• Biomolecules & Therapeutics
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• 제11권2호
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• pp.85-90
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• 2003

Microtubule-binding molecules have been developed as anti-cancer agents to overcome the toxicities of current chemotherapeutics and also have potential for use as anti-angiogenic agents. In this work, we examined the effect of novel triazine compounds, Tubulyzines (microTUBUle LYsing triaZINE), derived from the orthogonal synthesis of a triazine library, on endothelial progenitor cell differentiation. When mononuclear cells isolated from human cord blood were cultured on fibronectin-coated plates for 7 days, all the Tubulyzine compounds A, B, and C (TA, TB, and TC) tested decreased the number of adherent cells in a dose-dependent manner in a coo. centration ranges of 2-5 to $80\mu\textrm{M}$. TA ($IC_{50}$=$20\mu\textrm{M}$) showed slightly more potent activity than TB and TC. Adherent cells treated with TA also exhibited a lower level of ability to ac-LDL uptake, with low ratios of positive cells out of total adherent cells, in a dose-dependent manner and weak expression of endothelial lineage markers, KDR, CD31, and vWF at $20\mu\textrm{M}$. Therefore, these results suggest that tubulyzine A (TA) can be effectively used for the inhibition of new vessel growth by inhibiting differentiation of endothelial progenitor cells.

• Journal of Korean Society of Water and Wastewater
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• 제30권2호
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• pp.167-177
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• 2016

This work investigated the decomposition of aqueous anatoxin-a originated from cyanobacteria using an underwater dielectric barrier discharge plasma system based on a porous ceramic tube and an alternating current (AC) high voltage. Plasmatic gas generated inside the porous ceramic tube was uniformly dispersed in the form of numerous bubbles into the aqueous solution through the micro-pores of the ceramic tube, which allowed an effective contact between the plasmatic gas and the aqueous anatoxin-a solution. Effect of applied voltage, treatment time and the coexistence of nutrients such as $NO_3{^-}$, $H_2PO_4{^-}$ and glucose on the decomposition of anatoxin-a was examined. Chemical analyses of the plasma-treated anatoxin-a solution using liquid chromatography-mass spectrometry (LC-MS) and ion chromatography (IC) were performed to elucidate the mineralization mechanisms. Increasing the voltage improved the anatoxin-a decomposition efficiency due to the increased discharge power, but the energy required to remove a given amount of anatoxin-a was similar, regardless of the voltage. At an applied voltage of 17.2 kV (oxygen flow rate: $1.0L\;min^{-1}$), anatoxin-a at an initial concentration of $1mg\;L^{-1}$ (volume: 0.5 L) was successfully treated within 3 min. The chemical analyses using LC-MS and IC suggested that the intermediates with molecular weights of 123~161 produced by the attack of plasma-induced reactive species on anatoxin-a molecule were further oxidized to stable compounds such as acetic acid, formic acid and oxalic acid.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• 제21권5호
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• pp.82-89
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• 2007

AVR(Automatic Voltage Regulator) of exciter control system in AC generator controls voltage and current according to load and terminal voltage variations in order to remain at the bus voltage. The output characteristics of main generator is dependent on the control performance of AVR. This paper presents the PWM type exciter system with transient response compensator for robust control of load variations. Additional transient response compensator generates compensation signal for load variation. So the proposed excitation control system has fast dynamic response in transient period and can control terminal voltage constantly. The proposed method is verified by the computer simulation and experimental results in prototype generation system.

