• Title/Summary/Keyword: A375-S2

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Up-regulation of dynamin-2 gene expression in Ras-transformed cells (Ras에 의해 암화된 세포에서 dynamin-2의 발현 촉진)

  • Yoo, Ji-Yun
    • Journal of Life Science
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    • v.17 no.3 s.83
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    • pp.375-380
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    • 2007
  • Dynamin plays a key role in the scission event common to various types of endocytosis. It has been previously reported that the SH3 domain-mediated association of Grb2 with dynamin-2 was dominantly found in Ras transformed cells. However, whether this association results from the increased expression of dynamin-2 and Grb2 in Ras transformed cells or not is still unknown. So in this study we first analyzed the expression levels of dynamin-2 and Grb2 and found that the expression of dynamin-2 protein was dramatically increased in Ras-transformed NIH3T3 (NIH3T3(Ras)) cells. Furthermore competitive PCR data revealed that the mRNA transcripts for dynamin-2 were increased about 100-fold in NIH3T3(Ras) compared to those of NIH3T3 cells. However, the protein level and mRNA transcript of Grb2 were not changed in these two cells. We also examined promoter activity of dynamin-2 in NIH3T3(Ras) cells and suggest the existence of Ras-responsive sequence in promoter region -300 to -200.

Comparative Study on the Effects of Korean and Chinese Crataegus pinnatifida on Scopolamine-induced Memory Impairment in Mice (Scopolamine 유발 기억 손상 마우스 모델에서 국산 산사와 중국산 산사의 항건망 효과 비교)

  • Lee, Jihye;Kim, Hye-Jeong;Lee, Chanhee;Park, Sang Hyeok;Jung, Chul Jong;Beik, Gyung Yun;Shin, Jin Gi;Jung, Ji Wook
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.32 no.6
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    • pp.375-383
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    • 2018
  • This study was conducted to investigate the cognitive improvement and memory recovery effects of Korean and Chinese Crataegus pinnatifida ethanolic extracts on scopolamine-induced memory impairment in mice. In vivo studies were carried out with mice treated with Korean Crataegus pinnatifida extracts (KCF) and Chinese Crataegus pinnatifida extracts (CCF) in doses of 5 and 50 mg/kg (p.o.) and scopolamine was injected 30 min before the behavioral testing. Antioxidant activity was assessed by 2,2-diphenyl-1-picryl hydrazyl (DPPH) assay and 2,2-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assay, and acetylcholinesterase inhibition by Ellman's modified method. The chlorogenic acid and hyperoside as marker compounds of KCF and CCF was quantified by ultra-performance liquid chromatography analysis (UPLC). Results showed that KCF was more contained high content of chlorogenic acid and hyperoside than CCF. In addition, KCF was more exerted free radical (DPPH and ABTS) scavenging activity and blocked AChE activity than CCF. In vivo studies also showed that KCF administration has a further improved the memory of scopolamine-treated mice than CCF in Y-maze test, passive avoidance test and Morris water maze test. These results revealed that KCF more prevents scopolamine-induced memory impairments through antioxidant and acethylcholinesterase inhibition effect compared CCF.

Temperature-dependent Structural and Magnetic Properties of Diamagnetic $HgI_2$

  • Park, C.I.;Jin, Zhenlan;Hwang, I.H.;Yeo, S.M.;Han, S.W.
    • Proceedings of the Korean Vacuum Society Conference
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    • 2013.08a
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    • pp.291.1-291.1
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    • 2013
  • We examined the temperature-dependent structural and magnetic properties of HgI2 in the temperature range of 300~400 K. HgI2 is a diamagnetic material and can be used for X-ray or γ-ray detectors. DCmagnetization measurements on HgI2 showed that there is a small but distinguishable change in its diamagnetic properties near 375 K. The magnetic property change is not expected because Hg and I are known as nonmagnetic elements. X-ray diffraction (XRD) measurements revealed a structural transition in the temperature of 350~400 K. Temperature-dependent x-ray absorption fine structure (XAFS) demonstrated that the chemical valence states of both Hg and I did not changed in the temperature range of 300~400 K. However, XAFS revealed that the bond-length disorder was slightly increased in the temperature range, particularly, near Hg atoms. The structural changes of HgI2 are likely related to its diamagnetic property change. We will discuss the relation between the diamagnetic properties and local structural properties of HgI2 in detail.

