• Title/Summary/Keyword: AGING

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Development and Validation of AI Image Segmentation Model for CT Image-Based Sarcopenia Diagnosis (CT 영상 기반 근감소증 진단을 위한 AI 영상분할 모델 개발 및 검증)

  • Lee Chung-Sub;Lim Dong-Wook;Noh Si-Hyeong;Kim Tae-Hoon;Ko Yousun;Kim Kyung Won;Jeong Chang-Won
    • KIPS Transactions on Computer and Communication Systems
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    • v.12 no.3
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    • pp.119-126
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    • 2023
  • Sarcopenia is not well known enough to be classified as a disease in 2021 in Korea, but it is recognized as a social problem in developed countries that have entered an aging society. The diagnosis of sarcopenia follows the international standard guidelines presented by the European Working Group for Sarcopenia in Older People (EWGSOP) and the d Asian Working Group for Sarcopenia (AWGS). Recently, it is recommended to evaluate muscle function by using physical performance evaluation, walking speed measurement, and standing test in addition to absolute muscle mass as a diagnostic method. As a representative method for measuring muscle mass, the body composition analysis method using DEXA has been formally implemented in clinical practice. In addition, various studies for measuring muscle mass using abdominal images of MRI or CT are being actively conducted. In this paper, we develop an AI image segmentation model based on abdominal images of CT with a relatively short imaging time for the diagnosis of sarcopenia and describe the multicenter validation. We developed an artificial intelligence model using U-Net that can automatically segment muscle, subcutaneous fat, and visceral fat by selecting the L3 region from the CT image. Also, to evaluate the performance of the model, internal verification was performed by calculating the intersection over union (IOU) of the partitioned area, and the results of external verification using data from other hospitals are shown. Based on the verification results, we tried to review and supplement the problems and solutions.

Rehabilitation with minimal increase in occlusal vertical dimension in a patient with excessive tooth wear and edge-to-edge bite (과도한 치아 마모와 절단교합을 보이는 환자에서 최소한의 수직 고경 증가를 통한 구강회복 증례)

  • Hee-Young Kim;Seong-A Kim;Yong-Sang Lee;Keun-Woo Lee;Joo-Hyuk Bang
    • The Journal of Korean Academy of Prosthodontics
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    • v.61 no.2
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    • pp.143-152
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    • 2023
  • Although tooth wear is a normal process due to aging, severe tooth wear causes various complications such as increased tooth sensitivity, loss of tooth structure, and pulp complications. In the treatment of patients with excessive tooth wear, the evaluation of loss of vertical occlusal dimension should be prioritized. If it is necessary to increase the vertical dimension to secure the restoration space, it is important to establish a treatment plan with the comprehensive analysis and determine the minimum vertical dimension elevation. In this case, 66-year-old male patient with severe worn dentition wanted to restore masticatory function and improve esthetic restoration. In order to determine the appropriate vertical dimension of the patient, we evaluated oral examination, radiographic examination, and diagnostic cast examination, and performed rehabilitation with minimum vertical dimension elevation. As a result of observation for 8 months, the definitive prosthesis was completed with contact of all teeth in centric occlusion, and proper anterior/posterior guidance. Through the above process, satisfactory aesthetic and functional outcomes were obtained.

Research Trends on Compounds that Promote Melanin Production Related to Hair Graying (모발 백발화와 관련된 melanin 생성을 촉진시키는 화합물의 연구동향)

