• Title/Summary/Keyword: ACUTE TOXICITY

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Investigation of Eco-toxicological Substances in Banwol Industrial Drainages using the Regression Analysis (회귀분석을 이용한 반월 공단배수의 생태독성 원인물질 조사)

  • Kim, Yo-Yong;Woo, Jung-Sik;Hwang, Sun-Min;Kim, Moon-Jeong
    • Journal of Korean Society on Water Environment
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    • v.28 no.3
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    • pp.467-472
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    • 2012
  • In this study, water quality and acute toxicity using Daphnia magna were analyzed to investigate the eco-toxicological substances identified as statistical analysis and propose a management plan for the effluent of Banwol industrial complex, Ansan, Gyeonggi-do. Cu, Zn, F, Mn concentrations in the effluent far exceeded the US standards to protect the aquatic ecosystem and eco-toxicity values were 5 ~ 22 TU. However, concentrations of heavy metals significantly decreased after Ansan public wastewater treatment plant operating a biological treatment and toxicity values were 0 TU. Zn, Cr, F and Cu in the effluent showed very strong and strong positive correlations with eco-toxicity values, respectively. Regression analysis resulted in an equation between toxicity and Zn, TU = $4.884{\times}Zn$ (mg/L) -0.391 showing Zn concentration should be managed less than 0.285 mg/L to keep the eco-toxicity (TU) less than 1.

Single Dose Toxicity Studies of STB-HO-BM in Rats and Dogs (게르마늄 복합물 STB-HO-BM의 랫드 및 비글견에서 단회투여 독성연구)

  • Song Si-Whan;Jung Winston;Hong Dong-Ho
    • Toxicological Research
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    • v.22 no.2
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    • pp.153-156
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    • 2006
  • The acute toxicity of STB-HO-BM was evaluated in Sprague Dawley (SS) rats and beagle dogs. STB-HO-BM was administered orally to rats at dose levels of 0 and 2,000mg/kg/day and to dogs at dose levels of 0, 500, 1,000 and 2,000 mg/kg/day. In these experiments, there were no death and clinical changes which were related to STB-HO-BM administration. In addition, there were no significant changes between control and treated groups in body weights and autopsy findings. In conclusion, the administration of STB-HO-BM 2,000 mg/kg in SD rats and up to 2,000mg/kg in beagle dogs was proved to be safe, and it is thought that STB-HO-BM may not show any toxicity in its clinical use.

SINGLE OR FOUR-WEEK REPEATED INTRAVENOUS TOXICITY STUDIES OF A NEW CEPHALOSPORIN ANTffiIOTIC AGENT, IDC-7181 IN RATS

  • Zhang, Hu-Song;Huang, Zai-Zhi;Jung, Eun-Yong;Jung, Seong-Eui;Lim, Kwang-Hyun;In, Chang-Hoon;Kim, Dae-Joong;Nam, Sang-Yoon;Kang, Jong-Koo
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2001.10a
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    • pp.169-169
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    • 2001
  • This study was designed to evaluate an acute and subacute intravenous dose toxicity of a new cephalosporin antibiotic agent, IDC-7181 in 7-week-old Sprague-Dawley rats. IDC-7181 was intravenously injected to rats at dose levels of 0, 3.2, 16, 80, 400 and 2, 000 mg/kg/day for single dose toxicity study and at dose levels of 0, 10, 50 and 250 mg/kg/day for 4 week-repeated dose toxicity study. All rats survived throughout the study periods.(omitted)

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Pharmacological Effects of Puerariae Radix Butanol Extract on Cadmium Toxicity in Rats. (갈근 부탄올 엑기스가 흰쥐에 유발된 카드뮴 독성에 미치는 영향)

  • 손동헌;안형수;신승덕
    • YAKHAK HOEJI
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    • v.29 no.4
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    • pp.206-215
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    • 1985
  • 1) Puerariae Radix butanol ext. (100, 200, 400mg/kg, p.o. single treatment) alone partly showed blood pressure decreasing effect in SHRs and increasing effect of urinary volume in normal rats. 2) Cadmium nitrate (10mg/kg, s.c. single treatment) induced toxicity such as body weight decreasing effect, antidiuretic effect and muscle relaxant effect such as pull-up test, traction test and rota rod test in rats. However, Puerariae Radix butanol ext. (100, 200, 400mg/kg, p.o. single treatment) showed antidotal effects on the above and also in acute toxicity test when coadministered with both of them. 3) Cadmium nitrate (1mg/kg, s.c. 7 days consecutive treatment) did not showed toxicity in body weight change, blood pressure, change, serum biochemical parameters in rats. Puerariae Radix butanol ext. (100, 200, 400mg/kg, p.o. 7 days consecutive treatment) did not also showed any antidotal effects when coadministered with both of them for 7 days.

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Protective Effect of Licorice Water Extract against Cadmium-induced Nephro-toxicity in Rats

  • Lee, Jong-Rok;Kim, Sang-Chan
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.21 no.3
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    • pp.771-775
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    • 2007
  • Licorice has been used for cure of injuries and for detoxification in East Asia. This study investigated the protective effect of licorice water extract against cadmium (CdCl$_2$, Cd)-induced nephro-toxicity in rats. To induce acute toxicity, Cd (4 mg/kg body weight) was dissolved in normal saline and then, intravenously (i.v.) injected to animals. In experiments, animals were orally administrated with vehicle or licorice water extract (50-100 mg/kg) for 3 days, exposed to a single injection of Cd after 24 h the last licorice/vehicle treatment. Licorice protected kidney injuries by Cd treatment. The number of glomeruli showing vasodilatation and thickening of Bowman's capsule was dose-dependently decreased by licorice. These results suggest that licorice might be a potent preventive protector against Cd-induced nephro-toxicity in rats.

