• 대한임상검사과학회지
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• 제49권4호
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• pp.395-400
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• 2017

아토피 피부염은 만성염증 피부질환으로서 유전적 요소, 환경적 요소, 면역반응의이상, 피부장벽단백질의 기능 이상에 의하여 발생한다. 본 연구의 목적은 피부장벽단백질의 발현을 측정할 수 있는 ELISA 키트 개발에 있다. AriNo와 D-Squame 패치를 이용하여 비침습적으로 피부에서 단백질을 얻을 수 가 있었고, AriNO가 좀 더 많은 단백질을 획득하였다. 0.1% Triton X-100용액이 다른 용해용액인 0.1 M Tris-HCL, 5 mM KOH, 0.1% Tween-20보다 높은 단백질 수율을 나타냈다. 피부장벽 단백질 측정을 위한 ELISA 키트 개발을 위하여 분자생물학적인 방법을 이용하여 필라그린과 인보루크린의 재조합단백질을 생산하였고, 이에 대한 단일클론항체를 면역학적인 방법을 이용하여 만들었다. 아토피 피부염 환자의 피부에서는 필리그린의 발현이 유의하게 줄어들었고, 인보루크린은 정상인과 아토피 피부염 환자에서 차이를 나타내지 않았다. 본 연구의 결과를 통하여 아토피 피부염에서 피부장벽단백질의 중요성을 규명하였고, 향후 아토피 피부염의 진단키트를 개발하는데, 유용할 것이다.

• 천문학회지
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• 제29권spc1호
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• pp.227-228
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• 1996

The long-term light curves of the novalikes TT Ari, KR Aur, AM Her and MV Lyr, were compiled and analysed for solar-like cyclical behaviour. The frequency analysis showed long-term cyclical modulations of the brightness of the stars, which can be ascribed to changes of the radii of the late type secondaries in order of ${\Delta}R/R{\simeq} 10^{-4}-10^{-5}$.

• 한국원자력학회:학술대회논문집
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• 한국원자력학회 1996년도 춘계학술발표회논문집(1)
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• pp.15-20
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• 1996

이 논문에서는 육방형 노심 해석용으로 제작된 코드인 HEXFEM의 연소계산 결과의 정확성을 VVER-1000 연소계산 벤치마크 문제를 통하여 검증하였으며 집합체내 연소도 구배효과에 따른 오차를 분석하였다. 집합체내 연소도 구배효과를 고려했을 때 집합체내 균일한 연소도를 가정했을 때보다 오차가 현저히 감소하였으며 Cubic Option의 결과는 제어봉이 삽입된 1주기초(BOC1 ARI), 1주기초(BOC1), 1주기말(EOC1), 2주기초(BOC2)에 대해 집합체별 상대출력 오차가 최대 0,4%로 매우 정확한 결과를 얻었고 Quadratic Option외 결과도 최대 2.0%로 비교적 정확한 결과를 얻었다.

• 대한치과교정학회지
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• 제43권2호
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• pp.96-100
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• 2013

Objective: To evaluate the effects of contamination by either blood or a hemostatic agent on the shear bond strength (SBS) of orthodontic buttons. Methods: We used 45 freshly extracted, non-carious, impacted third molars that were divided into 3 groups of 15. Each tooth was etched with 37% phosphoric acid gel for 30 s. Human blood or the blood stopper agent was applied to the tooth surface in groups I and II, respectively. Group III teeth were untreated (controls). Orthodontic buttons were bonded to the teeth using light-curing composite resin. After bonding, the SBS of the button was determined using a Universal testing machine. Any adhesive remaining after debonding was assessed and scored according to the modified adhesive remnant index (ARI). ANOVA with post-hoc Tukey's test was used to determine significant differences in SBS and Fisher's exact test, to determine significant differences in ARI scores among groups. Results: ANOVA indicated a significant difference between groups (p < 0.001). The highest SBS values were measured in group III ($10.73{\pm}0.96$ MPa). The SBS values for teeth in groups I and II were significantly lower than that of group III (p < 0.001). The lowest SBS values were observed in group I teeth ($4.17{\pm}1.11$ MPa) (p < 0.001). Conclusions: Contamination of tooth surfaces with either blood or hemostatic agent significantly decreased the SBS of orthodontic buttons. When the contamination risk is high, it is recommended to use the blood stopper agent when bonding orthodontic buttons on impacted teeth.

