• Title/Summary/Keyword: Abnormal Liver Function

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A Study on Correlation of Melanin & Pigmentation Disorder and Viscera and Bowels(臟腑) (멜라닌 및 색소 이상 질환과 장부(臟腑)와의 연관성 고찰)

  • Jung, Yu-Jin;Ko, Woo-Shin;Yoon, Hwa-Jung
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.29 no.3
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    • pp.27-41
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    • 2016
  • Objectives : The purpose of this research is to understand melanin with both Korean and Western medicine.Methods : We investigated the comprehension of melanin in both western and Korean medicine through literature review and studied relationships between melanin and five viscera(五臟), especially liver(肝), spleen(脾), kidney(腎). We Also studied representative pigmentary disorders(melasma, vitiligo) in western and Korean medicine to figure out how to understand pigmentary disorders in oriental medicine.Results : The results are as follows. 1. Melanin is associate with liver, because free coursing(疎泄) function of liver is the origin of transport melanin to keratinocyte from melanocyte. Also, melanogenesis factors like MITF and CREB are closely associated with liver and pigmentary disorders occur frequently after stress conditions or women. 2. Melanin is absorbed and scattered in keratinocytes by the function of spleen. Pigmentary disorders result from failure of spleen and formation of phlegm-retained fluid(痰飮). 3. Kidney essence(腎精) is the origin of melanin formation. In addition, corticosteroid, the major hormone of melanogenesis is secreted by adrenalin and adrenalin belongs to kidney(腎) in Korean medicine. 4. Melasma is created by disorder of melanin transport and absorbtion, so melasma is associated liver (肝) and spleen(脾). Therefore the treatment for melasma may focus on improvement function of liver and spleen. 5. The destruction of melanocyte or abnormal melanogenesis by disorder of the immune system, metabolic and affective disorders can make vitiligo, so vitiligo is associated with liver and kidney which are major part of melanin formation. Therefore the treatment of vitiligo can focus on improvement function of liver(肝) and kidney(腎).Conclusion : We compared Korean and western medicine to understand melanin. We also interpreted the mechanism of melanin and pigmantary disorders in western medicine and considered the relationship with visceral manifestation theory(臟象論) in traditional Korean medicine. Further studies are needed to apply comprehension of melanin to clinical stage.

EFFECT OF PROLYL 4-HYDROXYLASE INHIBITOR HOE 077 AND ITS DERIVATIVES ON THE COLLAGEN SYNTHESIS IN HSC-T6 CELLS

  • Joo, Yang-Hee;Jung, Seung-Hyun;Kim, Hyun-Jung;Lee, Eung-Seok;Yi, Jung-Bum;Lee, Namkyu;Cho, Yong-Baik;Kwak, Wie-Jong;Dong, Mi-Sook
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2002.11b
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    • pp.161-161
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    • 2002
  • The abnormal accumulation of collagen is progressive and often results in impairment of liver function, i.e. liver cirrhosis. Collagen synthesis requires several posttranslational events. Prolyl 4-hydroxylase is the key enzyme in collagen synthesis that catalyzes the hydroxylation of peptide-bound proline residues to 4-hydroxyroline.(omitted)

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Function Disease Symptom And Organ Coordination of Tri-Energizer Based on the Materiality of Tri-Energizer (삼초유형(三焦有形)으로 살펴본 삼초(三焦)의 기능(機能), 병증(病證) 및 장부배합(臟腑配合))

  • Yoon, Chang-Yeol
    • Journal of Korean Medical classics
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    • v.26 no.2
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    • pp.1-7
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    • 2013
  • Objective & Method : By investigating physiological function of tri-energizer, symptoms, and organ coordination, we obtained following conclusion. Tri-energizer is the membrane structure that surrounds the five visceral organs and six hollow organs, and filled with fluid. Tri-energizer acts as the passage for the flow of qi energy. Result & Conclusion : Therefore, dysfunction of the tri-energizer is caused by abnormal evaporation and metabolism. Upper-energizer regulates cardiopulmonary function, middle-energizer regulates spleen and stomach functions, and lower-energizer regulates liver, kidneys, small and large intestines, and bladder functions. Such a functional specialization is possible by receiving the source of qi through the wall wrapping around the internal organs. Tri-energizer represents the exterior and interior relationship by acting as the membrane structure supporting the five visceral organs and six hollow organs and at the same time, as the pericardium surrounding the heart.

