• Korean Journal of Environmental Biology
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• v.24 no.4
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• pp.359-367
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• 2006

The vascular plants of this site were identified as 641 taxa through field investigation; 101 families, 340 genera, 547 species, 80 varieties, 12 forms, 1 subspecies and 1 hybrid. Based on the Rare plants of the Forest Service and Korea Forest Research Institute, 9 taxa were listed except implanted species; Loranthus tanakae, Aristolochia manshuriensis, Aristolochia contorta, Viola albida, Cypripedium macranthum, Schpolia japonioa, Acanthopanax chiisanensis, Rhododendron micranthum. Based on the Korean endemic plants, 18 taxa were listed; Salix purpurea var, japonica, Asarum sieboldii var. mandshuricum for. misnadrum, Persicaria lapathifolia for. alba, Pseudostellaria sylvatica, Aconitum pseudolaeve var. erectum, Corydalis maculata, Corydazis albipetala, Corydalis grandicazyx, Cardamine amaraeiormis, Chrysosplenium barbatum, Filipendula glaberrima, Lespedeza x tomentella, Acanthopanax chiisanensis, Melampyrum setaceum var. nakaianum, Weigela subsessilis, Adenophora triphylla var. hirsute, Cirsium setidens, Saussurea pseudogracilis. Specific plant species by floral region were total 81 taxa (12.6%); Prunus yedoensis in class V, 13 taxa (Thuja orientalis, Cimicifuga heracleiiolia, Sedum middendorffianutn, Rhododendron micranthum, etc.) in class IV, 17 taxa (Equisetum palustre, Aceriphyllum rossii, Angelica gigas, Cirsium setidens, etc.) in class III, 15 taxa (Heloniopsis orientalis, Lychnis cognata, Saxifraga oblongifolia, Viola orientalis, etc.) in class II, 35 taxa (Hosta capitata, Cimicifuga simplex, Chrysosplenium flagelliferum, Campanula punctata, etc.) in class I. So, the naturalized plants were listed 53 taxa and the naturalization index was 8.2%, urbanization index was 20.7%.

• Korean Journal of Pharmacognosy
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• v.23 no.4
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• pp.268-275
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• 1992

We studied to screen medicinal plants having hepatoprotective activity with the primary cultured rat hepatocytes intoxicated with carbon tetrachloride cytotoxicity. The lowest concentration and treatment time of carbon tetrachloride giving the greatest intoxication to the primary cultured hepatocytes were observed in 10mM and 60 minutes, respectively. GTP and GOT activity of culture broth of the primary cultured rat hepatocytes intoxicated by $CCl_4$ cytotoxicity at this condition were increased 135.9% and 178.3% compared with that of the primaries cultured hepatocytes not treated with $CCl_4$, respectively. This increased GPT activity was inhibited by glycyrrizin, which was known to have hepatoprotective activity, and the inhibition activity was dependent on the concentration of glycyrrhizin. Forty species among the extracts obtained from 117 species of medicinal plants were shown to have the hepatoprotective activity. Among these 40 species, Prunus persica, Scutellaria baicalensis, Astragalus membranaceus, Tribulus terrestris, Caragana chamlagu, Acanthopanax sessiliflorum and Achyranthes japonica were indicated a lower GPT activity than that of Glycyrrhiza uralensis containing glycyrrhizin and GPT activity of these were indicated 75.5%, 70.0%, 59.0%, 77.5%, 60.0%, 75.0% and 79.0%, respectively.

• Korean Journal Plant Pathology
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• v.14 no.6
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• pp.603-605
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• 1998

Soil and root samples were collected form the rhizoshpere of 11 different medicinal plants to determine the incidence, density and identification of root-knot nematode species associated with medicinal herbs. About 55% of medicinal herbs examined was found to be infested with root-knot nematodes. As a result of infection casued by three root-knot nematodes, M. hapla recorded 43.3% in medicinal herba whereas M. incognita and M. arenaria showed 7.9% and 3.7%, repectively. Forsythia koreana, Hemerocalis fulva, Hibuscus mutabilis and Petasites japonicus were the most severely infested herbs whereas Acanthopanax sessilflorus was least infested. Population of the second stage younger plants. Meloidogyne hapla, M. incognita and M. arenaria were the species associated with the medicinal herbs. The most abundant nematode observed in medicinal herbs was M. hapla and followed by M. incognita and M. arenaria. M. arenaria was observed firstly on Ficus carica, one of medicinal plant.

