• Title/Summary/Keyword: A6N01

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Development of Non-Narcotic Analgesic Agents

  • Park, No-Sang
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 1993.11a
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    • pp.1-6
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    • 1993
  • Capsaicin [N-(4-hydroxy-3-methoxybenzyl)-trans-8-methyl -6-nonenamide], a pungent principle of red pepper. is known to induce analgesia. Though it has shown remarkable pharmacological activity, the toxicity and side effects inhibited its wider application. The interest has been renewed by the emergence of its agonists, resineferatoxin and ruthenium red. Recently, few successful capsaicinoids including 01vanil (NE-19550), NE-28345, and NE-21610 were reported.

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Potassium Supply Characteristics in Different Forest Soils (지역별(地域別) 산림토양(山林土壤)의 K(Potassium) 공급(供給) 특성(特性))

  • Jin, Hyun-O;Kim, Jun-Hwan
    • Journal of Korean Society of Forest Science
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    • v.90 no.1
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    • pp.64-73
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    • 2001
  • Generally potassium in the soil can be remained as water soluble, exchangeable, and available types, respectively. Theses types of potassiums are also known to keep their kinetic relationships to each other. The Purpose on this research was to investigate types and relationships of potassium in the soil, and the characteristics of potassium supply in different forest soils. The results could be summarized as follows; 1. The amounts of available potassium in A and B horizon soils by continuous leaching with 0.01N-HCl were as follows : for A Horizon soils, pohang(Gray brown forest soils), Changsung (Brown forest soils), and Youngwol(Dark red forest soils) were ranged from 0.2me/l00g to 0.8me/100g, Taean(Red and Yellow forest soils) was 0.1-0.6me/100g, Kapyung(Brown forest soils) was 0.2-0.4me/100g. For the B layer, Youngwol was 0.1-0.5me/100g, Pohang, Taean, Kapyung were 0.1-0.4me/100g, Changsung was 0.1-0.3me/100g, respectivly. 2. Of ten times-pulse leaching with 0.01N-HCl for A layer soil, more 80% of total available potassium leaching were recovered by the second pulse as leachate for Pohang, Changsung, Youngwol, while similar amounts of potassium in the leachate were obtained with the third pulse leaching for Kapyung, Taean, respectively, On the other hand, the 80 % release of available potassium from the B layer soil was obtained by the second pulse leaching for all areas investigated. 3. For the relationships between soluble potassium and exchangeable potassium, the exchangeable potassium was increased while the soluble potassium was not changed significantly in B layer. And both soluble potassium and exchangeable potassium in A layer were similar. For the relationship between exchangeable potassium and available potassium in both A and B layers, the amounts of available potassium increased by 1.2 to 1.5 times as the exchangeable potassium increased. 4. For distribution of all types of potassium throughout locations investigated, the types of potassium were in the decreasing orders of available, exchangeable, and soluble. 5. The simplified method for an analysis of all types of potassium by sequential leaching with 0.01N-HCl should be developed not only with respect to time-saving and efficiency but also verification of the relationship between available potassium and tree growth.

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Effects of Amine Catalysts on Structure of Polyurethane Foams

  • Furukawa, Mutsuhisa;Takamatsu, Katsuhiro
    • Elastomers and Composites
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    • v.34 no.4
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    • pp.285-291
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    • 1999
  • Effects of catalysts on network structure, hard segment length and distribution of polyurethane foams in the absence of catalysts were investigated. CFC free all MDI-based poly urethane foams were prepared from poly(ethylene adipate)glycol, 4,4'-diphenylmethane diisocyanate, and water. Amino catalysts used were 1,4-diazabicyclo[2,2,2]octane(DABCO), N, N,N',N'-tetramethyl--hexane-1,6-diamine(MR), bis(2-methylamino ethyl)ether(ET), 1,8-diazabicyclo-[5,4,0]-undecene-7(DBU). Dibutyltindilaurate(DBTL) as control was also used. Hard segment components of polyurethane foams were obtained by a selective degradation of polyester chains with 0.01N KOH-methanol solution. The PUFs with DBU catalyst contained more amount of isocyanurate components than other PUFs. On the other hand, the PUFs with ET, MR, DBTL catalysts contained more amount of allophanate and biuret component than the other PUFs.

