• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.3
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• pp.678-683
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• 2008

Aconitum pseudo-laeve var. erectum has traditionally been used for the treatment of water retention in the body. Administration of the aqueous extract of Aconitum pseudo-laeve var. erectum has the efficiency of anti-inflammatory activity and modulates the intestinal immune system. However, the mechanism of anti-inflammatory action of Aconitum pseudo-laeve var. erectum has not been clarified yet. In the present study, the effect of Aconitum pseudo-laeve var. erectum against LPS-stimulated expressions of COX-2 and iNOS in cells of the murine RAW 264.7 macrophages was investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, reverse transcription- polymerase chain reaction (RT-PCR), PGE2 immunoassay, and NO detection. The results of the present study indicate that Aconitum pseudo-laeve var. erectum is a potent inhibitor of the LPS-induced NO and $PGE_{2}$ production by blocking iNOS and $NF{\kappa}B$ activation in RAW 264.7 macrophages. These findings suggest that Aconitum pseudo-laeve var. erectum is a potential therapeutic for the treatment of inflammatory syndrome.

• YAKHAK HOEJI
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• v.40 no.4
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• pp.418-421
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• 1996

From the ethanol extract of the whole plant of Aconitum pseudo-laeve var. erectum Nakai, three new aromatic amides, methyl-N-acetyl anthranilate, methyl-N-(3-ethox ycarbonylpropionyl)anthranilate, methyl-N-(3-methoxycarbonylpropionyl) anthranilate were isolated and characterized on the basis of spectral data.

• Archives of Pharmacal Research
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• v.21 no.3
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• pp.344-347
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• 1998

To overcome multidrug resistance (MDR) in cancer chemotherapy, we prepared various plant extracts and searched for a component which is effective for inhibition of MDR. MDR inhibition activity was determined by measuring cytotoxicity to MDR cells using multidrug resistant human fibrocarcinoma KB V20C, which is resistant to 20 nM vincristine and expresses high level of mdr1 gene. Of various plant extracts, the MeOH extract of the root of Aconitum pseudo-laeve var. erectum was found to have potent inhibitory activity on MDR. The bioassayguided fractionation of the MeOH extract of the plant led to the isolation of an alkaloid, lycaconitine, as an active principle. And the $IC_{50}$ of lycaconitne for KB V20C cells was $74\mu{g}$/ml.

• Journal of Korean Society of Forest Science
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• v.87 no.3
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• pp.459-465
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• 1998

To obtain the basic data for the conservation and cultivation of native herb species under the forest, the relations between distribution of native herb species and site factors, distribution of native herb species, and site factors were surveyed on natural forest at subalpine zone in Mt. Odae. Ainsliaea acerifolia, Pseudostellaria palibiniana and Pimpinedla brachycarpa were distributed mainly on broadleaved mixed forest, Clematis fusca var. coreana, Carex siderosticta. Isodon excisus and Vicia unijuga did mainly on gab sites. The distribution of Ligularia fisheri, Aconitum pseudo-laeve var. erectum, Cacalia hastata and Artemisia stolonifera were significantly differed between slope directions. Artemisia stolonifera was distributed more frequently in south directed slope, and Ligularia fisheri, Aconitum pseudo-laeve var. erectum and Cacalia hastata were distributed more frequently in north and west directed slope than the other. The distribution of Aconitum pseudo-laeve var. erectum and Artemisia stolonifera were significantly differed between soil moisture conditions. Artemisia stolonifera was distributed mainly on the dry site, but Aconitum pseudo-laeve var. erectum did mainly on the dry site. Negative correlations between density of Clematis fusca var. coreana, Carex siderosticta. Isodon excises and Vicia unijuga and crown coverage was proved. Aconitum pseudo-laeve var. erectum, Pimpinella brachycarpa, Meehania urticifolia, Smilacina japonica and Pseudostellaria palibiniana were mainly distributed on wet and shady sites under forest canopy, but Pedicularis resupinata, Clematis fusca var. coreana and Artemisia stolonifera did on sunny sites at forest edge or gab.

