• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.21 no.3
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• pp.150-165
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• 2008

Objective : An adequate measurement for Atopic Dermatitis(AD) is essential for studies about the treatment of AD. To establish a new and adequate scoring system for AD in Korean medicine, we reviewed existing studies on AD outcome measurement in Korean medicine. Method : We searched for reviews on measurements of AD or studies which used an AD outcome measurement at the Korean Traditional Knowledge Portal from 1995 to June, 2008. And then we reviewed the pattern identification in AD patients and the outcome measurements for AD in each study. Results : 1. Among 25 studies, the most common measurement for AD was SCORAD(the severity SCORing of Atopic Dermatitis index), there were 16 studies. There was one study which used the Jakob T scoring system, one study which used ADSI(the Atopic Dermatitis Severity Index), and there were 7 studies which established or used a new severity scoring system for AD. 2. In Korean medicine, AD caused by Damp-Heat is accompanied by erythema, papulation, oozing and crust, Damp-Heat accompanied by Spleen-Gi deficiency is frequently found in pediatric patients, and in adults who have indigestion. Symptoms of AD caused by blood deficiency and Wind-Dryness include lichenification, dryness, scale and pigmentation. AD caused by toxic Heat in the blood system has symptoms similar to some Damp-Heat pattern along with symptoms of blood deficiency and Wind-Dryness. Conclusion : We need to establish a new severity scoring system which reflects pattern identifications and treatments with Korean medicine, and we should assess the validity, reliability, and sensitivity of the new scoring system.

• Journal of Korea Multimedia Society
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• v.8 no.7
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• pp.974-987
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• 2005

As the ad hoc networks have been received a great deal of attention to not only the military but also the industry applications, some security mechanisms are required for implementing a practical ad hoc application. In this paper, we propose a security architecture in ad hoc networks for the purpose of supporting ID-based public key cryptosystems because of the advantage that ID-based schemes require less complex infrastructure compared with the traditional public key cryptosystems. We assume a trusted key generation center which only issues a private key derived from IDs of every nodes in the system setup phase, and use NIL(Node ID List) and NRL(Node Revocation List) in order to distribute the information about IDs used as public keys in our system. Furthermore, we propose a collaborative status checking mechanism that is performed by nodes themselves not by a central server in ad-hoc network to check the validity of the IDs.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.10 no.9
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• pp.1654-1662
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• 2006

An ad hoc network is multi-hop network composed of radio links. and the transmission quality of a radio link is more unstable than that of a wired circuit. Packet loss thus occurs frequently in an ad hoc network, and the consequent connection failure results in a severe deterioration of TCP performance. TCP performance also deteriorates because of the collision of data packets and ACK packets in the radio channel. In this paper we study to improve the performance of the Mobile Ad-hoc network by using Delayed ACK algorithm with our proposed ODA(Ordering-Delayed ACK) method. The proposed ODA algorithm increases the number of the data packets orderly at the receiver side which is going to be applied for the Mobile Ad-hoc network. We accomplished a computer simulation using NS-2. From the simulation results, we find the proposed ODA algorithm obviously enlarge the channel capacity and improve the network performance at the situation of multi-hop of ad-hoc network than the existing Delayed ACK algorithm.

• Journal of KIISE:Information Networking
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• v.33 no.4
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• pp.310-323
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• 2006

In this paper, we describe a secure cluster-routing protocol based on a multi-layer scheme in ad hoc networks. We propose efficient protocols, Authentication based on Multi-layer Clustering for Ad hoc Networks (AMCAN), for detailed security threats against ad hoc routing protocols using the selection of the cluster head (CH) and control cluster head (CCH) using a modification of cluster-based routing ARCH and DMAC. This protocol provides scalability of Shadow Key using threshold authentication scheme in ad hoc networks. The proposed protocol comprises an end-to-end authentication protocol that relies on mutual trust between nodes in other clusters. This scheme takes advantage of Shadow Key using threshold authentication key configuration in large ad hoc networks. In experiments, we show security threats against multilayer routing scheme, thereby successfully including, establishment of secure channels, the detection of reply attacks, mutual end-to-end authentication, prevention of node identity fabrication, and the secure distribution of provisional session keys using threshold key configuration.

• Journal of Satellite, Information and Communications
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• v.6 no.2
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• pp.60-65
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• 2011

Wireless devices can communicate between each other without existing infrastructure in mobile Ad-hod network. Ad hoc networks can be used under difficult conditions, where it is difficult to construct infrastructures, such as shadowing areas, disaster areas, war area, and so on. In order to support to considerable and various wireless services, more spectrum resources are needed. However, efficient utilization of the frequency resource is difficult because of spectrum scarcity and the conventional frequency regulation. Ad-hoc networks employing cognitive radio (CR) system that guarantee high spectrum utilization provide effective way to increase the network capacity. In this paper, to improve detection performance of the energy detection which is widely used in CR based ad-hoc network, we propose multiple antenna system for CR based ad-hoc networks.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2006.05a
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• pp.402-405
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• 2006

Mobile IP has been designed to have mobile host users move from place to plate without changing their IP address. Ad-hoc network is a provisional network whose mobile host users construct networks by themselves without any assistance of infra structure network, using wireless interface. In this paper we discuss the scheme with which Ad-hoc network users ran access the Internet freely, using mobile IP protocol, and Ad-hot networks are access networks in the spotlight. In this paper we propose algorithm that support enhanced mobility between two Ad-hoc networks applying mobile IP at Ad-hoc routing protocol.