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Quantitative Analysis of Phosphinothricin-N-acetyltransferase in Genetically Modified Herbicide Tolerant Pepper by an Enzyme-Linked Immunosorbent Assay

  • Shim, Youn-Young;Shin, Weon-Sun;Moon, Gi-Seong;Kim, Kyung-Hwan
    • Journal of Microbiology and Biotechnology
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    • v.17 no.4
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    • pp.681-684
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    • 2007
  • An immunoassay method was developed to quantitatively detect phosphinothricin-N-acetyltransferase (PAT) encoded by the Bialaphos resistance (bar) gene in genetically modified (GM) pepper. The histidine-tagged PAT was overexpressed in Escherichia coli M15 (pQE3l-bar) and efficiently purified by $Ni^{2+}$ affinity chromatography. A developed sandwich enzyme-linked immunosorbent assay (S-ELISA) method (detection limit: $0.01{\mu}g/ml$) was 100-fold more sensitive than a competitive indirect ELISA (CI-ELISA) method or Western blot analysis in detecting the recombinant PAT. In real sample tests, PAT in genetically modified herbicide-tolerant (GMHT) peppers was successfully quantified [$4.9{\pm}0.4{\mu}g/g$ of sample (n=6)] by the S-ELISA method. The S-ELISA method developed here could be applied to other GMHT crops and vegetables producing PAT.

Gentiana straminea supplementation improves feed intake, nitrogen and energy utilization, and methane emission of Simmental calves in northwest China

  • Xie, K.L.;Wang, Z.F.;Guo, Y.R.;Zhang, C.;Zhu, W.H.;Hou, F.J.
    • Animal Bioscience
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    • v.35 no.6
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    • pp.838-846
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    • 2022
  • Objective: Native plants can be used as additives to replace antibiotics to improve ruminant feed utilization and animal health. An experiment was conducted to evaluate the effects of Gentiana straminea (GS) on nutrient digestibility, methane emissions, and energy metabolism of Simmental calves. Methods: Thirty-two (5-week-old) male Simmental clves, with initial body weight (BW) of 155±12 kg were fed the same basal diet of concentrates (26%), alfalfa hay (37%), and oat hay (37%) and were randomly separated into four treatment groups according to the amount of GS that was added to their basal diet. The four different groups received different amounts of GS as a supplement to their basal diet during whole experiment: (0 GS) 0 mg/kg BW, the control; (100 GS) 100 mg/kg BW; (200 GS) 200 mg/kg BW; and (300 GS) 300 mg/kg BW. Results: For calves in the 200 GS and 300 GS treatment groups, there was a significant increase in dry matter (DM) intake (p<0.01), average daily gain (ADG) (p<0.05), organic matter intake (p<0.05), DM digestibility (p<0.05), neutral detergent fibre (NDF) digestibility (p<0.05), and acid detergent fibre (ADF) digestibility (p<0.05). Dietary GS supplementation result in quadratic increases of DM intake (p<0.01), ADG (p<0.05), NDF intake (p<0.05), and ADF intake (p<0.05). Supplementing the basal diet with GS significantly increased nitrogen (N) retention (p<0.001) and the ratio of retention N to N intake (p<0.001). Supplementing the basal diet with GS significantly decreased methane (CH4) emissions (p<0.01), CH4/BW0.75 (p<0.05) and CH4 energy (CH4-E) (p<0.05). Dietary GS supplementation result in quadratic increases of CH4 (p<0.01) and CH4/DM intake (p<0.01). Compared with 0 GS, GS-supplemented diets significantly improved their gross energy intake (p<0.05). The metabolizable energy and digestive energy intake were significantly greater for calves in the 100 GS and 200 GS calves than for 0 GS calves (p<0.05). Conclusion: From this study, we conclude that supplementing calf diets with GS could improve utilization of feed, energy, and N, and may reduce CH4 emissions without having any negative effects on animal health.

Effects of Type of Oilseed and Level of Concentrate on Fermentation, Biohydrogenation of Fatty Acids and Conjugated Linoleic Acid Production in a Rumen-Simulated Continuous Culture System (지방급원 형태와 수준에 따른 연속배양장치 내 반추위 발효성상, 지방산의 수소첨가 현상 및 Conjugated Linoleic Acid 생산에 미치는 영향 연구)

