• Nutrition Research and Practice
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• 제11권1호
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• pp.57-63
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• 2017

BACKGROUND/OBJECTIVES: The level of serum albumin is an index of nourishment care and management. However, the distribution and correlates of serum albumin levels among individuals with motor disorders have not been reported until now. Therefore, we examined the distribution and correlates of serum albumin levels among individuals with motor disorders. SUBJECTS/METHODS: A cross-sectional study on 249 individuals with motor disabilities (144 men, mean age: 51.4 years; 105 women, mean age: 51.4 years) was conducted at five institutions in Ibaraki Prefecture, Japan in 2008. The results were compared with data from the National Health and Nutrition Survey. RESULTS: The mean serum albumin levels were $4.0{\pm}0.4g/dL$ for men and $3.8{\pm}0.5g/dL$ for women. Overall, 17 (11.8%) men and 25 (23.8%) women had hypoalbuminemia (serum albumin level ${\leq}3.5g/dL$); these proportions were greater than those among healthy Japanese adults (${\leq}1%$). Low serum albumin level was related with female sex, older age, low calf circumference, low relative daily energy intake, low hemoglobin (Hb), low blood platelet count, low high-density lipoprotein cholesterol (HDL-C), low $HbA_{1c}$, and high C-reactive protein (CRP) levels. The strongest correlates, based on standardized betas, were Hb (0.321), CRP (-0.279), and HDL-C (0.279) levels. CONCLUSIONS: These results indicate that the prevalence of hypoalbuminemia is higher in individuals with motor disabilities than in healthy individuals and that inflammation is a strong negative correlate of serum albumin levels. Therefore, inflammation should be examined for the assessment of hypoalbuminemia among institutionalized individuals with motor disabilities.

• 한국수정란이식학회지
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• 제18권3호
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• pp.215-225
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• 2003

본 시험은 한우에서 연령에 따라 혈청성분들의 변화를 알아보기 위하여 한우 866두(거세 638, 비거세 228)에 대하여 혈청 농도를 분석하여 채혈시 일령을 독립 변량으로 하고 혈청 성분들을 종속변수로 하는 다항 회귀방정식으로 추정한 결과는 다음과 같다. 거세우나 비거세우 모두 같은 차수의 회귀방정식이 접합한 혈청 성분은 IGF- I (3차식) calium(1차식) 및 IP(1차식)이었고 거세우에서는 1차식이 적합하고 비거세우에서는 3차식이 적합한 혈청 성분은 testosterone와 creatinine었다. 반면에 HDLC는 거세우에서는 3차식이 적합하나 비거세우에서는 1차식이 적합한 것으로 나타났다. 그리고 거세우에서는 2차식이 적합한데 비거세우에서는 3차식이 적합한 혈청성분은 triglyceride 농도와 globulin농도 그리고 A/G비율 등이었고, 거세우에서는 3차식이 적합하고 비거세우에서는 2차식이 적합한 혈청성분은 BUN이었으며, 거세우에서는 2차식이 적합한데 비거세우에서는 1차식이 적합한 혈청성분은 TP와 albumin이었다. 한편 cortisol은 거세우나 비거세우에서 모두 3차식까지의 회귀방정식으로는 연령에 따른 변화를 설명하기가 적합하지 않았으며 glucose는 비거세우에서는 3차식 변화를 보이고 있으나 거세우에서는 3차식까지의 회귀방정식만으로는 연령에 따른 변화를 설명하기가 어려웠다. 가장 적합한 것으로 판단되는 혈청성분들의 회귀모형 중에서 비교적 R-SQUARE 값이 높은 것(R-SQUARE value>0.1)들은 거세우에서 ICF-I, albumin, creatinine, IP, HDLC 등이었으며, 비거세우에서 testosterone, IGF-I, TP, albumin, glucose, creatinine, IP, HDLC 등으로 나타났다. 따라서 IGF-I, albumin, creatinine, IP, HDLC 등은 거세우나 비거세우 모두에서 연령에 따라 비교적 큰 변화를 보이는 혈청 성분이라고 생각된다.

