• Genomics & Informatics
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• v.13 no.2
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• pp.45-52
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• 2015

Acute myeloid leukemia is a well characterized blood cancer in which the unnatural growth of immature white blood cell takes place, where several genes transcription is regulated by the micro RNAs (miRNAs). Argonaute (AGO) protein is a protein family that binds to the miRNAs and mRNA complex where a strong binding affinity is crucial for its RNA silencing function. By understanding pattern recognition between the miRNAs-mRNA complex and its binding affinity with AGO protein, one can decipher the regulation of a particular gene and develop suitable siRNA for the same in disease condition. In the current work, HOXA9 gene has been selected from literature, whose deregulation is well-established in acute myeloid leukemia. Four miRNAs (mir-145, mir-126, let-7a, and mir-196b) have been selected to target mRNA of HOXA9 (NCBI accession No. NM_152739.3). The binding interaction between mRNAs and mRNA of HOXA9 gene was studied computationally. From result, it was observed mir-145 has highest affinity for HOXA9 gene. Furthermore, the interaction between miRNAs-mRNA duplex of all chosen miRNAs are docked with AGO protein (PDB ID: 3F73, chain A) to study their interaction at molecular level through an in silico approach. The residual interaction and hydrogen bonding are inspected in Discovery Studio 3.5 suites. The current investigation throws light on understanding of AGO-assisted miRNA based gene silencing mechanism in HOXA9 gene associated in acute myeloid leukemia computationally.

• Journal of The Geomorphological Association of Korea
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• v.23 no.3
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• pp.79-92
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• 2016

Samples from two boreholes of coastal dune field at Jangho-ri coast, Gochang was studied. These were analyzed by grain size analysis geochemical analysis, and the application of OSL dating method to understand the development during the Holocene. The boreholes SB8 and SB9 were classified into three different sedimentary layers by their mean grain size and geochemical characteristics. The results revealed that the upper sand layer is equivalent to the present coastal dune layer, which developed since 1,200 years ago; the silt layer in the middle to the dune slack or lagoon sedimentation layer, which developed between 1,200 and 6,000 years ago; and the sand layer at the bottom to the paleo coastal dune that developed between 6,000 and 7,000 years ago. It was proposed that the forming material of current coastal dune was supplied from the sandy flat in coastal area, while the middle silt layer was supplied from the weathered soil of a bed rock by the comparison with material of surrounding area. In the case of coastal dune, concentrated layer of sands were identified which were buried about 300 and 1,200 years ago, which is identified as the little ice age. This study confirmed the development of Jangho-ri coastal dunes after Holocene Climate Optimum period, and it is likely to assist in the understanding of coastal dunes development.

• The Journal of Korea Assosiation for Disability and Oral Health
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• v.4 no.1
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• pp.26-31
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• 2008

Cerebrovascular Accident(stroke) is that a sudden, nonconvulsive loss of neurologic function due to an ischemic or hemorrhagic intracranial vascular event. If stroke happens at the portion of trigeminal motor nucleus or its control part of cerebral cortex, masticatory muscles will be atrophy or paralyzed. So it is possible that dental occlusion changes after stroke. A 74-aged woman recurred mild stroke 2 month ago, who had experienced severe stroke 2 years ago. After recurrence, suddenly her upper full denture was dropped when lower denture contacted upper one. According to the her occlusion exam, her lower jaw moved back slightly compared with the occlusion of old denture. And her face had asymmetry and lower jaw dislocated to paralyzed side. A 50-aged man was treated because many cervical caries, which would occur because of an aftereffect of stroke, long-herm hospitalization and limits of self oral-care. 6 years ago he had cerebral hemorrhage and he claimed that he cannot bite exactly. Just two pairs of teeth was contact on biting, his lower jaw was located back, too. This two case suggests that dental occlusion can change after stroke.

• Journal of Oral Medicine and Pain
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• v.25 no.2
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• pp.215-221
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• 2000

A 69-year-old male pateint was admitted for discomfort on right temporomandibular joint during opening, closing and chewing that started few months ago. The patient had no special medical history except for lung tuberculosis approximately 30 years ago and nothing specific appeared on a physical exam taken 2 months ago. Clinical tests show that mouth opening of 53mm which was normal and no joint sound, deviation, pain during opening. But tenderness to palpation on Rt masseter muscle and pain existed on Rt temporomandibular joint during loading test on the right joint. No pain existed during resistance test and protrusion and range of lateral movement was normal. Rt temporomandibular joint was not swollen and no palpable mass was observed. No previous trauma history to the face existed. On X-ray calcific material existed in the joint cavity and on CT image, approximately 2mm sized calcific material appeared on the Rt temporomandibular joint but no change in bone appeared on the condyle nor the temporal bone. The patient was diagnosed as loose body, and the symptoms were relived after 2 physical therapies and is under regular check ups. The purpose of this case is to review disease that cause loose bodies.

