• 한국문헌정보학회지
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• 제56권4호
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• pp.335-356
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• 2022

대학은 교육 및 연구 활동을 통하여 민주시민으로서의 소양과 자질을 구비한 전문 인력을 양성하고 지식을 축적·창출하여 국가와 사회발전에 기여한다. 이를 위하여 정부는 대학재정지원사업을 통하여 대학의 기본 역량을 향상시키고 자율적 혁신을 지원하고 있다. 재정지원사업은 공정한 평가를 통하여 비교 우위에 있는 대학에 한정된 정부의 재정을 차등 지원하므로 대학의 경쟁력을 강화하기 위해서는 교육과 연구를 지원하는 교육기본시설이자 핵심기관인 대학도서관의 역할과 기능이 중요하다. 하지만 대학도서관은 재정 및 인력 부족, 시설·설비·공간 등의 열악한 환경, 학생들의 참여율 저조 등의 이유로 정부의 재정지원사업에 적극적으로 참여하지 못하고 있다. 이에 본 연구는 ACE 사업(2010-2016)에 선정된 45개 대학 가운데 도서관이 참여한 18개 대학도서관의 프로그램 운영사례를 조사·분석하여 문제점과 시사점을 도출하고 담당 사서를 대상으로 대학도서관의 역할과 성과 등을 설문 조사하였다. 그 결과를 바탕으로 앞으로 정부의 대학재정지원사업에 대비하여 대학도서관이 고려해야 할 전략과 방안을 제안하였다.

• 약학회지
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• 제56권5호
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• pp.309-313
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• 2012

Antiobesity, hypotriglyceridemic and antihypertensive activities of isoflavone-free peptide mixture (black soybean peptide, BSP) were reported in our previous experiments. In the present study, angiotensin converting enzyme inhibitory (ACEi) activity was decreased in the aorta tissues of spontaneously hypertensive rats (SHRs) treated with BSP (1% in drink water) for 4 weeks, but not in serum. BSP administration significantly decreased ACE activity by 17.5% (from $33.2{\pm}4.5$ to $27.4{\pm}1.96$ mUnit/mg, p=0.0013) in aorta tissue hydrolysate. BSP treatment also decreased significantly mean blood pressure (BP) (from $213.0{\pm}16.96$ to $184.0{\pm}6.53$ mmHg, p<0.0001) as expected. These results indicate that BSP has antihypertensive activity as well as ACEi activity.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1998년도 추계학술대회 논문집 학회본부A
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• pp.248-252
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• 1998

The ACE Engineering, Inc. (ACE) of Seoul, Korea and The Energy Systems Institute (SEI) of Irkutsk, Russia has extensively studied the formation of an interconnected electric power systems throughout the North Eastern Asia Region(NEAR). The region encompasses East Siberia (ESR), Far East of Russia(FER), North East China(NEC), Mongolia(MON), North Korea(NKOR), South Korea(SKOR). Although geographically adjacent to each other, these countries and territories have different levels and rates of economic development, possess different reserves of energy resources which complement each other and hence, can interact to their mutual benefits. This Project is called Peace Network Project (PNP) because it seems to contribute for development of power economy and clean environment. In a word, the PEACE Network is expected to serve as "Power Economy And Clean Environment Network" and to promote the international cooperation. to expedite the peaceful reunification of North & South Korea and to revive the Korean culture in the North, and eventually contribute to the human prosperity.

• 한국미생물·생명공학회지
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• 제23권4호
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• pp.439-445
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• 1995

Identification of Actinomycetes isolate strain SH-8002, a producer of ACE inhibitor, based on procedures employed in the international Streptomyces project. The strain, designated as SH-8002, was identified as Streptomyces zoamyceticus SH-8002 based on its morphological, physiological, biochemical and chemotaxonomic characteristics. The ACE inhibitor produced by the strain was highly achieved in fermentation medium condition that was 1% soluble starch, 0.5% tryptone, 0.2% K$_{2}$HPO$_{4}$, 0.2% CaCO$_{3}$, 0.1% NaCl, pH 8.0 at 30$\circ$C for 144 hrs.