  • Moon-Moo Kim
    • Journal of Life Science
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    • v.33 no.5
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    • pp.445-454
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    • 2023
  • Hair graying is the result of a malfunction in the signaling pathways that control melanogenesis, and it is activated by UV light, melanocyte-stimulating hormone (MSH), stem cell factor (SCF), Wnt, and endothelin-1 (ET-1). To prevent hair graying, synthetic and natural compounds can be used to stimulate melanogenesis effectively under the control of tyrosinase, tyrosine hydroxylase, tyrosinase-related protein-1 (TRP-1), TRP-2, and microphthalmia-associated transcription factor (MITF). This article describes a crucial strategy to resolve the problem of hair graying, as well as recent advances in the signaling pathway related to melanogenesis and hair graying. In particular, the article reviews potentially effective therapeutic agents that promote melanogenesis, such as antioxidants that modulate catalase, methionine sulfoxide reductase, and sirtuin 1 (SIRT1) activators including resveratrol, fisetin, quercetin, and ginsenoside. It also discusses vitiligo inhibitors, such as corticosteroids, calcineurin inhibitors, and palmitic acid methyl ester, as well as activators of telomerase expression and activity, including estrogen, androgen, progesterone, and dihydrotestosterone. Furthermore, it explores compounds that can inhibit hair graying, such as latanoprost, erlotinib, imatinib, tamoxifen, and levodopa. In conclusion, this article focuses on recent research trends on compounds that promote melanin production related to hair graying.

Application of Cognitive Enhancement Protocol Based on Information & Communication Technology Program to Improve Cognitive Level of Older Adults Residents in Small-Sized City Community: A Pilot Study (중소도시 지역사회 거주 노인의 치매예방을 위한 Information & Communication Technology 프로그램 기반 인지향상 프로토콜 적용: 파일럿(Pilot) 연구)

  • Yun, Sohyeon;Lee, Hamin;Kim, Mi Kyeong;Park, Hae Yean
    • Therapeutic Science for Rehabilitation
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    • v.12 no.2
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    • pp.69-83
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    • 2023
  • Objective : This study, as a preliminary study, applied an Information & Communication Technology (ICT) home-based program to elderly people aged 65 years or older to confirm the effect of the cognitive enhancement program and to find the possibility of remote rehabilitation. Methods : This study from August to October 2022, three subjects were selected and the intervention was conducted for about 2 months. This intervention was conducted using Korean version of Mini-Mental State Examination, Korean version of Montreal Cognitive Assessment (MoCA-K), Computer Cognitive Senior Assessment System, and the Center for Epidemiologic Studies Depression scale to evaluate cognitive improvement before and after the program. The therapist remotely set the level of cognitive training according to the subject's level through weekly feedback. Results : After the intervention, all subjects showed improved scores in most items of the MoCA-K conducted before and after the intervention. In addition, among the items of Cotras-pro, upper cognition, language ability, attention, visual perception, and memory were improved. Conclusion : Cognitive rehabilitation training using an ICT home-based program not only prevented dementia but also made it habitual. Through this study, it was confirmed that remote rehabilitation for the elderly could be possible.

Neuroprotective Effect of Yukul-tang against the Oxidative Stress (육울탕(六鬱湯)의 산화적 스트레스에 대한 뇌세포 보호효과)

  • Jung, Sun-Hyung;Lee, Jin-Moo;Lee, Chang-Hoon;Cho, Jung-Hoon;Jang, Jun-Bock;Lee, Kyung-Sub
    • The Journal of Korean Obstetrics and Gynecology
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    • v.22 no.1
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    • pp.15-30
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    • 2009
  • Purpose: In this rapidly aging society, the research and development of traditional oriental medicine treatment is one of the critical factors to protect the increasing neuro-degenerative disorders. In this study, we wanted to verify the effect of Yukul-tang (YUT) on neuro-degenerative disease model by assessing the antioxidant and anti-inflammation effects. Methods: To assess the antioxidant effects of YUT, we carried out DPPH radical and ABTS radical scavenging assays and determined the total polyphenolic contents in YUT. To evaluate the neuro-protective effects of YUT, we performed the MTT and ROS assays and TH immunohistochemistry, NO and TNF-${\alpha}$ assays in SH-SY5Y or mesencephalic dopaminergic neurons damaged by 6-OHDA. Results: The treatment of YUT showed eliminating effects on DPPH radical and ABTS radical. it showed deterring effects on ROS, NO and TNF-${\alpha}$ and protecting effects on TH-positive cell in SH-SY5Y cells or mesencephalic dopaminergic neurons. Especially in the case of the treatment of YUT with 0.2ug/mL + 6-OHDA 10uM, the protective effect on dopaminergic neurons was most outstanding. Conclusion: In this study, we have demonstrated that YUT has an antioxidant effect and a neuro-protective effect on neuro-degenerative disease model caused by neurotoxin such as 6-OHDA. The results of our present study suggest that YUT can be useful agent to prevent and to treat neuro-degenerative diseases.

