• 한국컴퓨터정보학회논문지
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• 제26권8호
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• pp.197-207
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• 2021

2형 당뇨병환자에서 골밀도는 다양하게 보고되고 있다. 최근의 여러 역학조사 연구에 의하면 2형 당뇨병 환자에서 골밀도 상태와 무관하게 골절 위험이 증가한다는 보고들이 많다. 본 연구에서는 전국민을 대상으로 한 표본조사로부터 얻은 질병관리본부의 국민건강영양조사 2008-2011년 자료를 이용하여 2형 당뇨병이 있는 50세 이상 남성 및 폐경후여성에서 골밀도를 확인하고자 하였다. 골다공증약물을 사용한 경우 및 당뇨병 이외에 골밀도에 영향을 미치는 질환 및 악성질환 등이 있는 대상은 제외하였다. 신체계측, 설문조사, 혈액검사 등과 함께 이중에너지흡수방사선을 이용하여 요추 및 대퇴골에서 측정한 골밀도 결과를 이용하였다. 연령, 체질량지수, 월 가구수입, 교육수준, 신체활동, 1일 칼슘섭취량, 혈중 비타민 D 농도를 포함하는 다중회귀분석을 시행한 결과 2형 당뇨병이 있는 50세 이상 남성 및 폐경후여성 모두에서 당뇨병이 없는 군과 비교하여 요추골밀도가 유의하게 높게 나타났다.

• Animal Bioscience
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• 제35권2호
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• pp.224-235
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• 2022

Objective: Cage rearing has critical implications for the laying duck industry because it is convenient for feeding and management. However, caging stress is a type of chronic stress that induces maladaptation. Environmental stress responses have been extensively studied, but no detailed information is available about the comprehensive changes in plasma metabolites at different stages of caging stress in ducks. We designed this experiment to analyze the effects of caging stress on performance parameters and oxidative stress indexes in ducks. Methods: Liquid chromatography tandem mass spectrometry (LC/MS-MS) was used to determine the changes in metabolites in duck plasma at 5 (CR5), 10 (CR10), and 15 (CR15) days after cage rearing and traditional breeding (TB). The associated pathways of differentially altered metabolites were analyzed using Kyoto encyclopedia of genes and genomes (KEGG) database. Results: The results of this study indicate that caging stress decreased performance parameters, and the plasma total superoxide dismutase levels were increased in the CR10 group compared with the other groups. In addition, 1,431 metabolites were detected. Compared with the TB group, 134, 381, and 190 differentially produced metabolites were identified in the CR5, CR10, and CR15 groups, respectively. The results of principal component analysis (PCA) show that the selected components sufficiently distinguish the TB group and CR10 group. KEGG analysis results revealed that the differentially altered metabolites in duck plasma from the CR5 and TB groups were mainly associated with ovarian steroidogenesis, biosynthesis of unsaturated fatty acids, and phenylalanine metabolism. Conclusion: In this study, the production performance, blood indexes, number of metabolites and PCA were compared to determine effect of the caging stress stage on ducks. We inferred from the experimental results that caging-stressed ducks were in the sensitive phase in the first 5 days after caging, caging for approximately 10 days was an important transition phase, and then the duck continually adapted.

• 척추신경추나의학회지
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• 제16권2호
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• pp.79-86
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• 2021

Objectives This study aimed to assess the role of complex Korean medicinal treatment with Chuna manual therapy in two patients with chronic pain after posterior lumbar fusion surgery. Methods A retrospective analysis was performed on 2 patients postoperatively based on their medical records. The surgery regions were verified using T2-weighted axial magnetic resonance imaging. Patients with chronic pain after spondylolisthesis posterior lumbar fusion surgery received complex Korean medicinal treatment with Chuna manual therapy during hospitalization. Numeric rating scale (NRS) in the degree of 0-10 and Oswestry disability index (ODI) were measured before and after treatment. Results Case 1 had an improved NRS score from 7 to 4, and Case 2 had an improved NRS score from 7 to 5. In addition, ODI score improved in both cases. Conclusions Complex Korean medicinal treatment with Chuna manual therapy is effective for relief from chronic pain after posterior lumbar fusion surgery.