• Journal of Nutrition and Health
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• 제36권5호
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• pp.491-499
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• 2003

Selenium is a strong antioxidant trace mineral, scavenging free radicals. The prevalence of chronic degenerative diseases is increasing in Korean adults with increasing age. The increased cell damage from free radicals has been implicated in the etiology of these diseases, and evidence is accumulating that the low selenium status that comes with advanced aged is involved in the prevalence of age-associated diseases. However, little is known about the selenium status of Koreans, its age-related change and its relationship to dietary nutrient intake. In this study, the serum selenium levels of healthy adult females according to life cycle and its association with blood albumin levels and nutrient intake were examined. Serum selenium level was measured with the Huwo research reactor using the neutron activation analysis method (NAA). The overall proportion of women with selenium deficiency, serum selenium concentrations below 7.0 $\mu\textrm{g}$/dl, was 9.4%. The average serum selenium levels were 12.39 $\mu\textrm{g}$/dl, 9.45 $\mu\textrm{g}$/dl and 9.16 $\mu\textrm{g}$/dl in the young adult, middle-aged and elderly groups, respectively, showing a reduction of selenium status with advancing age. Selenium deficiency was seen only in the elderly group. Generally, serum selenium levels positively or negatively correlated with nutrient intake, but these association patterns differed depending on the age. The nutrients that showed positive correlations with selenium levels were proteins and phosphate in the young adult group (p < 0.05, p < 0.05), and total calcium, potassium and vegetable-origin calcium in the middle-aged group. Vitamin C and fiber were the negative correlated nutrients with serum selenium levels in the elderly group (p < 0.05, p < 0.05). Multiple stepwise regression analysis of the determining factors responsible for selenium status showed that age and serum albumin levels were important factors which explained up to 26.9% variances in serum selenium levels. The average selenium concentrations of Korean adult female subjects were above the deficiency levels in all three age groups. There was a tendency toward decreasing selenium levels as the age of the subjects increased. The factors with the strongest in-fluence on selenium status in healthy adult Korean females were age and serum protein status. (Korean J Nutrition 36(5): 491~499, 2003)

• Asian Pacific Journal of Cancer Prevention
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• 제14권5호
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• pp.2759-2763
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• 2013

Background: Impaired oxidative/antioxidative status plays an important role in the pathogenesis of many diseases like cancer. The aim of this study was to evaluate the levels of the novel marker ischemia modified albumin (IMA) and albumin adjusted-IMA (Adj-IMA) in patients with bladder cancer (BC) as well as its association with total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI). Materials and Methods: Forty male patients with BC (mean age, $67.4{\pm}12$ years) and forty age-sex matched healthy persons (mean age $56.0{\pm}1.7$ years) were included in this study. Serum levels of IMA, TAS, TOS were analyzed and Adj- IMA and OSI was calculated. Results: Serum IMA, TOS and OSI values were significantly higher in patients with BC compared to controls (p<0.0001, p=0.01 and p=0.01, respectively), whereas TAS was significantly lower in BC patients (p=0.04). There was no significant difference for serum albumin-adjusted IMA levels between groups (p=0.4). Conclusions: In this study, it was found that there was an impaired oxidative/antioxidant status in favor of oxidative stress in BC patients. This observation was not confirmed by Adj-IMA calculation. There is no published report about serum concentrations of IMA in patients with BC. Further studies are needed to establish the relationship of IMA and oxidative stress parameters in BC and the significance of IMA to other cancers.

