• Clinical and Experimental Pediatrics
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• 제52권9호
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• pp.991-998
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• 2009

목 적 : 갑상선호르몬은 소아에서 뇌의 발달에 매우 중요한 호르몬이므로 갑상선기능이상에 대한 조기진단 및 치료는 중요하다. 미숙아에서는 이러한 갑상선의 기능이상이 만삭아에 비해 많이 발생한다. 본 연구의 목적은 미숙아에서의 갑상선기능이상의 빈도, 임상양상 및 경과 등을 알아보고자 하였다. 방 법 : 1999년 4월에서 2008년 8월까지 단국대학교병원 신생아중환자실에 입원한 37주 미만의 미숙아 802명 중 초기 갑상선기능검사의 결과를 확인 할 수 있었던 599명의 환아를 대상으로 의무기록을 통해 후향적으로 연구하였다. 1, 2차 검사의 결과에 따라 정상군, 일차성 갑상선기능저하증군, 고갑상선자극호르몬혈증군, 저티록신혈증군, 지연된 일차성 갑상선기능저하증군, 지연된 고갑상선자극호르몬혈증군의 6군으로 나누었다. 각 군 간의 임상특징, APGAR 점수 및 여러 위험인자들, 검사결과 등을 비교하였고 갑상선기능이상의 빈도 및 경과, 위험요소 등을 분석하였다. 결 과 : 599명중 1차 갑상선기능이상을 보인 환아는 136명(23%)이었고 저티록신혈증이 20%로 가장 많았다. 처음 NST는 정상이었으나 생후 3-4주경 2차 검사를 시행한 46명 중 8명(17%)에서 갑상상선기능이상을 보였다. 갑상선호르몬은 총 10명에서 투여되었고, 9명에서는 호전을 보여 중단이 가능하였다. 1명은 이소성 갑상선으로 지속적인 복용이 필요한 상태이다. 결 론 : 미숙아에서 갑상선기능 이상은 매우 흔하였고, 대부분 일시적이었다. 때로는 초기 검사에서 정상이었다가 뒤늦은 이상을 보일 수 있으므로 미숙아의 경우 특히 33주 미만 또는 2,500 g 미만의 경우 처음 검사가 정상이더라도 3-4주경에 재검하는 것은 필요하다고 생각한다.

• Clinical and Experimental Reproductive Medicine
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• 제30권2호
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• pp.111-118
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• 2003

Objectives: The development of an useful method for obtaining metaphase chromosomes from a biopsied blastomere would allow differentiation between embryos with balanced and normal chromosome complements in the preimplantation genetic diagnosis for chromosomal translocations. This study was performed to evaluate the effects of microtubule depolymerizing agents (MTDAs) on the blastomeres of mouse and human preimplantation embryos, and to establish an effective method for obtaining metaphase chromosomes of biopsied blastomeres in human early embryos. Materials and Methods: Early embryos (2-4 cell stage) from superovulated mice (ICR strain) were collected and treated with single or mixture MTDAs, such as vinblastine, nocodazole and colcemid. After the treatment of MTDAs for 16 hours, the metaphase aquisition (MA) rates were evaluated by the observation of chromosome status with bis-benzimide or DAPI staining. The optimal condition from the above experiment was applied to human embryos, which were developed from abnormal fertilization (3-pronuclei). Fluorescence in-situ hybridization (FISH) with whole chromosome probes was conducted on the human metaphase chromosomes by the MTDAs. Results: In mouse embryos, the effective concentrations of each MTDAs for obtaining metaphase chromosomes were $1.0{\mu}M$ of vinblastine (20.3%), $5.0{\mu}M$ of nocodazole (28.1%) and $1.0{\mu}M$ colcemid (55.6%), respectively. The highest MA rate (91.2%) in the mouse embryos was obtained by a mixture of vinblastine ($1.0{\mu}M$) and nocodazole ($1.0{\mu}M$). In the human embryos, the metaphase chromosomes of blastomeres were obtained in 44 of 113 blastomeres (38.9%) by treatment of the mixture of vinblastine and nocodazole. FISH signals of the metaphase chromosomes were successfully observed in human individual blastomeres. Conclusions: The treatment of a mixture MTDAs for obtaining metaphase chromosomes was an efficient method, and the MA rate was above 90% in the mouse embryos. However, only a relatively small proportions of the blastomeres yielded metaphase chromosomes by the MTDAs in the human embryos. The inconsistent effects of MTDAs may be related to the variation of different species and the poor developmental potency of abnormally fertilized human embryos. We should develop more reliable and efficient methods for obtaining the metaphase chromosomes in the biopsied blastomeres of human preimplantation embryos.

