrated a significant reduction in 24h-proteinuria (weighted mean difference, 0.16 g/day, 95% CI, -0.26-0.05), but they did not translate into an improvement in GFR. Tests for heterogeneity showed no difference in effect among the studies. The combination therapy reduced proteinuria by 30% (95% CI, 23% to 37%) and 39% (95% CI, 31% to 48%) compared with ACEI monotherapy and ARB monotherapy, respectively. However, in patients who had proteinuria more than 0.5 g/day, the combination therapy failed to show significant reduction in urinary protein excretion. The current cumulative evidence suggests that diabetic patients with proteinuria on dual RAS blockade have an increase risk of adverse events such as hyperkalemia, hypotension, and so on, compared with ACEI or ARB alone. It is, therefore, proposed that the combination therapy should not be routinely used for the treatment of hypertension with or without compelling indications.

• The KSFM Journal of Fluid Machinery
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• v.18 no.6
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• pp.63-70
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• 2015

This paper proposes a novel airfoil named "KA2" for the blade of the wind turbine systems. Dynamic loads characteristics are analyzed and compared using aerodynamic data of ten airfoils including the proposed airfoil. The blade is divided into the sixteen elements in the longitudinal direction of the blade for applying the Blade Element Method Theory (BEMT) method, and in each element, torque, thrust, and pitching moment are calculated using turbulent time varying wind speed and aerodynamic data of each wing. Additionally, each force and torque is accumulated in the whole region of the blade for the estimation of representative values. The magnitude of such forces is comparatively analyzed for different airfoils. The angle of attack is constant below the rated wind speed due to the fact that the tip speed ratio is kept at the constant value, and it increases in the region of over rated wind speed as the tip speed ratio decreasing with constant rated rpm and increasing wind speed. Such increase in the angle of attack causes the changes of the force acting on the airfoil with different characteristics of lift and drag in the stall region of each different airfoil. Even though the mean wind speed is in the rated speed in a given time, because of the turbulence, it has either the over rated or under rated speed most of the time. Furthermore, the dynamic properties of each force are analyzed in this rated wind speed in order to objectively understand the dynamic properties of the blades which are designed based on the different airfoils. These dynamic properties are also compared by the standard deviation of time varying characteristics. Moreover, the output characteristics of the wind turbine are investigated with different airfoils and wind speeds. Based on these investigations, it was revealed that the proposed airfoil (KA2) is well applicable to the blade with passive pitch control system.

• Journal of Korean Philosophical Society
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• v.147
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• pp.261-281
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• 2018

This paper will cover recent discussions on the risks of human being due to the development of artificial intelligence(AI). We will consider AI research as artificial narrow intelligence(ANI), artificial general intelligence(AGI), and artificial super intelligence(ASI). First, we examine the risks of ANI, or weak AI systems. To maximize efficiency, humans will use autonomous AI extensively. At this time, we can predict the risks that can arise by transferring a great deal of authority to autonomous AI and AI's judging and acting without human intervention. Even a sophisticated system, human-made artificial intelligence systems are incomplete, and virus infections or bugs can cause errors. So I think there should be a limit to what I entrust to artificial intelligence. Typically, we do not believe that lethal autonomous weapons systems should be allowed. Strong AI researchers are optimistic about the emergence of artificial general intelligence(AGI) and artificial superintelligence(ASI). Superintelligence is an AI system that surpasses human ability in all respects, so it may act against human interests or harm human beings. So the problem of controlling superintelligence, i.e. control problem is being seriously considered. In this paper, we have outlined how to control superintelligence based on the proposed control schemes. If superintelligence emerges, it is judged that there is no way for humans to completely control superintelligence at this time. But the emergence of superintelligence may be a fictitious assumption. Even in this case, research on control problems is of practical value in setting the direction of future AI research.

• Journal of the Korean Society for Railway
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• v.16 no.3
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• pp.207-216
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• 2013

The components of concrete track (rail and rail fastening system) in railway bridge deck ends are damaged and deteriorated by track-bridge interaction forces such as uplift forces and compression forces owing to their structural flexural characteristics (bridge end rotation). This had led to demand for alternatives to improve structural safety and serviceability. In this study, the authors aim to develop a transition track to enhance the long term workability and durability of concrete track components in railway bridge deck ends and thereby improve the performance of concrete track. A time-history analysis and a three-dimensional finite element method analysis were performed to consider the train speed and the effect of multiple train loads and the results were compared with the performance requirements and German standard for transition track. Furthermore, two specimens, a normal concrete track and a transition track, were fabricated to evaluate the effects of application of the developed transition track, and static tests were conducted. From the results, the track-bridge interaction force acting on the track components (rail displacement, rail stress, and clip stress) of the railway bridge deck end were significantly reduced with use of the developed transition track compared with the non-transition track specimen.

