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Targeted alpha therapy (TAT) for cancer using metallic radioisotopes

  • Kang, Chi Soo;Lee, Kyo Chul;Lee, Yong Jin
    • Journal of Radiopharmaceuticals and Molecular Probes
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    • v.5 no.2
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    • pp.135-144
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    • 2019
  • Targeted alpha therapy (TAT) based on metallic radionuclides has attracted a lot of attention lately due to its impressive therapeutic efficacy displayed in couple of clinical studies for cancer. Representative metallic radionuclides emitting alpha-particle include 225Ac, 213Bi, and 227Th, and there have been variety of TAT formulations based on different targeting moiety and chelating agents. In this review, we introduce strategies to label metallic radioisotopes with biomolecules and look at some of recent preclinical and clinical results of TAT for cancer.

Static and Dynamic Characteristics of AC4C Aluminum Alloy (AC4C 알루미늄 합금의 정적 및 동적 특성)

  • Kwon, Y.G.;Ju, W.K.;Song, J.I.
    • Proceedings of the KSME Conference
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    • 2007.05a
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    • pp.220-225
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    • 2007
  • The mechanical characteristics of AC4C Aluminum Casting Alloy were investigated by tensile test and impact test. Based on the tensile test' s result, we found that the yield strength of a high speed was about 10% higher than that of a low speed test and the maximum rupture strain mostly occurred in low speed tensile test. The impact energy of curved surface specimen was higher than that of plane surface specimen that can be measured in impact test.

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Effect of Two-step Surface Modification of Activated Carbon on the Adsorption Characteristics of Metal Ions in Wastewater I. Equilibrium and Batch Adsorptions

  • Park, Geun-Il;Lee, Jae-Kwang;Ryu, Seung-Kon;Kim, Joon-Hyung
    • Carbon letters
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    • v.3 no.4
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    • pp.219-225
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    • 2002
  • The two-step surface modifications of activated carbon was carried out to improve the adsorption capacity of toxic heavy metal ions in liquid phase. Physical and chemical properties of the as-received activated carbon (AC) and two kinds of surface-modified activated carbons ($1^{st}AC$ and $2^{nd}AC$) were evaluated through the BET analysis, surface acidity, and oxides measurements. Specific surface area and pore volume did not significantly change, but surface oxide-group remarkably increased by the surface modification. Equilibrium and batch adsorptions of the various metals, such as Pb, Cd, and Cr, using AC, $1^{st}AC$, and $2^{nd}AC$ were performed at initial pH 5. The adsorption capacity and rate of $2^{nd}AC$ were higher than those of AC and $1^{st}AC$. The carboxylic/sodium carboxylate complex groups were developed from the two-step surface modification of activated carbon, which strongly affected the adsorption of metal ions.

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Reduced Rating T-Connected Autotransformer Based Thirty-Pulse AC-DC Converter for Vector Controlled Induction Motor Drives

  • Singh Bhim;Bhuvaneswari G.;Garg Vipin
    • Journal of Power Electronics
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    • v.6 no.3
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    • pp.214-225
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    • 2006
  • The design and performance analysis of a reduced rating autotransformer based thirty-pulse AC-DC converter is carried out for feeding a vector controlled induction motor drive (VCIMD). The configuration of the proposed autotransformer consists of only two single phase transformers, with their windings connected in a T-shape, resulting in simplicity in design, manufacturing and in a reduction in magnetics rating. The design procedure of the autotransformer along with the newly designed interphase transformer is presented. The proposed configuration has flexibility in varying the transformer output voltage ratios as required. The design of the autotransformer can be modified for retrofit applications, where presently a 6-pulse diode bridge rectifier is used. The proposed thirty-pulse AC-DC converter is capable of suppressing less than $29^{th}$ harmonics in the supply current. The power factor is also improved to near unity in the wide operating range of the drive. A comparison of different power quality indices at AC mains and DC bus is demonstrated in a conventional 6-pulse AC-DC converter and the proposed AC-DC converter feeding a VCIMD. A laboratory prototype of the proposed autotransformer based 30-pulse AC-DC converter was developed with test results validating the proposed design and system.

LGE's 60-inch AC Plasma Display Panel with $1365{\times}768$

  • Park, Myung-Ho
    • 한국정보디스플레이학회:학술대회논문집
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    • 2000.01a
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    • pp.225-227
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    • 2000
  • LGE developed and demonstrated the first 60-inch full color AC plasma display panel with the 1365 ${\times}$ 768 resolution. Both Sol-gel and E-beam method have been tried for MgO layer, and photolithography has been used for electrodes and phosphor layer to fabricate a 60-inch panel. Selective Erase, Selective Write, Address Display Separate, and Address While Display driving scheme have been tested. Its luminance and contrast ratio is about $550\;cd/m^2$ and 500:1, respectively.

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Research on the Effect of Interconnected Distributed Wind Power Generation(225[kV], AC Link Method) on Power Quality in System (연계형 풍력발전설비(225[kV], AC 링크방식)가 전력계통의 전원 품질에 미치는 영향에 관한 연구 분석)

  • Na, Chae-Dong;Park, Jung-Shin
    • Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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    • v.24 no.6
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    • pp.147-153
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    • 2010
  • When small scale wind and solar power generation systems are connected to conventional power distribution system. It is worried that it can affect the quality of electricity such as voltage variation, power factor, frequency, harmonics and flicker. Therefore, in this research, in order to investigate the effects of wind power generation equipments(AC link method) on electrical power quality, when they are connected to distribution system. Power quality analyzer was installed respectively at the front side of power conversion system of conventional wind generation system and secondary side of consumer's power supply at distribution line. Measurements on power quality were performed and the effects of the wind generation system on distribution system were analyzed when it was and was not operated. The results show that 0.34[%] increase on voltage variation, 0.145 increase on current crest factor and 0.6[$^{\circ}$] deviation on phase difference when the power generation system was operated.

