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Blood Gas Management of a Membrane Oxygenator During Cardiac Surgery with Deep Hypothermic Circulatory Arrest (막형산화기에 의한 저체온 순환정지 심장수술시 혈액가스 조절)

  • Kim, W. G.;Lim, C.;Baek, Y. H.
    • Journal of Biomedical Engineering Research
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    • v.19 no.3
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    • pp.279-284
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    • 1998
  • Deep hypothermic circulatory arrest(DHCA), in which systemic temperatures of 2$0^{\circ}C$ or less are used to allow temporary cessation of the circulation, is an useful adjunct in cardiac surgery. Because man in natural circumstances is never exposed to the extreme hypothermic condition, however, one of the controversial aspects is appropriate blood gas management($\alpha$STAT versus PH-STAT) during DHCA. This study aims to compare $\alpha$STAT with PH-STAT management for control of blood gases in experimental cardiopulmonary bypass(CPB) circuits with a membrane oxygenator. Fourteen young pigs were assigned to one of two strategies of gas manipulation. After a median sternotomy, CPB was established. Core cooling was initiated and continued until nasopharyngeal temperature fell below 2$0^{\circ}C$. The flow rate was set at 2,500 ml/min. Once their temperatures were below 2$0^{\circ}C$, the animals were subjected to circulatory arrest for 40mins. During cooling, blood gas was maintained according to either $\alpha$$\alpha$STAT or pH-STAT strategies. After DHCA, the body was rewarmed to normal body temperature. Arterial blood gases were measured before the onset of CPB, before cooling, before DHCA, at the point of 27$^{\circ}C$ during re-warming, on completion of re-warming. Cooling time was significantly shorter in $\alpha$-STAT than PH-STAT strategy, while there was no significant differences in rewarming time between two groups. Carbon dioxide was added between 5.5 and 3.0% in PH-STAT, while no carbon dioxide was added in $\alpha$STAT management. Amounts of oxygen administration were gradually lowered as temperature decreased. In this way, criteria of PH, PaCO, and PaO adjustments were satisfied in both $\alpha$STAT and PH-STAT management groups.

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A Study on the actual conditions of the use of them and the moves to strengthen home economics resources for school lifelong education in home economics teachers' view (가정과교사가 인식한 학교 평생교육을 위한 가정과 자원의 활용 실태 및 활성화 방안)

  • Kim, Sung-Hee;Chae, Jung-Hyun
    • Journal of Korean Home Economics Education Association
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    • v.18 no.4 s.42
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    • pp.127-141
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    • 2006
  • The purpose of this study was to investigate the actual conditions of the use of them and the moves to strengthen home economics resources for school lifelong education for parents and local residents. This study conducted a systematic random sampling. Questionnaires were distributed to home economics teachers from 285 middle schools, 123 high schools, and 130 of them were sampled as the subjects of this study. The results of this study were as follows. First, home economics teachers were active participating school lifelong educational program. But according to the result of research on the actual condition, the proportion of taking part in it was low. More than half of home economics teachers who took part in program's lecturer were in charge of computer courses. So they didn't show their ability as expert. Also they were in charge of several works than roll of lecturers. It was mentioned too great a burden. There is little in-service training for meeting specialization for school lifelong education. They wanted to take part of lecturers of program and preferred hours of being over class. More than half of them had intended to obtain a lifelong educator's license. The part of elective courses for obtaining a lifelong educator's license is similar to home economics educational contents. So, they have an advantage of obtaining it. Second, one-fifth of school that gave school life education carried out program of related home economics. Mostly they had mothers of students-oriented programs on artistic and leisure. But this is that home economics teachers mentioned less important teaching at society in the future. They importantly mentioned program on children's education in now and the future. Parents of students and local residents also extremely wanted it. For differentiated school life education, quality of programs is important greatly. Third, the actual condition of practical room relating home economics is only practice to cook mostly. So they are reluctant to be open it because of being responsible for the results from using there. It is necessary to ameliorate there's facilities and to increase there's area. Fourth, home economics teachers want to improve their specialization through in-service training, to develop and diffuse programs of superior quality, and to get extra pay for overtime from the government.

