• Asian-Australasian Journal of Animal Sciences
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• 제30권11호
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• pp.1529-1539
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• 2017

Objective: The objective of this study was to compare the DNA methylation profile in the longissimus dorsi muscle between Small Tailed Han and Dorper${\times}$Small Tailed Han crossbred sheep which were known to exhibit significant difference in meat-production. Methods: Six samples (three in each group) were subjected to the methylated DNA immunoprecipitation sequencing (MeDIP-seq) and subsequent bioinformatics analyses to detect differentially methylated regions (DMRs) between the two groups. Results: 23.08 Gb clean data from six samples were generated and 808 DMRs were identified in gene body or their neighboring up/downstream regions. Compared with Small Tailed Han sheep, we observed a tendency toward a global loss of DNA methylation in these DMRs in the crossbred group. Gene ontology enrichment analysis found several gene sets which were hypomethylated in gene-body region, including nucleoside binding, motor activity, phospholipid binding and cell junction. Numerous genes were found to be differentially methylated between the two groups with several genes significantly differentially methylated, including transforming growth factor beta 3 (TGFB3), acyl-CoA synthetase long chain family member 1 (ACSL1), ryanodine receptor 1 (RYR1), acyl-CoA oxidase 2 (ACOX2), peroxisome proliferator activated receptor-gamma2 (PPARG2), netrin 1 (NTN1), ras and rab interactor 2 (RIN2), microtubule associated protein RP/EB family member 1 (MAPRE1), ADAM metallopeptidase with thrombospondin type 1 motif 2 (ADAMTS2), myomesin 1 (MYOM1), zinc finger, DHHC type containing 13 (ZDHHC13), and SH3 and PX domains 2B (SH3PXD2B). The real-time quantitative polymerase chain reaction validation showed that the 12 genes are differentially expressed between the two groups. Conclusion: In the current study, a tendency to a global loss of DNA methylation in these DMRs in the crossbred group was found. Twelve genes, TGFB3, ACSL1, RYR1, ACOX2, PPARG2, NTN1, RIN2, MAPRE1, ADAMTS2, MYOM1, ZDHHC13, and SH3PXD2B, were found to be differentially methylated between the two groups by gene ontology enrichment analysis. There are differences in the expression of 12 genes, of which ACSL1, RIN2, and ADAMTS2 have a negative correlation with methylation levels and the data suggest that DNA methylation levels in DMRs of the 3 genes may have an influence on the expression. These results will serve as a valuable resource for DNA methylation investigations on screening candidate genes which might be related to meat production in sheep.

• ALGAE
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• 제24권1호
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• pp.1-29
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• 2009

