• Korean Journal of Veterinary Research
• /
• v.44 no.4
• /
• pp.507-513
• /
• 2004

Aflatoxins are produced mainly by Aspergillus flavus and Aspergillus parasiticus that grow in improperly stored cereals. Aflatoxin B1 ($AFB_1$) is a potent hepatocarcinogen in a variety of experimental animals including human beings. In spite of a high attention to the hepatocarcinogenecity of $AFB_1$, the relative toxicity of aflatoxins ($AFB_2$ and $AFG_1$) is not fully clarified. Sprague-Dawley male rats were orally administered with $AFB_1$, $AFB_2$, and $AFG_1$ at the dose of 250 ${\mu}g/kg$ (additionally including a dose of $1250{\mu}g/kg $ for $AFB_1$) body weight. Animals were then killed at 12, 24 or 48 hrs following aflatoxin exposure. Subsequently the immunohistochemical examination of p53, cytochrome p450 1A1 (CYP450 1A1), and glutathione-S-transferase placental form (GST-P) were performed. The level of the 8-OxodG in the liver was determined. Expressions of CYP450 1A1 and p53 were high in the liver of rats through 48 hrs after treatment of $AFB_1$ at the single dose of $250{\mu}g/kg $. This pattern was more clear as increasing doses. The treatment of $AFB_2$ and $AFG_1$ did not affect the expression of CYP450 1A1 but it caused weak expression of p53. The activity of GST were not found in the liver of rats treated with aflatoxins. The formation of 8-OxodG by $AFB_1$ increased in a dose-dependent manner up to 24 hrs after a single treatment of $AFB_1$ thereafter decreased to the level of control. The treatment of $AFB_2$ and $AFG_1$ did not affect the levels of 8-OxodG in the liver of rats with increasing time. These results in the present study indicate that $AFB_1$ among aflatoxins with low comparable levels is the most toxic as determined by early biomarkers such as CYP450 1A1, p53, GST-P, and 8-OxodG.

• Proceedings of the KIEE Conference
• /
• 2000.07a
• /
• pp.182-184
• /
• 2000

There are several facilities in Kochang distribution test center such as artificial fault generator(AFG), new distribution automation system(NDAS), communication networks (wireless and optic), lumped constant circuit, switches for distribution automation, overhead and underground distribution line. We have been field testing on remote control, data acquisition. remote metering, feeder automation and so on for distribution automation using those equipment.

• Proceedings of the Korean Institute of IIIuminating and Electrical Installation Engineers Conference
• /
• 2004.05a
• /
• pp.81-85
• /
• 2004

This paper describes the testing facility to demonstrate the performance of the distribution class circuit breakers and switchgears and the testing methods. The field-test evaluation system consists of two parts. One is the distribution system for simulation of the condition on interruption mode of switches which are installed in the system and tested by the AFG(Artificial Fault Generator) and the thunderbolt generator just like in the real field. The other is a laboratory for confirmation or the important characteristics regarding to the insulation, gas, environment durability of equipment. For the fatal failure mode, a FMEA(Failure Modes and Effects Analysis) technique which is a kind of a structural analysis to consider a counter-plan was emploved.

• Advances in nano research
• /
• v.13 no.6
• /
• pp.545-559
• /
• 2022

This paper studies the buckling response of nonuniform functionally graded micro-sized tubes according to the high-order tube theory (HOTT) and classical beam theory (CBT) in addition to nonlocal strain gradient theory. The microtube is made of axially functionally graded material (AFGM). Both inner and outer tube radiuses are changed along the tube length; the microtube is the truncated conical type of tube. The nonlinear partial differential (PD) the formulations are obtained on the basis of the energy conservation method. Then, the linear and nonlinear results are computed via a powerful numerical approach. Finally, the impact of various parameters on the stability of axially functionally graded (AFG) microtube regarding the buckling analysis is discussed.