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Comparison of High Resolution Image by Ortho Rectification Accuracy and Correlation Each Band (고해상도 영상의 정사보정 정확도 검증 및 밴드별 상관성 비교연구)

  • Jin, Cheong-Gil;Park, So-Young;Kim, Hyung-Seok;Chun, Yong-Sik;Choi, Chul-Uong
    • Journal of Korean Society for Geospatial Information Science
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    • v.18 no.2
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    • pp.35-45
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    • 2010
  • The objective of this study is to verify the positional accuracy by performing the orthometric corrections on the high resolution satellite images and to analyze the band correlation between the high resolution images corrected with orthometric correction. The objectives also included an analysis on the correlation of NDVI. For the orthometric correction of images from KOMPSAT2 and IKONOS, systematic errors were removed in use of RPC data, and non-planar distortions were corrected with GPS surveying data. Also, by preempting the image points at the same positions within ortho images, a comparison was performed on positional accuracies between image points of each image and GPS surveying points. The comparison was also made on the positional accuracies of image points. between the images. For correlation of band and correlation of NDVI, the descriptive statistics of DN values were acquired for respective bands by adding the Quickbird images and Aerial Photographs undergone through orthometric correction at the time of purchase. As result, from a comparison on positional accuracies of Orthoimages from KOMPSAT2 and Ortho Images of IKONOS was made. From the comparison the distance between the image points within each image and GPS surveying points was identified as 3.41m for KOMPSAT2 and as 1.45m for IKONOS, presenting a difference of 1.96m. Whereas, RMSE between image points was identified as 1.88m. The level of correlation was measured by using Quickbird, KOMPSAT2, IKONOS and Aerial Photographs between inter-image bands and NDVI, showing that there were high levels of correlation between Quickbird and IKONOS identified from all bands as well as from NDVI, except a high level of correlation that was identified between the Aerial Photographs and KOMPSAT2 from Band 2. Low levels of correlation were also identified between Quickbird and Aerial Photographs from Band 1. and between KOMPSAT2 and IKONOS from Band 2 and Band 4, whereas, KOMPSAT2 showed low correlations with Aerial Photographs from Band 3. For NDVI, KOMPSAT2 showed low level of correlations with both of QuickBird and IKONOS.

Iron Status According to Serum Selenium Concentration and Physique in Young Female Adults (젊은 여성의 혈청 셀레늄 농도 및 체격에 따른 체내 철 수준)

  • Lee, Ok-Hee;Chung, Yong-Sam;Moon, Jong-Wha
    • Journal of Nutrition and Health
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    • v.43 no.2
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    • pp.114-122
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    • 2010
  • Se and Fe are trace minerals acting as antioxidant scavenging free radicals. Iron deficiency is the most frequently reported nutritional deficiency in females. Body iron status are known to be dependent not only upon dietary iron intake, but also upon micro-mineral nutrition and obesity. Antioxidants such as selenium are reported to play an important role on the regulation of erythropoiesis by protecting RBC membrane from antioxidative damage. In this study, iron status in young females and its relationships with selenium status and physique were examined. Serum selenium and iron concentrations were measured by HANARO research reactor using neutron activation analysis method (NAA-method). The proportion with iron deficiency and anemia were 27.1% and 8.6%, respectively in young females, but the proportion with iron deficient anemia was 1.4%. The mean serum selenium level was $12.0\;{\mu}g/dL$ and in normal range in the young women. The study participants were tertiled according to BMI and serum selenium levels. Serum ferritin and iron levels inclined with increasing BMI tertiles. Serum iron and RBC count were higher in middle selenium group than low selenium group. Individuals had significantly lower hematocrit level in the lowest tertile for their serum selenium levels compared with the highest tertile. The serum ferritin level was predicted 25% by BMI and RBC count 26.2% by the serum selenium level and body fat%. In conclusion, this study shows that body iron status in young adult females are influenced by obesity and body selenium status.