A synthesis of early exploration and the discovery of marine algae in the upper North Pacific and Bering Sea is presented covering the period from the late 1730s to around 1900. Information is provided about these early efforts to gather natural objects, including seaweeds, and names of these algae are enumerated. The first collections of marine algae in this broad region were those made by steller and Kracheninnkov from the Kamchatka Peninsula,Russia,during the Second Kamchatkan Expedition (1735-1742) and were described by Gmelin (1768). The first known algal collections in Alaska were those made byMerck in his 1790-1791 visits to Unalaska Island during the Billings expedition (1785-1794). British-sponsored expeditions for commercial purposes and for exploration and dis-covery allowed surgeon-naturallist Archibald Menzies to garher seaweeds that Dawson Turner and others worked up back in Europe. Several of the Russian Expeditions during the first half of the 18'!' century had naturalists aboard. the first Russian circumnavigation of the globe (1803-1806), with the ships 'Nadeshda' and 'Neva,' under the com-mand of Capt. Adam von Krusenstern had naturalists Langsdorff, Tilesius, and Horner, all of whom collected sea-weeds. The naturalist Adelbert Chanmisso accompanied the Romanzof Expedition (1815-1818) on the Russian vessel 'Rurik' under the command of Otto von Kotzebue and made collections of algae in the Aleutians as well as in the Kurils and Kamchatka. The Lutke expedition of 1826-1829 consisted of thw ships. Feodor Lutke was in command of the 'Seniavin' with K.H. Mertens aboard as physician-naturalist, and the 'Moller' was under the command of staniukovich accompanied by the naturalist G. Kastalsky. The first American-sponsored scientific expedition (1838-1842) was that commanded by Charles Wilkes, and the algae that were collected were worked up by J.W. Bailey and W.H. Harvey. The Russian naturalist Ilya Voznesenskii spent the period 1839-1849 in Russian Americ (Alaska and northern California) energetically traveling and making numerous collections of natural objects as well as ethno-graphic artefact. His algae were described by F.j. Ruprecht back in St. petersbung. The Swedish scientific vessel, the'Vega' (1878-1880), was under the command of Nordenskiold. The naturalist F.R. Kjellman made algal collections from Port Clarence, Alaska, as well as from bering Island and St. Lawrence Island in the Bering sea. The Harriman Alaskan Expedition in the summer of 1899, with the ship 'George W. Elder,' was sponsored by railroad magnate E.H. Harriman of New York City and had several scientific personnel aborad, including the phycologist De Alton Saunders. Algae were collected in Alaska and Washington. During the same summer of 1899 a scientific expedition organized by the University of California and including W.L. Jepson, L.E. Hunt, A.A Lawson, and W.A. Setchell as participants also visited Alaska and made collections of alage from various locations.

• 대한기계학회논문집A
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• 제41권7호
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• pp.599-605
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• 2017

무인 자율 주행 차량이 야지 환경에서 안전하게 주행하기 위해서는 차량의 주행 안정성이 반드시 고려되어야 한다. 본 논문에서는 실시간 주행 안정성 분석을 위한 자율 주행 시뮬레이션에 적용되는 경로 추종 제어기를 제시한다. 경로 추종 제어기는 Preview 거리를 사용하여 차량의 지향 각을 제어하고, 요 모멘트 관측기로부터 추정된 외란 모멘트를 보상하여 지향 각 오차와 횡 방향 거리 오차를 감소시킨다. 곡선 경로에서는 곡률을 이용하여 차량의 주행 속도를 결정한다. 대상 차량은 6X6 스키드 조향 차량이기 때문에 6개의 휠에 서로 다른 구동력을 분배하는 방법을 사용하여 주어진 경로를 주행한다. ADAMS에서 모델링 된 차량을 MATLAB과 연동시켜 시뮬레이션하고, 경로 추종 제어기 성능을 검증하였다.

• 천문학논총
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• 제32권2호
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• pp.367-380
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• 2017

The life and astronomical activity of Lee Deok-Seong (李德星, 1720-1794) was studied using various historical sources, including the astronomical almanac, Seungjeongwon-Ilgi (Daily records of Royal Secretariat of Joseon dynasty), and the Gwansang-Gam's logbooks during Joseon dynasty (A.D. 1392-1910). We present the results of the study including the following main findings. First, from the investigation of Lee's family tree, we find that a number of his relatives were also astronomers, notably Samryeok-Gwan (三曆官, the post of calendrical calculation). Second, we find that he took part in the compilation of an annual astronomical almanac over a period of at least 16 years. His major achievements in the astronomy of the Joseon dynasty were to establish a new method of calendar-making calculation and to bring astronomical materials to the Joseon court through a visit to China. The Joseon dynasty enforced the Shixianli (時憲曆, a Chinese calendar made by Adam Shall) in 1654 without fully understanding the calendar. So an astronomer and an envoy were dispatched to China in order to master the intricacies of the calendar and to learn as much of Western science as was available in that time and place. Lee Deok-Seong worked at the Gwansang-Gam (觀象監, Royal Astronomical Bureau) during the reigns of King Yeongjo (英祖) and Jeongjo (正祖). As best as we can ascertain in relation with the calculations in the Shixian calendar, Lee visited China four times. During his trips and interactions, he learned a new method for calendar-making calculations, and introduced many Western-Chinese astronomical books to Joseon academia. Lee greatly improved the accuracy of calendrical calculations, even while simplifying the calculation process. With these achievements, he finally was promoted to the title of Sungrok-Daebu (崇祿大夫), the third highest grade of royal official. In conclusion, history demonstrates that Lee Deok-Seong was one of the most outstanding astronomers in the late-Joseon dynasty.