• Journal of Preventive Medicine and Public Health
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• 제45권2호
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• pp.98-104
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• 2012

Objectives: A positive association between serum albumin levels and metabolic syndrome has been reported in observation studies, but it has not been established in the Korean population. The purpose of this study was to evaluate the association between serum albumin levels and the presence of metabolic syndrome among a sample of apparently healthy Korean adults. Methods: This cross-sectional study analyzed data of 3189 community-dwelling people (1189 men and 2000 women) who were aged 40 to 87 years and were living in a rural area in Korea. Serum albumin levels were classified into quartile groups for each sex. Metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel III guidelines with an adjusted waist circumference cut-off value ${\geq}90\;cm$ for men and${\geq}85\;cm$ for women). An independent association between serum albumin levels and metabolic syndrome was assessed by multiple logistic regression analysis. Results: Higher serum albumin levels were associated with increased prevalence of metabolic syndrome. The odds ratio (95% confidence interval) of the prevalence of metabolic syndrome for the highest versus the lowest serum albumin quartiles was 2.81 (1.91 to 4.14) in men and 1.96 (1.52 to 2.52) in women, after adjusting for age, smoking status, alcohol consumption, and physical activity. When each metabolic abnormality was analyzed separately, higher serum albumin levels were significantly associated with hypertriglyceridemia and hyperglycemia in both sexes, and with abdominal obesity in men. Conclusions: These results suggest that higher serum albumin levels are positively associated with an increased risk of metabolic syndrome in Korean adults.

• 대한수의학회지
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• 제15권2호
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• pp.187-198
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• 1975

Although considerable research has been done on the blood chemistry of domestic animals, little work has been made of the changes associated with age. Moreover, the records about physiology of the goat were not much available in Korea, and a comprehensive survey of the blood values of the Korean native goat has not been made. The object of the present investigation was to make good this deficiency and to suggest standards for the blood chemical values of Korean native goats from birth to maturity. The goats were kept under average farming conditions in Korea. Blood samples were collected from the jugular vein at birth, at one and four days, at one, two, three and four weeks, and at two, three, six, nine and twelve months of age. The results obtained in this work were summarized as follows: 1. The highest concentration of serum glucose was observed at birth and it decreased gradually until three months of age, showing a steady state thereafter. 2. The concentration of total serum protein was a little higher at one day of age than at birth and showed a steady state until seven days of age; then it decreased slightly at two weeks of age and recovered at three weeks of age and showed a steady state until twelve months of age. The concentration of serum albumin was increased a little at one day of age and revealed a steady state thereafter. The concentration of serum globulin showed three phases - a fall during the first two weeks to reach minimum, a rise to the fourth week, and a fall at two months of age, showing a steady state thereafter. The lowest value of albumin fraction was observed at birth, then the value increased gradually until three months of age and revealed a stealer state thereafter. The highest value of globulin fraction was observed at birth, then the gradual decrease of the value was seen until three months of age; thereafter the value showed a steady state. 3. Albumin/globulin ratio was the minimum at birth, then it increased to reach a maximum at two weeks of age and decreased a little thereafter. 4. The concentration of total serum cholesterol showed a gradual increase during the first three months and fell to reach adult revel at six months of age. 5. Urea nitrogen in serum decreased during the first week to reach a minimum, then it increased at three months of age, and showed a fell to mature level at six mouths of age. 6. The concentration of serum creatinine was not affected by age. 7. The concentration of total serum calcium was a little higher during the first two weeks than the other period during the first year of life. 8. The concentration of serum inorganic phosphorus showed a gradual rise to reach a maximum and a gradual fall to reach adult level at nine months of age. 9. No significant sex differences of serum chemical values were recognized.

• Nutritional Sciences
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• 제4권2호
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• pp.112-119
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• 2001

This study was performed fir the purpose of finding the relationship between fat-free mass (FFM) which mainly represents muscle mass change, and muscle strength. The correlation between diet and exercise behaviors and FFM in healthy elderly men over age 55 was also investigated. FFM and corresponding hand grip strength declined significantly with increasing age. However the concentration of serum albumin, the indicator of protein nutritional status, showed no change with increases in age. The subjects were categorized into three groups according to FFM textiles. Anthropometry such as height, BMI, circumferences of waist and hips, body fat mass percent and hand grip strength decreased significantly in the lowest FFM group. But albumin level showed no change relative to FFM level. FFM showed a significant relationship to nutrient intake such as energy and fat. However, no association was found with exercise behavior probably because there were no instances of resistance exercise habits among the subjects studied. The variance in FFM could be attributed 86.2% to height and age. The variance of height-adjusted FFM could be attributed only 40.6% to age and fat intake. In conclusion decreases in FFM may cause reductions in muscle strength in elderly men. Increasing energy and fat intake were associated with increased FFM and may protect elderly men from the risk of sarcopenia. FFM had no association with endurance exercise habits.