• 한국조경학회지
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• 제33권5호통권112호
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• pp.69-82
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• 2005

These studies were carried out (1) to investigate the growth characteristics of Sedum album L. in the field, (2) to propose a suitable shallow peen roof system for this plant, and (3) to evaluate plant growth in the proposed system over the long term. The growth characteristics, such as morphological properties, growth habit, shade tolerance, and flowering, were surveyed. In experimental shallow green-roof systems, the effects of drainage type, substrate type, and soil depth on plant growth were investigated. Then drought tolerance was investigated. After planting Sedum album L. in the proposed system survival rate, cover, and resistance to insects, heal and cold were evaluated for about 2 years. The results of these studies are summarized below. 1. In the field, the aboveground part of Sedum album L. did not die back during the winter. Plant height was 4$\sim$7 cm. Roots were distributed to a depth of 5$\sim$7 cm. Sedum album L. is a compact ground-cover plant that spreads vigorously. Shading condition of less than $30\%$ of full sunlight didn't cause any trouble, but shading conditions above $87\%$ made the shape of the shoots and leaves abnormal. The plant bloomed from June to August and had a rather large compound umbel of white, star-shaped flowers. 2. Two systems, a drainage-blend-10 cm soil depth and a reservoir$\cdot$drainage-blend-15 cm soil depth, performed best in terms of cover, fresh weight, and dry weight. The first has an advantage for green roofs because it is lighter than the latter. 3. In drainage-blend-10 m soil depth and modified reservoir · drainage-blend-10 cm soil depth system no plants died for about 4 months after stopping the irrigation. The visual quality of the latter system was above 5 for 4 months and that of the former was under 5 after 2 months. In the field, however, the drought tolerance of Sedum album L. grown in the former would be enough to withstand the dry season. Considering the urban ecosystem and the importance of healthy growth the modified reservoir $\cdot$ drainage-blend-10 cm soil depth system was finally recommended. This system was composed of a 4 cm thick drainage layer and drain outlets placed at a height of 2.5 cm. 4. In the proposed system, the survival rate was $100\%$, and there was no injury induced by insects and heat. The leaf density decreased a little in winter. Cover increased throughout the year. Sedum album L. was planted with a cover of 72$cm^{2}$ on 3 April 2003; on 16 June 2003 and 15 June 2004, cover was $132.66\pm$5.87 $cm^{2}$(1.8 times) and $886.98\pm$63.51 $cm^{2}$(12.3 times), respectively.

• 한국수자원학회논문집
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• 제43권9호
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• pp.769-780
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• 2010

'위상적 평가'와 '수리학적 평가'를 통해 수요절점에서 필요한 수량을 필요한 압력으로 충분히 공급할 수 있는지의 여부를 정량화하고 이를 신뢰성의 산정을 위한 기준으로 사용하는 것은 대표적인 상수관망시스템의 신뢰성산정 방법이다. 하지만 '수리학적 평가'를 이용한 수요절점에서의 압력확보 여부를 신뢰성 산정에 사용한 기존의 연구들은 'Demand-Driven Analysis의 사용'과 '사용성의 미고려'라는 두 가지 측면에 있어서 문제가 있다. 또한 비정상상태인 상수관망시스템의 수리모의 적합한 Pressure-Driven Analysis를 이용한 연구들도 신뢰성 산정에 있어 가능공급량만을 고려하고 사용성을 고려하지 않아, Pressure-Driven Analysis의 장점이 효율적으로 사용되지 않은 단점이 있다. 본 연구에서는 기 개발 된 Pressure-Driven Analysis 모형인 HSPDA모형과, 거리척도 방법을 이용하여 수량과 수압을 동시에 고려하는 신뢰성 분석기법을 제안하였다. 제안된 기법을 상수관망에 적용하여 기존의 연구결과와 비교하였고 이를 바탕으로 수립 가능한 신뢰성 확보방안을 제시하였다.

• 대한간호학회지
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• 제7권2호
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• pp.1-10
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• 1977