• Korean Journal of Plant Resources
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• v.13 no.1
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• pp.61-65
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• 2000

It was investigated 91 families, 305 genera, 470 species, 1 subspecies, 30 varieties, 2 forma and total 503 taxa of herbal resources plants in Chollabuk-do area in this study. Among them 45 taxa belong to Compositae, 30 taxa belong to Rosaceae and 23 taxa belong to Leguminosae in order were occurred frequently. In general the herbal resources plants were distributed abundantly in Togyusan, Naejangsan, Changansan and Taedunsan area. Comparatively high frequent species was surveyed as follows: Schizandra chinensis, Cimicifuga heracleifolia, C. simplex, Asarum sieboldii, Arisaema amurense var. serratum, Polygonatum odoratum var. pluriflorum, Prunella vulgaris var. lilacina and Veratrum patulum etc. There was growing 30-50 individuals of Codonopsis lanceolata in 5m$\times$5m quadrat, 90 Chrysanthemum zawadskii var. latilobum plant in 1m$\times$1m and 100 Polygonatum odoratum var. pluriflorum plant in 1m$\times$1m quadrat from Togyusan quantitatively. Rare and herbal worth species were observed to distribute such as Gastrodia elata in Naejangsan and Togyusan and Acanthopanax senticosus in Mandoksan, Chinan-gun, respectively. Cultivating species in the farm now and/or favorable species in the future will be recommended here, for example, Codonopsis pilosus, A. senticosus, G. elata, Rubus coreanus, C. lanceolata and Pleuropterus multiflorus.

• Korean Journal of Pharmacognosy
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• v.7 no.3
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• pp.179-190
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• 1976

1. The Korean Acanthopanax genus includes 12 kinds consisting of 9 species and 3 forma. 2. The Korean Oga-pi which is on market sale has been used as bark for the medicinal purpose, and Oga-pi shall use Radicis Cortex. That is why it is basic rule that herbalogy shall use Radicis Cortex. 3. The origin of Oga-pi on sale is Acanthopanax sessiliflorum forma chungbunensis C.S. Yook. 4. $C_{HUNG}\;and\;N_AKAI'S}$ report on A. koreanum told us that there are brown hair on the mid-leaf junction, but in addition to it, our investigation was resulted in the fact that there are thorn along mid-rib sometimes. 5. 2 kinds of new forma are similar to A. sessiliflorum, but are different in the view-point of chemotaxonomy, compared with A. sessiliflorum. In its morphology, we can find some difference between 2 kinds of new forma and A. sessiliflorum. Our effort of examination on documents tell us that the all plants growing in the central part of our country is A. sessiliflorum forma chungbunensis C.S. Yook. The one which has thorn on both side among the plants collected in Mt. Dukyu, is called A. sessiliflorum forma nambunensis C.S. Yook. 6. A. sessiliflorum is growing in the southern part in Korea, and most Chungbu Oga-pi A. sessiliflorum forma chungbunensis in the central part of our country. For the convenience of our study, the key of Korean Acanthopanax plant is classified into, I-IV, as shown on the following items: I. No hair on both side of leaf A. Flower stalk is longer than petiole, and there are thorn under the petiole (5-7 stigma).${\cdots}A.\;sieboldianum$. B. Flower stalk is longer than petiole, or same length. The serration lie down, and the stem has short thorn (stigma is divided into 3 part).${\cdots\;\cdots}A.\;seoulense$ II. There are a lot of thorn or hair on back of leaf. A. A lot of thorn and hair on the vein of leaf back, and a number of small thorn on petiole.${\cdots}A.\;chiisanensis$. B. There are thorn on the vein of leaf back.${\cdots\;\cdots}A.\;sessiliflorum\;forma\;chungbunensis.$ III. There are hairs on both side of leaf. A. There are small hairs on the back of leaf.${\cdots\;\cdots}A.\;sessiliflorum.$ B. There are small hairs on both side of leaf.${\cdots\;\cdots}A.\;sessiliflorum\;f.\;nambunensis.$ C. There are thick hairs on junction of main vein on back of leaf.${\cdots\;\cdots}A.\;koreanum.$ D. There are brown hairs on vein of leaf back, and brown hairs on small petiole.${\cdots\;\cdots}A.\;rufinerve.$ E. There are shrunk hairs in grey-brown on back of leaf, and tense hairs on new branch (one stigma).${\cdots\;\cdots}A.\;divaricatum.$ IV. There are long thorn, just like needles, on the stem and petiole. A. Long needle grows on whole stem tensely, and long needles on petiole.${\cdots\;\cdots}A.\;senticosus.$ B. There are no needles, just like needles aid hairs on petiole, and needles grow on the stem thinly.${\cdots\;\cdots}A.\;asperatus.$ C. There are no needle on small brarch, leaf and inflorescence are larger than A. senticosus. ${\cdots\;\cdots}A.\;senticosus\;forma\;inermis.$.