The Safety and Efficacy of Herbal Medicine for 107 Psoriasis Patients: A Retrospective Chart Review (한약으로 치료 받은 건선 환자 107명의 안전성 및 유효성에 대한 고찰)

  • Lee, Byung-Chul;Choi, Eun-Ji
    • The Journal of Korean Medicine
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    • v.37 no.1
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    • pp.34-40
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    • 2016
  • Objectives: To observe safety and efficacy of herbal medicine for psoriasis patients. Methods: We did retrospective chart review for 107 psoriasis patients who had been treated by herbal medicine for 2 months, and we analyzed the liver function test (LFT) results and Psoriasis Area and Severity Index (PASI) scores of before and after the treatment. Results: The mean LFT and the number of patients with abnormal LFT decreased after the treatments. More than 95% of patients with normal LFT maintained normal results at after the treatment, and only 2.1% and 4.6% patients with normal LFT showed abnormal Glutamic Oxaloacetic Transaminase (GOT) and Glutamic Pyruvic Transaminase (GPT) results at after the treatment. Also, both mean PASI scores for all patients and patients with abnormal LFT before the treatment decreased significantly. Conclusions: This study suggest that herbal medicine may be safe and effective treatment for psoriasis.

Clinical Observations of Abnormal Glucose Tolerance in Hyperthyroidism (갑상선(甲狀腺) 기능항진증(機能亢進症)에서의 당부하(糖負荷)에 대(對)한 임상적(臨床的) 관찰(觀察))

  • Lee, Kyung-Ja;Lee, Hong-Kyu
    • The Korean Journal of Nuclear Medicine
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    • v.3 no.2
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    • pp.23-27
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    • 1969
  • Plasma glucose levels before and after oral glucose administration have been compared in a group of 76 thyrotoxic subjects and a group of 8 normal control subjects in order to study the effect of glucose loading in thyrotoxicosis. Following were the results: 1. The mean fasting plasma glucose level was elevated in the thyrotoxic group(95.5mg%) compared to normal control group (88mg%). 2. The peak of glucose tolerance curve is at 30 minutes after glucose administration in both groups, but its mean value was 44mg% higher in thyrotoxic group than in control group. 3. The plasma glucose levels returned towards the fasting level in the later stage of the test more rapidly in thyrotoxic group than in control group. 4. 69.6% of oral glucose tolerance tests were impaired in the thyrotoxic group, and the occurance of abnormal glucose tolerance could be related to the degree of thyrotoxicity, sex and age. 5. The mechanisms of the impaired glucose tolerance in thyrotoxicosis are thought to be related to an increased rate of glucose absorption from gastrointestinal tract, abnormal liver function with decreased hepatic glycogenesis, increased glucose oxidation, decreased pancreatic release of insulin, and genetic relationship between diabetes and thyrotoxicosis.

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A Case of Thickened Gallbladder Wall and Pneumonia in a Child with Infectious Mononucleosis (담낭염과 폐렴을 동반한 전염성 단핵구증 1례)

  • Kim, Hyun Soo;Kim, Hyung Suk;Shin, Young Kyoo;Eun, Baik Lin;Park, Sang Hee;Cha, Sang Hoon
    • Pediatric Infection and Vaccine
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    • v.4 no.1
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    • pp.167-173
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    • 1997
  • Acute infectious mononucleosis, caused by Epstein-Barr virus(EBV), is a self limited lymphoproliferative illness that is common in adolescents and young adults. It shows many complications in multiple organ systems, but the hepatobiliary and the respiratory complication is uncommon. We report a case with thickened gallbladder wall and pneumonia as complications of acute infectious mononucleosis in a child. Also the related literature were reviewed. A 4 year old boy presented with a history of high fever, cough, and abdominal distension for 20days. Physical Examination revealed audible crackles in whole lung field and gross hepatomegaly. Chest X-ray showed pneumonia and liver function tests were abnormal. Ultrasonography and computed tomography revealed a thickened gallbladder wall and hepatosplenomegaly. The diagnosis of primary Epstein-Barr viral infection was eventually made by specific serologic tests. The patients's fever subsided 6 weeks later and pneumonia was recovered around this time. Liver function tests returned near normal 2 months later and ultrasonography of gallbladder was normal at this time.