• 한국대기환경학회지
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• 제20권6호
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• pp.811-821
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• 2004

Low-Z particle electron probe X-ray microanalysis (low-Z particle EPMA) was applied to characterize aerosol particles collected at Gosan in Jeju island during an IOP (intensive observation period) for an international ACE-Asia project in April, 2001. Various types of atmospheric particles such as organics, carbon-rich, aluminosilicates, silicon oxide, sodium nitrate, sodium chloride, and ammonium sulfate were observed. The reacted sea salt particles such as sodium nitrate were the most abundantly encountered, but original sea salt particles were rarely observed. Since the Low-Z particle EPMA can provide quantitative information on the chemical composition of aerosol particles, many different particle types on the basis of their chemical compositions were observed and identified. In this study, it is demonstrated that the Low-Z particle EPMA can provide detailed information on the chemical compositions for the aerosol particles collected for six consecutive days in April, 2001, at Gosan super-site.

• IMMUNE NETWORK
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• 제24권2호
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• pp.7.1-7.19
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• 2024

Viral load and the duration of viral shedding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are important determinants of the transmission of coronavirus disease 2019. In this study, we examined the effects of viral doses on the lung and spleen of K18-hACE2 transgenic mice by temporal histological and transcriptional analyses. Approximately, 1×10⁵ plaque-forming units (PFU) of SARS-CoV-2 induced strong host responses in the lungs from 2 days post inoculation (dpi) which did not recover until the mice died, whereas responses to the virus were obvious at 5 days, recovering to the basal state by 14 dpi at 1×10² PFU. Further, flow cytometry showed that number of CD8+ T cells continuously increased in 1×10² PFU-virus-infected lungs from 2 dpi, but not in 1×10⁵ PFU-virus-infected lungs. In spleens, responses to the virus were prominent from 2 dpi, and number of B cells was significantly decreased at 1×10⁵ PFU; however, 1×1² PFU of virus induced very weak responses from 2 dpi which recovered by 10 dpi. Although the defense responses returned to normal and the mice survived, lung histology showed evidence of fibrosis, suggesting sequelae of SARS-CoV-2 infection. Our findings indicate that specific effectors of the immune response in the lung and spleen were either increased or depleted in response to doses of SARS-CoV-2. This study demonstrated that the response of local and systemic immune effectors to a viral infection varies with viral dose, which either exacerbates the severity of the infection or accelerates its elimination.

• 한국정보처리학회논문지
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• 제5권3호
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• pp.606-619
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• 1998

본 논문에서는 지역적으로 분산되어 있는 사람들간에 공동작업을 가능하게 하는 어플리케이션 공유 공동작업 엔진(ACE:Application sharing collaboration Engine)을 설계하고 구현하였다. 어플리케이션 공유는 한명 또는 그 이상의 사용자들이 개인 컴퓨터 시스템 상에서 실행되고 있는 전용 어플리케이션을 다른 사용자들과 함께 공유하도록 하는 기술이다. 우리는 실시간 어플리케이션 공유가 가능하도록 ASO(Application Sharing Object)객체와 그 행위들을 정의하였고, 공동작업 엔진은 ASO 객체들을 이용하여 분산된 시스템간에 공유기능을 처리한다. ASO 객체는 활성화 객체(activateASO), 수정 객체(updateASO), 입력 객체(inputASO) 그리고 제어 객체(controlASO)들로 구성되어 있다. ASO 행위는 키보드 입력과 마우스 클릭과 같은 특정 순간에 발생되는 이벤트와 뷰 이미지 같은 어떤 순간에 유지될 수 있는 상태들의 변화에 의하여 발생 된다. 구현된 어플리케이션 공유 공동작업 엔진은 데이터 회의 시스템, 원격 교육, 그리고 엔지니어를 위한 프로젝트 공동작업 등에 적용될 수 있다.