• Korean Journal of Food Science and Technology
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• v.46 no.2
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• pp.205-212
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• 2014

This study was designed to investigate the antioxidant activities (ORAC value, DPPH and ABTS radical scavenging activity, FRAP activity, and reducing power) and nitrite scavenging activities of Acanthopanax senticosus extracts fermented with the mycelia of three different mushroom species: Ganoderma lucidum, Phellinus linteus, and Hericium erinaceus. The highest total phenol content (42.09 GAE mg/g) and ORAC value ($74,912{\mu}M$ TE/g) were observed in a hot water extract of A. senticosus fermented with G. lucidum. The highest DPPH radical and nitrite scavenging activities were observed in a 70% ethanol extract of A. senticosus fermented with G. lucidum. In addition, ABTS radical scavenging activity (8-88%), FRAP activity (0.1-0.2), and reducing power (0.3-0.7) were increased by ethanol addition in all samples in a dose-dependent manner. These results provide a basic understanding of the antioxidant and nitrite-scavenging activities of A. senticosus extracts fermented with different mushroom mycelia.

• Asian-Australasian Journal of Animal Sciences
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• v.32 no.11
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• pp.1776-1788
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• 2019

Objective: The demands for measures to improve disease resistance and productivity of livestock are increasing, as most countries prohibit the addition of antibiotics to feed. This study therefore aimed to uncover functional feed additives to help enhance livestock immunity and disease resistance, using Acanthopanax sessiliflorus fruit extract (ASF). Methods: ASF was extracted with 70% EtOH, and total polyphenolic and catechin contents were measured by the Folin-Ciocalteu and vanillin assay, respectively. The 3D4/31 porcine macrophage cells ($M{\Phi}$) were activated by phorbol 12-myristate 13-acetate (PMA), and cell survival and growth rate were measured with or without ASF treatment. Flow-cytometric analysis determined the lysosomal activity, reactive oxygen species levels (ROS), and cell cycle distribution. Nuclear factor kappa B ($NF-{\kappa}B$) and superoxide dismutase (SOD) protein expression levels were quantified by western blotting and densitometry analysis. Quantitative polymerase chain reaction was applied to measure the lipid metabolism-related genes expression level. Lastly, the antibacterial activity of 3D4/31 $M{\Phi}$ cells was evaluated by the colony forming unit assay. Results: ASF upregulated the cell viability and growth rate of 3D4/31 $M{\Phi}$, with or without PMA activation. Moreover, lysosomal activity and intracellular ROS levels were increased after ASF exposure. In addition, the antioxidant enzyme SOD2 expression levels were proportionately increased with ROS levels. Both ASF and PMA treatment resulted in upregulation of $NF-{\kappa}B$ protein, tumor necrosis factor $(TNF){\alpha}$ mRNA expression levels, lipid synthesis, and fatty acid oxidation metabolism. Interestingly, co-treatment of ASF with PMA resulted in recovery of $NF-{\kappa}B$, $TNF{\alpha}$, and lipid metabolism levels. Finally, ASF pretreatment enhanced the in vitro bactericidal activity of 3D4/31 $M{\Phi}$ against Escherichia coli. Conclusion: This study provides a novel insight into the regulation of $NF-{\kappa}B$ activity and lipid metabolism in $M{\Phi}$, and we anticipate that ASF has the potential to be effective as a feed additive to enhance livestock immunity.