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Statistical Study on the Results of Daehan Life's Mediscreen(Human-dock) (당사(當社) 종합건강진단(綜合健康診斷)센터에서 실시(實施)한 수진자(受診者)의 통계학적관찰(統計學的觀察))

  • Kim, Byung-Kuck
    • The Journal of the Korean life insurance medical association
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    • v.4 no.1
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    • pp.24-37
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    • 1987
  • During the period from september, 1985 to september, 1986, 1,005 cases(475cases in male, 529 cases in female) of employees and family member were observed for the general physical examination(Human-dock) in Medical Department of Daehan Life Insurance Co. Ltd. The results were as follows. 1) The occurrence of obesity cases were observed as 130 cases(12.9%), and among the 130 cases, 34 cases(26.2%) were male and 96 cases(73.8%) were female. 2) Diabetes mellitus patients were detected as 93 cases(9.3%), and 53 cases(57.1%) were male and 40 cases(43.0%) were female. The most frequent age groups were demonstrated in age of 5th and 6th decades. 3) Hypertension patients were 85 cases(8.5%), and among the 85 cases, 42 cases (49.4%) were male and 43 cases(50.6%) were female. The most frequent age groups were 5th and 6th decades, and complication of hypertensive retinopathy revealed 54 cases(63.5%). 4) Hyperlipidemia cases were observed as 71(7.1%), and 42 cases(59.2%) were male and 29 cases(40.8%) were female. The most frequent age groups were 5th and 6th decades. 5) 69 cases(6.9%) of positive reaction of HBs Ag and 46 cases(4.6%) of abnormal erectrocardiography were detected in the total examination cases. 6) Abnormalities of liver function were observed as 58 cases(5.8%), and 46 cases(79.3%) were male and 12 cases(20.7%) were female. In ultrasonographic study, 25 cases of fatty liver were obtained in the abnormality cases of liver function. 7) Cholelithiasis and gastroduodenal ulcer patients were detected as 2 cases(2.0%) respectively. 8) In the total examination cases, pulmonary tuberculosis, positive reaction of syphilis and renal cysts(ultrasonography) were obtained as 9 cases(0.9%), 7 cases(0.7%) and 4 cases(0.4%) respectively. 9) In the total examination cases, gastric cancer and liver cancer patients were detected as 2 cases(0.2%) respectively.

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Relationships Between Alcohol Intake and Blood Pressure, Serum Lipids, Liver Function Tests and Obesity Indices in Middle-Aged Male Workers (중년 남성 근로자의 알코올 섭취와 혈압, 혈청 지질, 간기능검사치 및 비만지표와의 관련성)

  • Park, Sung-Kyeong;Cho, Young-Chae
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.16 no.5
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    • pp.3323-3332
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    • 2015
  • The purpose of this study was to investigated the effects of alcohol intake on blood pressure, serum lipids, liver function tests and obesity indices in middle-aged male workers. The 2,175 male workers aged 30-59 years who examined health checkup were recruited as the study subjects during the period between January to December, 2013. We observed the relationships between the amount of alcohol intake and blood pressure, serum lipids, liver function tests and obesity indices. As a result, the mean score of SBP, DBP, LDL-C and TG were significantly higher increasing with amount of alcohol increased, but HDL-C were significantly lower increasing with amount of alcohol increased. AST, ALT, ALP and ${\gamma}$-GTP were significantly higher increasing with amount of alcohol increased, but obesity indices were not significant. Age adjusted odds ratios(ORs) increasing with abnormal levels of SBP, DBP, HDL-C, LDL-C, TG, AST and ALT were significantly increased in heavy drinking group than light drinking group. Above results suggested that the heavy drink related with blood, serum lipid levels and liver function test levels, but not find out with obesity indices.