Expression of Green Fluorescent Protein in Both Spodoptera frugiperda Cells and Bombyx mori Larvae by Ac-Bm Hybrid Virus

  • Jin, Byung-Rae;Yoon, Hyung-Joo;Yun, Eun-Young;Kang, Seok-Woo;Cho, Eun-Sook;Kang, Seok-Kwon
    • The Journal of Korean Society of Virology
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    • v.28 no.3
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    • pp.225-232
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    • 1998
  • We have expressed GFP in Sf9 and Bm5 cells or Bombyx mori larvae by using Ac-Bm hybrid virus capable of replicating in both Bm5 and Sf9 cells. Genomic DNA of Ac-Bm hybrid virus expressing ${\beta}$-galactosidase was cotransfected with baculovirus transfer vector containing GFP gene, pBacPAK-GFP in Sf9 cells. The Ac-Bm hybrid virus harboring GFP was named as Ac-Bm hybrid virus-GFP. The Ac-Bm hybrid virus-GFP-infected insect cells were easily selected by detecting the emission of GFP from each well of cell culture dish on the UV illuminator. GFP produced by Ac-Bm hybrid virus-GFP in Sf9 and Bm5 cells or B. mori larvae was confirmed by SDS-PAGE and Western blot analysis using GFP antibody. In addition, B. mori larvae infected with Ac-Bm hybrid virus-GFP was apparently appeared fluorescence from the whole body at S days postinoculation. The fluorescence of GFP from the hemolymph and fat body of B. mori larvae infected with Ac-Bm hybrid virus-GFP was also observed by fluorescence microscope. In conclusion, our results demonstrated that in baculovirus expression vector system, use of Ac-Bm hybrid virus have an additional advantage of expanded host range for producing recombinant proteins.

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Damping Capacities of Mg-Al alloy with As-Cast and Discontinuous Precipitates Microstructures (주조 및 불연속 석출물 미세조직을 가지는 Mg-Al 합금의 진동감쇠능)

  • Jun, Joong-Hwan
    • Journal of the Korean Society for Heat Treatment
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    • v.34 no.5
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    • pp.218-225
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    • 2021
  • In this study, damping capacities were comparatively investigated for Mg-9%Al alloy with as-cast (AC) and fully discontinuous precipitates (DPs) microstructures, respectively. The DPs microstructure was obtained by solution treatment at 678 K for 24 h, followed by furnace cooling to RT. The AC microstructure was typically characterized by partially divorced eutectic β(Mg17Al12) phase particles distributed along the α-(Mg) matrix cell boundaries. The DPs microstructure showed lamellar morphology consisting of α and β thin layers with various interlamellar spacings. The DPs microstructure had better damping capacity than the AC microstructure in the strain-amplitude independent region, while in the strain-amplitude dependent region, the damping behavior was reversed. In view of the microstructural features of AC and DPs, the lower concentration of Al in the α-(Mg) phase for the DPs microstructure and the lower β phase number density for the AC microstructure would be responsible for the higher damping capacities in the strain-amplitude independent and strain-amplitude dependent regions, respectively.

Development of a Cutting Force Monitoring System for a CNC Lathe (CNC 선반에서의 절삭력 감지 시스템 개발)

  • Heo, Geon-Su;Lee, Gang-Gyu;Kim, Jae-Ok
    • Journal of the Korean Society for Precision Engineering
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    • v.16 no.1 s.94
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    • pp.219-225
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    • 1999
  • Monitoring of the cutting force signals in cutting process has been well emphasized in machine tool communities. Although the cutting force can be directly measured by a tool dynamometer, this method is not always feasible because of high cost and limitations in setup. In this paper an indirect cutting force monitoring system is developed so that the cutting force in turning process is estimated based on a AC spindle drive model. This monitoring system considers the cutting force as a disturbance input to the spindle drive and estimates the cutting force based on the inverse dynamic model. The inverse dynamic model represents the dynamic relation between the cutting force, the motor torque and the motor power. The proposed monitoring system is realized on a CNC lathe and its estimation performance is evaluated experimentally.

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Synchronization loop by vector product in single-phase system (단상시스템에서 벡터적(vector product)에 의한 동기 루프)

  • 배기훈;기상우;조국춘;최종묵
    • Proceedings of the KSR Conference
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    • 1998.11a
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    • pp.219-225
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    • 1998
  • A Diode bridge rectifier and a phase-controlled thyristor bridge rectifier generate harmonics in power system. Nowadays, power factor and harmonics are important performance in electrical equipment for railway vehicle. Many researchers have been trying to improve the power factor and ac-side harmonics. Therefore the PWM converter has been used to operate at unity power factor and to reduce ac-side current harmonics. This paper proposes the synchronization loop by vector product in single-phase PWM converter. The proposed control method can realize the sinusolidal input current waveform and the effective unity power factor. The validity of the proposed control method is verified through the experimental result.

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