• 디지털융복합연구
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• 제17권12호
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• pp.467-472
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• 2019

국내 스마트폰 이용률이 증가함에 따라 모바일 게임의 발전 속도도 빨라지고 있지만, 시장 규모가 커짐에 따라 경쟁이 심화되는 현상이 나타나고 있다. 이러한 모바일 게임 시장에서 게임을 성공시키기 위한 요소 중 하나로 UI를 제시하고 있는데, 이러한 모바일 게임 UI 설계 시 이전에 기능과 심미적 표현, 기능중심디자인과 정보 전달과 더불어 사용자의 경험을 설계하는 측면에서 접근되어야 한다는 주장이 제시되었다. 본 논문에서는 UX요소 중 경험을 이용해 효과적인 모바일 RPG의 로비 layout을 제시하였다. Ernest Adams와 Andrew Rollings의 레이아웃 분류 방법을 통해 google play 누적매출 순위 20위 내 모바일 RPG의 9개를 선정해 로비 layout을 분석한 결과 모바일 RPG장르의 첫 시장 흥행을 이끌었던 게임의 로비 layout이 이후 출시되어 흥행한 게임의 기준이 되었다는 결과가 나왔다. 이는 기존 RPG를 이용했던 경험에 의해 낮은 진입장벽과 학습이 불필요 하다는 점에서 이용자가 이전에 이용하였던 게임과 유사하게 느끼는 로비 layout이 효과적이라고 해석할 수 있다. 향후 연구에서는 RPG 이외의 다른 장르에 관한 최적의 UX를 측정할 수 있는 연구가 진행된다면 넓은 장르의 공통적인 layout을 도출해낼 수 있을 것이다.

• 대순사상논총
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• 제34집
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• pp.323-351
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• 2020

此论文的目的是通过横向比较 《圣经》 和 《典经》 中的道成肉身思想, 揭示基督教最终走向神本主义道路, 大巡真理会最终走向人文主义道路的根本原因。基督教和大巡真理会都承认人的世界之上另有一个人的感官触及不到的世界。而且他们都主张上面的世界有一个至高者, 而且这位至高者通过女人的身体来到了人的世界。但不同的是, 基督教认为2000多年前在伯利恒出生的耶稣就是那位至高者, 而大巡真理会认为100多年前出生在朝鲜客望里的姜一淳才是那位至高者。基督教的神来到人间是为了替人类赎罪, 为此道成肉身者被钉在了十字架上流干了血, 成了赎罪的羔羊。大巡真理会的上帝降诞人间是为了帮人类解冤, 为此道成肉身者大巡天地人三界, 探索偏斜的度数并将其调正。基督教所谓的"罪"本质上是对至高神的"背叛", 这意味着神的世界不能容忍罪, 所以当第一个人 (亚当) 背叛神以后被赶出了圣洁的伊甸园。从此人的世界与神的世界之间就产生了不能逾越的鸿沟。相反, 大巡真理会所谓"偏斜的度数"并非是对至高者的背叛, 而只是一种自然的结果而已。也就是说, 度数偏斜的现象不仅能发生在人的世界里, 也能发生在神明的世界之中, 而且两个世界还可以相互作用, 相互影响。因此可以说, 基督教思想中的两个世界是两个完全不同秩序和不同系统的世界, 而大巡真理会思想中的两个世界是同一个秩序和同一个系统下运转的世界。大多数将某一事物分割成两个部分的思想主要是为了强调一边比另一边更重要或更关键。基督教以神的世界为人世界的最终根源和终极关怀, 以人对神的绝对信仰和绝对崇拜为人生最高的价值。相反大巡真理会则认为人的世界决定了神明界的存在意义, 主张人与人之间, 人与自然之间的互利相生是人尊时代的核心价值。由此可以得出本论文的最终结论 : 导致基督教踏上神本主义道路的根本原因是他们相信在完全相隔绝的两个世界中, 神的世界是人世界的最终根源和终极关怀 ; 导致大巡真理会走向人文主义的根本原因是他们相信在可以相互作用且可以相互影响的神明界与人世界中, 人世界决定神明界的存在意义。