• 대한임상검사과학회지
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• 제42권1호
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• pp.32-37
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• 2010

The author was performed to investigation of current status of prevalence for anti-hepatitis C virus (HCV) among the health-checkup adults in Jeonbuk province. A toal of 1,553 (male 1,046, female 507) serum samples were diagnosed by 3rd generation enzyme immunoassay (EIA) for anti-HCV. Total prevalence of anti-HCV was 0.9%, and prevalence of male and female were 0.8% and 1.2%, respectively. The prevalence of female was higher than male. According to ages group, prevalence of anti-HCV was highest in 60 age group, but it was not found in 20 age group. 14 samples with anti-HCV positive were diagnosed by EIA for hepatitis B virus surface antigen (HBs Ag), by chemiluminescence immunoassay (CLIA) for serum albumin, alanine transaminase (ALT) and asparagine transaminase (AST). Positive for HBs Ag was not found. The mean of serum albumin levels was 4.5 g/dL, and mean of ALT and AST were 34.3 IU and 31.9 IU, respectively. Through this study, I know that the prevalence of anti-HCV among adults in Jeonbuk, and suggest that the positive of anti-HCV persons who have lower serum albumin, normal to mild elevations in serum enzymes are chronic hepatitis.

• Journal of Nutrition and Health
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• 제34권4호
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• pp.449-457
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• 2001

This study was performed to show change of fat-free mass(FFM), representing mostly the muscle mass change, and muscle strength with increasing age, and relationship between dietary, exercise behaviors and FFM in healthy middle-and old aged women who are of age over 55 years. The FFM and correspondingly hand grip strength showed significant positive correlation with age. But concentration of serum albumin showed no significant relationship with age. The subjects were categorized into groups according to FFM tertile. The anthropometry such as weight, BMI, fat mass, circumferences of waist and hip, WHR, and hand grip strength decreased significantly in the lowest FFM group. But the albumin level showed no change according to FFM level. The FFM showed significant correlation with nutrient intakes such as energy, carbohydrate, protein, Fe, P, Ca. No association, however, was shown with exercise behavior probably because of no case with resistance exercise habits. The variance of FFM was explained 55.2% by height and carbohydrate intake. The variance of height-adjusted FFM could be explained only 16.2% by intake amount of carbohydrate. In conclusion, the decrease of FFM may cause to reduce muscle strength in female elderly. The increasing nutrient intakes were associated with the increased FFM and may protect from risk of sarcopenia. However, only the carbohydrate intake could influence independently the FFM in middle- and old-aged women. The FFM has no association with endurance exercise habits. (Korean J Nutrition 34(4) : 449∼457, 2001)

• Journal of Nutrition and Health
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• 제26권2호
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• pp.189-195
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• 1993

This study conducted to investigate the effect of school lunch prgram on the blood composition of 50 children at the age 11 to 12 years old. Concentration of serum total protein, albumin, zinc and copper were measured at the begining of school lunch program(pre-feeding group) and at the one year later taken school lunch program(post-feeding group). Serum total protein and albumin concentrations in post-feeding group were higher than those in pre-feeding group, but showed no significant difference between groups. While serum zinc and copper concentrations in post-feeding group were significantly lower than those in pre-feeding group. Results indicated that school lunch program effective for improvement of potein nutrition in school children and it is nessessary futher investigation to disease the concentrations of serum zinc and copper in this age.