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The Effects of Walking and Turning and Treadmill Training on Postural Balance and Walking in People with Parkinson's Disease

  • Bang, Dae-Hyouk;Jeong, Wang-Mo
    • PNF and Movement
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    • v.17 no.2
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    • pp.189-197
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    • 2019
  • Purpose: The aim of our study was to evaluate the therapeutic effects of walking and turning plus treadmill training on the functional balance and walking ability of individuals with Parkinson's disease (PD). Methods: Twenty-four participants with Stage 1 to 3 ($2.13{\pm}0.64$) PD based on the Hoehn and Yahr scale were randomly allocated to the experimental group (EG) and control group (CG), with 12 participants in each group. The measured outcomes included the motor subscale of the unified Parkinson's disease rating scale (UPDRS-M), the Berg balance scale (BBS), the Timed Up and Go (TUG) test, the 10-meter walk test (10MWT), and the 6-minute walk test (6MWT). Results: Pre-to-post intervention improvements were noted for all the outcome measures for both groups (p < 0.05). Post intervention, there was a significant improvement in the EG compared to the CG for the following measured outcomes (p < 0.05): UPDRS-M (p = 0.021; 95% CI, 0.081-6.519), BBS (p = 0.042; 95% CI, 1.375-4.541), TUG (p = 0.034; 95% CI, -3.315--0.143), 10MWT (p = 0.011; 95% CI, -2.032--0.289), and 6MWT (p = 0.002; 95% CI, 24.39-91.273). Conclusion: Our study suggests that walking and turning plus treadmill training improves balance and walking compared to treadmill training only in patients with PD.

Islamic Religiosity Scale, and Its Applied on the Relationship between Religiosity and Selection of Islamic Bank

  • Usman, Hardius
    • Journal of Distribution Science
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    • v.14 no.2
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    • pp.23-32
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    • 2016
  • Purpose - The purposes of this research are to develop a measurement of Islamic religiosity and apply these measurements to examine the relationship between religiosity and selection of the Islamic bank. Research design, data, and methodology - Literature searches and in-depth interviews are used to obtain the statement items to build measurement. Furthermore, the result of religiosity measurement will be used to study the relationship between religiosity and the selection of the Islamic bank. Population of the study is Muslim who has bank(s) account. A total 375 questionnaires were distributed to the three groups of bank customers (125 respondents in each group). Result -This research has successfully developed a measurement of religiosity, which is called Islamic Religiosity Scale (IRS). Based on IRS, this study found that religiosity has a significant relationship to the selection of Islamic banks. Conclusions - The study indicates that religiosity plays a significant role on the decision of customers to choose Islamic banks. Nevertheless, this study also revealed that religiosity is not the only factor that influences customers to selecting the Islamic banks.

Measurement of Drape Appearance Similarity between Real and Digital Stretch Fabric

  • Kim, Hyeon-Ah;Lim, Ho-Sun
    • Fashion & Textile Research Journal
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    • v.23 no.5
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    • pp.645-654
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    • 2021
  • This study aimed to visually compare the implementation of digital virtual fabrics for stretch fabrics mainly used in clothing that closely touch the body, using CLO. A digital fabric was used in CLO after measuring the weight, thickness, bending, and tensile force of five adhering clothing fabrics using a CLO fabric kit. The visual similarity of draftability was compared by measuring the area of the bending angle and the shape of the wrinkles of the real and digital fabric. A comparison of the bending angles showed that Fabric A was -0.75° and Fabric D was -2.5°, showing slightly lower drape properties than the real fabric. Meanwhile, Fabric B was 2.75°, Fabric C was 2.13°, and Fabric E was 1.375°, showing slightly higher drape properties in the vertical direction than the real fabric. Comparing the widths of the drape shapes, Fabric A was 0.77%, Fabric B was 1.27%, Fabric C was 0.06%, and Fabric E was 1.48%, which showed a slight difference. Fabric D showed a difference of 3.17% and was implemented where the digital fabric spread a little wider. As a result, the stretch fabric was visually expressed similarly to the real fabric as a whole in CLO. For 3D virtual clothing technology to be used widely in the close clothing industry in the future, more research on real clothing is needed.

