• Title/Summary/Keyword: AR(l)

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Effects of β3-Adrenergic Receptor Polymorphism on the Hyperglycemia in Korean Subjects (베타 3-아드레날린 수용체의 유전자형이 고혈당증 유발에 미치는 영향)

  • 오현희;최선미;양현성;김길수;윤유식
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.33 no.1
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    • pp.83-90
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    • 2004
  • This study was conducted to examine the effects of $\beta$3-adrenergic receptor polymorphism on the blood glucose level and obesity in 530 volunteers, who attended a weight loss program in a local obesity clinic. The age differences in total subjects and the distribution of male and female were 26.55$\pm$0.31 yr, 9.1% (n=48), 90.9% (n=492). The genotype distribution of $\beta$3-AR gene polymorphism were WW type 75%, WR type 22% and RR type 3%. Among many parameters, fasting blood glucose was significantly higher in WR+RR type (p=0.001) compared with WW type. When the subjects were divided into two groups by 6.105 mmol/L of the fasting blood glucose level, the frequency of hyperglycemia was 23.3% in WW type subjects, while there was a increase to 35.6% in WR+RR type subjects (p=0.011, $\chi$$^2$-analysis). When hyperglycemia group was compared with normoglycemia group, obesity index (p=0.044), %body fat (p=0.046) and TG (p=0.000) were significantly higher, and HDL (p=0.006) was significantly lower in the hyperglycemia. When all of the above factors were included in stepwise logistic regression analysis to find risk factors of hyperglycemia, the results were that the odds ratio for hyperglycemia were 2.015 (p=0.011) for WR+RR type of $\beta$3-AR gene, 2.165 (p=0.000) for TG and 0.419 (p=0.059) for HDL cholesterol. There was a significantly positive correlation between the blood glucose vs BMI, WHR, body fat in the WW type (r=0.099, 0.119, 0.082) However, in the WR and RR type there were no significance between the blood glucose vs BMI, WHR, body fat. These data suggest that the WR+RR genotype of $\beta$3-AR has a very strong association with increased blood glucose level and might be a significant risk factor for hyperglycemia among Korean subjects.

ROBUST $L_{p}$-NORM ESTIMATORS OF MULTIVARIATE LOCATION IN MODELS WITH A BOUNDED VARIANCE

  • Georgly L. Shevlyakov;Lee, Jae-Won
    • The Pure and Applied Mathematics
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    • v.9 no.1
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    • pp.81-90
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    • 2002
  • The least informative (favorable) distributions, minimizing Fisher information for a multivariate location parameter, are derived in the parametric class of the exponential-power spherically symmetric distributions under the following characterizing restrictions; (i) a bounded variance, (ii) a bounded value of a density at the center of symmetry, and (iii) the intersection of these restrictions. In the first two cases, (i) and (ii) respectively, the least informative distributions are the Gaussian and Laplace, respectively. In the latter case (iii) the optimal solution has three branches, with relatively small variances it is the Gaussian, them with intermediate variances. The corresponding robust minimax M-estimators of location are given by the $L_2$-norm, the $L_1$-norm and the $L_{p}$ -norm methods. The properties of the proposed estimators and their adaptive versions ar studied in asymptotics and on finite samples by Monte Carlo.

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Age of the volcanism and deposition determined from the Cretaceous strata of the islands of Yeosu-si (여수시 도서지역의 백악기층에 나타나는 화성활동 및 퇴적시기)

  • Park, Kye-Hun;Paik, In-Sung;Huh, Min
    • The Journal of the Petrological Society of Korea
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    • v.12 no.2
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    • pp.70-78
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    • 2003
  • Sado, Chudo, Mokdo, Nangdo, and Jeokgeumdo are the islands which belong to Hwajeong-myeon, Yeosu-si, Jeollanam-do and there are various kinds of volcanic rocks, volcaniclastic sedimentary rocks, and dinosaur-fossil bearing sedimentary rocks on these islands. This study is designed to constrain geologic ages of these volcanic and sedimentary rocks. K-Ar ages of these rocks indicate that the volcanism of this area occurred mainly during the period of 91.8 ${\pm}$ 3.5∼65.5 ${\pm}$ 1.3(l$\sigma$) Ma. Deposition ages of the sedimentary rocks were bracketed based on the ages of the volcanic rocks and observed field relationship between sedimentary and volcanic rocks. The oldest sedimentary deposit of the area is the volcanic pebble bearing conglomerate of the Jeokgeumdo and its deposition age is ca. 81 Ma or less. The deposition age of the Chudo shale, which belongs to stratigraphically upper sequence and bears many dinosaur footprints, is at least ca. 77 Ma. Conglomerate of the Mokdo was deposited at ca. 72∼70 Ma. The deposition age of the dinosaur fossil deposit of the Sado is at least ca. 65 Ma. All the investigated volcanic and sedimentary rocks of the Yeosu islands were formed during the late Cretaceous and dinosaurs lived until the latest Cretaceous in this area.