• The Transactions of the Korean Institute of Electrical Engineers P
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• 제66권4호
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• pp.188-193
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• 2017

In this paper, a ZVS-PWM high-frequency inverter with a PWM control function is applied to commercial system 220[Vrms], and a resonator type ZVS-PWM high-frequency inverter circuit with a fixed-two methods were proposed. The parameters of the transformer model equivalent circuit of a copier fixing device, which is an essential element in the parameter optimization of the proposed circuit, are obtained by using a high-frequency amplifier and its frequency characteristics are described. The proposed method compared to the existing single-ended ZVS-PFM high frequency inverter can suppress the voltage and current peak value of the power semiconductor switching device and reduce the switching loss. The efficiency of the proposed method itself is 98[%] at rated power output. Also, the efficiency of 96[%] can be obtained even at low output, so that the proposed high frequency inverter is very efficient inverter. The total efficiency from the commercial AC input to the inverter output is 93[%] at rated, which is considered efficient for use in copying machines. In addition, the diode bridge loss accounts for the largest portion of the overall system efficiency distribution. On the other hand, the nonparallel filter has a very low loss.

• International Journal of Safety
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• 제1권1호
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• pp.36-42
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• 2002

This paper is aimed at predicting the life of rubber insulating gloves under normal operating stresses from relatively rapid test performed at higher stresses. Specimens of rubber insulating gloves are subject to multiple stress conditions, i.e. combined electrical and thermal stresses. Two modes of electrical stress, step voltage stress and constant voltage stress are used in specimen aging. There are two types of test for electrical stress in this experiment: the one is Breakdown Voltage (BDV) test under step voltage stress and thermal stress and the other is lifetime test under constant voltage stress and temperature stress. The ac breakdown voltage defined as the break-down point of insulation that leakage current excesses a limit value, l0mA in this experiment, is determined. Because the very high variability of aging data requires the application of statistical model, Weibull distribution is used to represent the failure times as the straight line on Weibull probability paper. Weibull parameters are deter-mined by three statistical methods i.e. maximum likelihood method, graphical method and least squares method, which employ SAS package, Weibull probability paper and FORTRAN, respectively. Two chosen models for predicting the life under simultaneous electrical and thermal stresses are inverse power model and exponential model. And the constants of life equation for multistress aging are calculated using numerical method, such as Gauss Jordan method etc.. The completion of life equation enables to estimate the life at normal stress based on the data collected from accelerated aging test. Also the comparison of the calculated lifetimes between the inverse power model and the exponential model is carried out. And the lifetimes calculated by three statistical methods with lower voltage than test voltage are compared. The results obtained from the suggested experimental method are presented and discussed.

• The Transactions of the Korean Institute of Electrical Engineers D
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• 제54권8호
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• pp.475-481
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• 2005

In the existing ICT technique, the mounted electronic devices on the printed circuit board are tested whether the devices are good or not by comparing and measuring the value of the devices after separating the devices to be tested from around it based on the guarding method. But, in case that resistance, inductor and capacitor are configured as a parallel circuit on the circuit pattern, values for each device can not be measured because the total impedance value of the parallel circuit is measured. Accordingly, it is impossible to test whether the parallel circuit is good or not in case that the measured impedance value is within the tolerance error. Also, it is difficult to identify that which device among R, L and C of the parallel circuit is bad in case that the measured impedance value is out of the tolerance error. Accordingly, this paper proposes a test method which can enhance the quality and productivity by separating and measuring accurately R, L and C components from the RLC parallel circuits on the device-mounted printed circuit board. First, the RLC parallel circuit to be test is separated electrically from around it using three-terminal guarding technique. And then R, L and C values are computed based on the total impedance values and phase angles between voltage and current of the parallel circuit measured from two AC input signals with other frequency, Finally, the availability and accuracy of the proposed test method is verified by reviewing the simulation results.

• BMB Reports
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• 제50권2호
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• pp.60-70
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• 2017