Personalized Patient centered nursing care is increasingly difficult to achieve despite the fact that it remains one of our consistent goals. So, we must find away to individualized nursing care. One means, to achieve this is by use of the nursing history form, which has been developed to help the nurse make maximum use of her limited time with the patient, by obtaining systematically the information needed to plan his nursing care. The nursing history form can be used to collect data about individual nursing needs but also it lends itself to the collection of epidemiological data relevant to the needs of patient population. So this study was undertaken in an attempt to describe the general characteristics of the population studied, to find out their perceptions and expectations related to their illness and hospitalization, to find out specific basic needs and to examine the relationship between the patients nursing needs and demographic characteristics through the responses to the nursing history questions. The study population defined and selected was all the patients (70) who were admitted to Yonsei University Hospital from October 1 - 15, 1975. The direct interview method was used and the data were categorized by the investigator, according to the nature of responses to each question and were subjected to the percentile and the chi- square tests. The findings can be summarized as follows 11. General characteristics of the study population ; The population was made up mainly of urban patients who were highly educated. The age was equally distributed. 2. Patients, perceptions and expectations related to illness and hospitalization ; 88.6% of the patients knew about the reason for hospitalization but 64. 5% could state symptoms only. 37.5% recognized the cause of illness. Approximately three fourth of the patients expressed on expectation for early recovery. 60.0% of the patient responses indicated, that they expected less than 10 days of hospitalization. Of the total responses regarding hospitalization, 45.7% were negative about the post -hospitalization expectation, 45.7% expected to return to work. As a result of these findings, we can see that there is a great educational need, a psychological need and environmental need for adaptation to the hospital and a socio- economic need for the post - hospitalization period. 3. Specific basic needs : The physical needs include the problem of getting sufficient sleep (50.0%), difficulty in food intake(47.1%), problems with hospital diet (47.0%), abnormal condition of the skin(44.3%), problems with bowel elimination(35.7%), assistance with bathing(35.7%), pain(30.0%), difficulty in walking(30.0%) , difficulty in seeing(30.0%) problems in urinary elimination(20.0%) , and difficulty in hearing(10.0%), 4. Nursing needs and epidemiological characteristics ; Age distribution was related to the rendition of the mouth but no significant differences were observed statistically with the patients responses to the other nursing history questions according to the epidemiological variables of age, sex, education and residence.

• 동아시아식생활학회지
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• 제23권5호
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• pp.620-628
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• 2013

In this study, the condition for preventing abnormal fermentation was set by heating the nuruk extract, such that glycosyl enzymes maintain its activity and unnecessary microbes are removed. The total colony of microbes in the heated nuruk extract was highest in number at $25^{\circ}C$ and began to reduce at 50, $60^{\circ}C$ and sharply reduced over $70^{\circ}C$. Saccharogenic power (SP), glucoamylase and acidic protease activities were highest at $50^{\circ}C$, 10, 20, 30min and ${\alpha}$-amylase activity was lower at $50^{\circ}C$ than at $25^{\circ}C$. In the pHs of the nuruk extract, as the heat temperature became higher and treatment time was longer, the pHs were reduced significantly. The total acidities of heat treatments at 50, $60^{\circ}C$ were lower by 0.2% than at $25^{\circ}C$, where as the 70, $80^{\circ}C$ treatments showed a sharp rise from the early stage of fermentation. Soluble solids showed the same aspects with the glycosyl enzymes cases. In reducing sugar, 25, $50^{\circ}C$ treatments were sharply increased from the first day of fermentation while $60^{\circ}C$ treatments began to rise from second day 70, $80^{\circ}C$ were slightly increased after the fourth day. The normally alcohol fermented treatments were 25, 50 and $60^{\circ}C$ 30min. The $70^{\circ}C$ treatments almost did not alcohol fermentation. In the preference tests, taste and total acceptability were high at 25, $50^{\circ}C$ treatments. These results suggest that makgeolli using heat treated nuruk extract also has good taste as well as did not.

• 대한소아치과학회지
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• 제44권3호
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• pp.378-383
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• 2017

치아 변색을 일으키는 다양한 원인들이 있다. 혈중 빌리루빈의 증가도 치아변색을 일으킬 수 있는데 이는 드문 경우이나, 대부분 초록색 변색이 보고 되었다. 본 증례는 신생아 고빌리루빈혈증 병력이 있는 환아의 유치의 초록색 변색에 대한 것이다. 16개월, 22개월 두 남아가 맹출한 치아의 비정상적인 색을 주소로 내원하였다. 두 환아의 유치는 법랑질저형성증을 수반한 초록색 변색을 보였다. 두 환아 모두 저체중, 조산아였으며, 신생아 고빌리루빈혈증을 진단받았다. 전신적인 질환은 치아의 형성시기에 경조직에 영향을 줄 수 있으며, 변색도 일으킬 수 있다. 정상적인 치아 발육과 환아의 심미적 요구를 충족시키기 위해 정기적인 관찰이 필요하다. 소아치과의사는 유치열기의 변색을 먼저 관찰 할 수 있다. 이와 같은 증례들을 통해 치과의사는 치아변색에 대해 전신적 질환을 추론할 수 있다.