• Advances in concrete construction
• /
• v.17 no.4
• /
• pp.187-210
• /
• 2024

Cantilever structures demonstrate diverse nonlocal effects, resulting in either stiffness hardening or dynamic softening behaviors, as various studies have indicated. This research delves into the free and forced vibration analysis of rotating nanoscale cylindrical beams and tubes under external dynamic stress, aiming to thoroughly explore the nonlocal impact from both angles. Utilizing Euler-Bernoulli and Reddy beam theories, in conjunction with higher-order tube theory and Hamilton's principle, nonlocal governing equations are derived with precise boundary conditions for both local and nonlocal behaviors. The study specifically examines two-dimensional functionally graded materials (2D-FGM), characterized by axially functionally graded (AFG) and radial porosity distributions. The resulting partial differential equations are solved using the generalized differential quadrature element method (GDQEM) and Newmark-beta procedures to acquire time-dependent results. This investigation underscores the significant influence of boundary conditions when nonlocal forces act on cantilever structures.

• The Korean Journal of Mycology
• /
• v.17 no.2
• /
• pp.66-75
• /
• 1989

Heterogeneity in antigenic composition of Aspergillus fumigatus isolates from clinical specimens and in antibody response of patients infected with this fungus was investigated by immunoblotting. A considerable quantitative and qualitative difference was found in composition of the culture filtrate antigens derived from a reference strain (ATCC 13073) and 8 clinical isolates of A. fumigatus on SDS-PAGE and immunoblots. The crude CF antigen of a strain AFG7 was selected to identify the serologically reactive and specific components by immunoblotting. Out of more than 36 components separated by electrophoresis, transblotted to nitrocellulose sheet, and reacted with sera that showed a positive reaction to A. fumigatus or other fungal antigens on immunodiffusion tests, merely four or so were found useful to serodiagnosis of aspergillosis. An antigen of 82KD was found most reactive and specific component so as to be contained in the standard preparation. Several other components, for example 11KD, 26KD, 30KD and 31KD, also possessed relatively high reactivity and specificity and seemed to be worth while purifying and characterizing. Antibody binding activity (reactivity) of the antigenic components was clearly shown on immunoblots because some were faintly stained with Coomassie blue but darkly stained on immunoblots, while some others behaved contrary to them. A number of components seemed to carry not only species specific but cross reactive antigenic determinants. Immunoblotting proved very useful to identify serologically reactive and specific components that should be present in the antigen to be employed to the serodiagnosis of aspergillosis.

• Journal of Ginseng Research
• /
• v.39 no.4
• /
• pp.384-391
• /
• 2015

It has been reported that Korean Red Ginseng has been manufactured for 1,123 y as described in the GoRyeoDoGyeong record. The Korean Red Ginseng manufactured by the traditional preparation method has its own chemical component characteristics. The ginsenoside content of the red ginseng is shown as Rg1: 3.3 mg/g, Re: 2.0 mg/g, Rb1: 5.8 mg/g, Rc:1.7 mg/g, Rb2: 2.3 mg/g, and Rd: 0.4 mg/g, respectively. It is known that Korean ginseng generally consists of the main root and the lateral or fine roots at a ratio of about 75:25. Therefore, the red ginseng extract is prepared by using this same ratio of the main root and lateral or fine roots and processed by the historical traditional medicine prescription. The red ginseng extract is prepared through a water extraction ($90^{\circ}C$ for 14-16 h) and concentration process (until its final concentration is 70-73 Brix at $50-60^{\circ}C$). The ginsenoside contents of the red ginseng extract are shown as Rg1: 1.3 mg/g, Re: 1.3 mg/g, Rb1: 6.4 mg/g, Rc:2.5 mg/g, Rb2: 2.3 mg/g, and Rd: 0.9 mg/g, respectively. Arginine-fructose-glucose (AFG) is a specific amino-sugar that can be produced by chemical reaction of the process when the fresh ginseng is converted to red ginseng. The content of AFG is 1.0-1.5% in red ginseng. Acidic polysaccharide, which has been known as an immune activator, is at levels of 4.5-7.5% in red ginseng. Therefore, we recommended that the chemical profiles of Korean Red Ginseng made through the defined traditional method should be well preserved and it has had its own chemical characteristics since its traditional development.