• Ocean and Polar Research
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• v.41 no.1
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• pp.35-46
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• 2019

The purpose of this study is to identify factors influencing fish production of shallow-sea aquaculture in South Korea. This study employed the two-way fixed effect and random effect models based on the panel models and also the difference between GMM and system GMM models based on the dynamic panel models using the amount of fish farming production, the number of stocked fry, the number of cultured fish, the amount of inputted feed, the farming area, the number of workers, and the sales price data from 2010 to 2017. First, the two-way fixed effect model of the panel models was selected by panel characteristics, time characteristics and Hausman tests and also the model was statistically significant. As a result of the two-way fixed effect model, the number of stocked fry, the amount of inputted feed, and the number of workers were identified as factors that increase the fish production of shallow-sea aquaculture. However, the number of cultured fish and the sales price were analyzed as factors that reduce the fish production of shallow-sea aquaculture. Second, the system GMM model of the dynamic panel models was selected by Hansen test and Arellano-Bond test in order to identify whether or not the over-discrimination condition is appropriate. Based on the system GMM model, the number of stocked fry, the amount of inputted feed, the number of workers in this year and 1 year ago, the number of cultured fish 2 years ago, and the sale price 3 years ago were analyzed as factors that increase the fish production of shallow-sea aquaculture. However, the amount of fish farming production 1, 2, 3 years ago, the farming area in this year, and the number of cultured fish in this year and 1 year ago were identified as factors that reduce the fish production of shallow-sea aquaculture. In conclusion, this study suggests that it is desirable to control the amount of stocked fry rather than to expand the farming area for fish farming in shallow-sea aquaculture, so as to keep the sale price at a certain level by maintaining the appropriate amount of fish production.

• Korean Journal of Organic Agriculture
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• v.10 no.3
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• pp.67-77
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• 2002

This study was conducted to investigate an effects on ago-chemical alternative materials such as the wood vinegar, a lactic acid bacteria serum, the fermented plant juice, the brown rice vinegar and a Chitosan used for amount and qualities of fruits and to examine the pest protection efficiency for their uses in the apple and pear orchard farms. An apple yields in the orchard cultivated with using the ago-chemical alternative materials without appling the fertilizer and pesticides were decreased at 56% relative to the conventional farming practice method. Also, it was indicated that there was difficult to produce the fruits with marketability because the small sizes of fruits were produced. For the quality of fruits, the brix of apple produced in the orchard cultivated with using the ago-chemical alternative materials was similar, but Vitamin C content was greater than that of the conventional farming practice method. As a results of treating with the wood vinegar, a lactic acid bacteria serum, the fermented plant juice, the brown rice vinegar and a Chitosan instead of applying pesticides, the fruit disease in the Chitosan treatment was a little decreased, but was great occurred in the other treatments compared with the conventional farming practice mehod. However, it observed that brix and Vitamin C content of apple produced in the Chitosan, brown rice vinegar, fermented plan juice and fish amino acid treatments and in the Chitosan, brown rice vinegar, charcoal power and peat moss treatments were greater than those of the conventional farming practice method, respectively. Over all, it considered that there was very difficult to manage the orchard depended on the ago-chemical alternative materials without appling the chemical fertilizer and pesticides in the apple orchard, but it might be proper to use the ago-chemical alternative materials as an auxiliary means to decrease the appling amount of chemical fertilizer and pesticides. Furthermore, the general effects on the ago-chemical alternative materials to the perennial fruits should be investigated with considering the changes of soil fertility, soil microbial status and natural enemy creatures after treating them for a long time.

• The Korean Nurse
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• v.21 no.3 s.116
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• pp.6-7
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• 1982

• Korean Architects
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• s.503
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• pp.14-14
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• 2011

• Computers and Concrete
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• v.25 no.6
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• pp.517-523
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• 2020

An experimental system on three point bending notched beams was established to study the fracture process of concrete. In this system, the acoustic emission (AE) was used to build the cumulative generation order (AGO) and dynamically track the process of microcrack evolution in concrete. A grey-cusp catastrophe model was built based on AE parameters. The results show that the concrete beams have significant catastrophe characteristic. The developed grey-cusp catastrophe model, based on AGO, can well describe the catastrophe characteristic of concrete fracture process. This study also provides a theoretical and technical support for the application of AE in concrete fracture prediction.

• Journal of Korean Academy of Oral and Maxillofacial Radiology
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• v.8 no.1
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• pp.23-27
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• 1978

The purpose of the present investigation is to determine how frequently radiopaque zones are seen on standard intraoral films and to research some other things about radiopaque zones. This study obtained the following results: 1. According to the standard intraoral films of the charts that were kept at the Dept. of Oral Diagnosis in Seoul National University Hospital, radiopaque zones were found in the rate of 4.1% among 1150 cases of amalgam-restored teeth that were treated at least two years ago. 2. Out of teeth that possessed radiopaque zones, 38.3% had radiolucent area between amalgam restoration and radiopaque zone. 3. Out of teeth that possessed radiopaque zones, 36.2% had cement base between amalgam restoration and radiopaque zone. 4. Out of teeth that possessed radiopaque zones, no tooth had periapical radiolucency. 5. Radiopaque zones were found more frequently in the mandibular teeth than the maxillary teeth. 6. According to the result of direct x-ray taking of 50 teeth that were treated at least 2 years ago, 6% had radiopaque zone.