• Journal of Microbiology and Biotechnology
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• 제21권6호
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• pp.556-566
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• 2011

A total of 31 Acinetobacter isolates were obtained from the rhizosphere of Pennisetum glaucum and evaluated for their plant-growth-promoting traits. Two isolates, namely Acinetobacter sp. PUCM1007 and A. baumannii PUCM1029, produced indole acetic acid (10-13 ${\mu}g$/ml). A total of 26 and 27 isolates solubilized phosphates and zinc oxide, respectively. Among the mineral-solubilizing strains, A. calcoaceticus PUCM1006 solubilized phosphate most efficiently (84 mg/ml), whereas zinc oxide was solubilized by A. calcoaceticus PUCM1025 at the highest solubilization efficiency of 918%. All the Acinetobacter isolates, except PUCM1010, produced siderophores. The highest siderophore production (85.0 siderophore units) was exhibited by A. calcoaceticus PUCM1016. Strains PUCM1001 and PUCM1019 (both A. calcoaceticus) and PUCM1022 (Acinetobacter sp.) produced both hydroxamate-and catechol-type siderophores, whereas all the other strains only produced catechol-type siderophores. In vitro inhibition of Fusarium oxysporum under iron-limited conditions was demonstrated by the siderophore-producing Acinetobacter strains, where PUCM1018 was the most potent inhibitor of the fungal phytopathogen. Acinetobacter sp. PUCM1022 significantly enhanced the shoot height, root length, and root dry weights of pearl millet seedlings in pot experiments when compared with controls, underscoring the plant-growth-promoting potential of these isolates.

• 대한치과교정학회지
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• 제43권3호
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• pp.127-133
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• 2013

Objective: We aimed to investigate the effects of silanation time on the shear bond strength (SBS) of metal brackets on gold alloy in a silicoating procedure and compare the SBS of metal brackets on gold alloy and enamel. Methods: Type III gold alloy plates were sandblasted with 30-${\mu}m$ silicon dioxide. Excess particles were removed with gentle air after silica coating, and silane was applied. Maxillary central-incisor metal brackets were bonded to each conditioned alloy surface with a light curing resin adhesive for 1 s, 30 s, 60 s, or 120 s after applying silane. The brackets were also bonded to 36 upper central incisors with the same adhesive. All samples were cured for 40 s with a light emitting diode curing light. The SBS was tested after 1 h and after 24 h. The adhesive remnant index (ARI) of the samples was also compared. Results: The 60-s and 120-s silanation time groups showed a higher SBS than the other groups (p < 0.05). Samples tested after 24 h showed a significantly higher SBS than did the samples tested after 1 h (p < 0.05). The 1-s group showed higher ARI scores. The one-way analysis of variance and Student-Newman-Keuls test showed that the SBS values of the 60-s and 120-s silanation time groups were not significantly different from the SBS values of enamel. Conclusions: Adequate silanation time is required to produce sufficient bond strength during silicoating.

• 생약학회지
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• 제40권4호
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• pp.394-399
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• 2009

Aldose reductase (AR) is a critical enzyme in the development of the diabetic complications. AR, the first enzyme in the polyol pathway, catalyzes the reduction of the aldehyde form of glucose to sorbitol with concomitant conversion of NADPH to $NADP^+$. None of aldose reductase inhibitor (ARI) has achieved worldwide use because of limited efficacy or undesirable side effects. Therefore, evaluating natural sources for ARI potential may lead to the development of safer and more effective agents against diabetic complications. Forty eight Chinese herbal medicines have been investigated for inhibitory activities on AR. Among them, seven herbal medicines, Buddleja officinalis (whole plant), Lonicera japonica (leaf and flower), Polygonum aviculare (aerial part), Polygonum aviculare (whole plant), Salvia miltiorrhiza (root), Schisandra chinensis (stem), and Zanthoxylum armatum (leaf and stem) exhibited a significant inhibitory activity against AR. Particularly, L. japonica and P. aviculare showed two times more potent inhibitory activity than the positive control, 3,3-tetramethyleneglutaric acid (TMG).