• Journal of Ginseng Research
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• 제46권5호
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• pp.628-635
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• 2022

Background: Ulcerative colitis (UC) is the large intestine disease that results in chronic inflammation and ulcers in the colon. Rg3-enriched Korean Red Ginseng extract (Rg3-RGE) is known for its pharmacological activities. Persicaria tinctoria (PT) is also used in the treatment of various inflammatory diseases. The aim of this study is to investigate the attenuating effects of Rg3-RGE with PT on oxazolone (OXA)-induced UC in mice. Methods: A total of six groups of mice including control group, OXA (as model group, 1.5%) group, sulfasalazine (75 mg/kg) group, Rg3-RGE (20 mg/kg) group, PT (300 mg/kg) group, and Rg3-RGE (10 mg/kg) with PT (150 mg/kg) group. Data on the colon length, body weight, disease activity index (DAI), histological changes, nitric oxide (NO) assay, Real-time PCR of inflammatory factors, ELISA of inflammatory factors, Western blot, and flow cytometry analysis were obtained. Results: Overall, the combination treatment of Rg3-RGE and PT significantly improved the colon length and body weight and decreased the DAI in mice compared with the treatment with OXA. Additionally, the histological injury was also reduced by the combination treatment. Moreover, the NO production level and inflammatory mediators and cytokines were significantly downregulated in the Rg3-RGE with the PT group compared with the model group. Also, NLR family pyrin domain containing 3 (NLRP3) inflammasome and nuclear factor kappa B (NF-𝛋B) were suppressed in the combination treatment group compared with the OXA group. Furthermore, the number of immune cell subtypes of CD4⁺ T-helper cells, CD19⁺ B-cells, and CD4⁺ and CD25⁺ regulatory T-cells (Tregs) was improved in the Rg3-RGE with the PT group compared with the OXA group. Conclusion: Overall, the mixture of Rg3-RGE and PT is an effective therapeutic treatment for UC.

• 한국가정과교육학회지
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• 제33권2호
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• pp.45-56
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• 2021

본 연구는 국민건강영양조사 제 7기 2016년~2018년 자료를 활용하여, 만 12~18세 남녀 청소년 1,068을 대상으로 영양표시 이용여부에 따른 식습관 및 영양소 섭취와 건강행태 등을 비교하여 영양표시 이용과 올바른 식생활 관리를 위한 기초자료로 제공하고자 하였다. 본 연구결과 전체적으로 영양표시를 인지하는 비율은 91.9%였고, 이들 중 영양표시를 이용하는 청소년은 27.9%로 인지율에 비해 이용률이 낮았다. 아침결식률과 외식빈도, 음주, 흡연, 주관적 건강상태의 경우는 영양표시 이용군과 비이용군별 간에 유의적인 차이는 보이지 않았다. 영양소 섭취량의 경우 무기질인 칼슘, 인, 칼륨 섭취량은 이용군이 비이용군의 섭취량 보다 더 높게 나타났다(p<0.01). 영양표시 이용군에게서 섭취 영양소 중 단백질(p<0.05), 칼슘(p<0.01), 인(p<0.01), 칼륨(p<0.01)의 섭취기준 비율이 비이용군에 비해 높게 나타났다. EQ-5D index로 분석한 건강 관련 삶의 질 점수는 영양표시 이용군은 0.97점, 비이용군은 0.96점으로 영양표시 이용군의 삶의 질 점수가 비이용군 보다 더 높았다(p<0.001). 이상의 연구결과 청소년들의 식생활 개선과 영양표시제 관련 영양교육이 매우 필요하며, 청소년들의 합리적인 식품선택을 도와주고 영양표시 활용도를 높일 수 있는 체계적인 영양 교육이 이루어져야 한다. 따라서 본 연구는 청소년의 올바른 영양표시 이용과 식생활 관리를 위한 영양교육의 기초자료를 마련하는데 유용한 정보로 활용 될 수 있을 것으로 기대된다.