• Archives of Plastic Surgery
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• 제38권1호
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• pp.27-34
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• 2011

Purpose: Anterolateral thigh (ALT) perforator free flap is commonly used because of its various benefits. The author reports important factors of preoperative and perioperative ALT perforator free flap and causes of failure. Methods: 84 patients who were treated with ALT perforator free flap from December 2004 to 2008, and February 2010 to April 2010 were studied. 61 patients were male and 23 were female. The mean age of patients was 51.1. The main cause was neoplasm and the main reconstructive areas were head and neck area. The size of flap was various from $3{\times}4$ to $12{\times}18$ cm. 6 patients received split thickness skin graft at donor site. Preoperative angiography was checked to all patients. Results: Among the 84 patients, partial necrosis of flaps occurred in 4 patients because of atherosclerosis, varicose vein, or inattention of patient, etc. And total flap necrosis in 5 patients because of abnormal vessels of recipient area or delay of operation, etc. One case of serous cyst was found as the complication of donor area. Two cases of skin graft on donor site were done because of suspected muscle compartment syndrome, 4 cases of that because of large flap. Septocutaneous perforators were found in 7 cases. The author couldn't find reliable perforator in 3 cases, ipsilateral anteromedial thigh perforator and contralateral ALT perforator and latissimus dorsi musculocutaneous free flap were done instead of ALT. There was no case which needed reoperation because of the impairment of blood supply, and 3 cases were revised by leech because of the burn injury by a lamp or venous congestion. Conclusion: Although ALT perforator free flap is widely used with its various merits, many factors such as preoperative condition of donor or recipient area, morphology of defect and operating time need to consider to prevent flap necrosis. And operators should need careful technique because septocutaneous perforator is uncommon, and musculocutaneous perforator is common but difficult to dissect.

• 한국전자거래학회지
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• 제23권2호
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• pp.111-121
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• 2018

항공기 엔진, 풍력발전기, 모터 등 회전기기에서 발생하는 많은 문제들은 진동이나 소음과 같은 신호 데이터를 측정하여 이상감지를 할 수 있으며, 주파수 분석 등 여러 가지 신호처리가 데이터 전처리 단계에서 필요하다. 본 논문에서는 진동 데이터를 분석하여 설비 이상상태를 감지하는 기법을 소개한다. 정상상태 데이터를 기반으로 마할라노비스 거리를 측정하여 이상상태 유무를 모니터링 하는 방식을 사용한다. 특히 신호 데이터의 전처리 기법들을 도입하여 이상상태 감지의 성능을 개선할 수 있음을 보여준다. 전처리 단계에서 신호 데이터 수집 과정에서 발생한 누설오차(leakage)를 없애기 위해 해밍 윈도우(Hamming window)를 적용하고, 신호 데이터의 원신호인 포먼트(formant)를 분리하기 위하여 켑스트럼(cepstrum) 분석을 실시한다. IMS 베어링 진동 공개데이터를 대상으로 시간 구간별로 6가지 통계지표를 추출한 후 마할라노비스 거리 분류기를 적용하여 성능을 검증하였다. 제시된 신호처리 전처리 기법을 적용함으로써 성능이 획기적으로 향상되는 것을 실험에서 보여주었다.

• 한국작물학회지
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• 제35권1호
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• pp.44-52
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• 1990

돼지감자의 괴경반식 대신 종자반식에 의해서 건전한 유묘와 식물체를 육성함으로써 돼지감자 유전소재의 수집과 보존 및 개량에 종자반식을 이용하고자 하였다. 이를 위하여 국내외에서 수집한 9종(Mammoth French White, D-19, JA6, K-8, JA 13, Violet de Renne, Medius, Nahodka, Fuseau 60) 돼지감자 화기에서 종자를 채취하여 종피제거 방법에 의해 종자휴면을 타파한 후 종자로부터 발아유도되어 발생한 유묘의 생육특성을 조사하였으며 최종적으로 종자반식에 의한 바이오매스 생산성을 괴경반식에 의한 경우와 비교하여 다음의 결과를 얻었다. 1. 돼지감자 휴면종자는 종피제거방법에 의해 완전한 발아유도가 가능하였다. 2. 종자에서 발생한 유묘는 왜성형태를 유지하며 동시에 하배축을 비대시켜 하배축을 증대시켜 생리적 왜성(physiolo-gical dwarfing)의 특성으로 발현되는 경우가 겨울동안 온실에서 육묘한 경우에 한하여 나타났다. 3. 종자에서 발생한 유묘의 생리적 왜성은 JA6 품종의 경우 유묘령과 무관하게 12시간 미만의 단일에 감응하여 나타난 결과이었다. 4. 일단 발현된 유묘의 생리적 왜성은 생육기간동안 일장이 증가함에 따라 정상 식물체로 회복되었다. 5. 종자반식에 의한 육묘이식 재배시 괴경수량은 3.51 ton/10a으로 괴경반식에 의한 경우 3.02ton/10a에 비교하여 오히려 많았다. 6. 종자를 직접파종하였을 때 괴경수량은 괴경반식에 의한 경우의 52%에 불과하였다.