• Molecular & Cellular Toxicology
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• v.5 no.3
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• pp.243-249
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• 2009

Melamine, which is used to produce melamine resin for various industrial applications, has a high nitrogen content by mass. For this reason, it has been illegally added to foods to increase their apparent protein content. In the present investigation, melamine-induced oxidative damage of human lymphocyte DNA was evaluated by Comet assay. The in vitro oxidative DNA damage caused by melamine increased in a dose-dependent manner. This DNA damage was significantly inhibited by treatment with ascorbate. Moreover, the traditional Korean medicinal herb, named Acanthopanax, red ginseng and green tea markedly reduced the DNA damage. Various edible plant extracts also inhibited melamine-induced oxidative DNA damage in vitro. Melamine enhanced intracellular ROS generation, and this effect was suppressed by treatment with various antioxidants.

• Korean Journal of Pharmacognosy
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• v.37 no.1 s.144
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• pp.1-10
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• 2006

'O Ga Pi Ip' has been used in Korea to cure rheumatism, neuralgia, edema, dematopathy, and impotence. The botanical origin of the crude drug has not been confirmed pharmacognostically. To clarify the botanical origin of 'O Ga Pi Ip', the morphological and anatomical characteristics of the leaves of Acanthopanax species growing in Korea and Japan, A. chi-isanensis Nakai, A. Koreanum Nakai, A. rufinerve Nakai, A. senticosus (Rupr.et Maxim). Harms, A senticosus (Rupr.et Maxim.) for inermis Harms, A. seoulense Nakai, A sessiliflorus (Rupr. et Maxim.) Seem, A. divaricatus Seem, A. sieboldianum Makino were compared. As a result, it was determined that 'O Ga Pi Ip' was the leaf of A. sessiliflorus (Rupr. et Maxim.) Seem, A chiisanensis Nakai, and A. koreanum $Nakai_I$.

• Journal of Environmental Science International
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• v.12 no.2
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• pp.125-132
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• 2003

This study was executed by China along with the Tumen river, which formed border of North Korea and China. As a result 91 family, 282 genera, 363 species, 57 variety 4 species, total 424 taxa of vascular plants were identified. The examination area was include the region that had various vegetation such as upper swampy land, seashore dune, a river, a high mountain grassy plain, deciduous tree zone, evergreen coniferous forest zone. The followings are representative plants, which found in an examination area but not in South Korea. Picea koraiensis, Larix gmelini var. principis-ruprechtii, Betula playphylla, Ulmus pumila, Populus koreana, Ledum palustre var. diversipilosum, Rhododendron parvifolium, Salix brachypoda, Phacelurus latifolius, Carex gotoi, Carex capricornis, Calla palustris, Aquilegia flabellata var. pumila, Lilium davuricum, Astragalus membranaceus, Trifolium lupinaster, Ledebourieila seselodeds, Polemonium racemosum, Scutellaria baicalensis, Linnaea borealis, Thladiantha dubia, Inula helenium, Trollius hondoensis, Hypocaeris ciliata, Aconitum kirinense, Aconitum arcuatum, Potentilla viscosa var. macrophylla. And there are 21 rare and endangered species, which Korean Forest Sevice designated, such as Aconitum koreanum, Acorus calamus var. angustatus, Polygonatum stenophyllum, Drosera rotundifolia, Iris setosa, Jeffersonia dubia, Lilium davuricum, Lilium cernum, Paeonia obovata, Penthorum chinense, Phacelurus latifolius, Rosa marretii, Sparganium stoloniferum, Thymus quinquecostatus, Trillium tschonoskii, Utricularia japonica, Tripterospermum japonicum, Vaccinium uliginosum, Vaccinium vitis-idaea, etc. Especially, plants like, Acanthopanax senticosus, Jeffersonia dubia and Lillum cernum which have high values of ornamental, and medical use are in an extinction crisis. High swampy land was formed to upper stream of Tumen river. It showed representative vegitation, like Carex sp., Scirpus radirans, Eriophorum latifolium. Wetlands plant and a dune plant were mixed in down stream area of Tumen river. On a dune, seashore plants, such as Carex kobomugi, Salsola collina, Raphanus sativus var. raphanistroides, Rosa rugosa, Scutellaria strigillosa, Linaria japonica, Phacelurus latifolius were appeared frequently.