Effects of packaging method and root trimming on quality of green onion (Allium fistulosum L.) during storage (대파(Allium fistulosum L.)의 포장 방법과 뿌리 손질이 저장 중 품질에 미치는 영향 )

  • Ji Weon Choi;MiAe Cho;Ki-Sik Jung;Jae Han Cho;Ji Hyun Lee;Sooyeon Lim
    • Food Science and Preservation
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    • v.31 no.3
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    • pp.433-443
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    • 2024
  • This study investigated the effect of packaging method and root trimming on quality of green onions during storage. Two packaging methods (tied with string, S or packaged with film bag, FP) and two root trimming states (attaching the roots without trimming, AR or cutting the roots leaving about 5 mm, CR) were treated after harvest. Then, the green onions stored at 20℃ for 8 days and 1℃ for 6 weeks to investigate changes in quality. When stored at 20℃, the differences in marketability between S and FP were minimal, while when stored at 1℃, the marketability of the FP remained higher than that of S. The leaf color change in CR progressed faster than in the AR treatment group, leading to faster quality deterioration. The occurrence of weight loss, browning, and softening of stems progressed as the storage period elapsed. However, except weight loss, they were at a level that did not affect marketability within the marketability limit period determined by color change and wiltig of leaves. The allicin and quercetin contents of stems increased in the early stages when quality deteriorated after harvest but decreased as quality deterioration became more severe.

Timing of the Hydrothermal Alteration Associated with the Fault Activities along the Ulsan Fault Bone, Southeast Korea (울산단층대의 단층활동에 수반된 열수변질작용시기)

  • 조규환;다카기히데오;이와무라아키라;아와지도타;장태우;손승완;이타야테츠마루;오카다도시노리
    • Economic and Environmental Geology
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    • v.34 no.6
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    • pp.583-593
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    • 2001
  • Clay minerals are common component of fault gouge and have been used to determine the fault activity age using K-Ar dating technique. We carried out XRD and K-Ar analyses of the mica clay minerals from the fault gouge along the Ulsan Fault Zone, southeastern Korea to estimate the timing of the major fault activity. Mica clay minerals for four grain size fractions of 5-2 Um, 2-1 $\mu$m, 1-0.35$\mu$m, and 0.35-0.05 $\mu$m were separated from the gouge samples in the three locations by the hydraulic elutriation and contrifugal separator. Fault gouges are composed of smectite, mica clay minerals, kaolinite, chlorite, quartz, and feldspar. The illite crystallinity of mica clay minerals is the highest in the finest grained fraction with lM polytype, indicating that the aulhigenic mica clay minerals have been concentrated in the fraction. K-Ar ages give some variation from 46 to 35 Ma (330-2), 45 to 39 Ma (16Ww), and 32 to 15 Ma (102Ws) and are the youngest in the finest grained fraction. These results suggest that the hydrothermal alteration associated with the major fault activities along the Ulsan fault Zone took place twice at 39-35 Ma and 15 Ma.

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Structural and Optical Properties of TiO2 Thin Films Prepared by RF Reactive Magnetron Sputtering (RF reactive magnetron sputtering으로 제조한 TiO2 박막의 구조 및 광학적 특성)

  • Gang, Gye-Won;Lee, Yeong-Hun;Gwak, Jae-Cheon;Lee, Dong-Gu;Jeong, Bong-Gyo;Park, Seong-Ho;Choe, Byeong-Ho
    • Korean Journal of Materials Research
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    • v.12 no.6
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    • pp.452-457
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    • 2002
  • Titanium oxide films were prepared by RF reactive magnetron sputtering. The effect of sputtering conditions on structural and optical properties was investigated systemically as a function of sputtering pressure(5~20 mTorr) and $O_2/Ar$ flow ratio(0.08~0.4). The results of the X-ray diffraction showed that all films had only the anatase $TiO_2$ phase. At low sputtering pressure and $O_2/Ar$ flow ratio, the films had preferred orientations along [101] and [200] directions. As the sputtering pressure and $O_2/Ar$ flow ratio increased, the intensity of the 101 and 200 diffraction peaks decreased gradually. The microstructure of the sputtered films showed the fine grain size (20nm~50nm) and columnar microcrystals perpendicular to the substrate. With increasing the sputtering pressure and decreasing $O_2/Ar$ flow ratio, the sputtered films showed the more porous columnar structure. XPS analysis showed that stoichiometric $TiO_2$ films were deposited at 7 mTorr sputtering pressure and 0.2 $O_2/Ar$ flow ratio. The results of the X-ray diffraction showed that all films had only the anatase $TiO_2$ phase. Ellipsometeric analysis showed that the refractive index increased from 2.32 to 2.46 as the sputtering pressure decreased. The packing density calculated using the refractive index varied from 0.923 to 0.976, indicating that $TiO_2$films became denser as the sputtering pressure decreased.