Comparison of Machine Learning Models to Predict the Occurrence of Ground Subsidence According to the Characteristics of Sewer (하수관로 특성에 따른 지반함몰 발생 예측을 위한 기계학습 모델 비교)

  • Lee, Sungyeol;Kim, Jinyoung;Kang, Jaemo;Baek, Wonjin
    • Journal of the Korean GEO-environmental Society
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    • v.23 no.4
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    • pp.5-10
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    • 2022
  • Recently, ground subsidence has been continuously occurring in downtown areas, threatening the safety of citizens. Various underground facilities such as water and sewage pipelines and communication pipelines are buried under the road. It is reported that the cause of ground subsidence is the deterioration of various facilities and the reckless development of the underground. In particular, it is known that the biggest cause of ground subsidence is the aging of sewage pipelines. As an existing study related to this, several representative factors of sewage pipelines were selected and a study to predict the risk of ground subsidence through statistical analysis has been conducted. In this study, a data SET was constructed using the characteristics of OO city's sewage pipe characteristics and ground subsidence data, The data set constructed from the characteristics of the sewage pipe of OO city and the location of the ground subsidence was used. The goal of this study was to present a classification model for the occurrence of ground subsidence according to the characteristics of sewage pipes through machine learning. In addition, the importance of each sewage pipe characteristic affecting the ground subsidence was calculated.

A Study on Effects of the Fall Prevention in the Rehabilitation Pilates Exercise (노인의 재활 필라테스 운동이 낙상 예방 효과에 대한 고찰)

  • Ji-Sun Kim
    • Journal of the Korean Applied Science and Technology
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    • v.40 no.2
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    • pp.290-300
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    • 2023
  • This study was understood the risk mechanism of falls in the elderly and reviewed previous research data to see if the principle of Pilates rehabilitation exercise could have a positive effect on balance ability and postural stabilization in the elderly, and the purpose of this study is to present literature-based data on the fall prevention effect of rehabilitation Pilates exercise. First, the rehabilitation Pilates exercise makes it available for strengthening the center of the body to stabilize the spine and pelvis and stimulates the nerve root, thereby having an effect on the balance and the joint stabilization. Second, a proprioceptive sensory impairment and a musculoskeletal degenerative disease due to aging increase the loss of balance ability and the instability in posture maintenance, thereby coming to raise the risk of a fall damage caused by the difficulty in performing motor functions and by the gait disturbance. Third, the rehabilitation Pilates exercise leads to improving the core muscle strength in older adults, resulting in being capable of expecting the betterment in the balance and the reaction time motor function. And there is a positive impact on the improvement in body imbalance and on the stability in movement involved in the fall prevention, resulting in being able to suggest the possibility of likely contributing to a reduction in a fall risk rate. In conclusion, the rehabilitation Pilates as the elderly exercise program showed effects on the improvement in the body's muscular strength, on the upgrade in a sense of balance, and on the stabilization of core. Thus, it was considered to diminish the risk factors for a fall damage caused by musculoskeletal degeneration and to be capable of preventing a serious disorder of activity due to a chronic senile disease.