• Korean Journal of Veterinary Research
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• v.2 no.1
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• pp.15-26
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• 1962

Decoctions of two Korean indigenous crude drugs. Radix Jingyu(the dried root of Aconitum pseudo-laeve Nakai var. erectum Nakai form. Genuinum Nakai) and Fructus ponciri (the transversely sliced and dried unripe fruit of Poncirus trifoliata Rafinesque), are being utilized by the inhabitants in certain parts of southeastern district of Korea with an empirical belief that these serve as effective insecticides for cattle ticks. Of the two species of cattle ticks so far identified in Korea, Boophilus microplus and Haemaphysalis bispinosum, the former was employed in this experiment as the species occupies nearly 99 percent of the tick population. The results of the experiments herein reported seen to indicate that although the killing power of aqueous extracts of the drugs is minimal, the repellent effect against the ticks, especially of Radix Jingyu, is excellent. It may be of interest to note that the aqueous extract of Radix Jingyu has not proved to be inferior to any of the most effective cattle repellents commercially available. Further studies on these Korean indigenous crude drugs as cattle tick repellents are indicated to find whether active ingredients can be extracted in a hope to materialize an extensive application of these drugs in the field.

• Korean Journal of Environment and Ecology
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• v.17 no.3
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• pp.210-223
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• 2003

This study was carried out to investigate the flora of Mt. Baekwoon. The flora of Mt. Baekwoon was surveyed from October, 2000 to August, 2001. In the results of survey, the vascular plant species in Mt. Baekwoon were summarized as 468 taxa; 90 families, 272 genera, 411 species, 1 subspecies 49 varieties and 7 forms. The rare plants designated by Korea Forestry Service were nine species; Lilium distichum, Gastrodia elata, Viola diamantica, Hylomecon hylomeconoides, Aristolochia contorta, Asarum maculatum, Rodgersia podophyllu, Viola albida, Scopolia japonica and Scrophularia koraiensis. And the endemic plants were nineteen species; Asarum maculatum, Melandryum seoulense, Clematis trichotoma, Aconitum pseudo-laeve var. erectum, Hylomecon hylomeconoides, Chrysosplenium barbatum, Spiraea prunifolia for. simpliciflora, Robus hongnoensis, Vicia venosa var. cuspidata, Tilia taquetii, Viola seoulensis, Viola diamantica, Ajuga spectubilis, Scrophularia koraiensis, Weigela subsessilis, Adenophora remotiflora, Cirsium setidens, Saussurea macrolepis and Saussurea seoulensis.

• Korean Journal of Plant Resources
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• v.17 no.2
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• pp.169-182
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• 2004

The purpose of this study is carried out accurately to grasp the vascular plants in Mt. Bakdal (825 m of sea level), Goesan-gun, Chungcheongbuk-do. In the results of survey from October, 2000 to August, 2001, the vascular plant species in Mt. Bakdal were summarized as 458 taxa; 91 families, 275 genera, 391 species, 62 varieties and 5 forms. The rare plants designated by Korea Forestry Service were six species; Lilium distichum, Iris uniflora var. carisina, Hylomecon hylomeconoides, Viola albida, Scopolia japonicus and Scrophularia koraiensis. And the endemic plants were seventeen species; Melandryum seoulense, Aconitum pseudo-laeve var. erectum, Hylomecon hylomeconoides, Spiraea prunifolia for. simpliciflora, Rubus hongnoensis, Gleditsia japonica var. koraiensis, Lespedeza ${\times}$ tomentella, Vicia venosa var. cuspidata, Vicia venosissima, Tilia taquetii, Ajuga spectabilis, Paulownia coreana, Scrophularia koraiensis, Weigela subsessilis, Lonicera subsessilis, Cirsium setidens and Saussurea seoulensis. The sixteen species were recorded in the surveyed sites as the naturalized plants; Rumex acetocella, Rumex crispus, Fallopia dumetora, Chenopodium glaucum, Amaranthus retroflexus, Robinia pseudo-acacia, Amorpha fruticosa, Trifolium repens, Abutilon avicennae, Hibiscus trionum, Oenothera odorata, Oenothera lamarckiana, Erigeron annuus, Erigeron canadensis, Bidens frondosa and Carduus crispus.