• 사상체질의학회지
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• 제13권3호
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• pp.59-74
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• 2001

In oriental medicine, food are regarded as important one like medicine. Especially Sasang medicine put emphasis on diet, it regarded food as a important one by taking food according to their own constitution in the point of improving health condition and preventing diseases. In this report, the author try to find out the relationship between food preference and each suitable food according to Sasang constitution by using survey data. The results are like this. 1. In constitutional distribution patterns among 203 person(male : 118 person, female : 85 person) reveal Soyang Group 58person(28.6%), Taeum Group 61(30%) and Soeum Group 84(41.4%). And their were no significant difference in their height in all group according to gender. Compared with the other groups, When compared with the other groups on body weight and BMI, Taeum Group indicate significantly high body weight and BMI(Body Mass Index) in both gender. 2. Taeum Group show significantly high smoking rate. But alcohol drinking rates reveal no significant difference in all groups. 3. In the Survey about food preference according to the constitution, rice, Soju, watermelon show significantly high preference in case of suitable food to each group. But perilla seeds, coffee, ginger tea show insignificant results. 4. In the survey about food preference according to the constitution and sex, welsh onion, crab preserved with soysauce, beer show significantly high preference in case of suitable food to each group. But glutinous rice, cooked barley, water dropwort muchim, lettuce, dog meat, egg, yellow croaker, coffee, ginger tea, and Soju show insignificant results. 5. In the survey about food preference according to the constitution and age, rice, watermelon, onion, garlic, salt and Soju show significantly high preference in case of suitable food to each group. But sugar and perilla seeds show insignificant results. 6. In the survey about food preference according to constitution, sex and age, glutinous rice, soybean milk, banana, crab preserved with soysauce, sea cucumber, sea mustard, Soju, beer, onion, garlic, salt show high preference in case of suitable food to each group. But cooked barley, sugar, water dropwort muchim, dog meat, puffer soup and perilla seeds show insignificant results.

• 사회복지연구
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• 제42권1호
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• pp.31-54
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• 2011

본 논문은 건강보험정책결정과정에서의 참여민주주의를 중심으로 김대중·노무현 정부 복지국가 성격을 연구하였다. 참여민주주의는 한국 민주주의의 질적 발전 보다는 외환위기 이후 자본주의 구조조정을 위한 정치적 정당성 확보 전략에 의해 도입되었다. 따라서 참여민주주의가 복지국가 발전의 한 지표인 보장성강화를 획득해내는데 긍정적인 역할을 하였음에도 불구하고 신자유주의적 이념 추구, 국가재정책임성 미약, 정책결정과정에 가입자의 실질적인 참여 배제로 2007년 보장성강화정책은 결국 실패로 돌아가게 되었다. 과거 복지제도와 마찬가지로 김대중·노무현 정부 참여민주주의제도도 정치적 정당성 확보를 위해 도입되었으나 경제성장우선이데올로기의 제약하에서 운영되었다고 볼 수 있다. 그러나 참여민주주의제도는 '서비스'가 아닌 '권력'형태의 제도라는 점, 참여민주주의제도로 인한 권력의 부여가 보장성 강화요구를 통해 복지국가 발전에 긍정적인 역할을 하였다는 사실로 미루어 볼 때 김대중·노무현 정부가 과거 복지국가와는 차별적이다.

• 한국지리정보학회지
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• 제27권2호
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• pp.1-18
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• 2024

본 연구는 서울시에서 도로 방향과 가로수 식재형태가 여름철 도시 열환경에 미치는 영향을 분석하여 최적의 식재방식을 찾는 것을 목표로 하였다. 컴퓨터 시뮬레이션 프로그램 ENVI-met을 이용하여, 도로 4방향과 가로수 식재형태에 따라 68가지 시나리오를 수행하였다. 그 결과, 수목 식재 시 기온, 평균복사온도, 인간 열환경지수가 개선되는 것으로 나타났다. 평균복사온도의 감소는 도로와 접한 건물에 의한 태양 복사에너지 차단과 수목의 그늘효과에 기인하였으며, 도로방향은 풍속 감소에 영향을 주는 것으로 나타났다. 모든 시나리오에서 낮은 수고(6m), 넓은 수관폭(9m), 높은 엽면적 지수(3.0), 좁은 식재간격(8m)일 때 가장 큰 열환경 개선효과를 보였다. 도로 방향은 동-서 방향의 북측 보도에서 열환경이 가장 크게 개선되었다. 본 연구는 컴퓨터 시뮬레이션을 이용해 현실도시공간과의 차이를 감안해야 하고, 현장 실측과 더 많은 변수 고려를 통한 추가연구가 필요하다.