• Journal of Korean Society of Health-System Pharmacists
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• v.35 no.4
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• pp.453-462
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• 2018

Background : The prevalence of chronic hepatitis C virus (HCV) tends to be higher in the elderly. Pegylated interferon and ribavirin therapy (Peg-IFN/RBV) was recommended as the first-line treatment in the past decades, but this regimen showed unsatisfactory results in terms of safety and efficacy especially in elderly patients. Recently, it was demonstrated that dual therapy with daclatasvir and asunaprevir was well tolerated and led to high sustained virological response (SVR) rates, irrespective of age. We conducted a study to evaluate the efficacy and safety of daclatasvir plus asunaprevir by involving elderly patients aged above 65 years. Methods : We retrospectively analyzed clinical data from chronic hepatitis C virus (HCV) genotype 1b patients treated with daclatasvir plus asunaprevir from September 2015 to December 2016 at Seoul St. Mary's hospital. The patients were divided into two groups as elderly patients (older than 65 years) and non-elderly patients (younger than 65 years) and compared the efficacy and safety. Results : A total of 112 patients were treated with daclatasvir plus asunaprevir for chronic hepatitis C. Among them, 101 patients completed the whole treatment, and in 88 patients the amount of HCV RNA was measured after 12 weeks of treatment. There was no significant difference in SVR at 12 weeks between both the groups (p=0.68). Typically, 91.4%(32/35) of elderly patients and 94.3%(50/53) of non-elderly patients achieved SVR12. Common adverse events included elevation in transaminase level, headache, and gastrointestinal disorders. There was no statistical difference in the symptoms between the two groups. Conclusions : The combination therapy with daclatasvir plus asunaprevir exhibited similar rates of SVR12 in HCV elderly patients without leading to further adverse events compared to non-elderly patients. Therefore, it is proposed that daclatasvir plus asunaprevir therapy could be considered as an effective and safe treatment, even in patients aged over 65 years.

• Journal of Aerospace System Engineering
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• v.15 no.1
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• pp.80-85
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• 2021

In this study, for conducting a static load test of an external fuel tank used for an aircraft, the flight load acting on the external fuel tank was converted to the test load and the suitability of the converted test loads was confirmed. In order to calculate the test load from the flight load, the external fuel tank was divided into several sections. Shear load, moment by unit shear load, and unit moment were calculated for each section. Test loads for each section were then calculated by computing the shear load, the moment of each section, and flight load condition. In actual static load tests, it might not be possible to impose the test load in the calculated position due to physical constraints. Therefore, after determining positions in which the load could be imposed in the actual test, the test load calculated for each section was redistributed to selected positions. Finally, a test load plan was established by applying a whiffle tree to enhance the efficiency of the test performance while making it easier to operate the actuator. The reliability of the test load plan was verified by comparing it with flight load conditions.

• Journal of Life Science
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• v.32 no.1
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• pp.36-43
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• 2022

Mucosal immunity is a well-designed defense system that builds precise and dynamic relationships against pathogens, and the gastrointestinal tract is the most important organ with this system, acting as a guardian at the forefront of its activity. Salmonella spp. cause food poisoning, entering the body orally and mainly invading the Peyer's patches of the small intestine. Although Salmonella strains share similar mechanisms for inducing innate immunity, different serotypes may have different effects on the intestinal mucosa due to host specificities and pathogenicity. In this study, we evaluated the effects of Salmonella enteritidis infections in mouse intestine and observed significantly reduced dose-dependent survival rates in a challenge test. Flow cytometry data showed no significant differences in intestinal immune cell populations, although histology indicated increased mucin production and decreased goblet cell counts in the Salmonella-treated groups. Furthermore, Claudin expression was significantly decreased in the samples with Salmonella. To investigate the relationship between S. enteritidis infection and inflammatory response, dextran sodium sulfate (DSS) was administered after infection and the results indicate lower survival rate after DSS treatment. In conclusion, we were able to identify the optimal concentration of S. enteritidis to modulate the intestinal mucosal immunity of mice and inflammatory response.

• Journal of Aerospace System Engineering
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• v.16 no.3
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• pp.99-104
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• 2022

Aircraft pylon connects the engine or external stores to the main wing, and transfers the load acting on the pylon to the main structure of the aircraft. In particular, it should perform the function of separating the external store mounted on the pylon in case of emergency or mission performance. At this time, if the separation of the external store is not performed properly due to peripheral air flow or functional problems during the separation process of the external store, it may seriously impact the survivability of the aircraft. For this reason, to apply an external attachment to an aircraft, it is necessary to prove the stability of the external attachment in the separation situation in advance. In this paper, we present the result of the ground separation test performed to confirm that the external fuel tank, which is an external attachment, can be safely separated from the pylon. As a result of the test, the separation movement of the external fuel tank was measured with a high-speed camera, and the stability of the separation of the external fuel tank from the pylon were confirmed through the ground separation test. Additionally, the test result provides basic data for the stability evaluation of the separation of external attachments in actual aircraft.