• Journal of Forest and Environmental Science
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• v.15 no.1
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• pp.44-64
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• 1999

The flora of vascular plants investigated in Mt. Hyangro-Bong was 450 taxa belonging to 86 families, 254 genera, 393 species, 2 subspecies, 51 varieties, 4 formae. Among the investigated vascular plants, Korean endemic plants (Carex okamotoi, Salix koriyanagi, Clematis chisanensis, Aconitum pseudo-laeve var. erectum, Viola diamantiaca, Sanguisorba hakusanensis, Vicia venosissima, Patrinia saniculaefolia, Hanabusaya asiatica, H. asiatica for. alba etc.) were 23 taxa; rare and endangered plants(Disporum ovale, Lilium distichum, Trillium kamtschaticum, Gastrodia elata. Clematis chisanensis, Rodgersia podophylla, Rosa marretii, Viola diamantiaca, Syringa wolfii, Hanabusaya asiatica etc.) were 17 taxa; naturalized plants(Dactylis glomerata. Poa pratensis, Rumex acetosella, Gypsophila oldhamiana, Lepidium apetalum, Oenothera odorata, Aster pilosus, Carduus crispus, Erigeron annuus, Taraxacum officinale etc.) were 14 taxa.

• Journal of Life Science
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• v.27 no.8
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• pp.902-908
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• 2017

In this study, the extracted phenolic compounds from 98 species of oriental herbal medicine were examined for biological activities to be used as functional resources. In particular, the anti-gout effect by xanthine oxidase (XOase) inhibition was determined using water and ethanol as extraction solvents because of their non-toxicity in the human body. The extracts of Chrysanthemum indicum L. (83.45%), Cuscuta chinensis (60.22%), Asiasarum sieboldi F. Maekawa (51.66%), Acorus gramineus (67.8%), Aconitum pseudo-laeve var. erectum (75.23%), Thuja orientalis (47.27%), Polygonum aviculare (53.98%), Carthami semen (63.99%), and Syzygium aromaticum (40.22%) showed relatively high XOase inhibitory activity. Chrysanthemum indicum L. was selected for its high XOase inhibitory activity. The biological compounds in Chrysanthemum indicum L. were identified to contain phenolics included in extracts of solids. Ultra-fine grind technology showed a higher extraction yield than normal grind and fine grind technology. Ethanol extracts showed relatively higher XOase inhibitory activity than water extracts. XOase inhibitory activity increased in a dependent manner as phenolic concentration increased. Therefore, ultra-fine grind technology was confirmed for use in increasing the extraction yield of XOase inhibitory compounds from Chrysanthemum indicum L.. Extracts from Chrysanthemum indicum L. are expected to be a useful functional resource for the prevention or treatment of gout.

• Journal of Korea Foresty Energy
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• v.20 no.2
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• pp.81-116
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• 2001

The flora of vascular plants investigated in civilian control line area was 730 taxa consisting of 104 families, 331 genera, 631 species, 2 subspecies, 90 varieties, 7 formae. The forest was comparatively well conserved by Pteridophyta calculation(Pte-Q), 1.27. Among the investigated vascular plants, Korean endemic plants(Carex okamotoi, Salix koriyanagi, Clematis chisanensis, Aconitum pseudo-laeve var. erectum, Viola diamantiaca etc.) were 31 taxa; rare and endangered plants(Disporum ovale, Lilium distichum, Trillium kamschaticum, Gastrodia elata etc.) were 35 taxa; naturalized plants(Dactylis glomerata, Poa pratensis, Rumex acetosella, Gypsophila oldamiana, Lepidium apetalum etc.) were 26 taxa. The forest vegetation was classified into 1 order, 1 alliances, 6 communities; Rhododendro-Quercetalia mongolicae Kim 1990(신갈나무-철쭉군목), Lindero-Quercion mongolicae Kim 1990(신갈나무-생강나무군단), A. Carex humilis v. nana- Phinus densiflora Community 소나무-산거울군락, B. Acer pseudo-sieboldianum-Quercus mongolica Community 당단풍-신갈나무군락, C. Styrax obassia-Quercus mongolica Community 쪽동백-신갈나무군락, D. Acer palmatum-Quercus mongolica Community 단풍나무-신갈나무군락, E. Rheodendron mucronulatum-Quercus mongolica Community 진달래-신갈나무군락, F. Betula schmiditii-Quercus mongolica Community 박달나무-신갈나무군락