Effect of Nonwoven Fabrics Materials on the Growth and Yield of Korea Melon (Cucumis melo L. var. makuwa Mak.) (보온부직포 재료가 참외의 생육 및 수량이 미치는 영향)

  • Shin, Yong-Seub;Lee, Ji-Eun;Yeon, Il-Kweon;Cheung, Jong-Do;Choi, Seong-Yong;Lee, Ki-Do
    • Journal of Bio-Environment Control
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    • v.18 no.2
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    • pp.101-106
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    • 2009
  • To study the effect of nonwoven fabric materials on growth and yield of korea melon, Medium denier nonwoven fabrics (MDNF), Polyster nonwoven fabrics (PENF) and 12 ounce nonwoven fabric (control) were used. Mean temperature at night was 13.1$^{\circ}C$ at control, 14.7$^{\circ}C$ at MDNF and 13.3$^{\circ}C$ at PENF from Feb. 6${\sim}$7, 2009. Because of higher temperature, early growth of korea melon of MDNF was better than control at 30 days after transplanting. Days required to harvesting (DRH) of control was 89, those of PENF and MDNF were 88, 78, respectively. First harvesting of MDNF was 11 days earlier than control. Harvested fruit of MDNF had higher weight, soluble solid and marketable fruit ratio than control. Yield ratio of control and PENF was 4:3:3 (early:middle:late harvesting season), but MDNF was 5:3:2. Using of MDNF provided earlier harvesting. Total yield of PENF was similar to control, 1,844kg per lOa, MDNF was increased by 9%.

The Inhibitory Effects of Bimanbang-1(肥滿1號方) on the Obese-mouse Fed High-fat Diet (비만1호방(肥滿1號方)이 고지방식이(高脂肪食餌)로 비만(肥滿) 유도(誘導)된 백서(白鼠)에 미치는 영향)

  • Shin, Hong-Jung;Yoon, Il-Ji
    • The Journal of Korean Medicine
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    • v.29 no.2
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    • pp.116-132
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    • 2008
  • Objective: This study investigated the effects of Bimanbang-1 (肥滿1號方: here in after referred to BMB-1) on the obese gene and obese inhibitory. Methods: C57BL/6 mice were induced by high fat diet. Mice were divided into three groups (normal, high fat diet with control, high fat diet with BMB-1 extract) and fed for 15 weeks. Items of this experimental study are as follows: body weight change, final body weight, the weight change of the adipocytes in body, the level change of LFT, NEFA and creatinine, the expression of ${\beta}3AR$ and leptin gene in primary adipocytes, the production change of leptin in primary adipocytes, the expression of ${\beta}3AR$, leptin and $TNF-{\alpha}$ in adipocytes tissue. Result: 1. All experimental groups showedthat the weight change decreased considerably and the high density group showedthat the final weight decreased considerably. 2. The high density group showed that the amount of the adipocyte in weight decreased considerably. 3. All experimental groups showedthat the amount of ALT decreased considerably, and AST decreased in the high density group. However, the amount of creatinine and glucose did not increase considerably. 4. All experimental groups showed that the amount of total cholesterol, LDL-cholesterol, triglyceride, and NEFA decreased, and HDL-cholesterol increased considerably. 5. The high density groups showedthat the amount of leptin decreased considerably. 6. All experimental groups showed that the revelation of ${\beta}3AR$ in primary adipose cell and 3T3-L1 cell increased considerably, and that the revelation of leptin and $TNF-{\alpha}$ in primary adipose cellsand 3T3-L1 cells decreased considerably. 7. All experimental groups showed that the size of adipocyte in adipocytes tissue decreased. 8. All experimental groups showed that the adipose vacuoles in liver tissue decreased considerably. Conclusion: The findings suggest that Bimanbang-1 causes weight loss and histological change, thus it may be effective to treat obesity.

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