Korean Journal of Clinical Pharmacy (한국임상약학회지)
- Volume 21 Issue 4
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- Pages.364-375
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- 2011
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- 1226-6051(pISSN)
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- 2508-786X(eISSN)
Systematic Review : Comparative Safety and Efficacy of Mono- and Combination Therapy of Anti-hypertensive Agents Acting on the Renin-Angiotensin System
레닌-안지오텐신계에 작용하는 항고혈압 약제의 단독요법과 병용요법의 안전성 및 유효성에 대한 체계적 문헌고찰
- Choi, Kyung-Eob (Korean Academy of Managed Care Pharmacy) ;
- Kim, Hyun-Kyung (CJ CheilJedang Corporation)
- Received : 2011.09.20
- Accepted : 2011.11.14
- Published : 2011.12.31
Abstract
Given that single blockade with angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) can achieve only partial and undurable suppression of the Renin Angiotensin System (RAS), it has been hypothesized that dual blockage would be more beneficial in the management of blood pressure (BP) reduction and prevention of progressive chronic kidney disease (CKD) than either agent alone. Thus, it has been suggested that the combination of an ACEI and an ARB might provide renal benefits to hypertensive patients over and above BP reduction. However, this might also expose patients to additive or synergistic side effects. We attempted to conduct a systematic review to evaluate the benefits and harms of combination therapy in hypertensive patients with or without kidney diseases. MEDLINE and KoreaMed were searched for relevant randomized clinical trials in adult hypertensive patients with or without diabetes (restricted to 1997, limited to trials published in English). Results were summarized using the random-effects model, and between-studies heterogeneity was estimated with
Keywords
- angiotensin converting enzyme inhibitors;
- angiotensin receptor blockers;
- combination therapy;
- hypertension;
- diabetes;
- proteinuria;
- systematic review