  • Choi, N.J.
    • Journal of Animal Science and Technology
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    • v.45 no.4
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    • pp.617-626
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    • 2003
  • This experiment employed a rumen simulated continuous culture system to examine the possibility of improving the rumen bypass of polyunsaturated fatty acids (PUFA) by using a high proportion of concentrate in the feed, and compared soya and linseed in terms of conjugated linoleic acid (CLA) production. No effect of type of fat source was observed on ruminal fermentation. A high proportion of concentrate (80%) in the feed decreased (P<0.001) vessel pH but increased (P<0.01) ammonia nitrogen, total VFA, acetate, butyrate and valerate concentrations compared with a low proportion (40%). Fat sources (soya vs. linseed) and concentrate ratio in the feed did not affect digestibilities of organic matter (OM), total nitrogen, neutral detergent fiber (NDF) and acid detergent fiber (ADF). Soya increased the flows of trans C18:1, C18:2 n-6 and C18:3 n-3 compared with linseed. The difference in fat source alone did not affect the flow of CLA but this was increased when high levels of soya and linseed were associated with a high proportion of concentrate in the feed. There was no effect of fat source on biohydrogenation of C18:1 n-9 and C18:2 n-6, but biohydrogenation of C18:3 n-3 and total C18 PUFA was higher with the linseed than with the soya treatment. A high proportion of concentrate decreased biohydrogenation of C18:2 n-6, C18:3 n-3 and total C18 PUFA compared with a low proportion.

A Evaluation Study on Nutrient Intake and Diet Quality of Male College Students According to Packyear in Korea (흡연력에 따른 남자 대학생의 영양소 섭취 상태와 식사의 질 평가)

  • Kim, Mi-Hyun;Bae, Yun-Jung;Sung, Chung-Ja
    • Journal of Nutrition and Health
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    • v.39 no.6
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    • pp.572-584
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    • 2006
  • The purpose of this study was to compare the nutrient intake and diet quality of male college student according to smoking groups. Subjects were recruited and divided into three groups according to the smoking, which included non-smoker (n = 100), light-smoker (n = 78; packyear < 5), and heavy-smoker (n = 76; packyear ${\geq}$ 5). Subjects were interviewed using a general questionnaire, 24-hour recall method for dietary intake and diet quality. The average age of the subjects were 22.7 years for non-smoker, 23.5 years for light-smoker, and 23.4 years for heavy-smoker. Also the results showed that the heavy-smoker was significantly more often to drink coffee and alcohol compared with the other two groups (p<0.001, p<0.05). The mean daily energy intake was 2278.1 kcal in non-smoker, 2148.3 kcal in light-smoker, and 2144.4 kcal in heavy-smoker. The heavy-smoker consumed significantly lower intakes of vitamin C (p<0.001), calcium (p<0.01), animal calcium (p<0.01), and potassium (p<0.05) compared to the non-smoker and light-smoker. Also NAR (Nutrient Adequacy Ratio), ND (Nutrient Density), and INQ (Index of Nutritional Quality) of these nutrients in heavy-smoker were lower than the other two groups. Mean adequacy ratio (MAR) was 0.78 in non-smoker, 0.78 in light-smoker, and 0.74 in heavy smoker (p<0.05). The heavy-smoker consumed significantly lower intakes of fruits (p<0.001) compared to the non-smoker and light-smoker. The DVS (Dietary Variety Score) of heavy-smoker (26.8) was significantly lower than that 30.4 of non-smoker and 31.5 of light-smoker (p<0.01). In conclusion, heavy-smoker man have low intake status of vitamin C, calcium and potassium, and partly low diet quality. Therefore it was needed that well planed diet to replace the nutrients supplied from excluded food groups in heavy- smoker.

Carcass Characteristics and Chemical Composition of the Longissimus Muscle of Puruna and 1/2 Puruna vs. 1/2 Canchin Bulls Meat Quality of Bulls

  • Nunes do Prado, Ivanor;Rotta, Polyana Pizzi;Martin do Prado, Rodolpho;Visantainer, Jesui Vergilio;Moletta, Jose Luis;Perotto, Daniel
    • Asian-Australasian Journal of Animal Sciences
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    • v.21 no.9
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    • pp.1296-1302
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    • 2008
  • This work was conducted to study the performance, carcass characteristics, chemical composition and fatty acid profile of the Longissimus muscle (LM) of first-generation Purunã (n = 7, PUR1), second-generation Purunã (n = 9, PUR2), and 1/2 Puruna vs. 1/2 Canchin (n = 13, PUCA) bulls finished in a feedlot. The animals averaged 18 months of age at the beginning of the experiment. The animals were kept in a feedlot from 18 to 22 months of age. They were fed twice a day with corn silage ad libitum, along with soybean meal, cracked corn, urea, limestone and mineral salt. PUR1 bulls had greater (p<0.05) final weight (496.0 kg) than PUCA bulls (449.2 kg). However, there was no difference (p>0.05) between PUR1 and PUR2 (472.0 kg), and between PUR2 and PUCA. Hot carcass weight was similar (p>0.05) among the different genetic groups. Hot carcass dressing percentage was similar (p>0.10) between PUR1 (50.4%) and PUCA (53.8%), and higher (p<0.10) than PUR2 (48.6%). Cushion thickness was greater (p<0.05) in PUCA bulls (27.12 cm). The other parameters were similar (p<0.05) among the three genetic groups. Total lipid and cholesterol contents were higher (p<0.01) in PUR2. Moisture, ash and crude protein contents were similar (p>0.05) among the three genetic groups. Saturated fatty acid (SFA) levels were higher (p<0.10) in PUR1 and PUR2 (51.58% and 50.41%, respectively). Polyunsaturated fatty acid levels were higher (p<0.05) in PUR1 and PUCA (6.50% and 8.29%, respectively). N-6, n-3 and PUFA/SFA ratios were higher (p<0.05) in PUCA. MUFA and n-6/n-3 ratios were similar (p>0.05) among the different genetic groups.