• Nutrition Research and Practice
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• v.17 no.6
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• pp.1128-1142
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• 2023

BACKGROUND/OBJECTIVES: Inonotus obliquus has been used as antidiabetic herb around the world, especially in the Russian and Scandinavian countries. Diabetes is widely believed to be a key factor in Alzheimer's disease (AD), which is widely considered to be type III diabetes. To investigate whether I. obliquus can also ameliorate AD, it would be interesting to identify new clues for AD treatment. We tested the anti-AD effects of raw Inonotus obliquus polysaccharide (IOP) in a mouse model of AD (3×Tg-AD transgenic mice). MATERIALS/METHODS: SPF-grade 3×Tg-AD mice were randomly divided into three groups (Control, Metformin, and raw IOP groups, n = 5 per group). β-Amyloid deposition in the brain was analyzed using immunohistochemistry for AD characterization. Gene and protein expression of pertinent factors of the ubiquitin-proteasome system (UPS) was determined using real-time quantitative polymerase chain reaction and Western blotting. RESULTS: Raw IOP significantly reduced the accumulation of amyloid aggregates and facilitated UPS activity, resulting in a significant reduction in AD-related symptoms in an AD mouse model. The presence of raw IOP significantly enhanced the expression of ubiquitin, E1, and Parkin (E3) at both the mRNA and protein levels in the mouse hippocampus. The mRNA level of ubiquitin carboxyl-terminal hydrolase isozyme L1, a key factor involved in UPS activation, also increased by approximately 50%. CONCLUSIONS: Raw IOP could contribute to AD amelioration via the UPS pathway, which could be considered as a new potential strategy for AD treatment, although we could not exclude other mechanisms involved in counteracting AD processing.

• The Journal of Korean Medicine
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• v.22 no.2
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• pp.10-21
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• 2001

Objectives : Atopic dermatitis(AD) assume an remarkable clinical aspect and it s diagnosis almost depends on clinical symptoms. Therefore, we aimed to study the clinical diagnostic standard of AD for more accurate treatment. We repert as follows; Methods : For 6 months from March to August in 2000 we selected fifty outpatients who were prognosis of AD in the department of dermatology, Oriental medical hospitol, Dong-eui University. Results and Conclusions : 1. We classified of the grade, the condition of AD patient was slight and severe, by the sum of total by the clinical index of AD (diagnostic features). 2. By consulting previous oriental medical theories, we divided symptom-complex of AD into two type ; one was damp-heat type and the other was deficiency of blood- wind-dryness type. 3. Male to female ratio was 17 : 33 and the third stage, more than half of the patients were adolescents. 4. According to the results of symptom-complex of AD patients, on the first examination damp-heat type was more than deficiency of blood-wind-dryness type and in progressing treatment, the condition has been change to deficiency of blood-wind-dryness type. 5. In the lesions of AD, arm and knee were most serious skin lesions and in symptoms of AD, pruritus was most complained, and in progressing treatment, erosion and erythema were greatly improved. 6. When we measured the levels of serum Total IgE, that of thirty eight patientswere higher than that of normal, but elevation of serum IgE levels was not correlated with the severity of AD.

• Biomolecules & Therapeutics
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• v.14 no.3
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• pp.148-151
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• 2006

We have previously reported that 2.4 kb of L-plastin promoter (LP) could regulate the expression of adenoviral vector (AV) exogenous genes in a tumor cell specific manner. In the present study, we tested if the replication competent AdLPE1A vector results in a direct cytotoxic effect in hepatocelluar carcinoma (HCC) cells. In vitro cytotoxicity tests were carried out with replication-competent (AdLPE1A) and -incompetent (AdLPCD) LP-driven vectors. AdLPE1A is an AV in which LP was inserted 5' to the E1A and E1B genes. The AdLPCD vector contains LP and the E. coli cytosine deaminase (CD) gene in transcription unit. Exposure of cells to AdLPE1A generated a significant cytotoxic effect as compared to the control. Almost 90% of the cell had manifested the characteristic cytopatic effect on day 9 after infection of cells with 10 MOI of AdLPE1A. On the other hand, almost 35% of the cells were left when the cells had been treated with 100 MOI of AdLPCD together with 5-FC on day 9 when compared with the cells which had never been exposed neither 5-FC nor AdLPCD. These results showed that the replication competent AdLPE1A vector could kill the HepG2 cells directly by the oncolytic effect of the virus. The replication competent AV vector carrying viral E1A generated greater cytotoxic effect than the replication incompetent AV, which contains the CD prodrug activation transcription unit without E1A, in HepG2 cells.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.34 no.4A
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• pp.309-315
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• 2009

Wireless Ad-hoc networks are dynamic networks that consist of mobile nodes. Nodes in Ad-hoc networks are usually laptops, PDAs or mobile phones. These devices feature Bluetooth and/or IEEE 802.11 (WiFi) network interfaces and communicate in a decentralized manner. Due to characteristics of Ad-hoc networks, Mobility is a key feature of routing protocol design. In this paper, we present an enhanced routing maintenance scheme that cope with topology changes pre-actively. The key feature of the proposed scheme is to switch next-hop node to alternative neighbor node before link breakage for preventing route failure. From extensive experiments by using NS2, the performance of the proposed scheme has been improved by comparison to AODV protocol.