• The Korean Journal of Physiology and Pharmacology
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• 제28권1호
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• pp.11-19
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• 2024

Acute kidney injury (AKI) is one of the major complications of sepsis. Aurantio-obtusin (AO) is an anthraquinone compound with antioxidant and anti-inflammatory activities. This study was developed to concentrate on the role and mechanism of AO in sepsis-induced AKI. Lipopolysaccharide (LPS)-stimulated human renal proximal tubular epithelial cells (HK-2) and BALB/c mice receiving cecal ligation and puncture (CLP) surgery were used to establish in vitro cell model and in vivo mouse model. HK-2 cell viability was measured using MTT assays. Histological alterations of mouse renal tissues were analyzed via hematoxylin and eosin staining. Renal function of mice was assessed by measuring the levels of serum creatinine (SCr) and blood urea nitrogen (BUN). The concentrations of pro-inflammatory cytokines in HK-2 cells and serum samples of mice were detected using corresponding ELISA kits. Protein levels of factors associated with nuclear factor kappa-B (NF-κB) pathway were measured in HK-2 cells and renal tissues by Western blotting. AO exerted no cytotoxic effect on HK-2 cells and AO dose-dependently rescued LPS-induced decrease in HK-2 cell viability. The concentrations of pro-inflammatory cytokines were increased in response to LPS or CLP treatment, and the alterations were reversed by AO treatment. For in vivo experiments, AO markedly ameliorated renal injury and reduced high levels of SCr and BUN in mice underwent CLP operation. In addition, AO administration inhibited the activation of NF-κB signaling pathway in vitro and in vivo. In conclusion, AO alleviates septic AKI by suppressing inflammatory responses through inhibiting the NF-κB pathway.

• Journal of Veterinary Science
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• 제25권3호
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• pp.37.1-37.10
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• 2024

Importance: The portal vein to aorta (PV/Ao) ratio is used to assess the clinical significance of extrahepatic portosystemic shunt (EHPSS). Previous studies using computed tomography (CT) were conducted in dogs but not in cats. Objective: This study aimed to establish normal reference values for PV indices (PV/Ao ratio and PV diameter) in cats and determine the usefulness of these for predicting symptomatic EHPSS. Methods: This study included 95 dogs and 114 cats that underwent abdominal CT. The canine normal (CN) group included dogs without EHPSS. The cats were classified into feline normal (FN, 88/114), feline asymptomatic (FA, 16/114), and feline symptomatic (FS, 10/114) groups. The PV and Ao diameters were measured in axial cross-sections. Results: The group FN had a higher PV/Ao ratio than the group CN (p < 0.001). Within the feline groups, the PV indices were in the order FN > FA > FS (both p < 0.001). The mean PV diameter and PV/Ao ratio for group FN were 5.23±0.77 mm and 1.46±0.19, respectively. The cutoff values between groups FN and FS were 4.115 mm for PV diameter (sensitivity, 100%; specificity, 97.7%) and 1.170 for PV/Ao ratio (90%, 92.1%). The cutoff values between group FA and FS were 3.835 mm (90%, 93.8%) and 1.010 (70%, 100%), respectively. Conclusions and Relevance: The results demonstrated significant differences in PV indices between dogs and cats. In cats, the PV/Ao ratio demonstrated high diagnostic performance for symptomatic EHPSS. The PV diameter also performed well, in contrast to dogs.

• 한국정보통신학회논문지
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• 제27권1호
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• pp.131-134
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• 2023

The age of information (AoI) was proposed to quantify the freshness of information about the status of a remote source system, which is defined as the amount of time that has elapsed since a packet was created at its source. This paper analyzes the age of information of a discrete time Geo/D/1/1 status update system. For this purpose, the system is modeled as a discrete-time two-state Markov chain. The stationary probability distributions for peak AoI and AoI are obtained. The average peak AoI, the average AoI, and the freshness ratio of information are also derived. Some numerical results of the analysis are presented.

• Current Optics and Photonics
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• 제8권2호
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• pp.183-191
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• 2024

High-resolution retinal imaging based on adaptive optics (AO) is important for early diagnosis related to retinal diseases. However, in practical applications, closed-loop AO correction takes a relatively long time, and traditional open-loop correction methods have low accuracy in correction, leading to unsatisfactory imaging results. In this paper, a SH-U-net-based open-loop AO wavefront correction method is presented for a retinal AO imaging system. The SH-U-net builds a mathematical model of the entire AO system through data training, and the Root mean square (RMS) of the distorted wavefront is 0.08λ after correction in the simulation. Furthermore, it has been validated in experiments. The method improves the accuracy of wavefront correction and shortens the correction time.

• 한국지구과학회지
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• 제29권5호
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• pp.375-385
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• 2008

The relationship between two interannual climate variabilities and the frequency of tropical cyclone (TC) that landed over the Korean Peninsula (KP) has investigated for the period of 1951-2004. In the analysis of the relationship between KP-landfall TC frequency and the ENSO phase, most TCs of C-14 (TCs that do not pass through mainland China before landing the KP) and C-23 (TCs that pass through mainland China before landing the KP) tended to more land in the warm phase than normal and cold phases. However, TC intensity at landfall was stronger in the cold and normal phases. In the analysis of the relationship between KP-landfall TC frequency and Arctic Oscillation (AO) phase, the TCs of C-14 tended to more land in the positive (POS) phase of AO and the negative (NEG) phase of AO for C-23. It was found that AO index was negatively correlated with the Ni$\tilde{n}$o-3.4 index. And then the TCs of C-14 landed more frequently over the KP in the AO POS - Ni$\tilde{n}$o-3.4 NEG phases and in the AO NEG - Ni$\tilde{n}$o-3.4 POS phases for the TCs of C-23.