Effects of Catalase and Cumulus Cells during In Vitro Maturation in Porcine Oocytes (돼지난자의 체외성숙시 Catalase와 난구세포의 영향)

  • Lee, S.Y.;Sa, S.J.;Kim, K.J.;Cheong, H.T.;Yang, B.K.;Park, C.K.;Kim, C.I.
    • Korean Journal of Animal Reproduction
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    • v.23 no.3
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    • pp.239-245
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    • 1999
  • The effect of catalase on in-vitro maturation in porcine oocytes with or without cumulus cells were studied. The maturation rates were not significantly different in medium with and without catalase during in vitro maturation of oocytes. However, the maturation rates of oocytes with cumulus cells were significantly higher (P<0.05) than in oocytes without cumulus cells regardless of the presence of catalase. On the other hand, the maturation rate in oocytes cultured with cumulus cells for 48 h (57%) was significantly (P<0.05) higher than in oocytes with cumulus cells for first 24 h period (42%) only. In another experiment, the maturation rate was significantly (P<0.05) higher in medium containing catalase for last 24 h period only than in medium containing catalase for first 24 h period during in vitro maturation of ooytes with or without cumulus cells. But the oocytes matured to M-II stage were observed at 24 h of culture of oocytes without cumulus cells only. When oocytes with cumulus cells were cultured for 72 h, the maturation rates was significantly (P<0.05) higher in medium with (79%) than without (65%) catalase during in vitro maturation. These results indicate that cumulus cells are necessary for in vitro maturation of porcine oocytes, catalase have effect according to the addition periods and can prevent aging of porcine oocytes during maturation in vitro.

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Using Photovoice A Study on the Perception of Death Readiness in Babyboomer Retirees (포토보이스를 활용한 베이비부머 은퇴자의 죽음준비 인식의 연구)

  • Chung, Ju-Young;Lee, Mi-Ran
    • Journal of Convergence for Information Technology
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    • v.12 no.3
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    • pp.171-177
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    • 2022
  • The retirement of the Korean baby boomer generation has become a major factor in an aging society as a large proportion of the population has moved from the middle-aged to the elderly. In addition, after being busy working at a structured workplace for over 30 years, after retirement, they could not adapt to the unstructured environment, causing depression and leading to social problems such as the risk of suicide. research was needed. This study uses photovoice to in-depth research on the research question of how retirees' perception of death preparation, who wants to live a life prepared until death, is used. This is the purpose of this study. The study participants were 7 baby boomer retirees, the data were collected for 2 months, and the perception derived as a result of analyzing the photos, explanations, and in-depth interviews taken by the subject analysis method was used to prepare It was a necessity for education. In the discussion of this study, it is urgent to develop a death preparation education program that can help the baby boomer retirees, and I would like to suggest that the cooperation of local organizations in charge of the program is necessary. This study is meaningful in that it presents basic data in preparing social welfare policy measures for the elderly after retirement through the awareness of death preparations of baby boomer retirees.

A Study on the Satisfaction of Senior Welfare Centers by Senior's Lifestyle (노인의 라이프스타일 유형에 따른 노인복지관에 대한 만족도 연구)

  • Lee, Song Hyun;Eo, Sung Sin;Hwang, Yeon Sook
    • Design Convergence Study
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    • v.15 no.3
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    • pp.171-186
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    • 2016
  • With the continuous rise of elderly population and rapid progression of aging in our society, greater emphasis is placed on the importance of local seniors welfare centers as representative service space that meets the diverse needs of local residents. In addition, there is a growing tendency among current users to seek high-quality service as their educational level, economic ability and lifestyle have changed for the better compared to past generations. Accordingly, this study analyzed the satisfaction of senior welfare centers according to life-style type of the elderly, using a lifestyle measurement tool which incorporates indicators of gerontographics. A survey was conducted with users of seven senior welfare centers located in Seoul. Analysis results are as follows: First, four types of lifestyle were derived through cluster analysis; independent activity type, protective activity type, active challenge type, and passive challenge type. Second, it was found that the overall satisfaction of seniors welfare centers by the life-style of the elderly is highest for the protective activity type followed by the passive challenge type, the active challenge type, and the independent activity type. Third, upon examining the effect of spatial characteristics of welfare centers on the satisfaction of elderly users by type of lifestyle, it was found that the independent activity type and the passive challenge type users are most influenced by intimacy, the protective activity type users by comfort, and the active challenge type users by convenience.