• Journal of Food Hygiene and Safety
• /
• v.34 no.2
• /
• pp.205-211
• /
• 2019

This study surveyed mycotoxin contamination in grains and grain products, which were purchased from supermarkets and traditional markets from October 2017 to September 2018 in Gwangju (Metropolitan City). A total of 127 samples including adlay, sorghum, millet, rice, oats, barley, buckwheat, corn as grains, and rice flour, buckwheat flour, roasted barley and corn, as grain products were surveyed. The tested mycotoxins were aflatoxin ($AFB_1$, $AFB_2$, $AFG_1$, $AFG_2$), fumonisin ($FUB_1$, $FUB_2$), ochratoxin A (OTA), and zearalenone (ZON). Mycotoxins were analyzed simultaneously with a UPLC-tandem mass spectrometry method. Fumonisin ($B_1+B_2$) was detected at the range of $4.8{\sim}738.5{\mu}g/kg$ in 35 samples and zearalenone at $8.4{\sim}507.6{\mu}g/kg$ in 20 samples, respectively. No other mycotoxins were detected. Risk assessment was evaluated by using estimated daily intake (EDI) and provisional maximum tolerable daily intake (PMTDI) in accordance with the Joint FAO/WHO Expert Committee on Food Additives (JECFA). When the hazard index (HI) was expressed as $(EDI/PMTDI){\times}100$, the HI (%) showed in the range of 0.0019~1.9526%. Based on these results, mycotoxin concentrations in the grains and grain products were within safe levels.

• Advances in nano research
• /
• v.12 no.2
• /
• pp.167-183
• /
• 2022

In this paper, the free and forced vibration analysis of rotating cantilever nanoscale cylindrical beams and tubes is investigated under the external dynamic load to examine the nonlocal effect. A couple of nonlocal strain gradient theories with different beams and tubes theories, involving the Euler-Bernoulli, Timoshenko, Reddy beam theory along with the higher-order tube theory, are assumed to the mathematic model of governing equations employing the Hamilton principle in order to derive the nonlocal governing equations related to the local and accurate nonlocal boundary conditions. The two-dimensional functional graded material (2D-FGM), made by the axially functionally graded (AFG) in conjunction with the porosity distribution in the radial direction, is considered material modeling. Finally, the derived Partial Differential Equations (PDE) are solved via a couple of the generalized differential quadrature element methods (GDQEM) with the Newmark-beta techniques for the time-dependent results. It is indicated that the boundary conditions equations play a crucial task in responding to nonlocal effects for the cantilever structures.

• Proceedings of the KIEE Conference
• /
• 2015.07a
• /
• pp.1034-1035
• /
• 2015

Watertight 25.8 kV/600 A/12.5 kA fault current limiters (FCLs) have successfully installed in five areas (Incheon, Seoul, Gyeong-gi, Daejeon, Suwon) on KEPCO power distribution line for the purpose of commercial demonstrations. The fault current limiting operation of this FCL, which includes functions of sensing, commutation, and reduction of fault currents, is perfectly completed within 1 cycle immediately after fault occurs. The performance of FCL was verified by short circuit test, impedance test, insulation test, temperature-rise test, and control test, etc at PT&T in LS industrial systems, which is the official certification institute in Korea. In 2013, and also the FCL field test was performed in order to test the protection coordination between conventional relays and FCL, on the 1.5 kA and 5.0 kA faults, which were made by connecting the Artificial Fault Generator (AFG) to the distribution line in test grid at KEPCO Power Testing Center. The next step of this project is to check the FCL conditions caused by real external environment, and acquire the various data from five regions installed with FCL. In this paper, we intend to explain the FCL specifications and performance characteristics, and check the expected effect by application of FCL to power distribution line based on the power system analysis of an application site.