Modulation of Immune Parameters by Aging Process (노화에 따른 면역지표의 변화에 관한 연구)

  • Lee, Ji-Hye;Jung, Ji-Hye;Kim, Hyun-Sook
    • Journal of Nutrition and Health
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    • v.43 no.2
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    • pp.152-160
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    • 2010
  • The purpose of this study was to investigate the effects of aging process on the immunity in human subjects. In this investigation, nineteen families of three generations (daughters on college age, their mothers, and grandmothers) participated to avoid genetic variation among individuals. Dietary food records, anthropometric measurements and biochemical assessments of serum nutrients were used to evaluate the nutritional status of subjects. The immune parameters of subjects were assessed by the total and differential WBC count. Total B and T lymphocytes, and T cell subsets were quantified by flowcytometer. Serum immunoglobulin G, A, M concentrations were also measured as an index of humoral immunity. The result of this study can be summarized as follows: 1. Along with the aging process, body fat was found to be increased whereas lean body mass and total body water were diminished. Since there were no significant difference in serum vitamin E levels in all age groups, serum retinal concentrations tended to decrease as one gets old. 2. Although total number of T lymphocytes seemed to be unchanged, B lymphocytes and NK cell numbers were increased by aging. The Percentage of CD8 + lymphocytes was lower in the elderly subjects compared with the younger, resulting in higher ratio of CD4 +/CD8 + lymphocytes in the elderly. Serum Ig G and Ig A levels remained unchanged, but IgM levels were significantly decreased as the age processes continue. Taking all together, it could be suggested that the alteration of immune cell population by aging is selective and possibly nonage factors such as nutrition may be attributable to the change of immunity in the elderly. The nutritional status and aging process may selectively affect both the cell-mediated (CD8 +, CD4 + CD8 + ratio, NK cell) and humoral (B lymphocyte, Immunoglobulin M, G) immune parameters in human subjects.

College Students' Dietary Behavior, Health-Related Lifestyles and Nutrient Intake Status by Physical Activity Levels using International Physical Activity Questionnaire (IPAQ) in Incheon Area (국제신체활동설문(IPAQ)을 이용한 신체활동도에 따른 인천지역 대학생의 식행동, 건강관련 생활습관 및 식이섭취 조사)

  • Yoo, Jeong-Soon;Chin, Jeong-Hee;Kim, Mi-Jung;Jang, Kyung-Ja
    • Journal of Nutrition and Health
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    • v.41 no.8
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    • pp.818-831
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    • 2008
  • The purpose of this study was to investigate the dietary behavior, health-related lifestyles and nutrient intake status of college students according to physical activity levels. The physical activity levels were measured using the Korean version of the International Physical Activity Questionnaire (IPAQ) short form. The subjects of this study were 438 college students (243 males and 195 females) in Incheon area and were divided by gender and by physical activity levels, which included low, moderate and high physical activity groups. The average age of male and female students were 23.7 and 21.0 years old, respectively. The prevalence of the low physical activity group was 11.5% for males and 30.8% for females and that of the high physical activity group was 38.7% for males and 22.6% for females. According to the criteria for obesity in Asia-Pacific region, 39.1% of the males and 64.1% of the female students investigated were in the normal range of BMI and 30.9% of the males and 4.6% of the female students were in the obesity category. However, percent of body fat in the female students was significantly higher than that of the male students. The soft lean mass of the high physical activity group was higher compared to the other groups. In the low physical activity group, frequency of “eating out” was lower compared to the other groups. The average consumption of energy was 74.4% for males and 80.1% for females of the estimated energy requirement (EER). The mean intakes of vitamin C, vitamin B2, folic acid and Ca were 67.3%, 84%, 52.7% and 36.7% for males and 64.8%, 99.9%, 51.1% and 40.1% for females of recommended intake (RI), respectively. Therefore, it was necessary for obesity prevention as well as health promotion to increase physical activity and to eat an adequate, balanced diet in female college students.