Glaucoma is characterized by a slow and progressive degeneration of the optic nerve, including retinal ganglion cell (RGC) axons in the optic nerve head (ONH), leading to visual impairment. Despite its high prevalence, the biological basis of glaucoma pathogenesis still is not yet fully understood, and the factors contributing to its progression are currently not well characterized. Intraocular pressure (IOP) is the only modifiable risk factor, and reduction of IOP is the standard treatment for glaucoma. However, lowering IOP itself is not always effective for preserving visual function in patients with primary open-angle glaucoma. The second messenger cyclic adenosine 3',5'-monophosphate (cAMP) regulates numerous biological processes in the central nervous system including the retina and the optic nerve. Although recent studies revealed that cAMP generated by adenylyl cyclases (ACs) is important in regulating aqueous humor dynamics in ocular tissues, such as the ciliary body and trabecular meshwork, as well as cell death and growth in the retina and optic nerve, the functional role and significance of cAMP in glaucoma remain to be elucidated. In this review, we will discuss the functional role of cAMP in aqueous humor dynamics and IOP regulation, and review the current medications, which are related to the cAMP signaling pathway, for glaucoma treatment. Also, we will further focus on cAMP signaling in RGC growth and regeneration by soluble AC as well as ONH astrocytes by transmembrane ACs to understand its potential role in the pathogenesis of glaucoma neurodegeneration.

• Journal of Advanced Marine Engineering and Technology
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• 제38권7호
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• pp.916-922
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• 2014

Diode rectifiers have been widely used for an AC to DC converter. But a big problem is that they include large harmonics components in the input currents. A 12-pulse configuration with phase shifting transformer is useful for reducing them. however, it still includes the ($12{\pm}1$)th (m; integer) harmonics in the input currents. In this paper, we propose a single-phase square wave auxiliary voltage supply which is inserted in the middle DC bus. It reduces harmonics especially the 11th and 13th and the harmonic characteristic becomes almost equivalent to a 24-pulse rectifier. Theoretical analysis of the combined 12-pulse diode rectifier with the auxiliary supply is presented and a control method of the auxiliary supply is proposed. The reduction in the input current harmonics is verified by simulation using software PSIM.

• The Transactions of The Korean Institute of Electrical Engineers
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• 제56권1호
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• pp.1-7
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• 2007

Generally, an electric railroad feeding system has many problems due to the different characteristics in contrast with a load of general three-phase AC electric power system. One of them is harmonics problem caused by the switching device existing in the feeding system, and moreover, the time-varying dynamic loads of rail way is inherently another cause to increase this harmonics problem. In Korea power systems, the electric railroad feeding system is directly supplied from the substation of KEPCO. Therefore, if voltages fluctuation or unbalanced voltages are created by the voltage and current distortion or voltage drop during operation, it affects directly the source of supply. The trainloads of electric railway system have non-periodic but iterative harmonic characteristics as operating condition, because the electric characteristic of the electric railroad feeding system is changed by physical conditions of the each trainload. According to the traditional study, the estimation of harmonics has been performed by deterministic way using the steady state data at the specific time. This method is easy to analyze harmonics, but it has limits in some cases which needs an assessment of dynamic load and reliability. Therefore, this paper proposes the probabilistic estimation method, moments matching method(MW) in order to overcome the drawback of deterministic method. In this paper, distributions for each harmonics are convolved to obtain the moments and cumulants of TDD(Total Demand Distortion), and this can be generalized for any number of trains. For the case study, the electric railway system of LAT(Intra Airport Transit) in Incheon International Airport is modeled using PSCAD/EMTDC dynamic simulator. The raw data of harmonics for the moments matching method is acquired from simulation of the LAT model.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• 제22권2호
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• pp.57-62
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• 2008

This paper deals with a comparison of individual and connecting grounding electrode for potential rise. When a test current flowed through grounding electrode, potential rise was measured and analyzed for grounding method using a electrolytic tank in real time. In order to analyze the potential rise of grounding systems, a hemispherical water tank experimental apparatus was studied. Potential rise was measured and analyzed regarding the grounding method and distance by using this apparatus. The apparatus was composed of a hemispherical water tank, AC power supply, a movable potentiometer, and test grounding electrodes. The potential rise was measured by the horizontal moving probe of the potentiometer. The grounding electrodes were designed and fabricated with ground rods on a scale of one-eightieth. Potential rises of individual grounding electrode were higher than those of connecting grounding electrode. The distributions of surface potential are dependent on the distance from grounding electrode.