Effects of High Frequency Herbal Medication Administrations on the Liver Functions in Rats - Focusing on Sipjeondaebo-tang, Yukmaijihwang-tang, Bojungikgi-tang, and Ojeoksan - (다용 한약처방 투여가 흰쥐의 간기능에 미치는 영향 - 십전대보탕, 육미지황탕, 보중익기탕 및 오적산을 중심으로 -)

  • Han Yong-Joo;Lee Sun-Dong;Choi Jong-Hwan;Park Jong-Goo;Jang In-Soo;Park Hae-Mo
    • The Journal of Korean Medicine
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    • v.27 no.1 s.65
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    • pp.78-90
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    • 2006
  • Background : Traditional herbal medicine is used extensively among the Korean populations, and other Asian countries employ similar therapies as well. In recent years, extensive focus was laid on adulteration of the herbal medicine with liver damage. The use of herbal preparations as remedies for various medical conditions has continuously increased in Korea. Large proportions of Korean patients use herbal medicinal products, folk remedies, and health food. However, studies on the safety of herbal products are conducted on a less than sufficient basis even in the countries like Korea where herbal medicine is being used extensively. Some of the reports on the safety of herbs were done by the doctors of western medicine but lack of knowledge and misclassification led to misunderstandings. Objectives : This study aims to verify the evidences on safety of frequently used 4 herbal medications (Sipjeondaebo-tang, Bojungikgi-tang, Ohjeok-San, Yukmaijihwang-tang) in the lab animal model. Methods : Sprague-Dawley rats was treated by 4 herbal medications during 31 days. After 1 month, we checked body weight, liver weight, and serum enzyme associated with liver function. Results : There is no significant difference in body weight and liver weight after 1 month of administrations. In all experimental groups, no abnormal findings was observed in histotogical research and lab liver Functions test(AST, ALT etc). Conclusions : These four herbal medications, frequently used in oriental medicine clinics and hospitals, are safe from hepatoxic events in the lab animal model.

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Transforming growth factor-beta and liver injury in an arginine vasopressin-induced pregnant rat model

  • Govender, Nalini;Ramdin, Sapna;Reddy, Rebecca;Naicker, Thajasvarie
    • Clinical and Experimental Reproductive Medicine
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    • v.48 no.2
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    • pp.124-131
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    • 2021
  • Objective: Approximately 30% of preeclamptic pregnancies exhibit abnormal liver function tests. We assessed liver injury-associated enzyme levels and circulating transforming growth factor beta (TGF-β) levels in an arginine vasopressin (AVP)-induced pregnant Sprague-Dawley rat model. Methods: Pregnant and non-pregnant Sprague-Dawley rats (n=24) received AVP (150 ng/hr) subcutaneously via mini-osmotic pumps for 18 days. Blood pressure was measured, urine samples were collected, and all animals were euthanized via isoflurane. Blood was collected to measure circulating levels of TGF-β1-3 isomers and liver injury enzymes in pregnant AVP (PAVP), pregnant saline (PS), non-pregnant AVP (NAVP), and non-pregnant saline (NS) rats. Results: The PAVP group showed significantly higher systolic and diastolic blood pressure than both saline-treated groups. The weight per pup was significantly lower in the AVP-treated group than in the saline group (p<0.05). Circulating TGF-β1-3 isomer levels were significantly higher in the PAVP rats than in the NS rats. However, similar TGF-β1 and TGF-β3 levels were noted in the PS and PAVP rats, while TGF-β2 levels were significantly higher in the PAVP rats. Circulating liver-type arginase-1 and 5'-nucleotidase levels were higher in the PAVP rats than in the saline group. Conclusion: This is the first study to demonstrate higher levels of TGF-β2, arginase, and 5'-nucleotidase activity in PAVP than in PS rats. AVP may cause vasoconstriction and increase peripheral resistance and blood pressure, thereby elevating TGF-β and inducing the preeclampsia-associated inflammatory response. Future studies should explore the mechanisms through which AVP dysregulates liver injury enzymes and TGF-β in pregnant rats.