• Journal of Astronomy and Space Sciences
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• 제23권2호
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• pp.143-152
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• 2006

밝은 장주기 변광성들을 효율적으로 관측하기 위하여 충북대학교 교내에 자동관측시스템을 구축하였다. 이 시스템의 구성을 위하여 기존의 Meade사 LX200 40cm 망원경의 구동부를 개선하고, ObsTool II라는 관측프로그램에 의하여 망원경, CCD 카메라, 돔의 제어가 하나의 프로그램으로 가능하도록 구성하였다. ObsTool II는 COM(Common Object Module)을 이용하여 개발한 프로그램으로서 시스템을 구성하는 망원경이나 CCD 카메라의 기종이 바뀌어도 큰 수정 없이 시스템을 재구성할 수 있다. 또한, 이 시스템은 광전측광관측처럼 변광성, 비교성, 검토성 등을 오가는 기능을 가지고 있어 CCD의 시야에 적당한 비교성이 함께 들어오지 않더라도 관측이 가능하다. 이 논문에서 새롭게 구성한 자동관측시스템의 안정성을 검토하기 위하여 W UMa형 변광성 V523 Cas와 자기 격변변광성 TT Ari를 관측하여 그 결과를 제시하면서 본 논문에서 개발한 시스템들의 활용가능성을 토의하였다.

• 한국통신학회논문지
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• 제32권3A호
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• pp.310-318
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• 2007

RFID 시스템은 작고 값싼 태그를 물품에 부착하여, 이를 이용해서 물품들을 식별하는 비접촉식 자동인식 시스템이다. 이 시스템은 현재 가장 많이 사용되고 있는 접촉식 판독 기법인 바코드를 대처할 것으로 예상된다. RFID 시스템은 다양한 응용분야가 존재한다. 그 중 Ari Juels는 2개의 태그가 동시에 인식된 것을 증명할 필요가 있는 환경을 설명하고, 이를 위한 프로토콜로 yoking proof 프로토콜을 제안하였다. 하지만 yoking proof 프로토콜은 재생 공격에 약하다. 이를 보완하기 위한 변형된 yoking proof 프로토콜들이 제안되었지만, 역시 재생 공격에 자유롭지 못했다. 본 논문에서는 기존 yoking proof프로토콜들의 문제점을 분석하고 이를 바탕으로 재생 공격을 어렵게 하는 새로운 프로토콜을 제안한다. 또한 이 프로토콜을 n개의 태그에 대한 yoking proof를 제공할 수 있도록 프로토콜을 확장시켰다.

• 대한치과교정학회지
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• 제41권2호
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• pp.121-126
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• 2011

Objective: The purpose of this study was to evaluate shear bond strength (SBS) and failure site location of brackets bonded to enamel with or without desensitizer application. Methods: Sixty-six freshly extracted human premolar teeth were randomly divided into 3 groups of 22. Group 1 served as the control. Desensitizer was applied to the remaining teeth at two time intervals (Group 2, bonded immediately after Pro-$Relief^{TM}$ (Colgate-Palmolive Co., New York, NY, USA) application and Group 3, bonded 30 days after Pro-$Relief^{TM}$ application with the teeth stored in artificial saliva during the 30 days). Orthodontic brackets were bonded with a light cure composite resin and cured with a halogen light. After bonding, the SBS of the brackets was tested using a universal testing device. Adhesive remnant index (ARI) scores were determined after the brackets failed. Data were analyzed with analysis of variance, Tukey's HSD, and G tests. Results: The SBS was significantly lower in Group 2 than in Groups 1 (p = 0.024) and 3 (p = 0.017). Groups 1 and Group 3 did not differ (p = 0.991). ARI scores did not differ significantly among groups. Conclusions: The Pro-$Relief^{TM}$ desensitizer agent applied immediately before bonding significantly reduces bond strength, but the SBS values still exceed the minimum 5.9 - 7.8 MPa required for adequate clinical performance. Immersing the teeth in artificial saliva for 30 days after applying the Pro-$Relief^{TM}$ desensitizer agent and before bonding increased the SBS to control levels.