• Korean Journal of Radiology
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• 제24권4호
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• pp.324-337
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• 2023

Objective: The objective of this study was to analyze the different brain oxygen metabolism statuses in preeclampsia using magnetic resonance imaging and investigate the factors that affect cerebral oxygen metabolism in preeclampsia. Materials and Methods: Forty-nine women with preeclampsia (mean age 32.4 years; range, 18-44 years), 22 pregnant healthy controls (PHCs) (mean age 30.7 years; range, 23-40 years), and 40 non-pregnant healthy controls (NPHCs) (mean age 32.5 years; range, 20-42 years) were included in this study. Brain oxygen extraction fraction (OEF) values were computed using quantitative susceptibility mapping (QSM) plus quantitative blood oxygen level-dependent magnitude-based OEF mapping (QSM + quantitative blood oxygen level-dependent imaging or QQ) obtained with a 1.5-T scanner. Voxel-based morphometry (VBM) was used to investigate the differences in OEF values in the brain regions among the groups. Results: Among the three groups, the average OEF values were significantly different in multiple brain areas, including the parahippocampus, multiple gyri of the frontal lobe, calcarine, cuneus, and precuneus (all P-values were less than 0.05, after correcting for multiple comparisons). The average OEF values of the preeclampsia group were higher than those of the PHC and NPHC groups. The bilateral superior frontal gyrus/bilateral medial superior frontal gyrus had the largest size of the aforementioned brain regions, and the OEF values in this area were 24.2 ± 4.6, 21.3 ± 2.4, and 20.6 ± 2.8 in the preeclampsia, PHC, and NPHC groups, respectively. In addition, the OEF values showed no significant differences between NPHC and PHC. Correlation analysis revealed that the OEF values of some brain regions (mainly involving the frontal, occipital, and temporal gyrus) were positively correlated with age, gestational week, body mass index, and mean blood pressure in the preeclampsia group (r = 0.361-0.812). Conclusion: Using whole-brain VBM analysis, we found that patients with preeclampsia had higher OEF values than controls.

• Korean Journal of Radiology
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• 제23권1호
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• pp.112-123
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• 2022

Objective: To investigate the relationship between ¹⁸F-FDG PET/CT semi-quantitative parameters and the International Association for the Study of Lung Cancer, American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) histopathologic classification, including histological subtypes, proliferation activity, and somatic mutations. Materials and Methods: This retrospective study included 419 patients (150 males, 269 females; median age, 59.0 years; age range, 23.0-84.0 years) who had undergone surgical removal of stage IA-IIIA lung adenocarcinoma and had preoperative PET/CT data of lung tumors. The maximum standardized uptake values (SUVmax), background-subtracted volume (BSV), and background-subtracted lesion activity (BSL) derived from PET/CT were measured. The IASLC/ATS/ERS subtypes, Ki67 score, and epidermal growth factor/anaplastic lymphoma kinase (EGFR/ALK) mutation status were evaluated. The PET/CT semi-quantitative parameters were compared between the tumor subtypes using the Mann-Whitney U test or the Kruskal-Wallis test. The optimum cutoff values of the PET/CT semi-quantitative parameters for distinguishing the IASLC/ATS/ERS subtypes were calculated using receiver operating characteristic curve analysis. The correlation between the PET/CT semi-quantitative parameters and pathological parameters was analyzed using Spearman's correlation. Statistical significance was set at p < 0.05. Results: SUVmax, BSV, and BSL values were significantly higher in invasive adenocarcinoma (IA) than in minimally IA (MIA), and the values were higher in MIA than in adenocarcinoma in situ (AIS) (all p < 0.05). Remarkably, an SUVmax of 0.90 and a BSL of 3.62 were shown to be the optimal cutoff values for differentiating MIA from AIS, manifesting as pure ground-glass nodules with 100% sensitivity and specificity. Metabolic-volumetric parameters (BSV and BSL) were better potential independent factors than metabolic parameters (SUVmax) in differentiating growth patterns. SUVmax and BSL, rather than BSV, were strongly or moderately correlated with Ki67 in most subtypes, except for the micropapillary and solid predominant groups. PET/CT parameters were not correlated with EGFR/ALK mutation status. Conclusion: As noninvasive surrogates, preoperative PET/CT semi-quantitative parameters could imply IASLC/ATS/ERS subtypes and Ki67 index and thus may contribute to improved management of precise surgery and postoperative adjuvant therapy.