A Study on the Correlation Between Satisfaction on a professional nail service and Hand Health Condition (전문 네일 서비스 이용 만족 인식과 손 건강 상태와의 상관관계 연구)

  • Hong, Da-Geom
    • Journal of the Korean Society of Industry Convergence
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    • v.20 no.5
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    • pp.365-375
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    • 2017
  • The purpose of this study is to establish the basement of nail industries and suggest a direction for the future of the specialized nail service. besides looks at characteristics of the aged 20's to 50's, who is expected as nail shop's main customers. The results of this study are briefly summarized as follows: First, the answer wanting professional hand care was more than half (53.3%). It turned out that customers prefer basic manicure such as hand massage(43.4%) and cuticle removal(31.1%) than nail art(15.2%) and nail improvement care(10.3%) in professional nail care. The basic manicure are in remarkably high demand which are often received with nail art and nail improvement care. There were more interests in nail services and better hand health condition in the 30's group than 40's. Also significantly higher in a unmarried group than married. this results show that professional hand care is highly related to a good condition of hands and additionally life satisfaction of customers. We were convinced of the direction of inner beauty and satisfaction beyond the visible. At the same time, exploring specific methods to internally satisfy customers remains to be a challenge.

A Study on the Preparation and Rheological Properties of Chik Mook (칡전분을 이용한 칡묵의 조리과학적 연구)

  • Lee, Young Soon;Kwak, Eun Jung;Lee, Kyung Hee
    • Korean journal of food and cookery science
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    • v.15 no.6
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    • pp.652-658
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    • 1999
  • Arrowroot Mook was prepared as a trial to develop new food items from natural resources, and its rheological properties were measured. 1. The starting point of gelatinization of 7% arrowroot starch solution was $67.5^{\circ}C$ as measured by amylograph. The viscosity of arrowroot starch reached the maximum 375 B.U. at $95^{\circ}C$ and decreased to 315 B.U. while holding at $95^{\circ}C$ for 15 min. When the temperature dropped to $50^{\circ}C$, the viscosity increased again to 530 B.U. 2. The gelatinization enthalpy of arrowroot starch was 15.603 J/g. 3. For the color, there were significant differences in b value for the arrowroot Mook made of arrowroot starch and in L value for the Mook made by the addition of arrowroot juice. 4. In descriptive analysis, $S_3$(14% arrowstarch) was most favored in color, and $S_1$(10% arrowstarch)was most favored in transparency, brittleness, fineness, and shininess. There were no significant differences in hardness, adhesiveness, and astringency. 5. On the contrary to mechanical measurement, there were no significant differences in hardness of samples as the addition of arrowroot juice increased, although there appeared a tendency to be softer in descriptive analysis. 6. The Mook prepared with 12% arrowroot starch was most favored by sensory evaluation. In case of adding arrowroot juice, the Mook containing 3% of arrowroot juice was most favored. Overall, arrowroot Mook showed a potential as a new food item.

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Development of a Highly Efficient Boiler System Using a Diesel Engine

  • Lee, D.-H;Lee, D.-Y;Jo, M.-C;Cho, H.-N;Kim, Y.-S
    • Journal of Advanced Marine Engineering and Technology
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    • v.28 no.2
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    • pp.367-375
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    • 2004
  • We have developed a highly efficient boiler system using the 2,600cc Diesel engine. In this system, the co-generation concept is utilized in that the electric power is produced by the generator connected to the engine, and waste heat is recovered from both the exhaust gases and the engine itself by the shell-and-tube heat exchangers. The heat exchanger connected to the engine outlet is specially designed such that it not only recovers waste heat effectively from the exhaust gases, but significantly reduces an engine noise. It is found that the total efficiency(thermal efficiency plus electric power generation efficiency) of this system reaches maximum 96.3% which is about 15% higher than the typical Diesel engine boiler system currently being used worldwide.

Modeling of Pulsed Laser Heating of Tissue: Implications or Skin Resurfacing (Pulsed Laser를 이용한 생체조직 가열을 위한 모델링 : Skin Resurfacing을 위한 연관성)

  • Kwon, Y.H.;Rastegar, S.
    • Proceedings of the KOSOMBE Conference
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    • v.1997 no.11
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    • pp.375-379
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    • 1997
  • Pulsed Er:YAG and $CO_2$ lasers induced temperature rise of tissue are studied using axisymmetric, two-dimensional, and transient Pennes' bio-heat equation or the implications of skin resurfacing. Model results indicate that Er:YAG laser induced temperature has much higher but more shallow distribution in tissue than that of the $CO_2$ laser because of its higher absorption coefficient. The increase of repetition rate does not affect the temperature rise too much because these laser modalities have much shorter heat diffusion time than the temporal length of each off-pulse. This model works as a tool to understand the photothermal effect in the laser-tissue interaction.

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