The Effects of a School Safety Education Program Based on the PRECEDE-PROCEED Model in Upper Grade Elementary Students (PRECEDE-PROCEED 모형 적용을 통한 초등학교 고학년 학교 안전교육 프로그램 중재 효과)

  • Kim, Chung-Nam;Lee, En-Young
    • Research in Community and Public Health Nursing
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    • v.21 no.4
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    • pp.419-428
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    • 2010
  • Purpose: The purpose of this study was to measure the effects of a school safety education program based on the PRECEDE-PROCEED model for upper grade elementary students. Methods: One hundred ten 6th-grade students sampled from an elementary school in D City were divided into the education group (n=55) and the non-education group (n=55). School safety education was provided to the education group for 8 weeks and a questionnaire survey about safety knowledge, safety practice and the frequency of safety negligence was carried out before and after the education from March 2 to July 13, 2010. Results: After the application of the safety education program, the education group got a higher safety knowledge score than the non-education group (p<.001). Both the education and non-education groups showed a significantly increased safety practice score (p<.01). In the comparison of safety negligence, the education group showed lower frequency (p<.01). In addition, according to the results of ANCOVA and t-test, the school safety education program influenced safety knowledge significantly (p<.001). Conclusion: This result shows that a school safety education program based on PRECEDE- PROCEED can improve safety knowledge. Further studies will be required to develop continuous and systematic safety education programs.

Effect of Conjugated Linoleic Acid Feeding on the Growth Performance and Meat Fatty Acid Profiles in Broiler: Meta-analysis

  • Cho, Sangbuem;Ryu, Chaehwa;Yang, Jinho;Mbiriri, David Tinotenda;Choi, Chang-Weon;Chae, Jung-Il;Kim, Young-Hoon;Shim, Kwan-Seob;Kim, Young Jun;Choi, Nag-Jin
    • Asian-Australasian Journal of Animal Sciences
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    • v.26 no.7
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    • pp.995-1002
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    • 2013
  • The effect of conjugated linoleic acid (CLA) feeding on growth performance and fatty acid profiles in thigh meat of broiler chicken was investigated using meta-analysis with a total of 9 studies. Overall effects were calculated by standardized mean differences between treatment (CLA fed) and control using Hedges's adjusted g from fixed and random effect models. Meta-regression was conducted to evaluate the effect of CLA levels. Subgroups in the same study were designated according to used levels of CLA, CP levels or substituted oils in diets. The effects on final body weight, weight gain, feed intake and feed conversion ratio were investigated as growth parameters. Total saturated and unsaturated fatty acid concentrations and C16:0, C18:0, C18:2 and C18:3 concentrations in thigh meat of broiler chicken were used as fatty acid profile parameters. The overall effect of CLA feeding on final weight was negative and it was only significant in fixed effect model (p<0.01). Significantly lower weight gain, feed intake and higher feed conversion ratio compared to control were found (p<0.05). CLA feeding on the overall increased total saturated fatty acid concentration in broilers compared to the control diet (p<0.01). Total unsaturated fatty acid concentration was significantly decreased by CLA feeding (p<0.01). As for individual fatty acid profiles, C16:0, C18:0 and C18:3 were increased and C18:2 was significantly decreased by CLA feeding (p<0.01). In conclusion, CLA was proved not to be beneficial for improving growth performance, whereas it might be supposed that CLA is effective modulating n-6/n-3 fatty acids ratio in thigh meat. However, the economical compensation of the loss from suppressed growth performance and increased saturated fatty acids with the benefit from enhanced n-6/n-3 ratio should be investigated in further studies in order to propose an appropriate use of dietary CLA in the broiler industry.