• 전자통신동향분석
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• 제15권5호통권65호
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• pp.94-102
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• 2000

시험기간 동안 수집된 고장 데이터를 이용하여 소프트웨어 신뢰도를 예측할 수 있는 모델은 많으나 이 예측 방법은 정확하지 못하며, 특히 초기 시험 단계에서는 더욱 더 부정확하여 예측자들은 이러한 소프트웨어 신뢰도 모델의 적용을 주저한다. 한편 소프트웨어 신뢰도 성장 모델은 유사 프로젝트나 개발 초기에 얻은 정보를 가지고는 신뢰도 예측 데이터로 활용이 불가능하다. 예를 들면 최근의 소프트웨어 시스템들은 항시 유사 프로젝트들로부터 활용이 가능한 일련의 정보와 동일 응용 영역의 초기 또는 최신의 정보들이 변경, 개선되기 때문이다. 본 논문에서는 유사한 프로젝트로부터 얻은 공통의 데이터들을 활용하여 소프트웨어 신뢰도를 예측할 수 있는 방법들을 제안한다. 특히 일반적으로 사용되고 있는 Goel-Okumoto(G-O) 모델이나 고장 검출률을 이용하거나 시험 데이터를 활용하는 방법 등을 이용하여 모델 파라미터를 추정하고 실제 프로젝트 수행중에 얻어진 각종 결과를 토대로 해서 Numerical Algorithm이 아닌 통계적인 관점의 분석 결과와 MLE(Maximum Likelihood Estimation) 추정 방법 등을 동원하여 초기에 우리 프로젝트에 맞는 정확한 소프트웨어 신뢰도 평가 방법을 제안하였다.

• Molecules and Cells
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• 제45권12호
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• pp.896-910
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• 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible and potentially fatal virus. So far, most comprehensive analyses encompassing clinical and transcriptional manifestation have concentrated on the lungs. Here, we confirmed evident signs of viral infection in the lungs and spleen of SARS-CoV-2-infected K18-hACE2 mice, which replicate the phenotype and infection symptoms in hospitalized humans. Seven days post viral detection in organs, infected mice showed decreased vital signs, leading to death. Bronchopneumonia due to infiltration of leukocytes in the lungs and reduction in the spleen lymphocyte region were observed. Transcriptome profiling implicated the meticulous regulation of distress and recovery from cytokine-mediated immunity by distinct immune cell types in a time-dependent manner. In lungs, the chemokine-driven response to viral invasion was highly elevated at 2 days post infection (dpi). In late infection, diseased lungs, post the innate immune process, showed recovery signs. The spleen established an even more immediate line of defense than the lungs, and the cytokine expression profile dropped at 7 dpi. At 5 dpi, spleen samples diverged into two distinct groups with different transcriptome profile and pathophysiology. Inhibition of consecutive host cell viral entry and massive immunoglobulin production and proteolysis inhibition seemed that one group endeavored to survive, while the other group struggled with developmental regeneration against consistent viral intrusion through the replication cycle. Our results may contribute to improved understanding of the longitudinal response to viral infection and development of potential therapeutics for hospitalized patients affected by SARS-CoV-2.

• 한국수소및신에너지학회논문집
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• 제26권6호
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• pp.567-580
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• 2015

In order to select an optimum gasifier for specific low rank coal, evaluation elements were studied by analyzing characteristics of low rank coal compared with those of high rank coal and the effects of each gasifier type in accordance with the characteristics. And syngas composition calculation model was made on the basis of thermochemical equilibrium to quantify some of the evaluation elements. And then the suitable gasifier was selected for a kind of Indonesian low rank coal through this syngas composition calculation model and the evaluation elements of selecting gasifier.