• Geomechanics and Engineering
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• 제35권2호
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• pp.121-133
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• 2023

The demand for cement and limestone crushed materials has increased many folds due to the tremendous increase in construction activities in Pakistan during the past few decades. The number of cement production industries has increased correspondingly, and so the rock-blasting operations at the limestone quarry sites. However, the safety procedures warranted at these sites for the blast-induced ground vibrations (BIGV) have not been adequately developed and/or implemented. Proper prediction and monitoring of BIGV are necessary to ensure the safety of structures in the vicinity of these quarry sites. In this paper, an attempt has been made to predict BIGV using artificial neural network (ANN) at three selected limestone quarries of Pakistan. The ANN has been developed in Python using Keras with sequential model and dense layers. The hyper parameters and neurons in each of the activation layers has been optimized using randomized and grid search method. The input parameters for the model include distance, a maximum charge per delay (MCPD), depth of hole, burden, spacing, and number of blast holes, whereas, peak particle velocity (PPV) is taken as the only output parameter. A total of 110 blast vibrations datasets were recorded from three different limestone quarries. The dataset has been divided into 85% for neural network training, and 15% for testing of the network. A five-layer ANN is trained with Rectified Linear Unit (ReLU) activation function, Adam optimization algorithm with a learning rate of 0.001, and batch size of 32 with the topology of 6-32-32-256-1. The blast datasets were utilized to compare the performance of ANN, multivariate regression analysis (MVRA), and empirical predictors. The performance was evaluated using the coefficient of determination (R²), mean absolute error (MAE), mean squared error (MSE), mean absolute percentage error (MAPE), and root mean squared error (RMSE)for predicted and measured PPV. To determine the relative influence of each parameter on the PPV, sensitivity analyses were performed for all input parameters. The analyses reveal that ANN performs superior than MVRA and other empirical predictors, andthat83% PPV is affected by distance and MCPD while hole depth, number of blast holes, burden and spacing contribute for the remaining 17%. This research provides valuable insights into improving safety measures and ensuring the structural integrity of buildings near limestone quarry sites.

• Hip & pelvis
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• 제35권3호
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• pp.183-192
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• 2023

Purpose: This study aims to determine which intertrochanteric (IT) hip fracture and patient characteristics predict the necessity for adjunct reduction aides prior to prep and drape aiming for a more efficient surgery. Materials and Methods: Institutional fracture registries from two academic medical centers from 2017-2022 were analyzed. Data on patient demographics, comorbidities, fracture patterns identified on radiographs including displacement of the lesser trochanter (LT), thin lateral wall (LW), reverse obliquity (RO), subtrochanteric extension (STE), and number of fracture parts were collected, and the need for additional aides following traction on fracture table were collected. Fractures were classified using the AO/OTA classification. Regression analyses identified significant risk factors for needing extra reduction aides. Results: Of the 166 patients included, the average age was 80.84±12.7 years and BMI was 24.37±5.3 kg/m². Univariate regression revealed increased irreducibility risk associated with RO (odds ratio [OR] 27.917, P≤0.001), LW (OR 24.882, P<0.001), and STE (OR 5.255, P=0.005). Multivariate analysis significantly correlated RO (OR 120.74, P<0.001) and thin LW (OR 131.14, P<0.001) with increased risk. However, STE (P=0.36) and LT displacement (P=0.77) weren't significant. Fracture types 2.2, 3.2, and 3.3 displayed elevated risk (P<0.001), while no other factors increased risk. Conclusion: Elderly patients with IT fractures with RO and/or thin LW are at higher risk of irreducibility, necessitating adjunct reduction aides. Other parameters showed no significant association, suggesting most fracture patterns can be achieved with traction manipulation alone.