Development and Evaluation of Alternative Nutrition Signposting Concepts (알기 쉬운 영양성분 전면표시 시안 개발 및 평가)

  • Oh, Se-Young;Kim, Woo-Kyung;Ahn, Hye-Jin;Lee, Ji-Won;Park, Hye-Kyung
    • Journal of Nutrition and Health
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    • v.41 no.8
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    • pp.851-859
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    • 2008
  • To promote the adoption of healthier eating patterns, this study was aimed to develop and evaluate alternative front of pack nutrition signposting concepts. Based on previous research, we developed two signposting concepts, Multiple Traffic Light (MTL) and Multiple Traffic Light with % Daily Value (MTL-%DV). The signposts featured three key nutrients, total sugar, saturated fat, and sodium. Actual food packaging with no front of pack signposting (NoSP) was included in the evaluation to act as a benchmark against which to compare the performance of the different signposting options. Using an interviewer administered method, we assessed the degree of understanding and time to interpret on a total of 534 subjects (194 elementary, 108 middle, and 103 high schoolers, 128 adults). In the individual product evaluations, MTL (87.0%) obtained the highest level of correct responses, followed by MTL-%DV (83.1%) and NoSP (52.2%). Except for signposting concepts, age, gender and living area were not associated with the degree of correct responses in multivariate analyses. When used to compare products with different colors of nutrient contents, correct responses were more than 90% for MTL-%DV (91.5%) and MTL (90.3%). The middle and high schoolers revealed the lower likelihood of correct response compared to the other two groups. In case of comparing products with same colors of nutrient contents, the proportion of correct responses was the highest in NoSP (90%), followed by MTL%DV (77.4%) and MTL (48.5%). In terms of time to interpret, MTL-%DV and MTL performed better than NoSP in the individual product evaluation and the comparison of two products with different colors of nutrient contents. NoSP performed the best in the comparison of two products with same colors of nutrient contents. A majority of the participants preferred MTL-%DV (78%) most and thought it the most useful in helping them make healthier food choices. Based on these findings, MTL-%DV was considered to most closely meet the objectives of the initiatives.

Plasma Levels of High Molecular Weight Adiponectin are Associated with Cardiometabolic Risks in Patients with Hypertension (고혈압 환자에서 혈장 고분자량 아디포넥틴 농도와 심장-대사위험인자와의 관련성 연구)

  • Chung, Hye-Kyung;Shin, Min-Jeong
    • Journal of Nutrition and Health
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    • v.41 no.8
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    • pp.733-741
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    • 2008
  • In the present study, we comprehensively examined the associations of plasma levels of total adiponectin and high molecular weight (HMW) adiponectin with the features of cardiometabolic risks including body fat distribution, dyslipidemia, insulin resistance and inflammatory markers in a cross-sectional study of 110 treated hypertensive patients. Blood lipid profiles, high sensitivity C-reactive protein (hsCRP) and homeostasis model assessment of insulin resistance (HOMA- IR) derived from fasting glucose and insulin concentrations were determined. Plasma levels of tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$), interleukin-6 (IL-6) and intercellular adhesion molecule-1 (ICAM-1) were analyzed using ELISA. The results showed that plasma levels of HMW-adiponectin were negatively associated with body mass index (BMI, r = - 0.203, p < 0.05) and waist circumference (r = -0.307, p < 0.01), which was not shown in total adiponectin. Plasma levels of HMW-adiponectin were negatively associated with triglyceride (r = -0.223, p < 0.05) and positively associated with HDL-cholesterol (r = 0.228, p < 0.05). Plasma levels of adiponectin were positively associated with HDL-cholesterol (r = 0.224, p < 0.05). Plasma levels of HMW-adiponectin were negatively associated with hsCRP (r = -0.276, p < 0.01) and IL-6 (r = -0.272, p < 0.01). In addition, there were weak associations between plasma levels of HMWadiponectin and TNF-${\alpha}$ (r = -0.163, p = 0.07) and ICAM-1 (r = -0.158, p = 0.09). However, there were no significant associations of total adiponectin with inflammatory markers except hsCRP (r = -0.203, p < 0.05). Stepwise multiple linear regression analysis showed that only plasma levels of HMW-adiponectin was an independent factor influencing serum levels of hsCRP, a marker of systemic low grade inflammation, after adjusting for age, gender, BMI, waist circumference, alcohol intake, smoking status, blood lipids, total adiponectin and drug use (p < 0.01). These results suggest that HMW-adiponectin, rather than total adiponectin, is likely to be closely associated with the features of cardiometabolic risks in treated hypertensive patients and might be effective biomarker for the prediction of cardiovascular disease.