Safety of radiotherapy in patients with Behcet's disease: a case report and review of the literature

  • Ko, Dahui;Kim, Young Suk;Choi, Yunseon
    • Journal of Medicine and Life Science
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    • v.18 no.2
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    • pp.35-39
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    • 2021
  • Exaggerated acute and late toxicities following radiotherapy have been reported in patients with pre-existing connective tissue diseases, such as systemic lupus and scleroderma. Behcet's disease (BD) is a relapsing multisystem connective tissue disease characterized by vasculitis in the mucocutaneous, ocular, gastrointestinal, respiratory, neurologic, urogenital, articular, and cardiovascular systems. Data concerning the relationship between radiotherapy toxicity and BD are limited in the literature. Here, we report a case of lung cancer treated with radiotherapy (60 Gy) in a patient with BD. No severe radiation-induced toxicity was observed. Radiation-induced toxicity in patients with BD has also been discussed.

TOXICOLOGICAL EVALUATION OF ETHANOLIC EXTRACT FROM THE ROOT OF SCUTELLARIAE RADIX (황금(Scutellariae Radix)의 에타놀추출물과 프랄보노이드 성분들의 독성평가)

  • Chung, Chong-Pyoung;Ku, Young;Bae, Gi-Hwan
    • Journal of Periodontal and Implant Science
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    • v.25 no.3
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    • pp.470-477
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    • 1995
  • Flavonoids from Scutellariae Radix possessed a dual function both as an anti-inflammatory agent and an enhancer of cellular activity in gingival fibroblast. The purpose of this study was to evaluate on the toxicity of ethanolic extract from the root of Scutellariae Radix Georgi and its flavonoids, Wogonin, Baicalein, and Baicalin were isolated and purified by the following method. The crude drug was extracted with ethyl acetate and the residue was dissolved in ethyl alcohol. The ethyl alcohol soluble fraction was separated, concentrated, and then chromatographed on a silica gel column. The acute oral LD 50 in rats was determined for EtOH ex. of Scutellariae Radix and three compounds were evaluated with a single oral gavage at three graded dosage levels. The acute intravenous LD 50 was determined with a single intravenous injection via the jugular vein at three graded dosage levels. Groups of 5 male and 5 female rats, 6 week of age at the start of the study, were fed diets containing 3 graded dosage levels for 14 days. Groups of 5 male and 5 female hamster received O.5ml of the test article at once in a day for 5 days to the buccal cheek pouch for two minutes each. The acute oral LD50 for EtOH ex. of Scutellariae Radix is 1430mg/kg, and for Wogonin 1320mg/kg, for Baicalein 1250mg/kg, for Baicalin 1330mg/kg. The acute intravenous toxicity of EtOH ex. of Scutellariae Radix and its extracts was found to be 27mg/kg body weight No toxic effects were observed in rats fed up to 200mg/kg of EtOH ex. of Scutellariae Radix, Wogonin, Baicalein and Baicalin in the diet for 14 days. The acute Mucouse Membrane LD 50 in hamsters was found to be greater than 100mg/kg. These results suggested that EtOH ex. of Scutellariae Radix and its flavonoids are safe for oral care products using limited amount of extract.

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Effects of the Administration of 5-(4'- Pipweisinomwrhylphwnly)-2,3-dihydroimidazo[2,1-a] is pquinoline (SDZ-62-434) on Rat Kidney

  • Yi, E.Y.;Ma, Y.;Choi, W.J.;Park, J.S.;Cheon, S.H.;Lim, D.K.
    • Toxicological Research
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    • v.12 no.2
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    • pp.277-281
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    • 1996
  • To evaluate the renal toxicity of the antitumor agent, 5-(piperidonomethylphenyl)-2,3-dihydroimidazo[2,1-a]isoquinoline (SDZ-62-434), rats were treated with SDZ-62-434 of 50 mg/Kg, i.p., once and 10 mg/Kg, i.p., daily for 7 days. The kidney weights and urine volume after and during the treatment were observed. The concentrations of urinary creatinine, protein, and the activities of N-acetyl-$\beta $D-glucosaminidase (NAG), alanine aminopeptidase (AAP), $\gamma$-glutamyl transpeptidase (GGT) and lactate dehydrogenase (LDH) in 24 hr urine were also determined. The kidney weights after acute and subacute administration was not affected. The urine excretions were increased 5 days after the acute administration and increased after the daily 3rd day-administration. The excretion of creatinine was similar as that of urine excretion. The excretion of creatinine was increased 5 days after the acute and subacute administration. However, the protein excretion didn't changed in both treatment. Those indicate that SDZ-62-434 might induce the diuresis and also suggest that diuresis might be due to the some metabolites rather than the compound itself. The urinary activities of NAG and LDH were not affected after the acute treatment. However, the urinary activities of AAP and GGT were slightly increased 3 days after the acute administration but, returned to the control value. In subacute treatment, the activities of GGT was not changed. And the activities of NAG were declined after the 7th day-administration. However, the activities of AAP were significantly increased after the 5th day-administration. Furthermore, the urinary activities of LDH were continuously increased during the subacute administration. These results indicate that the high and subacute administration might induce a weak damage on the kidney cells. Furtherrnore, the present results suggest that SDZ-62-434 might have relatively slow-emerging and mild toxicity to the kidney.

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