• Monthly Notices of the Royal Astronomical Society
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• 제489권3호
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• pp.4389-4417
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• 2019

We study the dust properties of 192 nearby galaxies from the JINGLE survey using photometric data in the 22-850 ㎛ range. We derive the total dust mass, temperature T, and emissivity index β of the galaxies through the fitting of their spectral energy distribution (SED) using a single modified blackbody model (SMBB). We apply a hierarchical Bayesian approach that reduces the known degeneracy between T and β. Applying the hierarchical approach, the strength of the T-β anticorrelation is reduced from a Pearson correlation coefficient R = -0.79 to R = -0.52. For the JINGLE galaxies we measure dust temperatures in the range 17-30 K and dust emissivity indices β in the range 0.6-2.2. We compare the SMBB model with the broken emissivity law modified blackbody (BMBB) and the two modified blackbody (TMBB) models. The results derived with the SMBB and TMBB are in good agreement, thus applying the SMBB, which comes with fewer free parameters, does not penalize the measurement of the cold dust properties in the JINGLE sample. We investigate the relation between T and β and other global galaxy properties in the JINGLE and Herschel Reference Survey (HRS) sample. We find that β correlates with the stellar mass surface density (R = 0.62) and anticorrelates with the H i mass fraction (M_{H i}/M_*, R = -0.65), whereas the dust temperature correlates strongly with the star formation rate normalized by the dust mass (R = 0.73). These relations can be used to estimate T and β in galaxies with insufficient photometric data available to measure them directly through SED fitting.

• 한국도시환경학회지
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• 제18권4호
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• pp.531-546
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• 2018

동아시아지역을 대상으로 황사배출량 산정 모듈 및 이를 적용한 예보시스템을 개발하였고, 개발된 모형의 화학수송모델링 정합도 및 실시간 예보 운영 평가를 진행하였다. 2015년 화학수송모델링 정합도 평가 결과, 중국 지역에서는 황사 배출량을 적용한 예보 모형이 과대평가하는 기간이 있으나 대부분 지역에서 저평가 되었던 $PM_{10}$ 을 보완하고, 통계수치가 개선되는 것을 확인할 수 있었다. 한국 지역에서는 황사 발생일인 2월 22일~24일, 3월 16일~17일(서울지역대상)에는 황사의 유입을 적절히 모사하였으나 황사가 관측되지 않은 4월에는 황사를 적용한 예보모델이 과대평가하는 것을 확인할 수 있었다. 그러나 황사를 적용한 예보모형은 한반도 대부분 지역에서 저평가 되었던 $PM_{10}$ 을 보완하고, 통계수치가 개선되는 것을 확인할 수 있었다. 2017년 예보 성능 평가 결과, 황사배출량을 적용한 예보모델은 기존 모델과 비교하였을 때, POD는 대부분 개선되지만, A는 유사 또는 감소, FAR는 대부분 증가하는 경향이 나타났다. 황사배출량을 적용한 예보모형은 동아시아 지역에 저평가 하고 있는 $PM_{10}$ 을 보완하는 장점이 있지만, 황사배출량 산정의 불확실성 등이 내제되어 모델이 측정값을 과대모의하여 오경보율이 높다. 따라서 한반도 지역에 대표 대기질 예보모형으로 사용하기는 부적절하다고 판단된다. 그러나 황사 기간에는 황사배출량 모델의 모사성능은 우수하였으므로, 황사가 발생하는 기간에는 기존 모델과 융합하여 예보관이 예보하는 것이 필요하다고 사료된다.