Removal of Organic Matter and Nitrogen from River Water in a Model System of Floodplain Filtration (홍수터 여과 모형을 이용한 하천수중의 유기물과 질소 제거)

  • Ha, Hyun-Soo;Kim, Sang-Tae;Kim, Seung-Hyun;Jeong, Byeong-Ryong;Lee, Young-Deuk;Eum, Jin-Sup;Ji, Seung-Hwan;Chung, Jong-Bae
    • Applied Biological Chemistry
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    • v.45 no.2
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    • pp.84-91
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    • 2002
  • If contaminated river water is sprayed over the floodplain, organic matter and nitrogen would be removed by microbial processes in the rhizosphere of vegetation during the filtration through soil. In this study we tested the organic matter and nitrogen removal from contaminated river water by the floodplain filtration. Model system of floodplain was constructed using a PVC pipe (15 cm i.d. ${\times}$ 150 cm L) which was packed with a loamy sand soil collected from a floodplain in Nakdong river. The model system was instrumented with soil solution samplers and gas samplers. A river water collected from Omogcheon in Kyongsan was sprayed from top of the model system at three different rates. The concentration of organic matter, DO, $NO_3^-$, $NO_2^-$, $NH_4^+$, $N_2$ and $N_2O$, and redox potential were measured as a function of soil depth for 24 days after the system reached a steady state. When river water was sprayed at the rates of 40.8 and 68.0 $l/m^2/day$, a significant reductive condition for denitrification was developed at below 5-cm depth of the soil. When the water reached at 90-cm depth of the soil, COD and concentration of inorganic nitrogen were lowered, on an average, from 18.7 to 5 mg/l and from 2.7 to 0.4 mg/l, respectively. $N_2$ comprised most of the N gas evolved from denitrification and $N_2O$ concentrations emitted at the surface of soil were less than 1 {\mu}l/l. The effective removal of organic matter and nitrogen by the filtration in the model system of floodplain demonstrates that the native floodplains, which include rhizosphere of vegetation at the top soil, could be more effective in the treatment of contaminated river waters and other industrial waste waters containing high concentration of organic matter and nitrogen.

Effects of rutin and hesperidin on total cholesterol concentration, transaminase and alkaline phosphatase activity in $CCl_4$ treated rats (루틴과 헤스페리딘이 간 독성을 일으킨 흰쥐의 cholesterol 함량, transaminase, alkaline phosphatase 효소활성에 미치는 영향)

  • Son, Heung-Soo;Kim, Hyun-Sook;Ju, Jin-Soon
    • Applied Biological Chemistry
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    • v.34 no.4
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    • pp.318-326
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    • 1991
  • This study was devised to investigate the effects of flavonoids on carbon tetrachloride toxicity of rats. Through the experiments, the contents of total cholesterol, transaminase(GOT, GPT) and alkaline phosphatase(Alk. P) activities in the liver and serum were determined. The results obtained are summarized as follows; (1) The liver cholesterol concentration of flavonoid injected groups were remarkably increased up to 45% at 2 days after $CCl_4$ injection and then the values were almost recovered to the level of control group at 4 days after $CCl_4$ injection. The increase of serum cholesterol content was inhibited by the flavonoids after $CCl_4$ injection, but the result was not significant. (2) Flavonoids injection was found to have the ability to decrease the elevated serum GOT, Alk. P activities resulting from injection of $CCl_4$ and induce rapid recovery from such an elevated level and the extent of such a decreasing action was greatest in hesperidin injection group. The liver microsomal Alk. P and GOT activities were not affected by the treatment of flavonoids. (3) The elevated serum and liver microsomal GPT activities induced by $CCl_4$ injection were inhibited by the injection of flavonoids.

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