• 대기
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• 제20권4호
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• pp.387-398
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• 2010

This study shows that frequency of tropical cyclone (TC) around Korea in summer (June-September) has positive relation with Arctic Oscillation (AO) in the preceding April. In a positive AO phase, each of anomalous cyclone and anomalous anticyclone is developed in low latitude and middle latitude regions of East Asia from the preceding April to summer. As a result, while anomalous southeasterly around Korea serves as a steering flow that TCs move toward this area is strengthened, northwesterly that reinforced in southeastern area of East Asia plays a role in preventing TCs from moving toward this area. In addition, due to this distribution of pressure systems developed in this AO phase, TCs tend to occur, move and recurve in further northeastern region in the western North Pacific than TCs in a negative AO phase. On the contrary, TCs in a negative AO phase mainly move westward toward southern China or Indochina Peninsula from Philippines. Eventually, intensity of TCs is weaker than those in a positive AO phase due to the terrain effect caused by high passage frequency of TCs in mainland China.

• Ocean and Polar Research
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• 제37권4호
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• pp.265-278
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• 2015

We analyzed the North Pacific Intermediate Water (NPIW) that was simulated in 25 coupled general circulation models (CGCMs) using historical and Representative Concentration Pathway 4.5 (RCP4.5) scenario experiments of Coupled Model Intercomparison Project Phase 5 (CMIP5), focusing on the evaluation of the performance of HadGEM2-AO. A large inter-model diversity in salinity, density, and depth of the NPIW exists even though the multi-model ensemble mean (MME) is comparable to observations. It was found that the depth of the NPIW tends to be deeper in the models in which the NPIW is relatively saltier. HadGEM2-AO simulates the lightest NPIW having the lowest salinity at shallower depth, compared with other CGCMs. Future projections of the NPIW show that the temperature of the NPIW increases, but the density decreases in all CMIP5 models. It was shown that the salinity of the NPIW decreases in most models and the decrease tends to be larger in models simulating the lighter NPIW. The HadGEM2-AO projects moderate changes in the temperature and density of the NPIW out of the CMIP5 models.

• 한국지구과학회지
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• 제40권1호
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• pp.1-8
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• 2019

Although recent reports suggest that the negative correlation between the Arctic Oscillation (AO) and the East Asian winter monsoon (EAWM) has been strengthened, it is not clear whether this intermittent relationship is an intrinsic oscillation in the climate system. We investigate the oscillating behavior of the AO-EAWM relationship at decadal time scales using the long-term (500-yr) climate model simulation. The results show that ice cover over the East Siberian Seas is responsible for the change in the coupling strength between AO and EAWM. We found that increased ice cover over these seas strengthens the AO-EAWM linkage, subsequently enhancing cold advection over the East Asia due to anomalous northerly flow via a weakened jet stream. Thus, this strengthened relationship favors more frequent occurrences of cold surges in the EAWM region. Results also indicate that the oscillating relationship between AO and EAWM is a natural variability without anthropogenic drivers, which may help us understand the AO-EAWM linkage under climate change.

• 대기
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• 제31권1호
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• pp.61-71
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• 2021

The relationship between the Arctic Oscillation (AO) and surface air temperature (SAT) over Korea is re-examined using the long-term observation and reanalysis datasets for the period of December 1958 to February 2020. Over the entire period, Korean SAT is positively correlated with the AO index with a statistically significant correlation coefficient, greater than 0.4, only in the boreal winter. It is found that this correlation is not static but changes on the decadal time scale. While the 15-year moving correlations are as high as 0.6 in 1980s and 1990s, they are smaller than 0.3 in the other decades. It is revealed that this decadal variation is partly due to the AO structure change over the North Pacific. In the period of 1980s-1990s, the AO-related sea level pressure fluctuation is strong and well defined over the western North Pacific and the related temperature advection effectively changes the winter SAT over Korea. In the other periods, the AO-related circulation anomaly is either weak or mostly confined within the central North Pacific. This result suggests that Korean SAT-AO index relationship, which becomes insignificant in recent decades is highly dependent on mean flow change in the North Pacific.

• 한국지구과학회지
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• 제32권7호
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• pp.732-749
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• 2011

본 연구에서는 HadGEM2-AO 자료를 처방한 RegCM4를 이용하여 CORDEX 동아시아 영역에 대한 27년(1979-2005)간의 장기적분을 수행하였고, 기온과 강수에 대한 모의성능을 분석하였다. RegCM4는 전반적으로 기온의 공간분포, 계절 및 경년변동을 현실성 있게 잘 모의한 반면, 강수의 경우 시 공간 분포를 적절히 모의하지 못하였다. 특히, RegCM4는 동아시아 여름몬순에 의한 강수대를 위도 $30^{\circ}N$ 이하에서 정체하게 모의하면서 여름철 남한의 강수를 매우 과소하게 모의하였다. HadGEM2-AO를 적용한 RegCM4는 기온모의에서는 재분석자료를 처방한 경우와 유사한 모의성능을 보이지만, 강수모의에서는 현저히 낮은 모의성능을 보였다. 이는 여름철 남서풍을 상대적으로 저위도에 치우치게 모의하는 HadGEM2-AO의 특성이 RegCM4에 영향을 주어 동아시아 여름몬순 강수대의 발달-쇠퇴과정을 RegCM4가 적절히 모의하지 못하면서 나타난 결과로 판단된다.